{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:11:40Z","timestamp":1778623900868,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Anesthesia"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.jclinane.2019.109627","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T19:09:00Z","timestamp":1574363340000},"page":"109627","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Methadone versus morphine for postoperative pain in patients undergoing surgery for gynecological cancer: A randomized controlled clinical trial"],"prefix":"10.1016","volume":"61","author":[{"given":"Sebastiano","family":"Mercadante","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Villari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenza Manuela","family":"Spedale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Casuccio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jclinane.2019.109627_bb0005","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/S0140-6736(06)68700-X","article-title":"Persistent postsurgical pain: risk factors and prevention","volume":"367","author":"Kehlet","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jclinane.2019.109627_bb0010","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1213\/01.ane.0000268145.52345.55","article-title":"Pain management: a fundamental human right","volume":"105","author":"Brennan","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jclinane.2019.109627_bb0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.acpain.2005.02.001","article-title":"A survey of postoperative pain management in fourteen hospitals in the UK","volume":"7","author":"Moss","year":"2005","journal-title":"Acute Pain"},{"issue":"Suppl. 1","key":"10.1016\/j.jclinane.2019.109627_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00115550-200607001-00001","article-title":"Acute post-surgical pain management: a critical appraisal of current practice","volume":"31","author":"Rathmell","year":"2006","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.jclinane.2019.109627_bb0025","first-page":"188","article-title":"A review of postoperative pain management and the challenges","volume":"20","author":"Taylor","year":"2009","journal-title":"Curr Anaesth Crit Care"},{"key":"10.1016\/j.jclinane.2019.109627_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003348.pub2","article-title":"Patient controlled opioid analgesia versus conventional opioid analgesia for postoperative pain","author":"Hudcova","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jclinane.2019.109627_bb0035","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1213\/ANE.0b013e3181fec9a3","article-title":"Intraoperative methadone: rediscovery, reappraisal, and reinvigoration?","volume":"112","author":"Kharasch","year":"2011","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jclinane.2019.109627_bb0040","series-title":"Handbook of methadone prescribing and buprenorphine therapy","first-page":"81","article-title":"Intravenous use of methadone: efficacy and safety","author":"Mercadante","year":"2013"},{"key":"10.1016\/j.jclinane.2019.109627_bb0045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00000542-198407000-00005","article-title":"Postoperative pain control with methadone: influence of supplementary methadone doses and blood concentration--response relationships","volume":"61","author":"Gourlay","year":"1984","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2019.109627_bb0050","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0304-3959(90)91151-8","article-title":"Does intravenous methadone provide longer lasting analgesia than intravenous morphine?","volume":"42","author":"Gourlay","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.jclinane.2019.109627_bb0055","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/00000542-198603000-00004","article-title":"A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control","volume":"64","author":"Gourlay","year":"1986","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2019.109627_bb0060","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00000542-198407000-00005","article-title":"Postoperative pain control with methadone: influence of supplementary methadone doses and blood concentration\u2013response relationships","volume":"61","author":"Gourlay","year":"1984","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2019.109627_bb0065","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/clpt.1987.47","article-title":"Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain","volume":"41","author":"Inturrisi","year":"1987","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jclinane.2019.109627_bb0070","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/00000542-198212000-00005","article-title":"Pharmacodynamics and pharmacokinetics of methadone during the perioperative period","volume":"57","author":"Gourlay","year":"1982","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2019.109627_bb0075","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0304-3959(89)90233-9","article-title":"Does intravenous methadone provide longer lasting analgesia than intravenous morphine? A randomized, double-blind study","volume":"38","author":"Grochow","year":"1989","journal-title":"Pain"},{"key":"10.1016\/j.jclinane.2019.109627_bb0080","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/ALN.0b013e3181c38c25","article-title":"Incidence, reversal, and prevention of opioid-induced respiratory depression","volume":"112","author":"Dahan","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2019.109627_bb0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejphar.2015.10.049","article-title":"Opioid metabolism and clinical aspects","volume":"769","author":"Mercadante","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jclinane.2019.109627_bb0090","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/ALN.0b013e3181986a9a","article-title":"Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport. Insights from methadone interactions with ritonavir\/indinavir","volume":"110","author":"Kharasch","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2019.109627_bb0095","first-page":"505","article-title":"Methadone patient-controlled analgesia for postoperative pain: a randomized, controlled, double-blind study","volume":"28","author":"Neto","year":"2014","journal-title":"J Anesth"},{"key":"10.1016\/j.jclinane.2019.109627_bb0100","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1213\/ANE.0b013e3181d8a095","article-title":"Intraoperative methadone improves postoperative pain control in patients undergoing complex spine surgery","volume":"112","author":"Gottschalk","year":"2011","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jclinane.2019.109627_bb0105","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1097\/ALN.0000000000000633","article-title":"Intraoperative methadone for the prevention of postoperative pain: a randomized, double-blinded clinical trial in cardiac surgical patients","volume":"122","author":"Murphy","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2019.109627_bb0110","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1097\/ALN.0000000000001609","article-title":"Clinical effectiveness and safety of intraoperative methadone in patients undergoing posterior spinal fusion surgery: a randomized, double-blinded, controlled trial","volume":"126","author":"Murphy","year":"2017","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2019.109627_bb0115","doi-asserted-by":"crossref","DOI":"10.1177\/0269216311406577","article-title":"Conversion ratios for opioid switching in the treatment of cancer pain: a systematic review","volume":"25","author":"Mercadante","year":"2011","journal-title":"Palliat Med"},{"key":"10.1016\/j.jclinane.2019.109627_bb0120","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0952-8180(91)90007-A","article-title":"Postoperative pain control with methadone following lower abdominal surgery","volume":"3","author":"Richlin","year":"1991","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.jclinane.2019.109627_bb0125","doi-asserted-by":"crossref","DOI":"10.1177\/0310057X9202000109","article-title":"A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine","volume":"20","author":"Chui","year":"1992","journal-title":"Anaesth Intensive Care"}],"container-title":["Journal of Clinical Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952818019307433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952818019307433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:16:36Z","timestamp":1760606196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952818019307433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":25,"alternative-id":["S0952818019307433"],"URL":"https:\/\/doi.org\/10.1016\/j.jclinane.2019.109627","relation":{},"ISSN":["0952-8180"],"issn-type":[{"value":"0952-8180","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methadone versus morphine for postoperative pain in patients undergoing surgery for gynecological cancer: A randomized controlled clinical trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jclinane.2019.109627","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109627"}}