{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T06:52:17Z","timestamp":1794293537958,"version":"4.9.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Anesthesia"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.jclinane.2020.109910","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T18:01:51Z","timestamp":1590861711000},"page":"109910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["First experience with a ROTEM-enhanced transfusion algorithm in patients undergoing aortic arch replacement with frozen elephant trunk technique. A theranostic approach to patient blood management"],"prefix":"10.1016","volume":"66","author":[{"given":"Fabrizio","family":"Monaco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Nardelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Denaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bertoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Castiglioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Zangrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jclinane.2020.109910_bb0005","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1053\/j.semtcvs.2019.03.011","article-title":"Contemporary Management of Aortic Arch Aneurysm","volume":"31","author":"Rommens","year":"2019","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jclinane.2020.109910_bb0010","first-page":"531","article-title":"Aortic arch repair today: open repair is best for most arch lesions","volume":"56","author":"Coselli","year":"2015","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"10.1016\/j.jclinane.2020.109910_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5090\/kjtcs.2017.50.1.1","article-title":"The frozen elephant trunk technique: European Association for Cardio-Thoracic Surgery Position and Bologna Experience","volume":"50","author":"Di Marco","year":"2017","journal-title":"Korean J Thorac Cardiovasc Surg"},{"issue":"Suppl. 6","key":"10.1016\/j.jclinane.2020.109910_bb0020","doi-asserted-by":"crossref","first-page":"S508","DOI":"10.21037\/jtd.2017.04.67","article-title":"Intraoperative care for aortic surgery using circulatory arrest","volume":"9","author":"Fern\u00e1ndez Su\u00e1rez","year":"2017","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.jclinane.2020.109910_bb0025","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.athoracsur.2015.08.047","article-title":"Changes in the hemostatic system of patients with acute aortic dissection undergoing aortic arch surgery","volume":"101","author":"Guan","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jclinane.2020.109910_bb0030","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1053\/j.jvca.2017.04.014","article-title":"Surgical and clinical outcome REsearch (SCORE) group. Hemodilution on cardiopulmonary bypass: thromboelastography patterns and coagulation-related outcomes","volume":"31","author":"Ranucci","year":"2017","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.jclinane.2020.109910_bb0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-9560-1-3","article-title":"Thrombin generation during cardiopulmonary bypass: the possible role of retransfusion of blood aspirated from the surgical field","volume":"1","author":"Weerwind","year":"2003","journal-title":"Thromb J"},{"key":"10.1016\/j.jclinane.2020.109910_bb0040","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s12967-016-0986-6","article-title":"Impact of intra-operative cell salvage on blood coagulation in high-bleeding-risk patients undergoing cardiac surgery with cardiopulmonary bypass: a prospective randomized and controlled trial","volume":"14","author":"Shen","year":"2016","journal-title":"J Transl Med"},{"key":"10.1016\/j.jclinane.2020.109910_bb0045","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.jtcvs.2015.01.044","article-title":"The elephant trunk is freezing: the Hannover experience","volume":"149","author":"Shrestha","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jclinane.2020.109910_bb0050","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/ALN.0000000000000514","article-title":"Characterizing the epidemiology of postoperative transfusion-related acute lung injury","volume":"122","author":"Clifford","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2020.109910_bb0055","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/ALN.0000000000000513","article-title":"Characterizing the epidemiology of perioperative transfusion-associated circulatory overload","volume":"122","author":"Clifford","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2020.109910_bb0060","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.athoracsur.2013.08.016","article-title":"Blood transfusions in cardiac surgery: indications, risks, and conservation strategies","volume":"97","author":"Kilic","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jclinane.2020.109910_bb0065","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/ejcts\/ezx325","article-title":"2017 EACTS\/EASTANDARD Guidelines on patient blood management for adult cardiac surgery","volume":"53","author":"Pagano","year":"2018","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jclinane.2020.109910_bb0070","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/bja\/aex100","article-title":"Routine use of viscoelastic blood tests for diagnosis and treatment of coagulopathic bleeding in cardiac surgery: updated systematic review and meta-analysis","volume":"118","author":"Serraino","year":"2017","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jclinane.2020.109910_bb0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejvs.2019.02.009","article-title":"Editor\u2019s choice - a rotational thromboelastometry driven transfusion strategy reduces allogenic blood transfusion during open thoraco-abdominal aortic aneurysm repair: a propensity score matched study","volume":"58","author":"Monaco","year":"2019","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jclinane.2020.109910_bb0080","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/anae.14495","article-title":"Fibrinogen concentrate vs. fresh frozen plasma for the management of coagulopathy during thoraco-abdominal aortic aneurysm surgery: a pilot randomised controlled trial","volume":"74","author":"Morrison","year":"2019","journal-title":"Anaesthesia"},{"key":"10.1016\/j.jclinane.2020.109910_bb0085","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/anae.14695","article-title":"Treating hypofibrinogenaemia in major aortic surgery","volume":"74","author":"Monaco","year":"2019","journal-title":"Anaesthesia"},{"key":"10.1016\/j.jclinane.2020.109910_bb0090","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13054-015-1172-6","article-title":"Safety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery","volume":"20","author":"Cappabianca","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.jclinane.2020.109910_bb0095","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ejcts.2009.07.038","article-title":"Rotation thromboelastometry (ROTEM) stability and reproducibility over time","volume":"37","author":"Theusinger","year":"2010","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jclinane.2020.109910_bb0100","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13049-015-0165-4","article-title":"Effect of coagulation factor concentrate administration on ROTEM\u00ae parameters in major trauma","volume":"23","author":"Ponschab","year":"2015","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"10.1016\/j.jclinane.2020.109910_bb0105","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4097\/kja.19169","article-title":"The role of evidence-based algorithms for rotational thromboelastometry-guided bleeding management","volume":"72","author":"G\u00f6rlinger","year":"2019","journal-title":"Korean J Anesthesiol"},{"key":"10.1016\/j.jclinane.2020.109910_bb0110","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00000542-200101000-00007","article-title":"Tranexamic acid administration after cardiac surgery: a prospective, randomized, double-blind, placebo-controlled study","volume":"94","author":"Casati","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2020.109910_bb0115","doi-asserted-by":"crossref","first-page":"e467","DOI":"10.1016\/j.athoracsur.2017.07.022","article-title":"Custom-Made E-Vita Graft for Frozen Elephant Trunk With Arch-First Technique","volume":"104","author":"Bertoglio","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jclinane.2020.109910_bb0120","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ccc.2016.09.002","article-title":"Management of Trauma-Induced Coagulopathy with Thrombelastography","volume":"33","author":"Gonzalez","year":"2017","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.jclinane.2020.109910_bb0125","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1055\/s-0037-1599153","article-title":"Point-of-care coagulation testing in cardiac surgery","volume":"43","author":"Bolliger","year":"2017","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jclinane.2020.109910_bb0130","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.jtcvs.2010.04.043","article-title":"Thromboelastometrically guided transfusion protocol during aortic surgery with circulatory arrest: a prospective, randomized trial","volume":"140","author":"Girdauskas","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jclinane.2020.109910_bb0135","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0741-5214(97)70346-X","article-title":"Primary fibrinolysis during supraceliac aortic clamping","volume":"25","author":"Illig","year":"1997","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jclinane.2020.109910_bb0140","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.forsciint.2012.12.007","article-title":"Biochemical markers of fatal hypothermia","volume":"226","author":"Palmiere","year":"2013","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.jclinane.2020.109910_bb0145","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1067\/mtc.2002.120334","article-title":"Tissue factor as the main activator of the coagulation system during cardiopulmonary bypass","volume":"123","author":"De Somer","year":"2002","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jclinane.2020.109910_bb0150","series-title":"Global status report on blood safety and availability 2016","year":"2017"},{"key":"10.1016\/j.jclinane.2020.109910_bb0155","doi-asserted-by":"crossref","first-page":"565","DOI":"10.4103\/0019-5049.144657","article-title":"Coagulation testing in the perioperative period","volume":"58","author":"Thiruvenkatarajan","year":"2014","journal-title":"Indian J Anaesth"},{"key":"10.1016\/j.jclinane.2020.109910_bb0160","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1213\/ANE.0000000000003508","article-title":"Fibrinogen concentrate in cardiovascular surgery: a meta-analysis of randomized controlled trials","volume":"127","author":"Li","year":"2018","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jclinane.2020.109910_bb0165","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.athoracsur.2018.10.013","article-title":"Prothrombin complex concentrate in cardiac surgery: a systematic review and meta-analysis","volume":"107","author":"Roman","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jclinane.2020.109910_bb0170","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1053\/j.jvca.2017.06.026","article-title":"2017 EACTS\/EACTA Guidelines on patient blood management for adult cardiac surgery","volume":"32","author":"Task Force on Patient Blood Management for Adult Cardiac Surgery of the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Cardiothoracic Anaesthesiology (EACTA)","year":"2018","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.jclinane.2020.109910_bb0175","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1053\/j.jvca.2017.11.043","article-title":"Anemia and Patient Blood Management in Cardiac Surgery-Literature Review and Current Evidence","volume":"32","author":"Dhir","year":"2018","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.jclinane.2020.109910_bb0180","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1053\/j.jvca.2019.04.003","article-title":"Society of cardiovascular anesthesiologists clinical practice improvement advisory for management of perioperative bleeding and hemostasis in cardiac surgery patients","volume":"33","author":"Raphael","year":"2019","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.jclinane.2020.109910_bb0185","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/ejcts\/ezx218","article-title":"Single-centre experience with the frozen elephant trunk technique in 251 patients over 15 years","volume":"52","author":"Shrestha","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jclinane.2020.109910_bb0190","article-title":"Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults or children with bleeding","volume":"8","author":"Wikkels\u00f8","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jclinane.2020.109910_bb0195","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD007871.pub2","article-title":"Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion","volume":"3","author":"Afshari","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jclinane.2020.109910_bb0200","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1097\/ALN.0b013e31823497dd","article-title":"First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study","volume":"115","author":"G\u00f6rlinger","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2020.109910_bb0205","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/ejcts\/ezy313","volume":"55","author":"Czerny","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"issue":"3","key":"10.1016\/j.jclinane.2020.109910_bb0210","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/ALN.0b013e318264c644","article-title":"Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients","volume":"117","author":"Weber","year":"2012","journal-title":"Anesthesiology"}],"container-title":["Journal of Clinical Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952818020304049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952818020304049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:14:33Z","timestamp":1760606073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952818020304049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":42,"alternative-id":["S0952818020304049"],"URL":"https:\/\/doi.org\/10.1016\/j.jclinane.2020.109910","relation":{},"ISSN":["0952-8180"],"issn-type":[{"value":"0952-8180","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First experience with a ROTEM-enhanced transfusion algorithm in patients undergoing aortic arch replacement with frozen elephant trunk technique. A theranostic approach to patient blood management","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jclinane.2020.109910","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109910"}}