{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:45:02Z","timestamp":1791924302326,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009477","name":"Lottery Health Research","doi-asserted-by":"publisher","award":["LHR-2020-126227"],"award-info":[{"award-number":["LHR-2020-126227"]}],"id":[{"id":"10.13039\/501100009477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001511","name":"Auckland Medical Research Foundation","doi-asserted-by":"publisher","award":["8119004"],"award-info":[{"award-number":["8119004"]}],"id":[{"id":"10.13039\/501100001511","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001511","name":"Auckland Medical Research Foundation","doi-asserted-by":"publisher","award":["CRF-8119004"],"award-info":[{"award-number":["CRF-8119004"]}],"id":[{"id":"10.13039\/501100001511","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Anesthesia"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jclinane.2026.112261","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:07:21Z","timestamp":1781323641000},"page":"112261","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effect of midodrine on orthostatic intolerance after hip and knee arthroplasty: A randomized controlled trial (the MObILE study)"],"prefix":"10.1016","volume":"113","author":[{"given":"Monica","family":"Skarin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Collier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"McNair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Kluger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jclinane.2026.112261_bb0005","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1532-5415.1988.tb04375.x","article-title":"Physiology and complications of bed rest","volume":"36","author":"Harper","year":"1988","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.jclinane.2026.112261_bb0010","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1161\/CIRCULATIONAHA.104.482018","article-title":"Neurocardiogenic syncope and related disorders of orthostatic intolerance","volume":"111","author":"Grubb","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jclinane.2026.112261_bb0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"21","author":"Freeman","year":"2011","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.jclinane.2026.112261_bb0020","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/ALN.0b013e31829ce4ea","article-title":"Does goal-directed fluid therapy affect postoperative orthostatic intolerance?: a randomized trial","volume":"119","author":"Bundgaard-Nielsen","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2026.112261_bb0025","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/aas.13238","article-title":"Orthostatic intolerance in enhanced recovery laparoscopic colorectal resection","volume":"63","author":"Eriksen","year":"2019","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.jclinane.2026.112261_bb0030","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/EJA.0000000000000940","article-title":"Orthostatic intolerance following hip arthroplasty: incidence, risk factors and effect on length of stay: a prospective cohort study","volume":"36","author":"Skarin","year":"2019","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.jclinane.2026.112261_bb0035","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3109\/17453674.2011.636682","article-title":"Why still in hospital after fast-track hip and knee arthroplasty?","volume":"82","author":"Husted","year":"2011","journal-title":"Acta Orthop"},{"key":"10.1016\/j.jclinane.2026.112261_bb0040","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2106\/JBJS.22.00600","article-title":"Orthostatic intolerance-type events following hip and knee arthroplasty: a systematic review and meta-analysis","volume":"105","author":"de Campos","year":"2023","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jclinane.2026.112261_bb0045","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/j.arth.2022.01.035","article-title":"Incidence and risk factors of orthostasis after primary hip and knee arthroplasty","volume":"37","author":"Kurkis","year":"2022","journal-title":"J Arthroplast"},{"key":"10.1016\/j.jclinane.2026.112261_bb0050","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/aas.14098","article-title":"Orthostatic intolerance after fast-track knee arthroplasty: incidence and hemodynamic pathophysiology","volume":"66","author":"Hristovska","year":"2022","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.jclinane.2026.112261_bb0055","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/bja\/aep083","article-title":"Orthostatic intolerance and the cardiovascular response to early postoperative mobilization","volume":"102","author":"Bundgaard-Nielsen","year":"2009","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jclinane.2026.112261_bb0060","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/bja\/aer403","article-title":"Orthostatic intolerance during early mobilization after fast-track hip arthroplasty","volume":"108","author":"Jans","year":"2012","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jclinane.2026.112261_bb0065","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s12630-016-0734-7","article-title":"Postoperative orthostatic intolerance: a common perioperative problem with few available solutions","volume":"64","author":"Jans","year":"2017","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.jclinane.2026.112261_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.artd.2025.101905","article-title":"Avoiding orthostatic intolerance during early ambulation after total knee arthroplasty: the impact of lying-to-standing time","volume":"36","author":"Jaruthien","year":"2025","journal-title":"Arthroplast Today"},{"key":"10.1016\/j.jclinane.2026.112261_bb0075","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/aas.13108","article-title":"Effect of pre-operative methylprednisolone on orthostatic hypotension during early mobilization after total hip arthroplasty","volume":"62","author":"Lindberg-Larsen","year":"2018","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.jclinane.2026.112261_bb0080","first-page":"168","article-title":"New horizons in orthostatic hypotension","volume":"46","author":"Frith","year":"2017","journal-title":"Age Ageing"},{"key":"10.1016\/j.jclinane.2026.112261_bb0085","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1097\/ALN.0000000000000890","article-title":"Oral midodrine hydrochloride for prevention of orthostatic hypotension during early mobilization after hip arthroplasty: a randomized, double-blind, placebo-controlled trial","volume":"123","author":"Jans","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2026.112261_bb0090","article-title":"Blood pressure and early mobilization after total hip and knee replacements: a pilot study on the impact of midodrine hydrochloride","volume":"4","author":"Smits","year":"2019","journal-title":"JB JS Open Access"},{"key":"10.1016\/j.jclinane.2026.112261_bb0095","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/0310057X241290536","article-title":"A randomised trial to assess the impact of midodrine on early mobilisation after elective primary hip replacement surgery","volume":"53","author":"Cammerman","year":"2025","journal-title":"Anaesth Intensive Care"},{"key":"10.1016\/j.jclinane.2026.112261_bb0100","author":"U.S Food and Drug Administration"},{"key":"10.1016\/j.jclinane.2026.112261_bb0105","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/bja\/aer394","article-title":"Investigation of the agreement of a continuous non-invasive arterial pressure device in comparison with invasive radial artery measurement","volume":"108","author":"Ilies","year":"2012","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jclinane.2026.112261_bb0110","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/bja\/aer499","article-title":"Clinical validation of a continuous non-invasive haemodynamic monitor (CNAP™ 500) during general anaesthesia","volume":"108","author":"Hahn","year":"2012","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jclinane.2026.112261_bb0115","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1042\/CS20060091","article-title":"Initial orthostatic hypotension: review of a forgotten condition","volume":"112","author":"Wieling","year":"2007","journal-title":"Clin Sci"},{"key":"10.1016\/j.jclinane.2026.112261_bb0120","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1093\/brain\/awp179","article-title":"Symptoms and signs of syncope: a review of the link between physiology and clinical clues","volume":"132","author":"Wieling","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.jclinane.2026.112261_bb0125","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1097\/HJH.0b013e32832b1145","article-title":"The consensus statement on the definition of orthostatic hypotension: a revisit after 13 years","volume":"27","author":"Wieling","year":"2009","journal-title":"J Hypertens"},{"key":"10.1016\/j.jclinane.2026.112261_bb0130","author":"Faculty of Pain Medicine Australian and New Zeland College of Anaesthetists"},{"key":"10.1016\/j.jclinane.2026.112261_bb0135","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2288-12-96","article-title":"A review of the reporting and handling of missing data in cohort studies with repeated assessment of exposure measures","volume":"12","author":"Karahalios","year":"2012","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.jclinane.2026.112261_bb0140","author":"International Council for Harmonisation"},{"key":"10.1016\/j.jclinane.2026.112261_bb0145","series-title":"Common Terminology Criteria for Adverse Events (CTCAE) version 5.0","author":"U.S. Department of Health and Human Services","year":"2017"},{"key":"10.1016\/j.jclinane.2026.112261_bb0150","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.clinthera.2008.09.001","article-title":"Pharmacokinetic and pharmacodynamic effects of midodrine on blood pressure, the autonomic nervous system, and plasma natriuretic peptides: a prospective, randomized, single-blind, two-period, crossover, placebo-controlled study","volume":"30","author":"Lamarre-Cliche","year":"2008","journal-title":"Clin Ther"},{"key":"10.1016\/j.jclinane.2026.112261_bb0155","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1212\/WNL.51.1.120","article-title":"A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension","volume":"51","author":"Wright","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.jclinane.2026.112261_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12893-023-02015-5","article-title":"Prevalence and associated factors of postoperative orthostatic intolerance at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2022: cross sectional study","volume":"23","author":"Gobezie","year":"2023","journal-title":"BMC Surg"},{"key":"10.1016\/j.jclinane.2026.112261_bb0165","article-title":"Feasibility of repeated early mobilization in orthostatic intolerance after total hip arthroplasty","volume":"57","author":"Frandsen","year":"2025","journal-title":"Int J Orthop Trauma Nurs"},{"key":"10.1016\/j.jclinane.2026.112261_bb0170","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/joim.12021","article-title":"Syndromes of orthostatic intolerance: a hidden danger","volume":"273","author":"Fedorowski","year":"2013","journal-title":"J Intern Med"},{"key":"10.1016\/j.jclinane.2026.112261_bb0175","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1161\/HYPERTENSIONAHA.119.13619","article-title":"Symptom recognition is impaired in patients with orthostatic hypotension","volume":"75","author":"Freeman","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.jclinane.2026.112261_bb0180","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.arth.2008.09.025","article-title":"Postoperative patient falls on an orthopedic inpatient unit","volume":"25","author":"Ackerman","year":"2010","journal-title":"J Arthroplast"},{"key":"10.1016\/j.jclinane.2026.112261_bb0185","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2519\/jospt.2013.4349","article-title":"Falls among patients who had elective orthopaedic surgery: a decade of experience from a musculoskeletal specialty hospital","volume":"43","author":"Mandl","year":"2013","journal-title":"J Orthop Sports Phys Ther"},{"key":"10.1016\/j.jclinane.2026.112261_bb0190","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1744-9987.2007.00455.x","article-title":"Midodrine hydrochloride and L-threo-3,4-dihydroxy-phenylserine preserve cerebral blood flow in hemodialysis patients with orthostatic hypotension","volume":"11","author":"Fujisaki","year":"2007","journal-title":"Ther Apher Dial"},{"key":"10.1016\/j.jclinane.2026.112261_bb0195","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.036752","article-title":"Cerebral blood flow in orthostatic intolerance","volume":"14","author":"Khan","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jclinane.2026.112261_bb0200","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s10286-019-00606-y","article-title":"A practical guide to active stand testing and analysis using continuous beat-to-beat non-invasive blood pressure monitoring","volume":"29","author":"Finucane","year":"2019","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.jclinane.2026.112261_bb0205","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1302\/2633-1462.511.BJO-2024-0125.R1","article-title":"Day-case success or why still in hospital after total hip, total knee, and medial unicompartmental knee arthroplasties?","volume":"5","author":"Danielsen","year":"2024","journal-title":"Bone Jt Open"},{"key":"10.1016\/j.jclinane.2026.112261_bb0210","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1302\/0301-620X.107B10.BJJ-2025-0066.R1","article-title":"Trends in day-case hip and knee replacement in England: an analysis of National Joint Registry and hospital episode statistics data","volume":"107-B","author":"French","year":"2025","journal-title":"Bone Joint J"}],"updated-by":[{"DOI":"10.1016\/j.jclinane.2026.112264","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000}},{"DOI":"10.1016\/j.jclinane.2026.112264","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000}}],"container-title":["Journal of Clinical Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095281802600139X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095281802600139X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:50:12Z","timestamp":1791921012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095281802600139X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":42,"alternative-id":["S095281802600139X"],"URL":"https:\/\/doi.org\/10.1016\/j.jclinane.2026.112261","relation":{},"ISSN":["0952-8180"],"issn-type":[{"value":"0952-8180","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of midodrine on orthostatic intolerance after hip and knee arthroplasty: A randomized controlled trial (the MObILE study)","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jclinane.2026.112261","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112261"}}