{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:20:41Z","timestamp":1781756441958,"version":"3.54.5"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":1902,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.jcmg.2008.04.001","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T15:28:46Z","timestamp":1211383726000},"page":"343-350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"title":["Limb Stress-Rest Perfusion Imaging With Contrast Ultrasound for the Assessment of Peripheral Arterial Disease Severity"],"prefix":"10.1016","volume":"1","author":[{"given":"Jonathan R.","family":"Lindner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Womack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene J.","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Weltman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Harthun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Kaul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Patrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2008.04.001_bib1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2214\/ajr.166.2.8553930","article-title":"Intraarterial pressure measurements during angiographic evaluation of peripheral vascular disease: techniques, interpretation, applications, limitations","volume":"166","author":"Kinney","year":"1996","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.jcmg.2008.04.001_bib2","first-page":"250","article-title":"Critical arterial stenosis","volume":"54","author":"May","year":"1963","journal-title":"Surgery"},{"key":"10.1016\/j.jcmg.2008.04.001_bib3","first-page":"200","article-title":"Impact of atherosclerotic risk factors on the anatomical distribution of peripheral vascular disease","volume":"20","author":"Haltmayer","year":"2001","journal-title":"Int Angiol"},{"key":"10.1016\/j.jcmg.2008.04.001_bib4","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0735-1097(95)00522-6","article-title":"Impaired nitric oxide-mediated vasodilation in patients with non-insulin dependent diabetes mellitus","volume":"27","author":"Williams","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2008.04.001_bib5","first-page":"E714","article-title":"Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound","volume":"282","author":"Dawson","year":"2002","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jcmg.2008.04.001_bib6","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1161\/CIRCULATIONAHA.104.481515","article-title":"Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression","volume":"111","author":"Leong Poi","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2008.04.001_bib7","first-page":"E123","article-title":"Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin","volume":"285","author":"Vincent","year":"2003","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jcmg.2008.04.001_bib8","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.2337\/db05-1373","article-title":"Obesity blunts insulin-mediated microvascular recruitment in human forearm skeletal muscle","volume":"55","author":"Clerk","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.jcmg.2008.04.001_bib9","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1249\/00005768-199104000-00003","article-title":"Progressive versus single-stage treadmill tests for evaluation of claudication","volume":"23","author":"Gardner","year":"1991","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jcmg.2008.04.001_bib10","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S1051-0443(07)61300-1","article-title":"Noninvasive vascular laboratory for evaluation of peripheral vascular occlusive disease: Part II","volume":"11","author":"Rose","year":"2000","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.jcmg.2008.04.001_bib11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.CIR.97.5.473","article-title":"Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion","volume":"97","author":"Wei","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2008.04.001_bib12","series-title":"Modeling Survival Data: Extending the Cox Model","author":"Therneau","year":"2000"},{"key":"10.1016\/j.jcmg.2008.04.001_bib13","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1002\/sim.2161","article-title":"Small-sample performance of the robust score test and its modifications in generalized estimating equations","volume":"24","author":"Guo","year":"2005","journal-title":"Stat Med"},{"key":"10.1016\/j.jcmg.2008.04.001_bib14","series-title":"Generalized Estimating Equations","author":"Hardin","year":"2003"},{"key":"10.1016\/j.jcmg.2008.04.001_bib15","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1001\/archinte.165.4.442","article-title":"Pulse oximetry as a potential screening tool for lower extremity arterial disease in asymptomatic patients with diabetes mellitus","volume":"165","author":"Parameswaran","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jcmg.2008.04.001_bib16","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.2337\/diacare.28.9.2206","article-title":"An evaluation of the efficacy of methods used in screening for lower-limb arterial disease in diabetes","volume":"28","author":"Williams","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcmg.2008.04.001_bib17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2337\/diacare.25.1.113","article-title":"Peripheral artery disease, diabetes, and reduced lower extremity functioning","volume":"25","author":"Dolan","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcmg.2008.04.001_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0140-6736(02)09327-3","article-title":"MRC\/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial","volume":"360","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jcmg.2008.04.001_bib19","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.2337\/diacare.27.12.2843","article-title":"Peripheral arterial disease, diabetes, and mortality","volume":"27","author":"Leibson","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcmg.2008.04.001_bib20","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/CIRCULATIONAHA.105.570903","article-title":"Mortality and cardiovascular risk across the ankle-arm index spectrum","volume":"113","author":"O'Hare","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2008.04.001_bib21","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1001\/jama.286.11.1317","article-title":"Peripheral arterial disease detection, awareness, and treatment in primary care","volume":"286","author":"Hirsch","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jcmg.2008.04.001_bib22","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1161\/CIRCULATIONAHA.105.548099","article-title":"Exertional leg pain in patients with and without peripheral arterial disease","volume":"112","author":"Wang","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2008.04.001_bib23","doi-asserted-by":"crossref","first-page":"873","DOI":"10.7326\/0003-4819-136-12-200206180-00008","article-title":"The ankle brachial index is associated with leg function and physical activity: the walking and leg circulation study","volume":"136","author":"McDermott","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jcmg.2008.04.001_bib24","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0140-6736(02)09670-8","article-title":"Therapeutic Angiogenesis using Cell Transplantation (TACT) Study Investigators","volume":"360","author":"Tateishi-Yuyama","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jcmg.2008.04.001_bib25","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1161\/CIRCULATIONAHA.106.644203","article-title":"Unblinded pilot study of autologous transplantation of bone marrow mononuclear cells in patients with thromboangiitis obliterans","volume":"114","author":"Miyamoto","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2008.04.001_bib26","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.jacc.2004.11.045","article-title":"Detection of peripheral vascular stenosis by assessing skeletal muscle flow reserve","volume":"45","author":"Bragadeesh","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2008.04.001_bib27","first-page":"43","article-title":"Exercise and insulin-mediated capillary recruitment in muscle","volume":"33","author":"Rattigan","year":"2005","journal-title":"Exerc Sport Sci Rev"},{"key":"10.1016\/j.jcmg.2008.04.001_bib28","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1056\/NEJM198805193182005","article-title":"Impaired neurogenic vascular responses in patients with diabetes and neuropathic foot lesions","volume":"318","author":"Parkhouse","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcmg.2008.04.001_bib29","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/eurheartj\/ehi636","article-title":"Contrast ultrasound perfusion imaging of lower extremeties in peripheral arterial disease: a novel diagnostic method","volume":"27","author":"Duerschmeid","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2008.04.001_bib30","series-title":"Nuclear Cardiology: State of the Art and Future Directions","first-page":"3","article-title":"Principles of tracer kinetics","author":"Bassingthwaighte","year":"1996"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X08001009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X08001009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:35:28Z","timestamp":1761845728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X08001009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S1936878X08001009"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2008.04.001","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Limb Stress-Rest Perfusion Imaging With Contrast Ultrasound for the Assessment of Peripheral Arterial Disease Severity","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2008.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}