{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:52:18Z","timestamp":1785912738341,"version":"3.56.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["R01 NS36286"],"award-info":[{"award-number":["R01 NS36286"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["R37 NS29993"],"award-info":[{"award-number":["R37 NS29993"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.jcmg.2012.10.019","type":"journal-article","created":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T16:25:18Z","timestamp":1362414318000},"page":"313-323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":118,"title":["LA Volumes and Reservoir Function Are Associated With Subclinical Cerebrovascular Disease"],"prefix":"10.1016","volume":"6","author":[{"given":"Cesare","family":"Russo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhezhen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin","family":"Tugcu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Yoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S.V.","family":"Elkind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Rundek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton B.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph L.","family":"Sacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco R.","family":"Di Tullio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2012.10.019_bib1","first-page":"e2","article-title":"Heart disease and stroke statistics\u20142012 update: a report from the American Heart Association","volume":"125","author":"Roger","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2012.10.019_bib2","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1056\/NEJMoa070972","article-title":"Incidental findings on brain MRI in the general population","volume":"357","author":"Vernooij","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcmg.2012.10.019_bib3","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1212\/WNL.0b013e31821f4472","article-title":"Lower prevalence of silent brain infarcts in the physically active: the Northern Manhattan Study","volume":"76","author":"Willey","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.jcmg.2012.10.019_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/hs0102.101629","article-title":"Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study","volume":"33","author":"Vermeer","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.jcmg.2012.10.019_bib5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.neurobiolaging.2004.05.004","article-title":"Measures of brain morphology and infarction in the framingham heart study: establishing what is normal","volume":"26","author":"Decarli","year":"2005","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jcmg.2012.10.019_bib6","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/01.STR.29.5.913","article-title":"Cigarette smoking and other risk factors for silent cerebral infarction in the general population","volume":"29","author":"Howard","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.jcmg.2012.10.019_bib7","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/01.STR.26.7.1171","article-title":"White matter hyperintensities on MRI in the neurologically nondiseased elderly","volume":"26","author":"Ylikoski","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.jcmg.2012.10.019_bib8","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1161\/01.STR.28.6.1158","article-title":"Silent brain infarction on magnetic resonance imaging and neurological abnormalities in community-dwelling older adults","volume":"28","author":"Price","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.jcmg.2012.10.019_bib9","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1161\/01.STR.0000165923.02318.22","article-title":"Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study","volume":"36","author":"Wright","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.jcmg.2012.10.019_bib10","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1161\/01.STR.0000068408.82115.D2","article-title":"Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study","volume":"34","author":"Vermeer","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.jcmg.2012.10.019_bib11","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/01.STR.0000132193.35955.69","article-title":"White matter hyperintensity on cranial magnetic resonance imaging: a predictor of stroke","volume":"35","author":"Kuller","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.jcmg.2012.10.019_bib12","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1212\/01.WNL.0000165985.97397.88","article-title":"Cerebral MRI findings and cognitive functioning: the Atherosclerosis Risk in Communities Study","volume":"64","author":"Mosley","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.jcmg.2012.10.019_bib13","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1212\/WNL.57.7.1222","article-title":"Silent MRI infarcts and the risk of future stroke: the cardiovascular health study","volume":"57","author":"Bernick","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.jcmg.2012.10.019_bib14","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1161\/01.STR.28.10.1932","article-title":"Subcortical silent brain infarction as a risk factor for clinical stroke","volume":"28","author":"Kobayashi","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.jcmg.2012.10.019_bib15","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa022066","article-title":"Silent brain infarcts and the risk of dementia and cognitive decline","volume":"348","author":"Vermeer","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcmg.2012.10.019_bib16","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1161\/01.CIR.92.4.835","article-title":"Left atrial size and the risk of stroke and death","volume":"92","author":"Benjamin","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2012.10.019_bib17","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1161\/01.STR.30.10.2019","article-title":"Left atrial size and the risk of ischemic stroke in an ethnically mixed population","volume":"30","author":"Di Tullio","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.jcmg.2012.10.019_bib18","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ahj.2005.04.031","article-title":"Left atrial diameter as an independent predictor of first clinical cardiovascular events in middle-aged and elderly adults: the Strong Heart Study (SHS)","volume":"151","author":"Kizer","year":"2006","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcmg.2012.10.019_bib19","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jacc.2005.08.077","article-title":"Prediction of cardiovascular outcomes with left atrial size: is volume superior to area or diameter?","volume":"47","author":"Tsang","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2012.10.019_bib20","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.amjcard.2008.01.051","article-title":"Left atrial reservoir function as a potent marker for first atrial fibrillation or flutter in persons > or = 65 years of age","volume":"101","author":"Abhayaratna","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcmg.2012.10.019_bib21","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/ejechocard\/jen235","article-title":"Minimum vs. maximum left atrial volume for prediction of first atrial fibrillation or flutter in an elderly cohort: a prospective study","volume":"10","author":"Fatema","year":"2009","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.jcmg.2012.10.019_bib22","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1016\/j.jacc.2009.07.047","article-title":"Improving global vascular risk prediction with behavioral and anthropometric factors: the multiethnic NOMAS (Northern Manhattan Cohort Study)","volume":"54","author":"Sacco","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2012.10.019_bib23","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","article-title":"Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group","volume":"18","author":"Lang","year":"2005","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jcmg.2012.10.019_bib24","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/01.CIR.55.4.613","article-title":"Echocardiographic determination of left ventricular mass in man","volume":"55","author":"Devereux","year":"1977","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2012.10.019_bib25","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.jacc.2010.10.042","article-title":"Effect of obesity and overweight on left ventricular diastolic function: a community-based study in an elderly cohort","volume":"57","author":"Russo","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2012.10.019_bib26","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.echo.2010.06.010","article-title":"Comparison of echocardiographic single-plane versus biplane method in the assessment of left atrial volume and validation by real time three-dimensional echocardiography","volume":"23","author":"Russo","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jcmg.2012.10.019_bib27","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1136\/heartjnl-2011-301388","article-title":"Left atrial minimum volume and reservoir function as correlates of left ventricular diastolic function: impact of left ventricular systolic function","volume":"98","author":"Russo","year":"2012","journal-title":"Heart"},{"key":"10.1016\/j.jcmg.2012.10.019_bib28","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/01.STR.0000052631.98405.15","article-title":"Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study","volume":"34","author":"Vermeer","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.jcmg.2012.10.019_bib29","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1161\/01.CIR.92.4.835","article-title":"Left atrial size and the risk of stroke and death","volume":"92","author":"Benjamin","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2012.10.019_bib30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00019052-200102000-00012","article-title":"Silent stroke: pathogenesis, genetic factors and clinical implications as a risk factor","volume":"14","author":"Masuda","year":"2001","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.jcmg.2012.10.019_bib31","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1212\/WNL.43.9.1683","article-title":"Pathologic correlates of incidental MRI white matter signal hyperintensities","volume":"43","author":"Fazekas","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.jcmg.2012.10.019_bib32","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/brain\/114.2.761","article-title":"Periventricular lesions in the white matter on magnetic resonance imaging in the elderly","volume":"114","author":"van Swieten","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.jcmg.2012.10.019_bib33","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1161\/01.HYP.0000145857.98904.20","article-title":"The association between blood pressure, hypertension, and cerebral white matter lesions: cardiovascular determinants of dementia study","volume":"44","author":"van Dijk","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.jcmg.2012.10.019_bib34","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1097\/HJH.0b013e3283232c96","article-title":"Detection of silent cerebrovascular disease refines risk stratification of hypertensive patients","volume":"27","author":"Henskens","year":"2009","journal-title":"J Hypertens"},{"key":"10.1016\/j.jcmg.2012.10.019_bib35","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1291\/hypres.27.747","article-title":"Smoking is associated with silent cerebrovascular disease in a high-risk Japanese community-dwelling population","volume":"27","author":"Eguchi","year":"2004","journal-title":"Hypertens Res"},{"key":"10.1016\/j.jcmg.2012.10.019_bib36","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1001\/archneur.65.5.642","article-title":"Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study","volume":"65","author":"Seshadri","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jcmg.2012.10.019_bib37","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/01.STR.31.2.425","article-title":"Aortic atherosclerosis at middle age predicts cerebral white matter lesions in the elderly","volume":"31","author":"de Leeuw","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.jcmg.2012.10.019_bib38","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/01.ATV.19.2.356","article-title":"Relationships of cerebral MRI findings to ultrasonographic carotid atherosclerosis in older adults: the Cardiovascular Health Study","volume":"19","author":"Manolio","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcmg.2012.10.019_bib39","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1161\/01.CIR.96.7.2455","article-title":"Incidence of and risk factors for atrial fibrillation in older adults","volume":"96","author":"Psaty","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2012.10.019_bib40","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0002-9149(99)80100-3","article-title":"Clinical and echocardiographic features of intermittent atrial fibrillation that predict recurrent atrial fibrillation","volume":"76","author":"Flaker","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcmg.2012.10.019_bib41","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1016\/0735-1097(93)90787-2","article-title":"Estimation of left ventricular filling pressures using two-dimensional and Doppler echocardiography in adult patients with cardiac disease","volume":"22","author":"Appleton","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2012.10.019_bib42","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/01.CIR.100.4.427","article-title":"Left atrial relaxation and left ventricular systolic function determine left atrial reservoir function","volume":"100","author":"Barbier","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2012.10.019_bib43","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/ejechocard\/jep198","article-title":"Long-term prognostic significance of three-dimensional echocardiographic parameters of the left ventricle and left atrium","volume":"11","author":"Caselli","year":"2010","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.jcmg.2012.10.019_bib44","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1476-7120-7-16","article-title":"Left atrial volume measurement with automated border detection by 3-dimensional echocardiography: comparison with magnetic resonance imaging","volume":"7","author":"Artang","year":"2009","journal-title":"Cardiovasc Ultrasound"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X12010042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X12010042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:39:35Z","timestamp":1761845975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X12010042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S1936878X12010042"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2012.10.019","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LA Volumes and Reservoir Function Are Associated With Subclinical Cerebrovascular Disease","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2012.10.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}