{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:56:14Z","timestamp":1776923774596,"version":"3.51.2"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Astellas Pharma Inc.;"},{"DOI":"10.13039\/100015703","name":"Philips Research North America","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015703","id-type":"DOI","asserted-by":"crossref"}]},{"name":"General Electric Global Research"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.jcmg.2014.10.014","type":"journal-article","created":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T17:20:13Z","timestamp":1427390413000},"page":"389-396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Prognostic Value of Echocardiographic Calcium Score in Patients With a Clinical Indication for Stress Echocardiography"],"prefix":"10.1016","volume":"8","author":[{"given":"Nicola","family":"Gaibazzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eustachio","family":"Agricola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Cioffi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine","family":"Mazzone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Lorenzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Albertini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Faden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Chamsi Pasha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bipul","family":"Biabhav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damiano","family":"Regazzoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Di Lenarda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pompilio","family":"Faggiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2014.10.014_bib1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jacc.2006.10.001","volume":"49","author":"Greenland","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2014.10.014_bib2","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1056\/NEJMoa071513","article-title":"Estrogen therapy and coronary-artery calcification","volume":"356","author":"Manson","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmg.2014.10.014_bib3","doi-asserted-by":"crossref","first-page":"438","DOI":"10.7326\/0003-4819-156-6-201203200-00006","article-title":"Evaluation of newer risk markers for coronary heart disease risk classification: a cohort study","volume":"156","author":"Kavousi","year":"2012","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jcmg.2014.10.014_bib4","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/jama.2012.9624","article-title":"Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals","volume":"308","author":"Yeboah","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.jcmg.2014.10.014_bib5","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1093\/eurheartj\/ehs092","volume":"33","author":"Perk","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2014.10.014_bib6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1056\/NEJM199907153410302","article-title":"Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly","volume":"341","author":"Otto","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmg.2014.10.014_bib7","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1161\/01.CIR.0000058168.26163.BC","article-title":"Mitral annular calcification predicts cardiovascular morbidity and mortality: the Framingham Heart Study","volume":"107","author":"Fox","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2014.10.014_bib8","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jcmg.2008.07.006","article-title":"Impact of\u00a0mitral annular calcification on cardiovascular events in a multiethnic community: the Northern Manhattan Study","volume":"1","author":"Kohsaka","year":"2008","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2014.10.014_bib9","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.amjcard.2011.11.043","article-title":"Mitral annular calcium, inducible myocardial ischemia, and cardiovascular events in outpatients with coronary heart disease (from the Heart and Soul Study)","volume":"109","author":"Holtz","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcmg.2014.10.014_bib10","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/S0735-1097(01)01678-3","article-title":"Association of mitral annulus calcification, aortic valve sclerosis and aortic root calcification with abnormal myocardial perfusion single photon emission tomography in subjects age > 65 years old","volume":"38","author":"Jeon","year":"2001","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2014.10.014_bib11","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.amjcard.2008.12.031","article-title":"Usefulness of echocardiographic assessment of cardiac and ascending aorta calcific deposits to predict coronary artery calcium and presence and severity of obstructive coronary artery disease","volume":"103","author":"Nucifora","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcmg.2014.10.014_bib12","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ijcard.2014.01.024","article-title":"Aortic valve sclerosis as a marker of coronary artery atherosclerosis; a multicenter study of a large population with a low prevalence of coronary artery disease","volume":"172","author":"Rossi","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcmg.2014.10.014_bib13","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ijcard.2009.06.057","article-title":"Can total cardiac calcium predict the coronary calcium score?","volume":"146","author":"Pressman","year":"2011","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcmg.2014.10.014_bib14","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.amjcard.2005.11.065","article-title":"Cardiovascular morbidity and mortality in community-dwelling elderly individuals with calcification of the fibrous skeleton of the base of the heart and aortosclerosis (The Cardiovascular Health Study)","volume":"97","author":"Barash","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcmg.2014.10.014_bib15","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.atherosclerosis.2009.10.030","article-title":"Heart valve sclerosis predicts all-cause and cardiovascular mortality","volume":"209","author":"V\u00f6lzke","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jcmg.2014.10.014_bib16","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.ijcard.2013.10.081","article-title":"Impact of aortic or mitral valve sclerosis and calcification on cardiovascular events and mortality: a meta-analysis","volume":"170","author":"Pradelli","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcmg.2014.10.014_bib17","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.2337\/dc12-0134","article-title":"Aortic and mitral annular calcifications are predictive of all-cause and cardiovascular mortality in patients with type 2 diabetes","volume":"35","author":"Rossi","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcmg.2014.10.014_bib18","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ijcard.2014.04.007","article-title":"Cardiac calcification at transthoracic echocardiography predicts stress echo results: a multicentre study","volume":"174","author":"Gaibazzi","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcmg.2014.10.014_bib19","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0735-1097(99)00250-8","article-title":"Cause of death in clinical research: time for a reassessment?","volume":"34","author":"Lauer","year":"1999","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2014.10.014_bib20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/sim.2929","article-title":"Evaluating the added predictive ability of a\u00a0new marker: from area under the ROC curve to reclassification and beyond","volume":"27","author":"Pencina","year":"2008","journal-title":"Stat Med"},{"key":"10.1016\/j.jcmg.2014.10.014_bib21","doi-asserted-by":"crossref","first-page":"dju041","DOI":"10.1093\/jnci\/dju041","article-title":"Net risk reclassification p values: valid or misleading?","volume":"106","author":"Pepe","year":"2014","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.jcmg.2014.10.014_bib22","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1002\/sim.5804","article-title":"A\u00a0note on the evaluation of\u00a0novel biomarkers: do not rely on integrated discrimination improvement and net reclassification index","volume":"33","author":"Hilden","year":"2014","journal-title":"Stat Med"},{"key":"10.1016\/j.jcmg.2014.10.014_bib23","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/CIRCULATIONAHA.109.912568","article-title":"Assessing the role of circulating, genetic, and imaging biomarkers in cardiovascular risk prediction","volume":"123","author":"Wang","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2014.10.014_bib24","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/aje\/kws207","article-title":"Interpreting incremental value of markers added to risk prediction models","volume":"176","author":"Pencina","year":"2012","journal-title":"Am J Epidemiol"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X15000819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X15000819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:41:07Z","timestamp":1761846067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X15000819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1936878X15000819"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2014.10.014","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic Value of Echocardiographic Calcium Score in Patients With a Clinical Indication for Stress Echocardiography","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2014.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}