{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:33:28Z","timestamp":1761863608408,"version":"build-2065373602"},"reference-count":25,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.jcmg.2015.07.026","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T17:40:36Z","timestamp":1463593236000},"page":"668-675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Plaque Neovascularization Is Increased in\u00a0Human Carotid Atherosclerosis Related\u00a0to Prior Neck Radiotherapy"],"prefix":"10.1016","volume":"9","author":[{"given":"Benoy N.","family":"Shah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy M.","family":"Gujral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navtej S.","family":"Chahal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Nutting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxy","family":"Senior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2015.07.026_bib1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1161\/ATVBAHA.108.179739","article-title":"Concept of vulnerable\/unstable plaque","volume":"30","author":"Finn","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcmg.2015.07.026_bib2","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1093\/eurheartj\/ehr054","article-title":"Intraplaque haemorrhages as the trigger of plaque vulnerability","volume":"32","author":"Michel","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2015.07.026_bib3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.2459\/JCM.0b013e3283590cd2","article-title":"Intraplaque neovascularization and hemorrhage: markers for cardiovascular risk stratification and therapeutic monitoring","volume":"13","author":"Koole","year":"2012","journal-title":"J\u00a0Cardiovasc Med (Hagerstown)"},{"key":"10.1016\/j.jcmg.2015.07.026_bib4","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1161\/01.ATV.0000178991.71605.18","article-title":"Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage","volume":"25","author":"Virmani","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcmg.2015.07.026_bib5","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1161\/CIRCULATIONAHA.109.887497","article-title":"Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study","volume":"121","author":"Hellings","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2015.07.026_bib6","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1161\/01.CIR.0000146787.16297.E8","article-title":"Arterial neovascularization and inflammation in vulnerable patients: early and late signs of symptomatic atherosclerosis","volume":"110","author":"Fleiner","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2015.07.026_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/STROKEAHA.109.560342","article-title":"Vasa vasorum and plaque neovascularization on contrast-enhanced carotid ultrasound imaging correlates with cardiovascular disease and past cardiovascular events","volume":"41","author":"Staub","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.jcmg.2015.07.026_bib8","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/1358863X07083363","article-title":"Contrast-enhanced ultrasound imaging of atherosclerotic carotid plaque neovascularization: a new surrogate marker of atherosclerosis?","volume":"12","author":"Shah","year":"2007","journal-title":"Vasc Med"},{"key":"10.1016\/j.jcmg.2015.07.026_bib9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jacc.2008.02.082","article-title":"Contrast-enhanced ultrasound imaging of intraplaque neovascularization in carotid arteries: correlation with histology and plaque echogenicity","volume":"52","author":"Coli","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2015.07.026_bib10","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1212\/WNL.0b013e3181c33b10","article-title":"Early-onset stroke and cerebrovascular disease in adult survivors of childhood cancer","volume":"73","author":"Jordan","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.jcmg.2015.07.026_bib11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.radonc.2013.08.009","article-title":"Radiation-induced carotid artery atherosclerosis","volume":"110","author":"Gujral","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.jcmg.2015.07.026_bib12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.radonc.2014.10.012","article-title":"Progression of carotid intima media thickness after radiotherapy: a long-term prospective cohort study","volume":"113","author":"Wilbers","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.jcmg.2015.07.026_bib13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000097034","article-title":"Mannheim carotid intima-media thickness consensus (2004\u20132006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany 2004, and Brussels, Belgium 2006","volume":"23","author":"Touboul","year":"2007","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.jcmg.2015.07.026_bib14","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1017\/S0022215100139167","article-title":"Contribution to the pathogenesis of radiation-induced injury to large arteries","volume":"111","author":"Zidar","year":"1997","journal-title":"J\u00a0Laryngol Otol"},{"key":"10.1016\/j.jcmg.2015.07.026_bib15","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1161\/STROKEAHA.111.615203","article-title":"Ischemic stroke and transient ischemic attack after head and neck radiotherapy: a review","volume":"42","author":"Plummer","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.jcmg.2015.07.026_bib16","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1097\/00005537-200210000-00034","article-title":"Relative risk of stroke in head and neck carcinoma patients treated with external cervical irradiation","volume":"112","author":"Haynes","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jcmg.2015.07.026_bib17","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1200\/JCO.2002.20.1.282","article-title":"Increased risk of ischemic stroke after radiotherapy on the neck in patients younger than 60\u00a0years","volume":"20","author":"Dorresteijn","year":"2002","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jcmg.2015.07.026_bib18","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1200\/JCO.2008.16.6546","article-title":"Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy","volume":"26","author":"Smith","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jcmg.2015.07.026_bib19","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1200\/JCO.2005.15.107","article-title":"Stroke as\u00a0a\u00a0late treatment effect of Hodgkin\u2019s Disease: a\u00a0report from the Childhood Cancer Survivor Study","volume":"23","author":"Bowers","year":"2005","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jcmg.2015.07.026_bib20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0735-1097(88)90356-7","article-title":"Angiographic progression of coronary artery disease and the development of myocardial infarction","volume":"12","author":"Ambrose","year":"1988","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2015.07.026_bib21","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1161\/01.CIR.78.5.1157","article-title":"Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease?","volume":"78","author":"Little","year":"1988","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2015.07.026_bib22","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1056\/NEJM199811123392002","article-title":"Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis","volume":"339","author":"Barnett","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmg.2015.07.026_bib23","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0140-6736(97)09292-1","article-title":"Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST)","volume":"351","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.jcmg.2015.07.026_bib24","first-page":"1012","article-title":"Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy","volume":"63","author":"Sonveaux","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmg.2015.07.026_bib25","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/jnci\/djs239","article-title":"Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors?","volume":"104","author":"Kozin","year":"2012","journal-title":"J\u00a0Natl Cancer Inst"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X16301425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X16301425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:42:35Z","timestamp":1761846155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X16301425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S1936878X16301425"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2015.07.026","relation":{},"ISSN":["1936-878X"],"issn-type":[{"type":"print","value":"1936-878X"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plaque Neovascularization Is Increased in\u00a0Human Carotid Atherosclerosis Related\u00a0to Prior Neck Radiotherapy","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2015.07.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the American College of Cardiology Foundation. Published by Elsevier","name":"copyright","label":"Copyright"}]}}