{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:51:52Z","timestamp":1790675512796,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jcmg.2015.11.008","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T14:41:03Z","timestamp":1451918463000},"page":"54-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":151,"title":["Automatic Measurement of the Myocardial\u00a0Interstitium"],"prefix":"10.1016","volume":"9","author":[{"given":"Thomas A.","family":"Treibel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Maestrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Castelletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Rosmini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Nasis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish N.","family":"Bhuva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heerajnarain","family":"Bulluck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amna","family":"Abdel-Gadir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Manisty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce S.","family":"Spottiswoode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan K.","family":"Piechnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kellman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Robson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik B.","family":"Schelbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2015.11.008_bib1","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1161\/01.CIR.83.6.1849","article-title":"Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system","volume":"83","author":"Weber","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2015.11.008_bib2","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1161\/01.CIR.82.3.848","article-title":"A\u00a0comparison of the pathological spectrum of hypertensive, diabetic, and hypertensive-diabetic heart disease","volume":"82","author":"van Hoeven","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2015.11.008_bib3","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/00004872-199816070-00018","article-title":"Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to\u00a0chronic arterial hypertension in humans","volume":"16","author":"Rossi","year":"1998","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.jcmg.2015.11.008_bib4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/01.CIR.89.1.151","article-title":"Structural basis of end-stage failure in ischemic cardiomyopathy in humans","volume":"89","author":"Beltrami","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2015.11.008_bib5","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.jacc.2010.11.013","article-title":"Assessment of myocardial fibrosis with cardiovascular magnetic resonance","volume":"57","author":"Mewton","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2015.11.008_bib6","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1093\/eurheartj\/ehr481","article-title":"Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology","volume":"33","author":"Ugander","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2015.11.008_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1532-429X-15-13","article-title":"Normal variation of magnetic resonance T1 relaxation times in the human population at 1.5 T using ShMOLLI","volume":"15","author":"Piechnik","year":"2013","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jcmg.2015.11.008_bib8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1532-429X-15-92","article-title":"Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement","volume":"15","author":"Moon","year":"2013","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jcmg.2015.11.008_bib9","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/CIRCULATIONAHA.111.089409","article-title":"Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality","volume":"126","author":"Wong","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2015.11.008_bib10","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/eurheartj\/eht193","article-title":"Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in diabetes and associated with mortality and incident heart failure admission","volume":"35","author":"Wong","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2015.11.008_bib11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/mrm.20110","article-title":"Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart","volume":"52","author":"Messroghli","year":"2004","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jcmg.2015.11.008_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1532-429X-12-69","article-title":"Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold","volume":"12","author":"Piechnik","year":"2010","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jcmg.2015.11.008_bib13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1532-429X-16-2","article-title":"T1-mapping in the heart: accuracy and precision","volume":"16","author":"Kellman","year":"2014","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jcmg.2015.11.008_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0730-725X(82)90172-2","article-title":"NMR relaxation of protons in tissues and other macromolecular water solutions","volume":"1","author":"Fullerton","year":"1982","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.jcmg.2015.11.008_bib15","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0730-725X(86)91038-6","article-title":"The measurement of extracellular water volumes in tissues by gadolinium modification of 1H-NMR spin lattice (T1) relaxation","volume":"4","author":"Braunschweiger","year":"1986","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.jcmg.2015.11.008_bib16","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/mrm.1910150107","article-title":"Determination of extracellular\/intracellular fluid ratios from magnetic resonance images: accuracy, feasibility, and implementation","volume":"15","author":"Martin","year":"1990","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jcmg.2015.11.008_bib17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/mrm.20178","article-title":"Determining the longitudinal relaxation time (T1) of blood at 3.0 Tesla","volume":"52","author":"Lu","year":"2004","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jcmg.2015.11.008_bib18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2463\/mrms.11.265","article-title":"In\u00a0vivo measurement of longitudinal relaxation time of human blood by inversion-recovery fast gradient-echo MR imaging at 3T","volume":"11","author":"Shimada","year":"2012","journal-title":"Magn Reson Med Sci"},{"key":"10.1016\/j.jcmg.2015.11.008_bib19","article-title":"Quantitative theory for the longitudinal relaxation time of blood water","author":"Li","year":"2015","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jcmg.2015.11.008_bib20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/mrm.1072","article-title":"Water proton MR properties of human blood at 1.5 Tesla: magnetic susceptibility, T(1), T(2), T*(2), and non-Lorentzian signal behavior","volume":"45","author":"Spees","year":"2001","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jcmg.2015.11.008_bib21","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","article-title":"Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases","volume":"29","author":"Elliott","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2015.11.008_bib22","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jacc.2005.05.073","article-title":"Noninvasive etiologic diagnosis of cardiac amyloidosis using 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy","volume":"46","author":"Perugini","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2015.11.008_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jcmg.2013.10.008","article-title":"Native T1 mapping in transthyretin amyloidosis","volume":"7","author":"Fontana","year":"2014","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2015.11.008_bib24","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jcmg.2013.01.011","article-title":"T1 mapping for myocardial extracellular volume measurement by CMR: bolus only versus primed infusion technique","volume":"6","author":"White","year":"2013","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2015.11.008_bib25","doi-asserted-by":"crossref","first-page":"e002613","DOI":"10.1161\/JAHA.115.002613","article-title":"Myocardial fibrosis quantified by extracellular volume is associated with subsequent hospitalization for heart failure, death, or both across the spectrum of ejection fraction and heart failure stage","volume":"4","author":"Schelbert","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jcmg.2015.11.008_bib26","first-page":"63","article-title":"Extracellular volume fraction mapping in the myocardium, part 1: evaluation of an automated method","volume":"14","author":"Kellman","year":"2012","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jcmg.2015.11.008_bib27","first-page":"64","article-title":"Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience","volume":"14","author":"Kellman","year":"2012","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jcmg.2015.11.008_bib28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1532-429X-10-35","article-title":"Standardized cardiovascular magnetic resonance imaging (CMR) protocols, society for cardiovascular magnetic resonance: board of trustees task force on standardized protocols","volume":"10","author":"Kramer","year":"2008","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jcmg.2015.11.008_bib29","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jcmg.2014.05.007","article-title":"Reply: effects of blood T1 on extracellular volume calculation","volume":"7","author":"White","year":"2014","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2015.11.008_bib30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1532-429X-15-56","article-title":"T1 and extracellular volume mapping in the heart: estimation of error maps and the influence of noise on precision","volume":"15","author":"Kellman","year":"2013","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jcmg.2015.11.008_bib31","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1002\/mrm.23153","article-title":"Motion correction for myocardial T1 mapping using image registration with synthetic image estimation","volume":"67","author":"Xue","year":"2012","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jcmg.2015.11.008_bib32","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1309\/T0FJYP2RBXEHX4","article-title":"Evaluation of the performance of the Sysmex XT-2000i Hematology Analyzer with whole bloods stored at room temperature","volume":"40","author":"Hill","year":"2009","journal-title":"Lab Med"},{"key":"10.1016\/j.jcmg.2015.11.008_bib33","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1016\/j.jacc.2014.01.068","article-title":"Therapeutic targets in heart failure: refocusing on the myocardial interstitium","volume":"63","author":"Schelbert","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2015.11.008_bib34","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1136\/heartjnl-2012-302346","article-title":"Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease","volume":"98","author":"Sado","year":"2012","journal-title":"Heart"},{"key":"10.1016\/j.jcmg.2015.11.008_bib35","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.jacc.2013.05.078","article-title":"Evaluation of age-related interstitial myocardial fibrosis with cardiac magnetic resonance contrast-enhanced T1 mapping: MESA (Multi-Ethnic Study of Atherosclerosis)","volume":"62","author":"Liu","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2015.11.008_bib36","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/eurheartj\/ehu444","article-title":"T1 mapping and survival in systemic light-chain amyloidosis","volume":"36","author":"Banypersad","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2015.11.008_bib37","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2165\/00007256-200333030-00005","article-title":"Haematocrit: within-subject and seasonal variation","volume":"33","author":"Thirup","year":"2003","journal-title":"Sports Med"},{"key":"10.1016\/j.jcmg.2015.11.008_bib38","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1148\/radiol.14140296","article-title":"Accuracy, precision, and reproducibility of four T1 mapping sequences: a head-to-head comparison of MOLLI, ShMOLLI, SASHA, and SAPPHIRE","volume":"272","author":"Roujol","year":"2014","journal-title":"Radiology"},{"key":"10.1016\/j.jcmg.2015.11.008_bib39","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jcmg.2013.02.002","article-title":"T1 mapping by CMR in cardiomyopathy: a noninvasive myocardial biopsy?","volume":"6","author":"Kramer","year":"2013","journal-title":"J\u00a0Am Coll Cardiol Img"},{"issue":"Suppl\u00a01","key":"10.1016\/j.jcmg.2015.11.008_bib40","doi-asserted-by":"crossref","first-page":"W6","DOI":"10.1186\/1532-429X-17-S1-W6","article-title":"Automated inline extracellular volume (ECV) mapping (abstr)","volume":"17","author":"Spottiswoode","year":"2015","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jcmg.2015.11.008_bib41","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1088\/0143-0815\/11\/4\/008","article-title":"Determination of dependence of spin-lattice relaxation rate in serum upon concentration of added iron by magnetic resonance imaging","volume":"11","author":"Yilmaz","year":"1990","journal-title":"Clin Phys Physiol Meas"},{"key":"10.1016\/j.jcmg.2015.11.008_bib42","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/jmri.1880010303","article-title":"1991 I.I. Rabi Award. Estimating oxygen saturation of blood in\u00a0vivo with MR imaging at 1.5 T","volume":"1","author":"Wright","year":"1991","journal-title":"J\u00a0Magn Reson Imaging"},{"key":"10.1016\/j.jcmg.2015.11.008_bib43","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/mrm.10370","article-title":"Effects of hematocrit and oxygen saturation level on blood spin-lattice relaxation","volume":"49","author":"Silvennoinen","year":"2003","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jcmg.2015.11.008_bib44","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1532-429X-14-90","article-title":"Diffuse myocardial fibrosis evaluation using cardiac magnetic resonance T1 mapping: sample size considerations for clinical trials","volume":"14","author":"Liu","year":"2012","journal-title":"J\u00a0Cardiovasc Magn Reson"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X15008955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X15008955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:42:40Z","timestamp":1761846160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X15008955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S1936878X15008955"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2015.11.008","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Automatic Measurement of the Myocardial\u00a0Interstitium","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2015.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}