{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:08:27Z","timestamp":1791594507963,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.jcmg.2016.02.033","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T13:46:56Z","timestamp":1474552016000},"page":"105-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"title":["Association of Insulin Resistance and Glycemic Metabolic Abnormalities With LV\u00a0Structure and Function in\u00a0Middle Age"],"prefix":"10.1016","volume":"10","author":[{"given":"Satoru","family":"Kishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Gidding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared P.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Colangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharath A.","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson C.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Isogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora E.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"David R.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o A.C.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2016.02.033_bib1","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.jacc.2013.01.022","article-title":"Lifetime risk for heart failure among white and black Americans: Cardiovascular Lifetime Risk Pooling Project","volume":"61","author":"Huffman","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2016.02.033_bib2","first-page":"e6","article-title":"Heart disease and stroke statistics\u20132013 update: a report from the American Heart Association [published correction appears in Circulation 2013;127:e841]","volume":"127","author":"Go","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2016.02.033_bib3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.amjcard.2013.08.052","article-title":"Relation of left ventricular mass at age 23 to 35 years to global left ventricular systolic function 20 years later (from the Coronary Artery Risk Development in Young Adults Study)","volume":"113","author":"Kishi","year":"2014","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcmg.2016.02.033_bib4","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1016\/j.jacc.2008.09.014","article-title":"The relationship of left ventricular mass and geometry to incident cardiovascular events. the MESA (Multi-Ethnic Study of Atherosclerosis) Study","volume":"52","author":"Bluemke","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2016.02.033_bib5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jcmg.2009.10.012","article-title":"The impact of obesity on the left ventricle. the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"3","author":"Turkbey","year":"2010","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2016.02.033_bib6","first-page":"500","article-title":"Association of obesity in early adulthood and middle age with incipient left ventricular dysfunction and structural remodeling: the CARDIA Study (Coronary Artery Risk Development in Young Adults)","volume":"2","author":"Kishi","year":"2014","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jcmg.2016.02.033_bib7","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.jacc.2006.03.072","article-title":"Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging. the Multiethnic Study of Atherosclerosis","volume":"48","author":"Heckbert","year":"2006","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2016.02.033_bib8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/CIRCIMAGING.109.862334","article-title":"Prediction of all-cause mortality from global longitudinal speckle strain: comparison with ejection fraction and wall motion scoring","volume":"2","author":"Stanton","year":"2009","journal-title":"Circ Cardiovasc Img"},{"key":"10.1016\/j.jcmg.2016.02.033_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0002-9149(74)90089-7","article-title":"Role of diabetes in congestive heart failure: the Framingham study","volume":"34","author":"Kannel","year":"1974","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcmg.2016.02.033_bib10","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0895-4356(88)90080-7","article-title":"CARDIA: study design, recruitment, and some characteristics of the examined subjects","volume":"41","author":"Friedman","year":"1988","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.jcmg.2016.02.033_bib11","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.2337\/diacare.26.11.3160","article-title":"Follow-up report on the diagnosis of diabetes mellitus","volume":"26","author":"Genuth","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcmg.2016.02.033_bib12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2337\/diacare.23.1.57","article-title":"Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity","volume":"23","author":"Bonora","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcmg.2016.02.033_bib13","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1111\/echo.12832","article-title":"Quality control and reproducibility in M-mode, two-dimensional, and speckle tracking echocardiography acquisition and analysis: the CARDIA Study, Year 25 examination experience","volume":"32","author":"Armstrong","year":"2014","journal-title":"Echocardiography"},{"key":"10.1016\/j.jcmg.2016.02.033_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jcmg.2016.02.033_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.echo.2008.11.023","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography","volume":"22","author":"Nagueh","year":"2009","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jcmg.2016.02.033_bib16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.echo.2014.11.003","article-title":"Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging","volume":"28","author":"Voigt","year":"2015","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jcmg.2016.02.033_bib17","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/S0140-6736(14)60611-5","article-title":"Effects of intensive glycaemic control on ischaemic heart disease: analysis of data from the randomised, controlled ACCORD trial","volume":"384","author":"Gerstein","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jcmg.2016.02.033_bib18","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/CIRCIMAGING.112.000450","article-title":"Longitudinal determinants of left ventricular mass and geometry: the CARDIA Study","volume":"6","author":"Gidding","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2016.02.033_bib19","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.jacc.2013.01.053","article-title":"Insulin resistance, subclinical left ventricular remodeling, and the obesity paradox: MESA (Multi-Ethnic Study of Atherosclerosis)","volume":"61","author":"Shah","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2016.02.033_bib20","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/01.CIR.0000045671.62860.98","article-title":"Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study","volume":"107","author":"Rutter","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2016.02.033_bib21","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/ejechocard\/jep097","article-title":"Subclinical left ventricular dysfunction in\u00a0asymptomatic diabetic patients assessed by two-dimensional speckle tracking echocardiography: correlation with diabetic duration","volume":"10","author":"Nakai","year":"2009","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.jcmg.2016.02.033_bib22","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1161\/CIRCULATIONAHA.106.679597","article-title":"Diabetic cardiomyopathy revisited","volume":"115","author":"Boudina","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2016.02.033_bib23","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.jacc.2010.11.013","article-title":"Assessment of myocardial fibrosis with cardiovascular magnetic resonance","volume":"57","author":"Mewton","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2016.02.033_bib24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacc.2010.02.047","article-title":"Assessment of nonischemic myocardial fibrosis","volume":"56","author":"Jellis","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2016.02.033_bib25","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1161\/CIRCULATIONAHA.106.662882","article-title":"Global diastolic strain rate\u00a0for the assessment of left ventricular relaxation and filling pressures","volume":"115","author":"Wang","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2016.02.033_bib26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jacc.2009.07.029","article-title":"Glucose, obesity, metabolic syndrome, and diabetes. Relevance to Incidence of Heart Failure","volume":"55","author":"Horwich","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2016.02.033_bib27","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1001\/jama.294.3.334","article-title":"Insulin resistance and risk of\u00a0congestive heart failure","volume":"294","author":"Ingelsson","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.jcmg.2016.02.033_bib28","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jacc.2009.12.003","article-title":"The development of heart failure in patients with diabetes mellitus and pre-clinical diastolic dysfunction. a population-based study [published correction appears in J Am Coll Cardiol 2010;56:1612]","volume":"55","author":"From","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2016.02.033_bib29","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jacc.2008.10.008","volume":"53","author":"Skyler","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2016.02.033_bib30","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1056\/NEJMoa0806470","article-title":"10-Year follow-up of intensive glucose control in type 2 diabetes","volume":"359","author":"Holman","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmg.2016.02.033_bib31","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.numecd.2004.10.002","article-title":"Insulin resistance, dietary fat intake and blood pressure predict left ventricular diastolic function 20 years later","volume":"15","author":"\u00c4rnl\u00f6v","year":"2005","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.jcmg.2016.02.033_bib32","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1067\/mhj.2001.116957","article-title":"Several factors associated with the insulin resistance syndrome are predictors of left ventricular systolic dysfunction in a male population after 20 years of follow-up","volume":"142","author":"\u00c4rnl\u00f6v","year":"2001","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcmg.2016.02.033_bib33","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/ehjci\/jet184","article-title":"EACVI-ASE-industry initiative to standardize deformation imaging: a brief update from the co-chairs","volume":"14","author":"Thomas","year":"2013","journal-title":"Eur Heart J Cardiovasc Imaging"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X16304594?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X16304594?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:43:55Z","timestamp":1761846235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X16304594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S1936878X16304594"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2016.02.033","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of Insulin Resistance and Glycemic Metabolic Abnormalities With LV\u00a0Structure and Function in\u00a0Middle Age","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2016.02.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the American College of Cardiology Foundation. Published by Elsevier","name":"copyright","label":"Copyright"}]}}