{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:38:40Z","timestamp":1790419120725,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.jcmg.2016.05.015","type":"journal-article","created":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T19:02:22Z","timestamp":1473966142000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Asymptomatic Severe Aortic Stenosis in\u00a0the Elderly"],"prefix":"10.1016","volume":"10","author":[{"given":"Robert","family":"Zilberszac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schemper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Laufer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Rosenhek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2016.05.015_bib1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jcmg.2016.05.015_bib2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/01.CIR.38.1S5.V-61","article-title":"Aortic stenosis","volume":"38","author":"Ross","year":"1968","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2016.05.015_bib3","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.hlc.2013.01.008","article-title":"Outcomes of surgical aortic valve replacement in octogenarians","volume":"22","author":"Harris","year":"2013","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.jcmg.2016.05.015_bib4","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.jacc.2014.02.536","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Nishimura","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2016.05.015_bib5","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1093\/eurheartj\/ehs109","article-title":"Guidelines on the management of valvular heart disease (version 2012)","volume":"33","author":"Vahanian","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2016.05.015_bib6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/CIRCULATIONAHA.109.894170","article-title":"Natural history of very severe aortic stenosis","volume":"121","author":"Rosenhek","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2016.05.015_bib7","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1056\/NEJM200008313430903","article-title":"Predictors of outcome in severe, asymptomatic aortic stenosis","volume":"343","author":"Rosenhek","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmg.2016.05.015_bib8","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1001\/jama.2013.279194","article-title":"Asymptomatic aortic stenosis in the elderly: a clinical review","volume":"310","author":"Manning","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.jcmg.2016.05.015_bib9","first-page":"1417","article-title":"Should early elective surgery be performed in patients with severe but asymptomatic aortic stenosis?","volume":"23","author":"Rosenhek","year":"2002","journal-title":"Eur\u00a0Heart J"},{"key":"10.1016\/j.jcmg.2016.05.015_bib10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jtcvs.2008.08.015","article-title":"Isolated aortic valve replacement in North America comprising 108,687 patients in 10 years: changes in risks, valve types, and outcomes in the Society of Thoracic Surgeons national database","volume":"137","author":"Brown","year":"2009","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jcmg.2016.05.015_bib11","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1161\/01.CIR.95.9.2262","article-title":"Prospective study of asymptomatic valvular aortic stenosis. Clinical, echocardiographic, and exercise predictors of outcome","volume":"95","author":"Otto","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2016.05.015_bib12","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1161\/CIRCULATIONAHA.104.495903","article-title":"Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up","volume":"111","author":"Pellikka","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2016.05.015_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/CIRCULATIONAHA.108.808857","article-title":"Risk score for predicting outcome in patients with asymptomatic aortic stenosis","volume":"120","author":"Monin","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2016.05.015_bib14","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1161\/CIRCULATIONAHA.109.909903","article-title":"Early surgery versus conventional treatment in asymptomatic very severe aortic stenosis","volume":"121","author":"Kang","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2016.05.015_bib15","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/eurheartj\/ehq076","article-title":"Usefulness of exercise-stress echocardiography for risk stratification of true asymptomatic patients with aortic valve stenosis","volume":"31","author":"Marechaux","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2016.05.015_bib16","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1136\/hrt.2009.190942","article-title":"Risk stratification in asymptomatic moderate to severe aortic stenosis: the importance of the valvular, arterial and ventricular interplay","volume":"96","author":"Lancellotti","year":"2010","journal-title":"Heart"},{"key":"10.1016\/j.jcmg.2016.05.015_bib17","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1093\/eurheartj\/ehi471","article-title":"Decision-making in elderly patients with severe aortic stenosis: why are so many denied surgery?","volume":"26","author":"Iung","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2016.05.015_bib18","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1093\/eurheartj\/ehi250","article-title":"Exercise testing to stratify risk in aortic stenosis","volume":"26","author":"Das","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2016.05.015_bib19","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1161\/CIRCULATIONAHA.112.091371","article-title":"Long-term survival after aortic valve replacement among high-risk elderly patients in the United States: insights from the Society of Thoracic Surgeons Adult Cardiac Surgery Database, 1991 to 2007","volume":"126","author":"Brennan","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2016.05.015_bib20","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.athoracsur.2013.08.059","article-title":"Impact of preoperative symptoms on postoperative survival in severe aortic stenosis: implications for the timing of surgery","volume":"97","author":"Pierard","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jcmg.2016.05.015_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ehj.2003.12.002","article-title":"Mild and moderate aortic stenosis. Natural history and risk stratification by echocardiography","volume":"25","author":"Rosenhek","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2016.05.015_bib22","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1136\/heartjnl-2013-303754","article-title":"Specialist valve clinics: recommendations from the British Heart Valve Society working group on improving quality in the delivery of care for patients with heart valve disease","volume":"99","author":"Chambers","year":"2013","journal-title":"Heart"},{"key":"10.1016\/j.jcmg.2016.05.015_bib23","first-page":"1104","article-title":"Heart valve clinic: rationale and organization","volume":"30","author":"Lancellotti","year":"2014","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jcmg.2016.05.015_bib24","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/eurheartj\/ehr061","article-title":"ESC Working Group on Valvular Heart Disease position paper: assessing the risk of interventions in patients with valvular heart disease","volume":"33","author":"Rosenhek","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2016.05.015_bib25","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/j.jacc.2015.03.014","article-title":"Transcatheter versus surgical aortic valve replacement in patients with severe aortic valve stenosis: one-year results from the all-comers Nordic Aortic Valve Intervention (NOTION) randomized clinical trial","volume":"65","author":"Thyregod","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2016.05.015_bib26","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/01.CIR.0000126825.50903.18","article-title":"Natriuretic peptides predict symptom-free survival and postoperative outcome in severe aortic stenosis","volume":"109","author":"Bergler-Klein","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2016.05.015_bib27","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1136\/heartjnl-2012-303284","article-title":"Prognostic value of B-type natriuretic peptide in elderly patients with aortic valve stenosis: the COFRASA-GENERAC study","volume":"99","author":"Cimadevilla","year":"2013","journal-title":"Heart"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X16305265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X16305265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:43:18Z","timestamp":1761846198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X16305265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S1936878X16305265"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2016.05.015","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726749240.793536523","asserted-by":"object"}]},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Asymptomatic Severe Aortic Stenosis in\u00a0the Elderly","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2016.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}