{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:20:27Z","timestamp":1788337227478,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T00:00:00Z","timestamp":1585785600000},"content-version":"vor","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.jcmg.2017.09.013","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T14:12:09Z","timestamp":1513174329000},"page":"665-677","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":148,"title":["Mitral Valve Adaptation to Isolated\u00a0Annular Dilation"],"prefix":"10.1016","volume":"12","author":[{"given":"Dae-Hee","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Handschumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahmin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Sil","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Ri","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yewon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Kyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Bischoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Aikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Min","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk-Hyun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Kwan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2017.09.013_bib1","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.jacc.2013.01.064","article-title":"Mitral valve enlargement in chronic aortic regurgitation as a compensatory mechanism to prevent functional mitral regurgitation in the dilated left ventricle","volume":"61","author":"Beaudoin","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2017.09.013_bib2","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/0002-9149(93)90912-V","article-title":"Comparison of mitral valve dimensions in adults with valvular aortic stenosis, pure aortic regurgitation and hypertrophic cardiomyopathy","volume":"71","author":"Mautner","year":"1993","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcmg.2017.09.013_bib3","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1161\/01.CIR.96.6.1999","article-title":"Insights from three-dimensional echocardiography into the mechanism of functional mitral regurgitation: direct in\u00a0vivo demonstration of altered leaflet tethering geometry","volume":"96","author":"Otsuji","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2017.09.013_bib4","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1161\/01.CIR.102.12.1400","article-title":"Determinants of the degree of functional mitral regurgitation in patients with systolic left ventricular dysfunction: a quantitative clinical study","volume":"102","author":"Yiu","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2017.09.013_bib5","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1161\/CIRCULATIONAHA.107.749440","article-title":"Mitral leaflet adaptation to ventricular remodeling: occurrence and adequacy in patients with functional mitral regurgitation","volume":"118","author":"Chaput","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2017.09.013_bib6","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1161\/CIRCULATIONAHA.108.846782","article-title":"Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation","volume":"120","author":"Dal-Bianco","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2017.09.013_bib7","doi-asserted-by":"crossref","first-page":"19943","DOI":"10.1073\/pnas.1106954108","article-title":"Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve","volume":"108","author":"Balachandran","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmg.2017.09.013_bib8","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1161\/CIRCIMAGING.113.001976","article-title":"Aortic valve adaptation to aortic root dilatation: insights into the mechanism of functional aortic regurgitation from 3-dimensional cardiac computed tomography","volume":"7","author":"Kim","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2017.09.013_bib9","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1161\/01.CIR.82.3.792","article-title":"Atrial enlargement as a consequence of atrial fibrillation: a prospective echocardiographic study","volume":"82","author":"Sanfilippo","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2017.09.013_bib10","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/S0735-1097(02)01838-7","article-title":"Isolated annular dilation does not usually cause important functional mitral regurgitation: comparison between patients with lone atrial fibrillation and those with idiopathic or ischemic cardiomyopathy","volume":"39","author":"Otsuji","year":"2002","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2017.09.013_bib11","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1540-8175.2009.00904.x","article-title":"Mitral regurgitation associated with mitral annular dilation in patients with lone atrial fibrillation: an echocardiographic study","volume":"26","author":"Kihara","year":"2009","journal-title":"Echocardiography"},{"key":"10.1016\/j.jcmg.2017.09.013_bib12","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.jacc.2011.06.032","article-title":"Evidence of atrial functional mitral regurgitation due to atrial fibrillation: reversal with arrhythmia control","volume":"58","author":"Gertz","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2017.09.013_bib13","first-page":"284","article-title":"Pure annular dilation as a cause of mitral regurgitation: a clinically distinct entity of female heart disease","volume":"18","author":"Glower","year":"2009","journal-title":"J\u00a0Heart Valve Dis"},{"key":"10.1016\/j.jcmg.2017.09.013_bib14","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.athoracsur.2010.03.026","article-title":"Severe functional mitral regurgitation arising from isolated annular dilatation","volume":"90","author":"Kilic","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jcmg.2017.09.013_bib15","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.jacc.2011.06.033","article-title":"Atrial functional mitral regurgitation: the left atrium gets its due respect","volume":"58","author":"Hoit","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2017.09.013_bib16","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1093\/ehjci\/jet191","article-title":"Mechanisms of atrial mitral regurgitation: insights using 3D transoesophageal echo","volume":"15","author":"Ring","year":"2014","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2017.09.013_bib17","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1253\/circj.CJ-16-0435","article-title":"Novel mechanistic insights into atrial functional mitral regurgitation: 3-dimensional echocardiographic study","volume":"80","author":"Machino-Ohtsuka","year":"2016","journal-title":"Circ J"},{"key":"10.1016\/j.jcmg.2017.09.013_bib18","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0022-5223(19)39144-5","article-title":"Cardiac valve surgery\u2014the \u201cFrench correction.\u201d","volume":"86","author":"Carpentier","year":"1983","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jcmg.2017.09.013_bib19","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/europace\/eur098","article-title":"The impact of mitral regurgitation on patients undergoing catheter ablation of atrial fibrillation","volume":"13","author":"Gertz","year":"2011","journal-title":"Europace"},{"key":"10.1016\/j.jcmg.2017.09.013_bib20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/icvts\/ivv119","article-title":"Mitral valve repair for atrial functional mitral regurgitation in patients with chronic atrial fibrillation","volume":"21","author":"Takahashi","year":"2015","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.jcmg.2017.09.013_bib21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1540-8191.1992.tb00777.x","article-title":"Stress\/strain characteristics of porcine mitral valve tissue: parallel versus perpendicular collagen orientation","volume":"7","author":"Kunzelman","year":"1992","journal-title":"J\u00a0Card Surg"},{"key":"10.1016\/j.jcmg.2017.09.013_bib22","first-page":"H1319","article-title":"Biaxial mechanical behavior of excised porcine mitral valve leaflets","volume":"269","author":"May-Newman","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jcmg.2017.09.013_bib23","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1161\/CIRCIMAGING.113.000561","article-title":"Assessment of mitral valve adaptation with gated cardiac computed tomography: validation with three-dimensional echocardiography and mechanistic insight to functional mitral regurgitation","volume":"6","author":"Beaudoin","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2017.09.013_bib24","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0894-7317(03)00335-3","article-title":"Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography","volume":"16","author":"Zoghbi","year":"2003","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jcmg.2017.09.013_bib25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/echo.12391","article-title":"Measurement of left and right atrial volume in patients undergoing ablation for atrial arrhythmias: comparison of a manual versus semiautomatic algorithm of real time 3D echocardiography","volume":"31","author":"Muller","year":"2014","journal-title":"Echocardiography"},{"key":"10.1016\/j.jcmg.2017.09.013_bib26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jacc.2015.10.092","article-title":"Myocardial infarction alters adaptation of the tethered mitral valve","volume":"67","author":"Dal-Bianco","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2017.09.013_bib27","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1161\/CIRCULATIONAHA.109.935551","article-title":"In\u00a0vivo measurement of mitral leaflet surface area and subvalvular geometry in patients with asymmetrical septal hypertrophy: insights into the mechanism of outflow tract obstruction","volume":"122","author":"Kim","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2017.09.013_bib28","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jcct.2014.09.009","article-title":"A\u00a0simplified D-shaped model of the mitral annulus to facilitate CT-based sizing before transcatheter mitral valve implantation","volume":"8","author":"Blanke","year":"2014","journal-title":"J\u00a0Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.jcmg.2017.09.013_bib29","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/heartjnl-2014-306854","article-title":"Basal chordae sites on the mitral valve determine the severity of secondary mitral regurgitation","volume":"101","author":"Song","year":"2015","journal-title":"Heart"},{"key":"10.1016\/j.jcmg.2017.09.013_bib30","doi-asserted-by":"crossref","first-page":"S250","DOI":"10.1161\/CIRCULATIONAHA.107.746776","article-title":"Saddle-shaped mitral valve annuloplasty rings experience lower forces compared with flat rings","volume":"118","author":"Jensen","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2017.09.013_bib31","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/j.semtcvs.2015.06.001","article-title":"Posterior leaflet detachment, augmentation, and reconstruction for treatment of functional mitral valve regurgitation","volume":"27","author":"Suri","year":"2015","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jcmg.2017.09.013_bib32","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1161\/CIRCINTERVENTIONS.108.837781","article-title":"Percutaneous treatment of mitral regurgitation","volume":"2","author":"Masson","year":"2009","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcmg.2017.09.013_bib33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.carrev.2009.10.004","article-title":"Remodeling of the mitral valve using radiofrequency energy: review of a new treatment modality for mitral regurgitation","volume":"11","author":"Rahman","year":"2010","journal-title":"Cardiovasc Revasc Med"},{"key":"10.1016\/j.jcmg.2017.09.013_bib34","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nrcardio.2015.2","article-title":"Inflammation and the pathogenesis of atrial fibrillation","volume":"12","author":"Hu","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jcmg.2017.09.013_bib35","article-title":"Endothelial-mesenchymal transition in human atrial fibrillation","volume":"130","author":"Kato","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2017.09.013_bib36","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1161\/CIRCRESAHA.116.309598","article-title":"CD45 expression in mitral valve endothelial cells after myocardial infarction","volume":"119","author":"Bischoff","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jcmg.2017.09.013_bib37","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.bbrc.2014.03.014","article-title":"Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-beta-induced phosphorylation of ERK","volume":"446","author":"Wylie-Sears","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jcmg.2017.09.013_bib38","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jacc.2017.07.734","article-title":"Effect of losartan on mitral valve changes after myocardial infarction","volume":"70","author":"Bartko","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X17309774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X17309774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:45:53Z","timestamp":1761846353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X17309774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S1936878X17309774"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2017.09.013","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitral Valve Adaptation to Isolated\u00a0Annular Dilation","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2017.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}