{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:19:22Z","timestamp":1791404362674,"version":"4.3.3"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030-118353"],"award-info":[{"award-number":["310030-118353"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["33CM30-124112"],"award-info":[{"award-number":["33CM30-124112"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.jcmg.2018.08.024","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T17:14:51Z","timestamp":1544634891000},"page":"1518-1528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"special_numbering":"P1","title":["Changes in Coronary Plaque Composition in Patients With Acute Myocardial Infarction Treated With High-Intensity Statin Therapy (IBIS-4)"],"prefix":"10.1016","volume":"12","author":[{"given":"Lorenz","family":"R\u00e4ber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos C.","family":"Koskinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyohei","family":"Yamaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Taniwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Roffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Holmvang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector M.","family":"Garcia Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Zanchin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Moschovitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pedrazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Zaugg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouke","family":"Dijkstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M.","family":"Matter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Serruys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"L\u00fcscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Kelbaek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexios","family":"Karagiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria D.","family":"Radu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2018.08.024_bib1","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1056\/NEJMra1216063","article-title":"Mechanisms of the acute coronary syndromes and their implications for therapy","volume":"368","author":"Libby","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmg.2018.08.024_bib2","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/eurheartj\/ehv642","article-title":"Intracoronary imaging of coronary atherosclerosis: validation for diagnosis, prognosis and treatment","volume":"37","author":"Koskinas","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2018.08.024_bib3","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/eurheartj\/ehx566","article-title":"Effect of statins and nonstatin LDL-lowering medications on cardiovascular outcomes in secondary prevention: a meta-analysis of randomized trials","volume":"39","author":"Koskinas","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2018.08.024_bib4","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1161\/CIRCULATIONAHA.108.773747","article-title":"Effect of rosuvastatin therapy on coronary artery stenoses assessed by quantitative coronary angiography: a study to evaluate the effect of rosuvastatin on intravascular ultrasound-derived coronary atheroma burden","volume":"117","author":"Ballantyne","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2018.08.024_bib5","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1056\/NEJMoa1110874","article-title":"Effect of two intensive statin regimens on progression of coronary disease","volume":"365","author":"Nicholls","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmg.2018.08.024_bib6","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/01.CIR.103.7.993","article-title":"Statins alter smooth muscle cell accumulation and collagen content in established atheroma of Watanabe heritable hyperlipidemic rabbits","volume":"103","author":"Fukumoto","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2018.08.024_bib7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jcmg.2011.11.012","article-title":"Impact of statin therapy on plaque characteristics as assessed by serial OCT, grayscale and integrated backscatter-IVUS","volume":"5","author":"Hattori","year":"2012","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2018.08.024_bib8","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1016\/j.jacc.2014.08.045","article-title":"Effect of atorvastatin therapy on fibrous cap thickness in coronary atherosclerotic plaque as assessed by optical coherence tomography: the EASY-FIT study","volume":"64","author":"Komukai","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2018.08.024_bib9","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.amjcard.2015.11.062","article-title":"Comparison of intensive versus moderate lipid-lowering therapy on fibrous cap and atheroma volume of coronary lipid-rich plaque using serial optical coherence tomography and intravascular ultrasound imaging","volume":"117","author":"Hou","year":"2016","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcmg.2018.08.024_bib10","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/eurheartj\/ehu373","article-title":"Effect of high-intensity statin therapy on atherosclerosis in noninfarct-related coronary arteries (IBIS-4): a serial intravascular ultrasonography study","volume":"36","author":"R\u00e4ber","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2018.08.024_bib11","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s10554-015-0631-0","article-title":"Long-term safety and feasibility of three-vessel multimodality intravascular imaging in patients with ST-elevation myocardial infarction: the IBIS-4 (integrated biomarker and imaging study) substudy","volume":"31","author":"Taniwaki","year":"2015","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2018.08.024_bib12","doi-asserted-by":"crossref","first-page":"e003163","DOI":"10.1161\/CIRCINTERVENTIONS.115.003163","article-title":"Diagnosis of thin-capped fibroatheromas in intravascular optical coherence tomography images: effects of light scattering","volume":"9","author":"Phipps","year":"2016","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcmg.2018.08.024_bib13","doi-asserted-by":"crossref","first-page":"987","DOI":"10.4244\/EIJV12I8A162","article-title":"Variability in the measurement of minimum fibrous cap thickness and reproducibility of fibroatheroma classification by optical coherence tomography using manual versus semi-automatic assessment","volume":"12","author":"Radu","year":"2016","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcmg.2018.08.024_bib14","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.jacc.2011.09.079","article-title":"Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the InternationalWorking Group for intravascular optical coherence tomography standardization and validation","volume":"59","author":"Tearney","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2018.08.024_bib15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1161\/01.CIR.0000044384.41037.43","article-title":"Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography","volume":"107","author":"Tearney","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2018.08.024_bib16","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/01.CIR.0000029927.92825.F6","article-title":"Characterization of human atherosclerosis by optical coherence tomography","volume":"106","author":"Yabushita","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2018.08.024_bib17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jcmg.2014.09.019","article-title":"OCT imaging of macrophages: a bright spot in the study of inflammation in human atherosclerosis","volume":"8","author":"Tearney","year":"2015","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2018.08.024_bib18","first-page":"63","article-title":"Macrophages and intravascular OCT bright spots: a quantitative study","volume":"8","author":"Phipps Phipps","year":"2015","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2018.08.024_bib19","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.jcmg.2011.05.005","article-title":"Association between IVUS findings and adverse outcomes in patients with coronary artery disease: the VIVA (VH-IVUS in Vulnerable Atherosclerosis) study","volume":"4","author":"Calvert","year":"2011","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2018.08.024_bib20","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.jacc.2012.10.054","article-title":"Histopathologic characteristics of atherosclerotic coronary disease and implications of the findings for the invasive and noninvasive detection of vulnerable plaques","volume":"61","author":"Narula","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2018.08.024_bib21","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.2337\/dc14-1121","article-title":"High-intensity statin therapy alters the natural history of diabetic coronary atherosclerosis: insights from SATURN","volume":"37","author":"Stegman","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcmg.2018.08.024_bib22","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.jcmg.2012.04.011","article-title":"Reproducibility of in\u00a0vivo measurements for fibrous cap thickness and lipid arc by OCT","volume":"5","author":"Kim","year":"2012","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2018.08.024_bib23","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jacc.2016.10.029","article-title":"Intracoronary imaging, cholesterol efflux, and transcriptomes after intensive statin treatment: the YELLOW II study","volume":"69","author":"Kini","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2018.08.024_bib24","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature11260","article-title":"Myocardial infarction accelerates atherosclerosis","volume":"487","author":"Dutta","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jcmg.2018.08.024_bib25","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1161\/01.CIR.0000139858.69915.2E","article-title":"Comparison of coronary plaque rupture between stable angina and acute myocardial infarction: a three-vessel intravascular ultrasound study in 235 patients","volume":"110","author":"Hong","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2018.08.024_bib26","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1161\/ATVBAHA.114.303932","article-title":"Antiatherosclerotic effects of long-term maximally intensive statin therapy after acute coronary syndrome. Insights from study of coronary atheroma by intravascular ultrasound: effect of rosuvastatin versus atorvastatin","volume":"34","author":"Puri","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcmg.2018.08.024_bib27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10554-016-1037-3","article-title":"Lipid lowering therapy stabilizes the complexity of non-culprit plaques in human coronary artery: a quantitative assessment using OCT bright spot algorithm","volume":"33","author":"Minami","year":"2017","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2018.08.024_bib28","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1161\/STROKEAHA.110.580811","article-title":"Atorvastatin reduces macrophage accumulation in atherosclerotic plaques: a comparison of a nonstatin-based regimen in patients undergoing carotid endarterectomy","volume":"41","author":"Puato","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.jcmg.2018.08.024_bib29","doi-asserted-by":"crossref","unstructured":"Prati F, Romagnolia E, Gattoa L, et\u00a0al. Relationship between coronary plaque morphology of the left anterior descending artery and long term clinical outcome: the CLIMA study. Presented at EuroPCR, May\u00a02018.","DOI":"10.1016\/j.jacc.2018.08.1140"},{"key":"10.1016\/j.jcmg.2018.08.024_bib30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jcmg.2012.08.010","article-title":"Dynamic nature of nonculprit coronary artery lesion morphology in STEMI: a serial IVUS analysis from the HORIZONS-AMI trial","volume":"6","author":"Zhao","year":"2013","journal-title":"J\u00a0Am Coll Cardiol Img"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X18307526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X18307526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:46:25Z","timestamp":1761846385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X18307526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S1936878X18307526"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2018.08.024","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in Coronary Plaque Composition in Patients With Acute Myocardial Infarction Treated With High-Intensity Statin Therapy (IBIS-4)","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2018.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}