{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:46:36Z","timestamp":1762659996020,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jcmg.2020.09.031","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T06:56:18Z","timestamp":1605768978000},"page":"525-536","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Structural and Functional Correlates of Gradient-Area Patterns in Severe Aortic Stenosis and Normal Ejection Fraction"],"prefix":"10.1016","volume":"14","author":[{"given":"Alisson","family":"Slimani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clotilde","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"de Meester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Bouzin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Pasquet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Catherine","family":"Pouleur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Vancraeynest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Noirhomme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gebrine","family":"El Khoury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard L.","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Vanoverschelde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2020.09.031_bib1","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1016\/j.jacc.2014.02.537","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease","volume":"63","author":"Nishimura","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2020.09.031_bib2","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2020.09.031_bib3","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/eurheartj\/ehm543","article-title":"Inconsistencies of echocardiographic criteria for the grading of aortic valve stenosis","volume":"29","author":"Minners","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2020.09.031_bib4","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1161\/CIRCULATIONAHA.106.668681","article-title":"Paradoxical low-flow, low-gradient severe aortic stenosis despite preserved ejection fraction is associated with higher afterload and reduced survival","volume":"115","author":"Hachicha","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2020.09.031_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/CIRCIMAGING.111.967554","article-title":"Low-flow, low-gradient severe aortic stenosis despite normal ejection fraction is associated with severe left ventricular dysfunction as assessed by speckle-tracking echocardiography: a multicenter study","volume":"5","author":"Adda","year":"2012","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2020.09.031_bib6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jacc.2011.02.059","article-title":"Low-gradient aortic valve stenosis myocardial fibrosis and its influence on function and outcome","volume":"58","author":"Herrmann","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2020.09.031_bib7","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1093\/eurheartj\/eht094","article-title":"Differential left ventricular remodelling and longitudinal function distinguishes low flow from normal-flow preserved ejection fraction low-gradient severe aortic stenosis","volume":"34","author":"Mehrotra","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2020.09.031_bib8","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.jacc.2011.12.054","article-title":"Outcome of patients with aortic stenosis, small valve area, and low-flow, low-gradient despite preserved left ventricular ejection fraction","volume":"60","author":"Clavel","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2020.09.031_bib9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jacc.2011.08.072","article-title":"Clinical outcome in asymptomatic severe aortic stenosis: insights from the new proposed aortic stenosis grading classification","volume":"59","author":"Lancellotti","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2020.09.031_bib10","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1161\/CIRCIMAGING.113.001695","article-title":"Natural history of paradoxical low-gradient severe aortic stenosis","volume":"7","author":"Maes","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2020.09.031_bib11","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.amjcard.2015.05.023","article-title":"Progression of low-gradient, low-flow, severe aortic stenosis with preserved left ventricular ejection fraction","volume":"116","author":"Tribouilloy","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcmg.2020.09.031_bib12","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/CIRCULATIONAHA.110.983510","article-title":"Outcome of patients with low-gradient \u201csevere\u201d aortic stenosis and preserved ejection fraction","volume":"123","author":"Jander","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2020.09.031_bib13","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.echo.2017.02.009","article-title":"Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update","volume":"30","author":"Baumgartner","year":"2017","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jcmg.2020.09.031_bib14","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/01.CIR.55.4.613","article-title":"Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method","volume":"55","author":"Devereux","year":"1977","journal-title":"Circulation"},{"issue":"Pt 2","key":"10.1016\/j.jcmg.2020.09.031_bib15","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jcmg.2019.05.020","article-title":"Relative contribution of afterload and interstitial fibrosis to myocardial function in severe aortic stenosis","volume":"13","author":"Slimani","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2020.09.031_bib16","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12968-015-0150-0","article-title":"Histological validation of measurement of diffuse interstitial myocardial fibrosis by myocardial extravascular volume fraction from Modified Look-Locker imaging (MOLLI) T1 mapping at 3 T","volume":"17","author":"de Meester de Ravenstein","year":"2015","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jcmg.2020.09.031_bib17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12968-017-0371-5","article-title":"Age and sex corrected normal reference values of T1, T2 T2\u2217 and ECV in healthy subjects at 3T CMR","volume":"19","author":"Roy","year":"2017","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jcmg.2020.09.031_bib18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12968-016-0242-5","article-title":"A\u00a0new automatic algorithm for quantification of myocardial infarction imaged by late gadolinium enhancement cardiovascular magnetic resonance: experimental validation and comparison to expert delineations in multi-center, multi-vendor patient data","volume":"18","author":"Engblom","year":"2016","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jcmg.2020.09.031_bib19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2342-10-16","article-title":"An open-source software tool for the generation of relaxation time maps in magnetic resonance imaging","volume":"10","author":"Messroghli","year":"2010","journal-title":"BMC Med Imaging"},{"key":"10.1016\/j.jcmg.2020.09.031_bib20","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1093\/eurheartj\/ehr084","article-title":"Alterations in multidirectional myocardial functions in patients with aortic stenosis and preserved ejection fraction: a two-dimensional speckle tracking analysis","volume":"32","author":"Ng","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2020.09.031_bib21","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1001\/jamacardio.2018.2288","article-title":"Association of left ventricular global longitudinal strain with asymptomatic severe aortic stenosis: natural course and prognostic value","volume":"3","author":"Vollema","year":"2018","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jcmg.2020.09.031_bib22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jcmg.2018.11.005","article-title":"Distribution and prognostic significance of left ventricular global longitudinal strain in asymptomatic significant aortic stenosis: an individual participant data meta-analysis","volume":"12","author":"Magne","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2020.09.031_bib23","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/hrt.2010.192997","article-title":"Prognostic value of inappropriately high left ventricular mass in asymptomatic severe aortic stenosis","volume":"97","author":"Cioffi","year":"2011","journal-title":"Heart"},{"key":"10.1016\/j.jcmg.2020.09.031_bib24","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/0735-1097(93)90595-R","article-title":"Left ventricular hypertrophy and mortality after aortic valve replacement for aortic stenosis: a high risk subgroup identified by preoperative relative wall thickness","volume":"22","author":"Orsinelli","year":"1993","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2020.09.031_bib25","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1161\/01.CIR.79.4.744","article-title":"Left ventricular myocardial structure in aortic valve disease before, intermediate, and late after aortic valve replacement","volume":"79","author":"Krayenbuehl","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2020.09.031_bib26","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jacc.2009.12.074","article-title":"Prognostic significance of myocardial fibrosis quantification by histopathology and magnetic resonance imaging in patients with severe aortic valve disease","volume":"56","author":"Azevedo","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2020.09.031_bib27","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jacc.2011.03.064","article-title":"Midwall fibrosis is an independent predictor of mortality in patients with aortic stenosis","volume":"58","author":"Dweck","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2020.09.031_bib28","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jcmg.2019.06.014","article-title":"Sex-related differences in the extent of myocardial fibrosis in patients with aortic valve stenosis","volume":"13","author":"Tastet","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2020.09.031_bib29","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/CIRCIMAGING.113.000515","article-title":"Aortic valve area, stroke volume, left ventricular hypertrophy, remodeling, and fibrosis in aortic stenosis assessed by cardiac magnetic resonance imaging: comparison between high and low gradient and normal and low flow aortic stenosis","volume":"6","author":"Barone-Rochette","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2020.09.031_bib30","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1161\/CIRCULATIONAHA.117.032839","article-title":"Myocardial scar and mortality in severe aortic stenosis","volume":"138","author":"Musa","year":"2018","journal-title":"Circulation"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X20309207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X20309207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:51:01Z","timestamp":1761846661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X20309207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1936878X20309207"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2020.09.031","relation":{},"ISSN":["1936-878X"],"issn-type":[{"type":"print","value":"1936-878X"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural and Functional Correlates of Gradient-Area Patterns in Severe Aortic Stenosis and Normal Ejection Fraction","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2020.09.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}