{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:11:56Z","timestamp":1793391116657,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jcmg.2021.09.032","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T15:16:48Z","timestamp":1639581408000},"page":"594-603","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Myocardial Composition in Light-Chain Cardiac Amyloidosis More Than 1 Year After Successful Therapy"],"prefix":"10.1016","volume":"15","author":[{"given":"Sarah A.M.","family":"Cuddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Jerosch-Herold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney H.","family":"Falk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Foley","family":"Kijewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasvi","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick L.","family":"Ruberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishali","family":"Sanchorawala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Landau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo F.","family":"Di Carli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronglih","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Y.","family":"Kwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Dorbala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jcmg.2021.09.032_bib1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.jacc.2016.06.053","article-title":"AL (light-chain) cardiac amyloidosis: a review of diagnosis and therapy","volume":"68","author":"Falk","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"14","key":"10.1016\/j.jcmg.2021.09.032_bib2","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1161\/circ.104.14.1594","article-title":"Infusion of light chains from patients with cardiac amyloidosis causes diastolic dysfunction in isolated mouse hearts","volume":"104","author":"Liao","year":"2001","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.jcmg.2021.09.032_bib3","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1161\/01.RES.0000126569.75419.74","article-title":"Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress","volume":"94","author":"Brenner","year":"2004","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.jcmg.2021.09.032_bib4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1148\/radiol.2015141744","article-title":"Differential myocyte responses in patients with cardiac light-chain amyloidosis: a cardiac MR imaging study","volume":"277","author":"Fontana","year":"2015","journal-title":"Radiology"},{"issue":"25","key":"10.1016\/j.jcmg.2021.09.032_bib5","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1016\/j.jacc.2018.03.536","article-title":"Myocardial edema and prognosis in amyloidosis","volume":"71","author":"Kotecha","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.jcmg.2021.09.032_bib6","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.jcmg.2020.02.025","article-title":"Improved quantification of cardiac amyloid burden in systemic light chain amyloidosis: redefining early disease?","volume":"13","author":"Cuddy","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Img"},{"issue":"4","key":"10.1016\/j.jcmg.2021.09.032_bib7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/ajh.20381","article-title":"Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis","volume":"79","author":"Gertz","year":"2005","journal-title":"Am J Hematol"},{"issue":"1","key":"10.1016\/j.jcmg.2021.09.032_bib8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1532-429X-11-56","article-title":"T2 quantification for improved detection of myocardial edema","volume":"11","author":"Giri","year":"2009","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"issue":"1","key":"10.1016\/j.jcmg.2021.09.032_bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1532-429X-15-53","article-title":"Myocardial T1 and T2 mapping at 3 T: reference values, influencing factors and implications","volume":"15","author":"von Knobelsdorff-Brenkenhoff","year":"2013","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"issue":"1","key":"10.1016\/j.jcmg.2021.09.032_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/mrm.20110","article-title":"Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart","volume":"52","author":"Messroghli","year":"2004","journal-title":"Magn Reson Med"},{"issue":"1","key":"10.1016\/j.jcmg.2021.09.032_bib11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1161\/CIRCIMAGING.112.979815","article-title":"Role of transcytolemmal water-exchange in magnetic resonance measurements of diffuse myocardial fibrosis in hypertensive heart disease","volume":"6","author":"Coelho-Filho","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"issue":"6","key":"10.1016\/j.jcmg.2021.09.032_bib12","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jcmg.2012.09.020","article-title":"Myocardial extracellular volume fraction from T1 measurements in healthy volunteers and mice: relationship to aging and cardiac dimensions","volume":"6","author":"Neilan","year":"2013","journal-title":"J\u00a0Am Coll Cardiol Img"},{"issue":"1","key":"10.1016\/j.jcmg.2021.09.032_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12968-015-0111-7","article-title":"Normal values for cardiovascular magnetic resonance in adults and children","volume":"17","author":"Kawel-Boehm","year":"2015","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"issue":"5 Pt 1","key":"10.1016\/j.jcmg.2021.09.032_bib14","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/0002-8703(93)91004-X","article-title":"Variation in left ventricular regional wall stress with cine magnetic resonance imaging: normal subjects versus dilated cardiomyopathy","volume":"125","author":"Fujita","year":"1993","journal-title":"Am Heart J"},{"issue":"36","key":"10.1016\/j.jcmg.2021.09.032_bib15","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1200\/JCO.2011.37.7614","article-title":"New criteria for response to treatment in immunoglobulin light chain amyloidosis based on free light chain measurement and cardiac biomarkers: impact on survival outcomes","volume":"30","author":"Palladini","year":"2012","journal-title":"J\u00a0Clin Oncol"},{"issue":"1","key":"10.1016\/j.jcmg.2021.09.032_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jcmg.2019.03.026","article-title":"Noncontrast magnetic resonance for the diagnosis of cardiac amyloidosis","volume":"13","author":"Baggiano","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Img"},{"issue":"1","key":"10.1016\/j.jcmg.2021.09.032_bib17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12968-018-0478-3","article-title":"Myocardial native T2 measurement to differentiate light-chain and transthyretin cardiac amyloidosis and assess prognosis","volume":"20","author":"Ridouani","year":"2018","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"issue":"3","key":"10.1016\/j.jcmg.2021.09.032_bib18","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1161\/CIRCIMAGING.112.000192","article-title":"Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume","volume":"6","author":"Miller","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"issue":"5","key":"10.1016\/j.jcmg.2021.09.032_bib19","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.jcmg.2018.03.029","article-title":"The \u201cnative T1 versus extracellular volume fraction paradox\u201d in cardiac amyloidosis: answer to the million-dollar question?","volume":"12","author":"Yilmaz","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Img"},{"issue":"31","key":"10.1016\/j.jcmg.2021.09.032_bib20","doi-asserted-by":"crossref","first-page":"8160","DOI":"10.1523\/JNEUROSCI.4809-05.2006","article-title":"Prefibrillar amyloid aggregates could be generic toxins in higher organisms","volume":"26","author":"Baglioni","year":"2006","journal-title":"J\u00a0Neurosci"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X21008329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X21008329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:52:41Z","timestamp":1761846761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X21008329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S1936878X21008329"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2021.09.032","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial Composition in Light-Chain Cardiac Amyloidosis More Than 1 Year After Successful Therapy","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2021.09.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}