{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:09:23Z","timestamp":1788480563353,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jcmg.2021.12.010","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T16:04:53Z","timestamp":1645027493000},"page":"1046-1058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Diagnostic and Clinical Value of FFRCT in\u00a0Stable Chest Pain Patients With Extensive Coronary Calcification"],"prefix":"10.1016","volume":"15","author":[{"given":"Hans","family":"Mickley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten T.","family":"Veien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oke","family":"Gerke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess","family":"Lambrechtsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Rohold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming H.","family":"Steffensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirza","family":"Husic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Akkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Busk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise B.","family":"Jessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette O.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Diederichsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian A.","family":"\u00d8vrehus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2021.12.010_bib1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2021.12.010_bib2","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1016\/j.jacc.2012.07.013","volume":"60","author":"Fihn","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2021.12.010_bib3","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.ahj.2014.03.001","article-title":"Prevalence and predictors of non-obstructive coronary artery disease identified with coronary angiography in contemporary clinical practice","volume":"167","author":"Patel","year":"2014","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcmg.2021.12.010_bib4","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.jacc.2008.07.031","article-title":"Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY trial","volume":"52","author":"Budoff","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2021.12.010_bib5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jacc.2011.06.079","volume":"59","author":"Arbab-Zadeh","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2021.12.010_bib6","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.jcmg.2013.02.011","article-title":"Predictors of inaccurate coronary arterial stenosis assessment by CT angiography","volume":"6","author":"Yan","year":"2013","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2021.12.010_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jcmg.2013.07.013","article-title":"Impact of coronary artery calcification characteristics on accuracy of CT angiography","volume":"7","author":"Kruk","year":"2014","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2021.12.010_bib8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10554-011-9955-6","article-title":"The effect of calcium score on the diagnostic accuracy of coronary computed tomography angiography","volume":"27","author":"Chen","year":"2011","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2021.12.010_bib9","doi-asserted-by":"crossref","first-page":"1323.e1","DOI":"10.1016\/j.ahj.2005.12.027","article-title":"Accuracy of 64-row multidetector computed tomography in detecting coronary artery disease in 134 symptomatic patients: influence of calcification","volume":"151","author":"Ong","year":"2006","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcmg.2021.12.010_bib10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jcct.2016.10.002","article-title":"SCCT guidelines for the performance and acquisition of coronary computed tomographic angiography: a report of the Society of Cardiovascular Computed Tomography Guidelines Committee. Endorsed by the North American Society for Cardiovascular Imaging (NASCI)","volume":"10","author":"Abbara","year":"2016","journal-title":"J\u00a0Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.jcmg.2021.12.010_bib11","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/j.jacc.2011.06.066","volume":"58","author":"Koo","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2021.12.010_bib12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jcct.2012.04.010","article-title":"Effect of image quality on diagnostic accuracy of noninvasive fractional flow reserve: Results from the prospective multicenter international DISCOVER-FLOW study","volume":"6","author":"Min","year":"2012","journal-title":"J\u00a0Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.jcmg.2021.12.010_bib13","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jacc.2013.11.043","article-title":"Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: The NXT trial","volume":"63","author":"N\u00f8rgaard","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2021.12.010_bib14","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jcmg.2015.06.003","article-title":"Influence of coronary calcification on the diagnostic performance of CT angiography derived FFR in coronary artery disease. A substudy of the NXT Trial","volume":"8","author":"N\u00f8rgaard","year":"2015","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2021.12.010_bib15","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jcmg.2019.06.027","article-title":"Influence of coronary calcium on diagnostic performance of machine learning CT-FFR: results from MACHINE registry","volume":"13","author":"Tesche","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2021.12.010_bib16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000499667","article-title":"Functional and anatomical testing in intermediate risk chest pain patients with a high coronary calcium score: rationale and design of the FACC study","volume":"142","author":"\u00d8vrehus","year":"2019","journal-title":"Cardiology"},{"key":"10.1016\/j.jcmg.2021.12.010_bib17","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1093\/eurheartj\/eht296","article-title":"2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology","volume":"34","author":"Montalescot","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2021.12.010_bib18","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatson","year":"1990","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2021.12.010_bib19","first-page":"122","article-title":"SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography","volume":"3","author":"Raff","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2021.12.010_bib20","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.jcmg.2016.11.024","article-title":"Noninvasive FFR derived from coronary CT angiography. Manage and outcome from the PROMISE trial","volume":"10","author":"Lu","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2021.12.010_bib21","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1016\/j.jacc.2016.03.523","article-title":"Sex differences in functional stress versus CT angiography in symptomatic patients with suspected CAD: Insights from PROMISE","volume":"67","author":"Pagidipati","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2021.12.010_bib22","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.jcmg.2015.08.006","article-title":"Non-invasive fractional flow reserve derived from coronary CT angiography: clinical data and scientific principles","volume":"8","author":"Min","year":"2015","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2021.12.010_bib23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/ehjci\/jew148","article-title":"Fractional flow reserve by computerized tomography and subsequent coronary revascularization","volume":"18","author":"Packard","year":"2017","journal-title":"Eur Heart J Imaging"},{"key":"10.1016\/j.jcmg.2021.12.010_bib24","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jcmg.2015.11.025","article-title":"Clinical use of coronary CTA-derived FFR for decision-Making in stable CAD","volume":"10","author":"N\u00f8rgaard","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2021.12.010_bib25","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/j.jacc.2018.07.043","article-title":"Clinical outcomes using coronary CT angiography and FFR-CT guided management of stable chest pain patients","volume":"72","author":"N\u00f8rgaard","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2021.12.010_bib26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jcmg.2019.03.003","article-title":"1-year impact on medical practice and clinical outcomes of FFRCT. The ADVANCE registry","volume":"13","author":"Patel","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2021.12.010_bib27","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/biomet\/26.4.404","article-title":"The use of confidence or fiducial limits illustrated in the case of the binomial","volume":"26","author":"Clopper","year":"1934","journal-title":"Biometrika"},{"key":"10.1016\/j.jcmg.2021.12.010_bib28","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.jcmg.2021.12.010_bib29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10877-014-9577-3","article-title":"Improvements in the application and reporting of advanced Bland-Altman methods of comparison","volume":"29","author":"Olofsen","year":"2015","journal-title":"J\u00a0Clin Monit Comput"},{"key":"10.1016\/j.jcmg.2021.12.010_bib30","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jcmg.2017.11.022","article-title":"The location of distal coronary artery pressure measurement matters for computed tomography \u2013derived fractional flow reserve (answer to letter)","volume":"11","author":"N\u00f8rgaard","year":"2018","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2021.12.010_bib31","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1093\/eurheartj\/ehv444","volume":"36","author":"Douglas","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2021.12.010_bib32","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/ehjci\/jeaa173","article-title":"Clinical outcomes following real-world computed tomography angiography-derived fractional flow reserve testing in chronic coronary syndrome patients with calcification","volume":"22","author":"N\u00f8rgaard","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2021.12.010_bib33","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.ahj.2014.03.003","article-title":"PROspective Multicenter Imaging Study for Evaluation of chest pain: rationale and design of the PROMISE trial","volume":"167","author":"Douglas","year":"2014","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcmg.2021.12.010_bib34","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1161\/CIRCULATIONAHA.117.030578","article-title":"prognostic value of coronary artery calcium in the PROMISE Study (Prospective Multicenter Imaging Study for Evaluation of Chest Pain)","volume":"136","author":"Budoff","year":"2017","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.jcmg.2021.12.010_bib35","first-page":"604","article-title":"Fractional flow reserve derived from coronary computed tomography angiography safely defers invasive coronary angiography in patients with stable coronary artery disease","volume":"9","author":"Rabbat","year":"2020","journal-title":"J\u00a0Clin Med"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X21009104?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X21009104?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:53:23Z","timestamp":1761846803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X21009104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S1936878X21009104"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2021.12.010","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic and Clinical Value of FFRCT in\u00a0Stable Chest Pain Patients With Extensive Coronary Calcification","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2021.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}