{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:54:55Z","timestamp":1768002895194,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2019R1A2C2084099"],"award-info":[{"award-number":["2019R1A2C2084099"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["03-2020-0430"],"award-info":[{"award-number":["03-2020-0430"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jcmg.2021.12.014","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T16:05:23Z","timestamp":1645027523000},"page":"974-986","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Network Analysis of Cardiac Remodeling by Primary Mitral Regurgitation Emphasizes the Role of Diastolic Function"],"prefix":"10.1016","volume":"15","author":[{"given":"You-Jung","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaemin","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doyeon","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woong","family":"Kook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hozumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinori","family":"Yuasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lieng Hsi","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheuk-Man","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Won","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Otsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Kwan","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-Won","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon-Hee","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Pyo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2021.12.014_bib1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0195-668X(03)00201-X","article-title":"A\u00a0prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease","volume":"24","author":"Iung","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2021.12.014_bib2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jcmg.2021.12.014_bib3","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2021.12.014_bib4","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jacc.2020.11.035","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2021.12.014_bib5","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/srep01236","article-title":"Extracting insights from the shape of complex data using topology","volume":"3","author":"Lum","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmg.2021.12.014_bib6","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1016\/j.jmb.2018.05.037","article-title":"Patient Similarity Networks for Precision Medicine","volume":"430","author":"Pai","year":"2018","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.jcmg.2021.12.014_bib7","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/hbm.23461","article-title":"Integrated multimodal network approach to PET and MRI based on multidimensional persistent homology","volume":"38","author":"Lee","year":"2017","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.jcmg.2021.12.014_bib8","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1038\/s41598-020-59921-4","article-title":"Maturational delay and asymmetric information flow of brain connectivity in SHR model of ADHD revealed by topological analysis of metabolic networks","volume":"10","author":"Ha","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmg.2021.12.014_bib9","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1073\/pnas.1102826108","article-title":"Topology based data analysis identifies a subgroup of breast cancers with a unique mutational profile and excellent survival","volume":"108","author":"Nicolau","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmg.2021.12.014_bib10","doi-asserted-by":"crossref","first-page":"311ra174","DOI":"10.1126\/scitranslmed.aaa9364","article-title":"Identification of type 2 diabetes subgroups through topological analysis of patient similarity","volume":"7","author":"Li","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jcmg.2021.12.014_bib11","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jcmg.2018.11.025","article-title":"Network Tomography for Understanding Phenotypic Presentations in Aortic Stenosis","volume":"12","author":"Casaclang-Verzosa","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2021.12.014_bib12","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.jcmg.2020.02.008","article-title":"A\u00a0network-based \u201cphenomics\u201d approach for discovering patient subtypes from high-throughput cardiac imaging data","volume":"13","author":"Cho","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2021.12.014_bib13","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.jcmg.2020.11.009","article-title":"Topological data analysis of coronary plaques demonstrates the natural history of coronary atherosclerosis","volume":"14","author":"Hwang","year":"2021","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2021.12.014_bib14","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00380-019-01514-x","article-title":"Changes of echocardiographic parameters in primary mitral regurgitation and determinants of symptom: an assessment from the Asian Valve Registry data","volume":"35","author":"Amano","year":"2020","journal-title":"Heart Vessels"},{"key":"10.1016\/j.jcmg.2021.12.014_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and\u00a0the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jcmg.2021.12.014_bib16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jcmg.2021.12.014_bib17","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","volume":"23","author":"Rudski","year":"2010","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jcmg.2021.12.014_bib18","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Magnetic Resonance","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jcmg.2021.12.014_bib19","article-title":"Topological methods for the analysis of high dimensional data\u00a0sets and 3D object recognition","volume":"2","author":"Singh","year":"2007","journal-title":"Eurographics\u00a0Symposium on Point-Based Graphics"},{"key":"10.1016\/j.jcmg.2021.12.014_bib20","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1090\/S0273-0979-09-01249-X","article-title":"Topology and data","volume":"46","author":"Carlsson","year":"2009","journal-title":"Bulletin of the American Mathematical Society"},{"key":"10.1016\/j.jcmg.2021.12.014_bib21","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/eurheartj\/ehx465","article-title":"The MIDA Mortality Risk Score: development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation","volume":"39","author":"Grigioni","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2021.12.014_bib22","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.118.007471","article-title":"Hemodynamics in primary mitral regurgitation: support for and challenges to the conventional wisdom","volume":"11","author":"Gillam","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2021.12.014_bib23","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1161\/01.CIR.83.3.797","article-title":"Left ventricular passive diastolic properties in chronic mitral regurgitation","volume":"83","author":"Corin","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2021.12.014_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1161\/01.CIR.91.1.161","article-title":"Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat","volume":"91","author":"Conrad","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2021.12.014_bib25","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1097\/HJH.0b013e3282eee9cf","article-title":"Left ventricular diastolic dysfunction in elderly hypertensives: results of the APROS-diadys study","volume":"25","author":"Zanchetti","year":"2007","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.jcmg.2021.12.014_bib26","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1161\/CIRCULATIONAHA.107.716886","article-title":"Role of left ventricular stiffness in heart failure with normal ejection fraction","volume":"117","author":"Westermann","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2021.12.014_bib27","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1067\/mje.2001.111475","article-title":"Mitral regurgitation and left ventricular diastolic dysfunction similarly affect mitral and pulmonary vein flow Doppler parameters: the advantage of end-diastolic markers","volume":"14","author":"Rossi","year":"2001","journal-title":"J\u00a0Am Soc Echocardiogr"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X22000080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X22000080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:53:11Z","timestamp":1761846791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X22000080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S1936878X22000080"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2021.12.014","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Network Analysis of Cardiac Remodeling by Primary Mitral Regurgitation Emphasizes the Role of Diastolic Function","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2021.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}