{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:37:41Z","timestamp":1792640261014,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.jcmg.2022.01.003","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T14:58:28Z","timestamp":1647442708000},"page":"1291-1304","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography in Acute Aortic Syndrome"],"prefix":"10.1016","volume":"15","author":[{"given":"Maaz B.J.","family":"Syed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Debono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel O.","family":"Forsythe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle C.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Dweck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop S.V.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Macaskill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Denvir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Kaczynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Sellers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Masson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orwa","family":"Falah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick T.A.","family":"Chalmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Tambyraja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin J.R.","family":"van Beek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Newby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2022.01.003_bib1","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1161\/CIRCULATIONAHA.117.031264","article-title":"Insights from the International Registry of Acute Aortic Dissection","volume":"137","author":"Evangelista","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2022.01.003_bib2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s11748-017-0817-6","article-title":"The IRAD and beyond: what have we unravelled so far?","volume":"67","author":"Yuan","year":"2019","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jcmg.2022.01.003_bib3","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/path.4949","article-title":"Aortic microcalcification is associated with elastin fragmentation in Marfan syndrome: microcalcification and elastin fragmentation in Marfan syndrome","volume":"243","author":"Wanga","year":"2017","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jcmg.2022.01.003_bib4","doi-asserted-by":"crossref","first-page":"7495","DOI":"10.1038\/ncomms8495","article-title":"Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography","volume":"6","author":"Irkle","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmg.2022.01.003_bib5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1161\/CIRCIMAGING.113.001508","article-title":"18F-sodium fluoride uptake is a marker of active calcification and disease progression in patients with aortic stenosis","volume":"7","author":"Dweck","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2022.01.003_bib6","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1016\/j.jacc.2020.04.046","article-title":"Coronary 18F-sodium fluoride uptake predicts outcomes in patients with coronary artery disease","volume":"75","author":"Kwiecinski","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2022.01.003_bib7","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jacc.2017.11.053","article-title":"18F\u2013sodium fluoride uptake in abdominal aortic aneurysms: the SoFIA3 study","volume":"71","author":"Forsythe","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2022.01.003_bib8","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2022.01.003_bib9","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ejvs.2013.03.013","article-title":"Distinction between acute and chronic type B aortic dissection: is there a sub-acute phase?","volume":"45","author":"Steuer","year":"2013","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jcmg.2022.01.003_bib10","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.005131","article-title":"Optimization and reproducibility of aortic valve 18F-fluoride positron emission tomography in patients with aortic stenosis","volume":"9","author":"Pawade","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2022.01.003_bib11","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0140-6736(13)61754-7","article-title":"18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial","volume":"383","author":"Joshi","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jcmg.2022.01.003_bib12","first-page":"1801","article-title":"Phosphate, pyrophosphate, and vascular calcification: a question of balance","volume":"38","author":"Villa-Bellosta","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2022.01.003_bib13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-020-0352-5","article-title":"T\u00a0cell subsets and functions in atherosclerosis","volume":"17","author":"Saigusa","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jcmg.2022.01.003_bib14","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jacc.2021.06.049","article-title":"Medial arterial calcification","volume":"78","author":"Lanzer","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2022.01.003_bib15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tcm.2014.10.021","article-title":"Vascular calcification: mechanisms of vascular smooth muscle cell calcification","volume":"25","author":"Leopold","year":"2015","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.jcmg.2022.01.003_bib16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bone.2017.07.006","article-title":"Vascular ossification: pathology, mechanisms, and clinical implications","volume":"109","author":"Fuery","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.jcmg.2022.01.003_bib17","doi-asserted-by":"crossref","first-page":"15320","DOI":"10.1038\/s41598-019-51558-2","article-title":"Modeling lamellar disruption within the aortic wall using a particle-based approach","volume":"9","author":"Ahmadzadeh","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmg.2022.01.003_bib18","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1067\/mva.2001.112231","article-title":"Molecular mechanisms of aortic wall remodeling in response to hypertension","volume":"33","author":"Xu","year":"2001","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jcmg.2022.01.003_bib19","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1136\/jcp.39.10.1074","article-title":"Histological pattern and changes in extracellular matrix in aortic dissections","volume":"39","author":"Sariola","year":"1986","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.jcmg.2022.01.003_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000342436","article-title":"Possible mechanical roles of glycosaminoglycans in thoracic aortic dissection and associations with dysregulated transforming growth factor-\u03b2","volume":"50","author":"Humphrey","year":"2013","journal-title":"J\u00a0Vasc Res"},{"key":"10.1016\/j.jcmg.2022.01.003_bib21","article-title":"Association between acute aortic dissection and the distribution of aortic calcification","volume":"14","author":"Yang","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmg.2022.01.003_bib22","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1136\/heartjnl-2015-308779","article-title":"Monitoring the biological activity of abdominal aortic aneurysms beyond ultrasound","volume":"102","author":"Forsythe","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.jcmg.2022.01.003_bib23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000481930","article-title":"Prevention of aortic dissection suggests a diameter shift to a lower aortic size threshold for intervention","volume":"139","author":"Mansour","year":"2018","journal-title":"Cardiology"},{"key":"10.1016\/j.jcmg.2022.01.003_bib24","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1001\/jama.287.22.2968","article-title":"Rupture rate of large abdominal aortic aneurysms in patients refusing or unfit for elective repair","volume":"287","author":"Lederle","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.jcmg.2022.01.003_bib25","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1007\/s12350-019-01940-4","article-title":"Iterative reconstruction incorporating background correction improves quantification of [18F]-NaF PET\/CT images of patients with abdominal aortic aneurysm","volume":"28","author":"Akerele","year":"2019","journal-title":"J\u00a0Nucl Cardiol"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X22000468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X22000468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:52:49Z","timestamp":1761846769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X22000468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S1936878X22000468"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2022.01.003","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography in Acute Aortic Syndrome","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2022.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier on behalf of the American College of Cardiology Foundation","name":"copyright","label":"Copyright"}]}}