{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:07:35Z","timestamp":1793138855298,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jcmg.2022.02.004","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T16:02:58Z","timestamp":1649865778000},"page":"1078-1088","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":175,"title":["Pericoronary Adipose Tissue Attenuation, Low-Attenuation Plaque Burden, and 5-Year Risk of Myocardial Infarction"],"prefix":"10.1016","volume":"15","author":[{"given":"Evangelos","family":"Tzolos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle C.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"McElhinney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajetan","family":"Grodecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Flores Tomasino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Cadet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Kwiecinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mhairi","family":"Doris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip D.","family":"Adamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair J.","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirjel","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop S.V.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas L.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Pawade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Weir-McCall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giles","family":"Roditi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin J.R.","family":"van Beek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslee J.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D.","family":"Nicol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Berman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr J.","family":"Slomka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Dweck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Newby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damini","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2022.02.004_bib1","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1016\/j.jacc.2018.02.079","article-title":"Coronary atherosclerotic precursors of acute coronary syndromes","volume":"71","author":"Chang","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2022.02.004_bib2","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1001\/jama.2014.14681","article-title":"Nonobstructive coronary artery disease and risk of myocardial infarction","volume":"312","author":"Maddox","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jcmg.2022.02.004_bib3","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1161\/CIRCULATIONAHA.119.044720","article-title":"Low-attenuation noncalcified plaque on coronary computed tomography angiography predicts myocardial infarction","volume":"141","author":"Williams","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2022.02.004_bib4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmg.2022.02.004_bib5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1161\/01.CIR.89.1.36","article-title":"Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology","volume":"89","author":"van der Wal","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2022.02.004_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal2658","article-title":"Detecting human coronary inflammation by imaging perivascular fat","volume":"9","author":"Antonopoulos","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jcmg.2022.02.004_bib7","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1093\/eurheartj\/ehz592","article-title":"A\u00a0novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography","volume":"40","author":"Oikonomou","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2022.02.004_bib8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijcard.2021.03.019","article-title":"Prognostic value of pericoronary inflammation and unsupervised machine-learning-defined phenotypic clustering of CT angiographic findings","volume":"333","author":"Hoshino","year":"2021","journal-title":"Int J Cardiol"},{"issue":"9","key":"10.1016\/j.jcmg.2022.02.004_bib9","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1001\/jamacardio.2018.1997","article-title":"Pericoronary adipose tissue computed tomography attenuation and high-risk plaque characteristics in acute coronary syndrome compared with stable coronary artery disease","volume":"3","author":"Goeller","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"3","key":"10.1016\/j.jcmg.2022.02.004_bib10","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/ehjci\/jeaa224","article-title":"Pericoronary adipose tissue computed tomography attenuation distinguishes different stages of coronary artery disease: a cross-sectional study","volume":"22","author":"Lin","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2022.02.004_bib11","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/1745-6215-13-184","article-title":"Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial","volume":"13","author":"Newby","year":"2012","journal-title":"Trials"},{"key":"10.1016\/j.jcmg.2022.02.004_bib12","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jcct.2009.09.004","article-title":"Automated three-dimensional quantification of non-calcified and calcified coronary plaque from coronary CT angiography","author":"Dey","year":"2009","journal-title":"J\u00a0Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.jcmg.2022.02.004_bib13","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2022.02.004_bib14","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1001\/jamacardio.2018.1997","article-title":"Pericoronary adipose tissue CT attenuation and high-risk plaque characteristics in acute coronary syndrome compared to stable coronary artery disease","volume":"3","author":"Goeller","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"1","key":"10.1016\/j.jcmg.2022.02.004_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jcct.2020.03.007","article-title":"Repeatability of quantitative pericoronary adipose tissue attenuation and coronary plaque burden from coronary CT angiography","volume":"15","author":"Tzolos","year":"2021","journal-title":"J\u00a0Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.jcmg.2022.02.004_bib16","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/0895-4356(95)00530-7","article-title":"Computerised record linkage: compared with traditional patient follow-up methods in clinical trials and illustrated in a prospective epidemiological study. The West of Scotland Coronary Prevention Study Group","volume":"48","year":"1995","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.jcmg.2022.02.004_bib17","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"2007","journal-title":"Biometrics"},{"key":"10.1016\/j.jcmg.2022.02.004_bib18","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.1007\/s00330-020-07069-0","article-title":"Towards reference values of pericoronary adipose tissue\u00a0attenuation: impact of coronary artery and tube\u00a0voltage in coronary computed tomography\u00a0angiography","volume":"30","author":"Ma","year":"2020","journal-title":"Eur Radiol"},{"key":"10.1016\/j.jcmg.2022.02.004_bib19","article-title":"Determinants of pericoronary adipose tissue attenuation on computed tomography angiography in coronary artery disease","volume":"9","author":"Sugiyama","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jcmg.2022.02.004_bib20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ijcard.2017.09.178","article-title":"Gender differences in the association of epicardial adipose tissue and coronary artery calcification: EPICHEART study: EAT and coronary calcification by gender","volume":"249","author":"Mancio","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcmg.2022.02.004_bib21","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.atherosclerosis.2010.06.044","article-title":"Age and sex mediated changes in epicardial fat adipokines","volume":"212","author":"Fei","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jcmg.2022.02.004_bib22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11892-018-1031-3","article-title":"Gender and sex differences in adipose tissue","volume":"18","author":"Chang","year":"2018","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.jcmg.2022.02.004_bib23","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jcct.2015.07.011","article-title":"CT-based analysis of pericoronary adipose tissue density: relation to cardiovascular risk factors and epicardial adipose tissue volume","volume":"10","author":"Hell","year":"2016","journal-title":"J\u00a0Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.jcmg.2022.02.004_bib24","article-title":"Coronary inflammation by computed tomography pericoronary fat attenuation in MINOCA and Tako-Tsubo syndrome","volume":"8","author":"Gaibazzi","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jcmg.2022.02.004_bib25","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jcct.2015.03.015","article-title":"Distribution and burden of newly detected coronary artery calcium: results from the Multi-Ethnic Study of Atherosclerosis","volume":"9","author":"Alluri","year":"2015","journal-title":"J\u00a0Cardiovasc Comput Tomogr"},{"issue":"8","key":"10.1016\/j.jcmg.2022.02.004_bib26","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.jcmg.2021.02.026","article-title":"Prognostic value of RCA pericoronary adipose tissue CT-attenuation beyond high-risk plaques, plaque volume, and ischemia","volume":"14","author":"van Diemen","year":"2021","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2022.02.004_bib27","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0140-6736(18)31114-0","article-title":"Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data","volume":"392","author":"Oikonomou","year":"2018","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.jcmg.2022.02.004_bib28","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/ehjci\/jez013","article-title":"Relationship between changes in pericoronary adipose tissue attenuation and coronary plaque burden quantified from coronary computed tomography angiography","volume":"20","author":"Goeller","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2022.02.004_bib29","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1016\/j.jcmg.2020.06.033","article-title":"Myocardial infarction associates with a distinct pericoronary adipose tissue radiomic phenotype: a prospective case-control study","volume":"13","author":"Lin","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Img"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X22001024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X22001024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:54:02Z","timestamp":1761846842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X22001024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S1936878X22001024"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2022.02.004","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pericoronary Adipose Tissue Attenuation, Low-Attenuation Plaque Burden, and 5-Year Risk of Myocardial Infarction","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2022.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}