{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:17:42Z","timestamp":1792844262192,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jcmg.2023.07.013","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T13:56:55Z","timestamp":1695823015000},"page":"284-297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Clinical Outcomes Based on Coronary Computed Tomography-Derived Fractional Flow Reserve and Plaque\u00a0Characterization"],"prefix":"10.1016","volume":"17","author":[{"given":"Yoshihiro","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadako","family":"Motoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Miyajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Sarai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Naruse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9079-1103","authenticated-orcid":false,"given":"Yukio","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Izawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagat","family":"Narula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2023.07.013_bib1","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1056\/NEJMoa0806576","article-title":"Diagnostic performance of coronary angiography by 64-row CT","volume":"359","author":"Miller","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmg.2023.07.013_bib2","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.jacc.2008.08.058","article-title":"Diagnostic accuracy of 64-slice computed tomography coronary angiography: a prospective, multicenter, multivendor study","volume":"52","author":"Meijboom","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2023.07.013_bib3","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/2012.jama.11274","article-title":"Diagnostic accuracy of fractional flow reserve from anatomic CT angiography","volume":"308","author":"Min","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.jcmg.2023.07.013_bib4","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/j.jacc.2018.07.043","article-title":"Coronary CT angiographic and flow reserve-guided management of patients with stable ischemic heart disease","volume":"72","author":"N\u00f8rgaard","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2023.07.013_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jacc.2018.10.056","article-title":"Comparison of coronary computed tomography angiography, fractional flow reserve, and perfusion imaging for ischemia diagnosis","volume":"73","author":"Driessen","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2023.07.013_bib6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.jcmg.2016.07.005","article-title":"Noninvasive CT-derived FFR based on structural and fluid analysis: a comparison with invasive FFR for detection of functionally significant stenosis","volume":"10","author":"Ko","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcmg.2023.07.013_bib7","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s00380-020-01606-z","article-title":"On-site assessment of computed tomography-derived fractional flow reserve in comparison with myocardial perfusion imaging and invasive fractional flow reserve","volume":"35","author":"Miyajima","year":"2020","journal-title":"Heart Vessels"},{"key":"10.1016\/j.jcmg.2023.07.013_bib8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/ehjci\/jey104","article-title":"Diagnostic performance of on-site computed CT-fractional flow reserve based on fluid structure interactions: comparison with invasive fractional flow reserve and instantaneous wave-free ratio","volume":"20","author":"Fujimoto","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2023.07.013_bib9","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1056\/NEJMoa1408758","article-title":"Fractional flow reserve-guided PCI for stable coronary artery disease","volume":"371","author":"Bruyne","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmg.2023.07.013_bib10","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJMoa1205361","article-title":"Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease","volume":"367","author":"Bruyne","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmg.2023.07.013_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jacc.2010.04.012","article-title":"Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) study","volume":"56","author":"Pijls","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.jcmg.2023.07.013_bib12","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jcmg.2015.11.025","article-title":"Clinical use of coronary CTA\u2013derived FFR for decision-making in stable CAD","volume":"10","author":"N\u00f8rgaard","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Img"},{"issue":"4","key":"10.1016\/j.jcmg.2023.07.013_bib13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/ehjci\/jex068","article-title":"Computed tomography derived fractional flow reserve testing in stable patients with typical angina pectoris: influence on downstream rate of invasive coronary angiography","volume":"19","author":"Jensen","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"3","key":"10.1016\/j.jcmg.2023.07.013_bib14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes: the task force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC)","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur Heart J"},{"issue":"22","key":"10.1016\/j.jcmg.2023.07.013_bib15","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1016\/j.jacc.2021.07.053","article-title":"2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR guideline for the evaluation and diagnosis of chest pain: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"78","author":"Gulati","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.jcmg.2023.07.013_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jacc.2009.02.068","article-title":"Computed tomographic angiography characteristics of atherosclerotic plaques subsequently resulting in acute coronary syndrome","volume":"54","author":"Motoyama","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.jcmg.2023.07.013_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jacc.2015.05.069","article-title":"Plaque characterization by coronary computed tomography angiography and the likelihood of acute coronary events in mid-term follow-up","volume":"66","author":"Motoyama","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.jcmg.2023.07.013_bib18","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jcct.2014.07.003","article-title":"SCCT guidelines for the interpretation and reporting of coronary CT angiography: a report of the Society of Cardiovascular Computed Tomography Guidelines Committee","volume":"8","author":"Leipsic","year":"2014","journal-title":"J\u00a0Cardiovasc Comput Tomogr"},{"issue":"4","key":"10.1016\/j.jcmg.2023.07.013_bib19","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jacc.2007.03.044","article-title":"Multislice computed tomographic characteristics of coronary lesions in acute coronary syndromes","volume":"50","author":"Motoyama","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.jcmg.2023.07.013_bib20","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1253\/circj.71.363","article-title":"Atherosclerotic plaque characterization by 0.5-mm-slice multislice computed tomographic imaging","volume":"71","author":"Motoyama","year":"2007","journal-title":"Circ J"},{"key":"10.1016\/j.jcmg.2023.07.013_bib21","article-title":"A\u00a0novel CT-FFR method for the coronary artery based on 4D-CT image analysis and structural and fluid analysis","volume":"9412","author":"Hirohata","year":"2015","journal-title":"SPIE Med Imaging"},{"key":"10.1016\/j.jcmg.2023.07.013_bib22","series-title":"Proceedings of the ASME 2015 International Mechanical Engineering Congress and Exposition. Volume 3: Biomedical and Biotechnology Engineering","article-title":"Fast CT-FFR analysis method for the coronary artery based on 4D-CT image analysis and structural and fluid analysis","author":"Kato","year":"2015"},{"issue":"6","key":"10.1016\/j.jcmg.2023.07.013_bib23","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jcct.2017.09.009","article-title":"Fractional flow reserve derived from coronary computed tomography angiography reclassification rate using value distal to lesion compared to lowest value","volume":"11","author":"Kueh","year":"2017","journal-title":"J\u00a0Cardiovasc Comput Tomogr"},{"issue":"5","key":"10.1016\/j.jcmg.2023.07.013_bib24","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jcct.2017.06.002","article-title":"Interpreting results of coronary computed tomography angiography-derived fractional flow reserve in clinical practice","volume":"11","author":"Rabbat","year":"2017","journal-title":"J\u00a0Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.jcmg.2023.07.013_bib25","doi-asserted-by":"crossref","first-page":"e618","DOI":"10.1161\/CIR.0000000000000617","article-title":"Fourth Universal Definition of Myocardial Infarction (2018)","volume":"138","author":"Thygesen","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2023.07.013_bib26","first-page":"371","article-title":"The Canadian Cardiovascular Society grading of angina pectoris revisited 30 years later","volume":"18","author":"Campeau","year":"2002","journal-title":"Can J Cardiol"},{"issue":"37","key":"10.1016\/j.jcmg.2023.07.013_bib27","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1093\/eurheartj\/ehab444","article-title":"Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial","volume":"42","author":"Curzen","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2023.07.013_bib28","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1093\/eurheartj\/ehv444","article-title":"Clinical outcomes of fractional flow reserve by computed tomographic angiography-guided diagnostic strategies vs. usual care in patients with suspected coronary artery disease: the prospective longitudinal trial of FFRCT: outcome and resource impacts study","volume":"36","author":"Douglas","year":"2015","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.jcmg.2023.07.013_bib29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jacc.2016.05.057","article-title":"1-Year outcomes of FFRCT-guided care in patients with suspected coronary disease: the\u00a0PLATFORM study","volume":"68","author":"Douglas","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2023.07.013_bib30","first-page":"604","article-title":"Fractional flow reserve derived from coronary computed tomography angiography safely defers invasive coronary angiography in patients with stable coronary artery disease","volume":"9","author":"Rabbat","year":"2020","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.jcmg.2023.07.013_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jcmg.2019.03.003","article-title":"1-Year impact on medical practice and clinical outcomes of FFRCT: the ADVANCE Registry","volume":"13","author":"Patel","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Img"},{"issue":"18","key":"10.1016\/j.jcmg.2023.07.013_bib32","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1161\/CIRCULATIONAHA.119.044720","article-title":"Low-attenuation noncalcified plaque on coronary computed tomography angiography predicts myocardial infarction: results from the multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART)","volume":"141","author":"Williams","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2023.07.013_bib33","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1016\/j.jacc.2018.02.079","article-title":"Coronary atherosclerotic precursors of acute coronary syndromes","volume":"71","author":"Chang","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2023.07.013_bib34","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jcmg.2020.08.025","article-title":"CT Angiographic and plaque predictors of functionally significant coronary disease and outcome using machine learning","volume":"14","author":"Yang","year":"2021","journal-title":"J\u00a0Am Coll Cardiol Img"},{"issue":"10","key":"10.1016\/j.jcmg.2023.07.013_bib35","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/ehjci\/jeaa173","article-title":"Clinical outcomes following real-world computed tomography angiography-derived fractional flow reserve testing in chronic coronary syndrome patients with calcification","volume":"22","author":"N\u00f8rgaard","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"15","key":"10.1016\/j.jcmg.2023.07.013_bib36","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1915922","article-title":"Initial invasive or conservative strategy for stable coronary disease","volume":"382","author":"Maron","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmg.2023.07.013_bib37","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.jcmg.2010.04.011","article-title":"Serial coronary CT angiography-verified changes in plaque characteristics as an end point: evaluation of effect of statin intervention","volume":"3","author":"Inoue","year":"2010","journal-title":"J\u00a0Am Coll Cardiol Img"},{"issue":"5","key":"10.1016\/j.jcmg.2023.07.013_bib38","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1253\/circj.CJ-21-0615","article-title":"Effect of omega-3 fatty acids on coronary plaque morphology - a serial computed tomography angiography study","volume":"86","author":"Motoyama","year":"2022","journal-title":"Circ J"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X23003820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X23003820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:55:33Z","timestamp":1761846933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X23003820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1936878X23003820"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2023.07.013","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Outcomes Based on Coronary Computed Tomography-Derived Fractional Flow Reserve and Plaque\u00a0Characterization","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2023.07.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}