{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:45:54Z","timestamp":1787971554779,"version":"build-2784847793"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jcmg.2024.11.002","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T16:03:42Z","timestamp":1740413022000},"page":"696-706","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association Between Physiological Significance and Vulnerable Plaque Characteristics in Patients With Myocardial Infarction"],"prefix":"10.1016","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0539-6417","authenticated-orcid":false,"given":"Ketina","family":"Arslani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Engstr\u00f8m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Maeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Kj\u00f8ller-Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Maehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Ben-Yehuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Erik","family":"B\u00f8tker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-0247","authenticated-orcid":false,"given":"Mitsuaki","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S.","family":"Mintz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Fr\u00f6bert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6722-8745","authenticated-orcid":false,"given":"Jonas","family":"Persson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune","family":"Wiseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alf I.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette O.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan E.","family":"Nordrehaug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8yvind","family":"Bleie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmir","family":"Omerovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes","family":"Held","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan K.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad A.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Erlinge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2024.11.002_bib1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/eurheartj\/ehu505","article-title":"Cardiovascular risk in post-myocardial infarction patients: nationwide real world data demonstrate the importance of a long-term perspective","volume":"36","author":"Jernberg","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2024.11.002_bib2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1161\/CIRCULATIONAHA.120.047065","article-title":"Trends in recurrent coronary heart disease after myocardial infarction among US women and men between 2008 and 2017","volume":"143","author":"Peters","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2024.11.002_bib3","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0140-6736(21)00249-X","article-title":"Identification of vulnerable plaques and patients by intracoronary near-infrared spectroscopy and ultrasound (PROSPECT II): a prospective natural history study","volume":"397","author":"Erlinge","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jcmg.2024.11.002_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.121.011314","volume":"14","author":"Denormandie","year":"2021","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcmg.2024.11.002_bib5","first-page":"386","article-title":"Relationship between intravascular ultrasound parameters and fractional flow reserve in intermediate coronary artery stenosis of left anterior descending artery: intravascular ultrasound volumetric analysis","volume":"83","author":"Yang","year":"2014","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcmg.2024.11.002_bib6","doi-asserted-by":"crossref","first-page":"E694","DOI":"10.25270\/jic\/20.00653","article-title":"Translesional fractional flow reserve is related to plaque components in coronary artery disease: a study combining pressure wire and NIRS-IVUS analysis","volume":"33","author":"Jin","year":"2021","journal-title":"J Invasive Cardiol"},{"key":"10.1016\/j.jcmg.2024.11.002_bib7","doi-asserted-by":"crossref","first-page":"824","DOI":"10.4244\/EIJV9I7A136","article-title":"Clinical outcomes after intravascular ultrasound and fractional flow reserve assessment of intermediate coronary lesions. Propensity score matching of large cohorts from two institutions with a differential approach","volume":"9","author":"de la Torre Hernandez","year":"2013","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcmg.2024.11.002_bib8","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1161\/CIRCULATIONAHA.116.024433","article-title":"Fractional flow reserve and cardiac events in coronary artery disease: data from a prospective IRIS-FFR registry (Interventional Cardiology Research Incorporation Society Fractional Flow Reserve)","volume":"135","author":"Ahn","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2024.11.002_bib9","first-page":"247","article-title":"Long-term outcome after deferred revascularization due to negative fractional flow reserve in intermediate coronary lesions","volume":"97","author":"Weerts","year":"2021","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcmg.2024.11.002_bib10","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1093\/eurheartj\/ehab433","article-title":"Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT-FFR trial","volume":"42","author":"Kedhi","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2024.11.002_bib11","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/j.jacc.2020.09.547","article-title":"Percutaneous coronary intervention for vulnerable coronary atherosclerotic plaque","volume":"76","author":"Stone","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2024.11.002_bib12","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.jcmg.2008.06.001","article-title":"Detection of lipid core coronary plaques in autopsy specimens with a novel catheter-based near-infrared spectroscopy system","volume":"1","author":"Gardner","year":"2008","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2024.11.002_bib13","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1056\/NEJMoa1002358","article-title":"A prospective natural-history study of coronary atherosclerosis","volume":"364","author":"Stone","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcmg.2024.11.002_bib14","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/S0140-6736(19)31794-5","article-title":"Identification of patients and plaques vulnerable to future coronary events with near-infrared spectroscopy intravascular ultrasound imaging: a prospective, cohort study","volume":"394","author":"Waksman","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jcmg.2024.11.002_bib15","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jjcc.2015.10.012","article-title":"Association between fractional flow reserve and coronary plaque characteristics assessed by optical coherence tomography","volume":"68","author":"Lee","year":"2016","journal-title":"J Cardiol"},{"key":"10.1016\/j.jcmg.2024.11.002_bib16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1001\/jamacardio.2021.5705","article-title":"Association of plaque location and vessel geometry determined by coronary computed tomographic angiography with future acute coronary syndrome-causing culprit lesions","volume":"7","author":"Han","year":"2022","journal-title":"JAMA Cardiol"},{"issue":"2","key":"10.1016\/j.jcmg.2024.11.002_bib17","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.jacc.2021.09.006","article-title":"2021 ACC\/AHA\/SCAI guideline for coronary artery revascularization: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"79","author":"Lawton","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2024.11.002_bib18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2024.11.002_bib19","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jcin.2020.02.030","article-title":"Evaluation and management of nonculprit lesions in STEMI","volume":"13","author":"Thim","year":"2020","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcmg.2024.11.002_bib20","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0140-6736(15)60648-1","article-title":"Complete revascularisation versus treatment of the culprit lesion only in patients with ST-segment elevation myocardial infarction and multivessel disease (DANAMI-3-PRIMULTI): an open-label, randomised controlled trial","volume":"386","author":"Engstrom","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jcmg.2024.11.002_bib21","first-page":"397","article-title":"Fractional flow reserve-guided multivessel angioplasty in myocardial infarction","volume":"377","author":"Smits","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcmg.2024.11.002_bib22","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1056\/NEJMoa1907775","article-title":"Complete revascularization with multivessel PCI for myocardial infarction","volume":"381","author":"Mehta","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcmg.2024.11.002_bib23","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1016\/j.jacc.2019.09.051","article-title":"Timing of staged nonculprit artery revascularization in patients with ST-segment elevation myocardial infarction: COMPLETE Trial","volume":"74","author":"Wood","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2024.11.002_bib24","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1056\/NEJMoa2104650","article-title":"Multivessel PCI guided by FFR or angiography for myocardial infarction","volume":"385","author":"Puymirat","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcmg.2024.11.002_bib25","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1056\/NEJMoa2314149","article-title":"FFR-guided complete or culprit-only PCI in patients with myocardial infarction","volume":"390","author":"Bohm","year":"2024","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.jcmg.2024.11.002_bib26","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1001\/jamacardio.2023.2910","article-title":"Fractional flow reserve-negative high-risk plaques and clinical outcomes after myocardial infarction","volume":"8","author":"Mol","year":"2023","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jcmg.2024.11.002_bib27","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/ehjci\/jeu173","article-title":"Morphological features of non-culprit plaques on optical coherence tomography and integrated backscatter intravascular ultrasound in patients with acute coronary syndromes","volume":"16","author":"Maejima","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2024.11.002_bib28","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4244\/EIJ-D-19-01120","article-title":"Clinical outcomes of calcified nodules detected by optical coherence tomography: a sub-analysis of the CLIMA study","volume":"16","author":"Prati","year":"2020","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcmg.2024.11.002_bib29","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.008768","article-title":"Nonculprit lesion plaque morphology in patients with ST-segment-elevation myocardial infarction: results from the COMPLETE trial optical coherence tomography substudy","volume":"13","author":"Pinilla-Echeverri","year":"2020","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcmg.2024.11.002_bib30","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/S0140-6736(24)00413-6","article-title":"Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicentre, open-label, randomised controlled trial","volume":"403","author":"Park","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jcmg.2024.11.002_bib31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jcin.2019.09.034","article-title":"Fractional flow reserve or optical coherence tomography to guide management of angiographically intermediate coronary stenosis: a single-center trial","volume":"13","author":"Burzotta","year":"2020","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcmg.2024.11.002_bib32","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1001\/jama.2020.22708","article-title":"Association between adherence to fractional flow reserve treatment thresholds and major adverse cardiac events in patients with coronary artery disease","volume":"324","author":"Sud","year":"2020","journal-title":"JAMA"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X25000221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X25000221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T03:13:48Z","timestamp":1780283628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X25000221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1936878X25000221"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2024.11.002","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association Between Physiological Significance and Vulnerable Plaque Characteristics in Patients With Myocardial Infarction","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2024.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}