{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:15:01Z","timestamp":1790946901537,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000016","name":"Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jcmg.2025.01.019","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T14:28:09Z","timestamp":1749047289000},"page":"973-984","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mid- to Late-Life Traditional Cardiovascular Risk Factor Exposure and Zero Coronary Artery Calcium"],"prefix":"10.1016","volume":"18","author":[{"given":"Frances M.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoshana H.","family":"Ballew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron R.","family":"Folsom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne E.","family":"Wagenknecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace M.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Coresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Budoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Blaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2025.01.019_bib1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.jacc.2019.11.062","article-title":"Biological versus chronological aging: JACC focus seminar","volume":"75","author":"Hamczyk","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2025.01.019_bib2","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1161\/CIR.0000000000000758","article-title":"The American Heart Association 2030 impact goal: a presidential advisory from the American Heart Association","volume":"141","author":"Angell","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2025.01.019_bib3","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/CIRCULATIONAHA.115.018524","article-title":"Role of coronary artery calcium score of zero and other negative risk markers for cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"133","author":"Blaha","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2025.01.019_bib4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jacc.2019.05.032","article-title":"Coronary Artery calcium scores of zero and establishing the concept of negative risk factors","volume":"74","author":"Blaha","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2025.01.019_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.122.015145","article-title":"Defining demographic-specific coronary artery calcium percentiles in the population aged >\/=75: the ARIC study and MESA","volume":"16","author":"Wang","year":"2023","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2025.01.019_bib6","doi-asserted-by":"crossref","first-page":"e285","DOI":"10.1016\/j.jacc.2018.11.003","article-title":"2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"73","author":"Grundy","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2025.01.019_bib7","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.jacc.2019.03.009","article-title":"2019 ACC\/AHA guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"74","author":"Arnett","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2025.01.019_bib8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jacl.2020.12.005","article-title":"The National Lipid Association scientific statement on coronary artery calcium scoring to guide preventive strategies for ASCVD risk reduction","volume":"15","author":"Orringer","year":"2021","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.jcmg.2025.01.019_bib9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk","volume":"41","author":"Mach","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2025.01.019_bib10","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.jcmg.2015.01.025","article-title":"A 15-year warranty period for asymptomatic individuals without coronary artery calcium: a prospective follow-up of 9,715 individuals","volume":"8","author":"Valenti","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2025.01.019_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.amjcard.2008.08.031","article-title":"Arterial age as a function of coronary artery calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA])","volume":"103","author":"McClelland","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcmg.2025.01.019_bib12","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.jacc.2006.10.079","article-title":"Long-term prognosis associated with coronary calcification: observations from a registry of 25,253 patients","volume":"49","author":"Budoff","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2025.01.019_bib13","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1056\/NEJMoa072100","article-title":"Coronary calcium as a predictor of coronary events in four racial or ethnic groups","volume":"358","author":"Detrano","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcmg.2025.01.019_bib14","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.jcmg.2020.06.048","article-title":"Warranty period of a calcium score of zero: comprehensive analysis from MESA","volume":"14","author":"Dzaye","year":"2021","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2025.01.019_bib15","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1093\/eurheartj\/ehy217","article-title":"Ten-year association of coronary artery calcium with atherosclerotic cardiovascular disease (ASCVD) events: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"39","author":"Budoff","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2025.01.019_bib16","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jcmg.2015.09.020","article-title":"The association of coronary artery calcium with noncardiovascular disease: the Multi-Ethnic Study of Atherosclerosis","volume":"9","author":"Handy","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2025.01.019_bib17","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.122.015026","article-title":"Coronary artery calcification and one-year cardiovascular disease incidence in the 75-and-older population: the ARIC study","volume":"16","author":"Mok","year":"2023","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2025.01.019_bib18","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1093\/eurheartj\/ehs230","article-title":"Coronary artery calcium for the prediction of mortality in young adults <45 years old and elderly adults >75 years old","volume":"33","author":"Tota-Maharaj","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2025.01.019_bib19","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1016\/j.jacc.2021.04.035","article-title":"The ARIC (Atherosclerosis Risk in Communities) study: JACC Focus Seminar 3\/8","volume":"77","author":"Wright","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2025.01.019_bib20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1055\/s-0038-1646519","article-title":"ARIC hemostasis study\u2014I. Development of a blood collection and processing system suitable for multicenter hemostatic studies","volume":"61","author":"Papp","year":"1989","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jcmg.2025.01.019_bib21","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jcmg.2025.01.019_bib22","first-page":"1985","article-title":"The national glycohemoglobin standardization program: a five-year progress report","volume":"47","author":"Little","year":"2001","journal-title":"Clin Chem"},{"key":"10.1016\/j.jcmg.2025.01.019_bib23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2025.01.019_bib24","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC guidelines on cardiovascular disease prevention in clinical practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2025.01.019_bib25","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.jcmg.2015.06.019","article-title":"Predictors of long-term healthy arterial aging: coronary artery calcium nondevelopment in the MESA study","volume":"8","author":"Whelton","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2025.01.019_bib26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jcmg.2020.06.047","article-title":"Predicting long-term absence of coronary artery calcium in metabolic syndrome and diabetes: the MESA study","volume":"14","author":"Razavi","year":"2021","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2025.01.019_bib27","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/j.jacc.2004.03.046","article-title":"Optimal low-density lipoprotein is 50 to 70 mg\/dl: lower is better and physiologically normal","volume":"43","author":"O\u2019Keefe","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2025.01.019_bib28","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.jacc.2007.03.009","article-title":"Early adult risk factor levels and subsequent coronary artery calcification: the CARDIA study","volume":"49","author":"Loria","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2025.01.019_bib29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/jamacardio.2019.2946","article-title":"Association of genetically predicted lipid levels with the extent of coronary atherosclerosis in Icelandic adults","volume":"5","author":"Bjornsson","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jcmg.2025.01.019_bib30","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1001\/jama.1979.03290450033020","article-title":"Diabetes and cardiovascular disease. The Framingham study","volume":"241","author":"Kannel","year":"1979","journal-title":"JAMA"},{"key":"10.1016\/j.jcmg.2025.01.019_bib31","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.2337\/dc11-1950","article-title":"Fasting glucose, obesity, and coronary artery calcification in community-based people without diabetes","volume":"35","author":"Rutter","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcmg.2025.01.019_bib32","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1161\/ATVBAHA.116.307612","article-title":"Relationship of insulin resistance to prevalence and progression of coronary artery calcification beyond metabolic syndrome components: Shiga Epidemiological Study of Subclinical Atherosclerosis","volume":"36","author":"Yamazoe","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcmg.2025.01.019_bib33","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1016\/j.jacc.2021.03.335","article-title":"Glycated hemoglobin and subclinical atherosclerosis in people without diabetes","volume":"77","author":"Rossello","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2025.01.019_bib34","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1001\/jama.2019.10575","article-title":"Association of midlife to late-life blood pressure patterns with incident dementia","volume":"322","author":"Walker","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.jcmg.2025.01.019_bib35","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1001\/jama.2017.3090","article-title":"Association between midlife vascular risk factors and estimated brain amyloid deposition","volume":"317","author":"Gottesman","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jcmg.2025.01.019_bib36","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/CIR.0b013e3182285a81","article-title":"Value of primordial and primary prevention for cardiovascular disease: a policy statement from the American Heart Association","volume":"124","author":"Weintraub","year":"2011","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.jcmg.2025.01.019_bib37","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.008741","article-title":"Twenty-year trends in the American Heart Association cardiovascular health score and impact on subclinical and clinical cardiovascular disease: the Framingham Offspring Study","volume":"7","author":"Enserro","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jcmg.2025.01.019_bib38","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ypmed.2015.02.006","article-title":"Prevalence and changes over time of ideal cardiovascular health metrics among African-Americans: the Jackson Heart Study","volume":"74","author":"Djousse","year":"2015","journal-title":"Prev Med"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X25001792?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X25001792?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:36:24Z","timestamp":1788233784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X25001792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1936878X25001792"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2025.01.019","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mid- to Late-Life Traditional Cardiovascular Risk Factor Exposure and Zero Coronary Artery Calcium","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2025.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}