{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T09:37:55Z","timestamp":1793698675681,"version":"4.5.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jcmg.2025.10.012","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T21:35:00Z","timestamp":1764624900000},"page":"478-489","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Statin Effects on Pericoronary Adipose Tissue Density in People With HIV"],"prefix":"10.1016","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-4827","authenticated-orcid":false,"given":"Borek","family":"Foldyna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Hadzic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Mayrhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia","family":"Kar\u00e1dy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Taron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rton","family":"Kolossv\u00e1ry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet K.","family":"Raghu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"McCallum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Paradis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa R.","family":"Diggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex B.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charurut","family":"Somboonwit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose I.","family":"Bernardino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Dub\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig A.","family":"Sponseller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4711-3956","authenticated-orcid":false,"given":"Markella V.","family":"Zanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald S.","family":"Bloomfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos D.","family":"Malvestutto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Fichtenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Aberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith S.","family":"Currier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Ribaudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9876-4049","authenticated-orcid":false,"given":"Pamela S.","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K.","family":"Grinspoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jcmg.2025.10.012_bib1","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1161\/CIR.0000000000000695","article-title":"Characteristics, prevention, and management of cardiovascular disease in people living with HIV: a scientific statement from the American Heart Association","volume":"140","author":"Feinstein","year":"2019","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.jcmg.2025.10.012_bib2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1001\/jamainternmed.2013.3728","article-title":"HIV infection and the risk of acute myocardial infarction","volume":"173","author":"Freiberg","year":"2013","journal-title":"JAMA Intern Med"},{"issue":"11","key":"10.1016\/j.jcmg.2025.10.012_bib3","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/CIRCULATIONAHA.117.033369","article-title":"Global burden of atherosclerotic cardiovascular disease in people living with HIV","volume":"138","author":"Shah","year":"2018","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.jcmg.2025.10.012_bib4","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1210\/jc.2006-2190","article-title":"Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease","volume":"92","author":"Triant","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.jcmg.2025.10.012_bib5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/jama.2012.6698","article-title":"Arterial inflammation in patients with HIV","volume":"308","author":"Subramanian","year":"2012","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.jcmg.2025.10.012_bib6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/QAI.0000000000000138","article-title":"Increased arterial inflammation relates to high-risk coronary plaque morphology in HIV-infected patients","volume":"66","author":"Tawakol","year":"2014","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"8","key":"10.1016\/j.jcmg.2025.10.012_bib7","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/infdis\/jix095","article-title":"Application of a novel CD206+ macrophage-specific arterial imaging strategy in HIV-infected individuals","volume":"215","author":"Zanni","year":"2017","journal-title":"J Infect Dis"},{"issue":"6","key":"10.1016\/j.jcmg.2025.10.012_bib8","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.14923","article-title":"Assessment of coronary artery disease with computed tomography angiography and inflammatory and immune activation biomarkers among adults with HIV eligible for primary cardiovascular prevention","volume":"4","author":"Hoffmann","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"3","key":"10.1016\/j.jcmg.2025.10.012_bib9","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/QAI.0b013e3181a9992c","article-title":"Association of C-reactive protein and HIV infection with acute myocardial infarction","volume":"51","author":"Triant","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.jcmg.2025.10.012_bib10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/QAI.0b013e3181f4b752","article-title":"Association of immunologic and virologic factors with myocardial infarction rates in a U.S. health care system","volume":"55","author":"Triant","year":"2010","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"8","key":"10.1016\/j.jcmg.2025.10.012_bib11","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1097\/QAD.0b013e32835eca9b","article-title":"Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men","volume":"27","author":"Zanni","year":"2013","journal-title":"AIDS"},{"issue":"10","key":"10.1016\/j.jcmg.2025.10.012_bib12","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1093\/infdis\/jiac301","article-title":"Increased macrophage-specific arterial infiltration relates to noncalcified plaque and systemic immune activation in people with human immunodeficiency virus","volume":"226","author":"Toribio","year":"2022","journal-title":"J Infect Dis"},{"issue":"398","key":"10.1016\/j.jcmg.2025.10.012_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal2658","article-title":"Detecting human coronary inflammation by imaging perivascular fat","volume":"9","author":"Antonopoulos","year":"2017","journal-title":"Sci Transl Med"},{"issue":"12","key":"10.1016\/j.jcmg.2025.10.012_bib14","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1093\/cid\/ciad419","article-title":"Pericoronary adipose tissue density, inflammation, and subclinical coronary artery disease among people with HIV in the REPRIEVE cohort","volume":"77","author":"Foldyna","year":"2023","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jcmg.2025.10.012_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ahj.2018.12.016","article-title":"Rationale and design of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE)","volume":"212","author":"Grinspoon","year":"2019","journal-title":"Am Heart J"},{"issue":"8","key":"10.1016\/j.jcmg.2025.10.012_bib16","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1056\/NEJMoa2304146","article-title":"Pitavastatin to prevent cardiovascular disease in HIV infection","volume":"389","author":"Grinspoon","year":"2023","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.jcmg.2025.10.012_bib17","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1001\/jamacardio.2023.5661","article-title":"Effects of pitavastatin on coronary artery disease and inflammatory biomarkers in HIV: mechanistic substudy of the REPRIEVE randomized clinical trial","volume":"9","author":"Lu","year":"2024","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jcmg.2025.10.012_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ahj.2019.02.011","article-title":"Rationale and design of the mechanistic substudy of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE): effects of pitavastatin on coronary artery disease and inflammatory biomarkers","volume":"212","author":"Hoffmann","year":"2019","journal-title":"Am Heart J"},{"issue":"25 Pt B","key":"10.1016\/j.jcmg.2025.10.012_bib19","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1016\/j.jacc.2013.11.005","article-title":"2013 ACC\/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Goff","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.jcmg.2025.10.012_bib20","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.atherosclerosis.2009.08.032","article-title":"Computer-aided non-contrast CT-based quantification of pericardial and thoracic fat and their associations with coronary calcium and metabolic syndrome","volume":"209","author":"Dey","year":"2010","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.jcmg.2025.10.012_bib21","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.jcmg.2025.10.012_bib22","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jcct.2014.07.003","article-title":"SCCT guidelines for the interpretation and reporting of coronary CT angiography: a report of the Society of Cardiovascular Computed Tomography Guidelines Committee","volume":"8","author":"Leipsic","year":"2014","journal-title":"J Cardiovasc Comput Tomogr"},{"issue":"17","key":"10.1016\/j.jcmg.2025.10.012_bib23","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1056\/NEJMc2400870","article-title":"Trial update of pitavastatin to prevent cardiovascular events in HIV infection","volume":"390","author":"Grinspoon","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcmg.2025.10.012_bib24","author":"Lu"},{"issue":"6","key":"10.1016\/j.jcmg.2025.10.012_bib25","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jcct.2020.04.004","article-title":"Feasibility of measuring pericoronary fat from precontrast scans: Effect of iodinated contrast on pericoronary fat attenuation","volume":"14","author":"Almeida","year":"2020","journal-title":"J Cardiovasc Comput Tomogr"},{"issue":"suppl 2","key":"10.1016\/j.jcmg.2025.10.012_bib26","article-title":"Reduction of perivascular inflammation following long-term statin treatment\u2014a coronary CT follow-up study using fat attenuation index","volume":"44","author":"Matyas","year":"2023","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.jcmg.2025.10.012_bib27","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/ehjci\/jeaf062","article-title":"Effect of statin therapy on coronary inflammation assessed by pericoronary adipose tissue computed tomography attenuation","volume":"26","author":"Cheng","year":"2025","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"6","key":"10.1016\/j.jcmg.2025.10.012_bib28","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jcct.2023.08.008","article-title":"Pericoronary adipose tissue attenuation is associated with non-calcified plaque burden in patients with chronic coronary syndromes","volume":"17","author":"Giesen","year":"2023","journal-title":"J Cardiovasc Comput Tomogr"},{"issue":"10","key":"10.1016\/j.jcmg.2025.10.012_bib29","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.jcmg.2018.04.015","article-title":"Effects of statins on coronary atherosclerotic plaques: the PARADIGM study","volume":"11","author":"Lee","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"issue":"2","key":"10.1016\/j.jcmg.2025.10.012_bib30","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1016\/S2352-3018(14)00032-0","article-title":"Effects of statin therapy on coronary artery plaque volume and high-risk plaque morphology in HIV-infected patients with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial","volume":"2","author":"Lo","year":"2015","journal-title":"Lancet HIV"},{"issue":"10444","key":"10.1016\/j.jcmg.2025.10.012_bib31","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1016\/S0140-6736(24)00596-8","article-title":"Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study","volume":"403","author":"Chan","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jcmg.2025.10.012_bib32","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/S0735-1097(22)02227-6","article-title":"Usefulness of new method to quantify pericoronary adipose tissue on ECG-gated non-contrast chest CT scan","volume":"79","author":"Takahashi","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2025.10.012_bib33","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/j.jcct.2023.05.172","article-title":"AI analysis of pericoronary adipose tissue (PCAT) and MACE prediction in non-contrast CT calcium score images","volume":"17","author":"Kindi","year":"2023","journal-title":"J Cardiovasc Comput Tomogr"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X25005947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X25005947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T18:35:24Z","timestamp":1775500524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X25005947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1936878X25005947"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2025.10.012","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Statin Effects on Pericoronary Adipose Tissue Density in People With HIV","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2025.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}