{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:45:36Z","timestamp":1792215936848,"version":"4.4.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Imaging"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jcmg.2026.07.029","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:42:39Z","timestamp":1792096959000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Calcium Density as a Marker of Coronary Plaque Stabilization in Primary Prevention"],"prefix":"10.1016","author":[{"given":"Sheran A.","family":"Vasanthakumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Nicholls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3437-8648","authenticated-orcid":false,"given":"Nitesh","family":"Nerlekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9065-0899","authenticated-orcid":false,"given":"Thomas H.","family":"Marwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-7697","authenticated-orcid":false,"given":"Andrew","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmg.2026.07.029_bib1","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1016\/j.jacc.2018.09.051","article-title":"Impact of statins on cardiovascular outcomes following coronary artery calcium scoring","volume":"72","author":"Mitchell","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2026.07.029_bib2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jcmg.2017.01.029","article-title":"Statin trials, cardiovascular events, and coronary artery calcification","volume":"11","author":"Mortensen","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2026.07.029_bib3","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S0140-6736(23)00215-5","article-title":"Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomized trials","volume":"401","author":"Ridker","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.jcmg.2026.07.029_bib4","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/ATVBAHA.118.311999","article-title":"Highlighting residual atherosclerotic cardiovascular disease risk","volume":"39","author":"Matsuura","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcmg.2026.07.029_bib5","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jcmg.2024.12.004","article-title":"Vulnerable or high-risk plaque","volume":"18","author":"Vergallo","year":"2025","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2026.07.029_bib6","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1007\/s11010-023-04689-0","article-title":"Residual risks and evolving atherosclerotic plaques","volume":"478","author":"Noothi","year":"2023","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jcmg.2026.07.029_bib7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41569-023-00979-8","article-title":"Atherosclerotic plaque stabilization and regression: a review of clinical evidence","volume":"21","author":"Sarraju","year":"2024","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jcmg.2026.07.029_bib8","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1056\/NEJMoa1110874","article-title":"Effect of two intensive statin regimens on progression of coronary disease","volume":"365","author":"Nicholls","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcmg.2026.07.029_bib9","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.jacc.2015.01.036","article-title":"Impact of statins on serial coronary calcification during atheroma progression and regression","volume":"65","author":"Puri","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2026.07.029_bib10","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.jcmg.2018.04.015","article-title":"Effects of statins on coronary atherosclerotic plaques: the PARADIGM study","volume":"11","author":"Lee","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2026.07.029_bib11","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0140-6736(25)00055-8","article-title":"Rethinking coronary artery disease: moving from ischaemia to atheroma","volume":"405","author":"Zaman","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.jcmg.2026.07.029_bib12","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41569-025-01191-6","article-title":"Coronary CT angiography evaluation with artificial intelligence for individualized medical treatment of atherosclerosis: a consensus statement from the QCI study group","volume":"23","author":"Schulze","year":"2026","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jcmg.2026.07.029_bib13","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jcmg.2024.07.024","article-title":"Coronary artery calcium density and risk of cardiovascular events: a systematic review and meta-analysis","volume":"18","author":"Yong","year":"2025","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2026.07.029_bib14","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1001\/jamacardio.2019.5315","article-title":"Association of high-density calcified plaque with risk of acute coronary syndrome","volume":"5","author":"van Rosendael","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jcmg.2026.07.029_bib15","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1007\/s10554-025-03561-0","article-title":"Impact of statins on progression of coronary artery calcium composition and density as assessed by noncontrast CT","volume":"41","author":"Giovannucci","year":"2025","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2026.07.029_bib16","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1001\/jamacardio.2021.3055","article-title":"Association of statin treatment with progression of coronary atherosclerotic plaque composition","volume":"6","author":"van Rosendael","year":"2021","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jcmg.2026.07.029_bib17","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1001\/jama.2025.0584","article-title":"Effects of combining coronary calcium score with treatment on plaque progression in familial coronary artery disease: a randomized clinical trial","volume":"333","author":"Nerlekar","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.jcmg.2026.07.029_bib18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ahj.2017.09.011","article-title":"Rationale and design of a trial to personalize risk assessment in familial coronary artery disease","volume":"199","author":"Marwick","year":"2018","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcmg.2026.07.029_bib19","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1016\/j.jacc.2025.11.016","article-title":"ACC\/AHA\/AACVPR\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of dyslipidemia: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"87","author":"Blumenthal","year":"2026","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2026.07.029_bib20","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1093\/eurheartj\/eht084","article-title":"Factors underlying regression of coronary atheroma with potent statin therapy","volume":"34","author":"Puri","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcmg.2026.07.029_bib21","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.atherosclerosis.2015.05.011","article-title":"Natural progression of atherosclerosis from pathologic intimal thickening to late fibroatheroma in human coronary arteries: a pathology study","volume":"241","author":"Otsuka","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jcmg.2026.07.029_bib22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jcmg.2017.10.012","article-title":"Coronary artery calcification and its progression: what does it really mean?","volume":"11","author":"Mori","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2026.07.029_bib23","doi-asserted-by":"crossref","first-page":"e185","DOI":"10.1161\/ATVBAHA.120.315737","article-title":"Statin effects on vascular calcification: microarchitectural changes in aortic calcium deposits in aged hyperlipidemic mice","volume":"41","author":"Xian","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcmg.2026.07.029_bib24","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1161\/ATVBAHA.119.313832","article-title":"Statins disrupt macrophage Rac1 regulation leading to increased atherosclerotic plaque calcification","volume":"40","author":"Healy","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcmg.2026.07.029_bib25","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1016\/j.jacc.2018.06.078","article-title":"Effect of evolocumab on coronary plaque composition","volume":"72","author":"Nicholls","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcmg.2026.07.029_bib26","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jcmg.2022.06.018","article-title":"Major global coronary artery calcium guidelines","volume":"16","author":"Golub","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2026.07.029_bib27","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jcct.2024.05.232","article-title":"Standards for quantitative assessments by coronary computed tomography angiography (CCTA): an expert consensus document","volume":"18","author":"Nieman","year":"2024","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.jcmg.2026.07.029_bib28","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jcmg.2025.11.008","article-title":"Quantitative coronary plaque analysis in clinical practice: 2025 ACC scientific statement: a report of the American College of Cardiology","volume":"19","year":"2026","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jcmg.2026.07.029_bib29","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.amjmed.2022.10.021","article-title":"Integrating coronary atherosclerosis burden and progression with coronary artery disease risk factors to guide therapeutic decision making","volume":"136","author":"Freeman","year":"2023","journal-title":"Am J Med"},{"key":"10.1016\/j.jcmg.2026.07.029_bib30","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jcct.2021.03.006","article-title":"Artificial intelligence in cardiovascular CT: current status and future implications","volume":"15","author":"Lin","year":"2021","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.jcmg.2026.07.029_bib31","doi-asserted-by":"crossref","first-page":"e256","DOI":"10.1016\/S2589-7500(22)00022-X","article-title":"Deep learning-enabled coronary CT angiography for plaque and stenosis quantification and cardiac risk prediction: an international multicenter study","volume":"4","author":"Lin","year":"2022","journal-title":"Lancet Digit Health"},{"key":"10.1016\/j.jcmg.2026.07.029_bib32","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.jcmg.2024.05.016","article-title":"Rationale and design of SCOT-HEART 2 trial","volume":"17","author":"McDermott","year":"2024","journal-title":"JACC Cardiovasc Imaging"}],"container-title":["JACC: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X26004559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936878X26004559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:32:07Z","timestamp":1792215127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936878X26004559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":32,"alternative-id":["S1936878X26004559"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmg.2026.07.029","relation":{},"ISSN":["1936-878X"],"issn-type":[{"value":"1936-878X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Calcium Density as a Marker of Coronary Plaque Stabilization in Primary Prevention","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmg.2026.07.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}