{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:56:26Z","timestamp":1790423786324,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T00:00:00Z","timestamp":1415232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.jcmgh.2014.08.001","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T20:53:21Z","timestamp":1418849601000},"page":"55-74.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Antifibrogenic Effects of the Antimicrobial Peptide Cathelicidin in Murine Colitis-Associated Fibrosis"],"prefix":"10.1016","volume":"1","author":[{"given":"Jun Hwan","family":"Yoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna Hoang-Yen","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriaki","family":"Bakirtzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzu","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Hoang-Ngoc","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tressia C.","family":"Hing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Q.","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Issacson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Fiocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalabos","family":"Pothoulakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hon Wai","family":"Koon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 3","key":"10.1016\/j.jcmgh.2014.08.001_bib1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000342585","article-title":"Genes and \u2018in-vironment\u2019: how will our concepts on the pathophysiology of inflammatory bowel disease develop in the future?","volume":"30","author":"Fiocchi","year":"2012","journal-title":"Dig Dis"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib2","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.3109\/00365529108998629","article-title":"Risk of recurrence and reoperation after resection for ileocolic Crohn\u2019s disease","volume":"26","author":"Wettergren","year":"1991","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib3","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2174\/138945010790309984","article-title":"Intestinal fibrosis in Crohn\u2019s disease: medical treatment or surgery?","volume":"11","author":"Spinelli","year":"2009","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s00384-005-0739-0","article-title":"Selective effect of infliximab on the inflammatory component of a colonic stricture in Crohn\u2019s disease","volume":"21","author":"Sorrentino","year":"2006","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib5","first-page":"40","article-title":"Antimicrobial peptides and colitis","volume":"19","author":"Ho","year":"2013","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib6","doi-asserted-by":"crossref","first-page":"6982","DOI":"10.1128\/IAI.01043-06","article-title":"Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infection","volume":"74","author":"Bergman","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib7","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1172\/JCI17545","article-title":"An angiogenic role for the human peptide antibiotic LL-37\/hCAP-18","volume":"111","author":"Koczulla","year":"2003","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib8","doi-asserted-by":"crossref","first-page":"L842","DOI":"10.1152\/ajplung.00286.2004","article-title":"Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure","volume":"289","author":"Shaykhiev","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib9","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/jid.2008.320","article-title":"Collagen synthesis is suppressed in dermal fibroblasts by the human antimicrobial peptide LL-37","volume":"129","author":"Park","year":"2009","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib10","first-page":"799","article-title":"A\u00a0new role for cathelicidin in ulcerative colitis in mice","volume":"232","author":"Tai","year":"2007","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib11","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1053\/j.gastro.2011.06.079","article-title":"Cathelicidin signaling via the Toll-like receptor protects against colitis in mice","volume":"141","author":"Koon","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib12","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1136\/gutjnl-2012-302180","article-title":"The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice","volume":"62","author":"Hing","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib13","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1053\/j.gastro.2007.12.043","article-title":"Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis","volume":"134","author":"Grassl","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib14","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1053\/j.gastro.2003.08.027","article-title":"A\u00a0murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-kappa B","volume":"125","author":"Lawrance","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib15","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.2353\/ajpath.2010.100314","article-title":"Substance P modulates colitis-associated fibrosis","volume":"177","author":"Koon","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib16","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/S0016-5085(98)70431-7","article-title":"Proinflammatory cytokines differentially modulate their own expression in human intestinal mucosal mesenchymal cells","volume":"114","author":"Strong","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib17","doi-asserted-by":"crossref","first-page":"11382","DOI":"10.1073\/pnas.93.21.11382","article-title":"Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector","volume":"93","author":"Naldini","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib18","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1128\/MCB.7.8.2745","article-title":"High-efficiency transformation of mammalian cells by plasmid DNA","volume":"7","author":"Chen","year":"1987","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib19","first-page":"1705","article-title":"smg\/rap1\/Krev-1 p21s inhibit the signal pathway to the c-fos promoter\/enhancer from c-Ki-ras p21 but not from c-raf-1 kinase in NIH3T3 cells","volume":"7","author":"Sakoda","year":"1992","journal-title":"Oncogene"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib20","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1006\/jmcc.1999.1035","article-title":"A\u00a0high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes","volume":"31","author":"Sakoda","year":"1999","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/978-1-59745-471-1_21","article-title":"Lentiviral transgenesis","volume":"530","author":"Pfeifer","year":"2009","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib22","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1023\/A:1012334727509","article-title":"Changes of colonic mucosal microcirculation and histology in two colitis models: an experimental study using intravital microscopy and a new histological scoring system","volume":"46","author":"Kruschewski","year":"2001","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib23","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/ibd.21812","article-title":"Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: impact of a \u201ctop-down\u201d approach to intestinal fibrosis in mice","volume":"18","author":"Johnson","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib24","doi-asserted-by":"crossref","first-page":"e91559","DOI":"10.1371\/journal.pone.0091559","article-title":"Interleukin-1\u03b2 attenuates myofibroblast formation and extracellular matrix production in dermal and lung fibroblasts exposed to transforming growth factor-\u03b21","volume":"9","author":"Mia","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbadis.2013.10.012","article-title":"Prophylactic systemic P2X7 receptor blockade prevents experimental colitis","volume":"1842","author":"Marques","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3892\/mmr.2013.1807","article-title":"P2X7 blockade attenuates mouse liver fibrosis","volume":"9","author":"Huang","year":"2013","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib27","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/labinvest.2014.86","article-title":"LL-37 secreted by epithelium promotes fibroblast collagen production: a potential mechanism of small airway remodeling in chronic obstructive pulmonary disease","volume":"94","author":"Sun","year":"2014","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2014.08.001_bib28","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/00042737-200606000-00007","article-title":"Heterogeneous expression of human cathelicidin hCAP18\/LL-37 in inflammatory bowel diseases","volume":"18","author":"Schauber","year":"2006","journal-title":"Eur J Gastroenterol Hepatol"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X14000022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X14000022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T15:10:21Z","timestamp":1566141021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X14000022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S2352345X14000022"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2014.08.001","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antifibrogenic Effects of the Antimicrobial Peptide Cathelicidin in Murine Colitis-Associated Fibrosis","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2014.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}