{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:28:53Z","timestamp":1792250933951,"version":"4.4.0"},"reference-count":141,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.jcmgh.2015.05.005","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T16:07:31Z","timestamp":1433520451000},"page":"368-380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":106,"title":["Functional and Structural Features of Cholangiocytes in Health and Disease"],"prefix":"10.1016","volume":"1","author":[{"given":"Luca","family":"Maroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai","family":"Haibo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debolina","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanyin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Marzioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Alpini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2015.05.005_bib1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/hep.1840140324","article-title":"Mechanisms and regulation of bile secretion","volume":"14","author":"Nathanson","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrgastro.2012.23","article-title":"The biliary tree\u2014a reservoir of multipotent stem cells","volume":"9","author":"Cardinale","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1172\/JCI113355","article-title":"Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules","volume":"81","author":"Alpini","year":"1988","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib4","first-page":"27","article-title":"Recent advances on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangiocyte pathophysiology","volume":"1","author":"Franchitto","year":"2013","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib5","first-page":"29","article-title":"The physiological roles of secretin and its receptor","volume":"1","author":"Afroze","year":"2013","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib6","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1152\/physrev.00027.2002","article-title":"Bile salt transporters: molecular characterization, function, and regulation","volume":"83","author":"Trauner","year":"2003","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib7","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1053\/j.gastro.2004.08.006","article-title":"The cholangiopathies: disorders of biliary epithelia","volume":"127","author":"Lazaridis","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib8","series-title":"The liver: biology and pathobiology","first-page":"421","article-title":"The pathobiology of biliary epithelia","author":"Alpini","year":"2001"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib9","first-page":"393","article-title":"Electron microscopic studies of normal and proliferated bile ductules","volume":"38","author":"Schaffner","year":"1961","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1055\/s-2008-1040584","article-title":"New concepts in biliary cirrhosis","volume":"7","author":"Ludwig","year":"1987","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib11","first-page":"84","article-title":"Bile ductules in cholestasis: morphologic evidence for secretion and absorption in man","volume":"16","author":"Sasaki","year":"1967","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib12","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1053\/gast.1996.v110.pm8613073","article-title":"Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver","volume":"110","author":"Alpini","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib13","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/labinvest.2009.6","article-title":"Morphological and functional heterogeneity of the mouse intrahepatic biliary epithelium","volume":"89","author":"Glaser","year":"2009","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib14","doi-asserted-by":"crossref","first-page":"G1064","DOI":"10.1152\/ajpgi.1997.272.5.G1064","article-title":"Large but not small intrahepatic bile ducts are involved in secretin-regulated ductal bile secretion","volume":"272","author":"Alpini","year":"1997","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib15","first-page":"G1289","article-title":"Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver","volume":"276","author":"LeSage","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib16","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0168-8278(96)80014-6","article-title":"A\u00a0morphometric study of the epithelium lining the rat intrahepatic biliary tree","volume":"24","author":"Benedetti","year":"1996","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib17","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1002\/dvdy.21530","article-title":"Cholangiocyte primary cilia in liver health and disease","volume":"237","author":"Masyuk","year":"2008","journal-title":"Dev Dyn"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib18","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1002\/hep.23883","article-title":"Adenosine triphosphate release and purinergic (P2) receptor-mediated secretion in small and large mouse cholangiocytes","volume":"52","author":"Woo","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib19","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1074\/jbc.M110.164970","article-title":"Identification and functional characterization of TMEM16A, a Ca2+-activated Cl\u2212 channel activated by extracellular nucleotides, in biliary epithelium","volume":"286","author":"Dutta","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib20","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.2353\/ajpath.2010.090677","article-title":"After damage of large bile ducts by gamma-aminobutyric acid, small ducts replenish the biliary tree by amplification of calcium-dependent signaling and de novo acquisition of large cholangiocyte phenotypes","volume":"176","author":"Mancinelli","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib21","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/hep.26308","article-title":"GABA induces the differentiation of small into large cholangiocytes by activation of Ca2+\/CaMK I-dependent adenylyl cyclase 8","volume":"58","author":"Mancinelli","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib22","doi-asserted-by":"crossref","first-page":"C499","DOI":"10.1152\/ajpcell.00369.2007","article-title":"Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3\/CaMK I\/CREB pathway","volume":"295","author":"Francis","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1053\/j.gastro.2006.07.023","article-title":"Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver","volume":"132","author":"Alvaro","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib24","doi-asserted-by":"crossref","first-page":"G634","DOI":"10.1152\/ajpgi.00206.2011","article-title":"Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors","volume":"301","author":"Renzi","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib25","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/hep.23810","article-title":"The biliary HCO3\u2212 umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies","volume":"52","author":"Beuers","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib26","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/MEG.0b013e32832e9df0","article-title":"Morphometrical and immunohistochemical study of intrahepatic bile ducts in biliary atresia","volume":"23","author":"Yamaguti","year":"2011","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib27","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1038\/ajg.2010.216","article-title":"Baseline ductopenia and treatment response predict long-term histological progression in primary biliary cirrhosis","volume":"105","author":"Kumagi","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib28","doi-asserted-by":"crossref","first-page":"G307","DOI":"10.1152\/ajpgi.00507.2005","article-title":"Administration of r-VEGF-A prevents hepatic artery ligation-induced bile duct damage in bile duct ligated rats","volume":"291","author":"Gaudio","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib29","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1053\/j.gastro.2005.12.034","article-title":"Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism","volume":"130","author":"Gaudio","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib30","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/MOG.0b013e3283369d19","article-title":"Vascular factors, angiogenesis and biliary tract disease","volume":"26","author":"Glaser","year":"2010","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib31","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S0016-5085(96)70081-1","article-title":"Hepatic microcirculation and peribiliary plexus in experimental biliary cirrhosis: a morphological study","volume":"111","author":"Gaudio","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib32","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1002\/hep.27715","article-title":"Liver alkaline phosphatase: a missing link between choleresis and biliary inflammation","volume":"61","author":"Poupon","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib33","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1002\/hep.24229","article-title":"Drug-induced cholestasis","volume":"53","author":"Padda","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib34","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1556\/ABiol.63.2012.3.2","article-title":"Ductular reaction at the early terms of common bile duct ligation in the rats","volume":"63","author":"Azmaiparashvili","year":"2012","journal-title":"Acta Biol Hung"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib35","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1002\/hep.24590","article-title":"Multipotent stem\/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets","volume":"54","author":"Cardinale","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib36","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/S0016-5085(96)70027-6","article-title":"Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal secretion","volume":"111","author":"Lesage","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib37","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1053\/j.gastro.2014.02.030","article-title":"Secretin stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice","volume":"146","author":"Glaser","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib38","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/hep.23657","article-title":"Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation","volume":"52","author":"Glaser","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib39","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.ajpath.2013.11.008","article-title":"Regulation of the histamine\/VEGF axis by miR-125b during cholestatic liver injury in mice","volume":"184","author":"Meng","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib40","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1016\/j.ajpath.2011.08.028","article-title":"Biliary infection may exacerbate biliary cystogenesis through the induction of VEGF in cholangiocytes of the polycystic kidney (PCK) rat","volume":"179","author":"Ren","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib41","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.dld.2010.02.008","article-title":"Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats","volume":"42","author":"Glaser","year":"2010","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib42","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3181\/0808-RM-255","article-title":"Taurocholate feeding to bile duct ligated rats prevents caffeic acid-induced bile duct damage by changes in cholangiocyte VEGF expression","volume":"234","author":"Mancinelli","year":"2009","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib43","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.jhep.2010.04.022","article-title":"Pancreatic Duodenal Homeobox-1 de novo expression drives cholangiocyte neuroendocrine-like transdifferentiation","volume":"53","author":"Marzioni","year":"2010","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib44","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/hep.22015","article-title":"Epithelial expression of angiogenic growth factors modulate arterial vasculogenesis in human liver development","volume":"47","author":"Fabris","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib45","doi-asserted-by":"crossref","first-page":"G11","DOI":"10.1152\/ajpgi.00025.2009","article-title":"Follicle-stimulating hormone increases cholangiocyte proliferation by an autocrine mechanism via cAMP-dependent phosphorylation of ERK1\/2 and Elk-1","volume":"297","author":"Mancinelli","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib46","doi-asserted-by":"crossref","first-page":"G473","DOI":"10.1152\/ajpgi.00482.2011","article-title":"Autocrine regulation of biliary pathology by activated cholangiocytes","volume":"302","author":"Jensen","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib47","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/labinvest.2011.158","article-title":"Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3\/Ca2+ and cAMP-dependent signaling mechanisms","volume":"92","author":"Francis","year":"2012","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib48","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1053\/j.gastro.2004.06.023","article-title":"Nerve growth factor modulates the proliferative capacity of the intrahepatic biliary epithelium in experimental cholestasis","volume":"127","author":"Gigliozzi","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib49","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1053\/gast.2002.34169","article-title":"Effect of ovariectomy on the proliferative capacity of intrahepatic rat cholangiocytes","volume":"123","author":"Alvaro","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib50","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.jhep.2005.10.032","article-title":"Estrogens maintain bile duct mass and reduce apoptosis after biliodigestive anastomosis in bile duct ligated rats","volume":"44","author":"Svegliati-Baroni","year":"2006","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib51","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.ajpath.2014.12.004","article-title":"Gonadotropin-releasing hormone stimulates biliary proliferation by paracrine\/autocrine mechanisms","volume":"185","author":"Ray","year":"2015","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib52","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1053\/j.gastro.2004.10.002","article-title":"Autocrine\/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin","volume":"128","author":"Marzioni","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib53","doi-asserted-by":"crossref","first-page":"G303","DOI":"10.1152\/ajpgi.00368.2010","article-title":"Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults","volume":"300","author":"Omenetti","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib54","doi-asserted-by":"crossref","first-page":"G894","DOI":"10.1152\/ajpgi.00288.2014","article-title":"Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis","volume":"307","author":"Han","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib55","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/hep.26105","article-title":"Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes in rats","volume":"57","author":"Renzi","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib56","first-page":"4","article-title":"Inhibition of the liver expression of arylalkylamine N-acetyltransferase increases the expression of angiogenic factors in cholangiocytes","volume":"3","author":"Renzi","year":"2014","journal-title":"Hepatobiliary Surg Nutr"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib57","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/labinvest.3700533","article-title":"H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA\/ERK1\/2\/ELK-1 pathway","volume":"87","author":"Francis","year":"2007","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib58","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jhep.2011.09.023","article-title":"Histamine regulation of biliary proliferation","volume":"56","author":"Francis","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib59","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1136\/gutjnl-2011-300007","article-title":"Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma","volume":"61","author":"Francis","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib60","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1146\/annurev-physiol-021014-071733","article-title":"Hippo pathway regulation of gastrointestinal tissues","volume":"77","author":"Yu","year":"2015","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib61","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.cell.2013.08.025","article-title":"Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin\/NF2","volume":"154","author":"Yin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib62","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.cell.2014.03.060","article-title":"Hippo pathway activity influences liver cell fate","volume":"157","author":"Yimlamai","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib63","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.humpath.2011.12.001","article-title":"Expression of Yes-associated protein modulates Survivin expression in primary liver malignancies","volume":"43","author":"Bai","year":"2012","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib64","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.devcel.2010.06.015","article-title":"The Merlin\/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals","volume":"19","author":"Zhang","year":"2010","journal-title":"Dev Cell"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2015.02.027","article-title":"YAP inhibition restores hepatocyte differentiation in advanced HCC, leading to tumor regression","author":"Fitamant","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib66","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.clinre.2013.05.008","article-title":"Notch signalling beyond liver development: emerging concepts in liver repair and oncogenesis","volume":"37","author":"Morell","year":"2013","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib67","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/hep.22381","article-title":"Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice","volume":"48","author":"Geisler","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib68","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jhep.2013.02.025","article-title":"Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice","volume":"59","author":"Fiorotto","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib69","doi-asserted-by":"crossref","first-page":"e1851","DOI":"10.1371\/journal.pone.0001851","article-title":"Notch signaling regulates bile duct morphogenesis in mice","volume":"3","author":"Lozier","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib70","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1242\/dev.052118","article-title":"Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome","volume":"137","author":"Hofmann","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib71","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/hep.21460","article-title":"Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage","volume":"45","author":"Loomes","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib72","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/hep.23431","article-title":"Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice","volume":"51","author":"Sparks","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib73","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1242\/dev.029140","article-title":"Notch signaling controls liver development by regulating biliary differentiation","volume":"136","author":"Zong","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib74","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1053\/j.gastro.2004.09.004","article-title":"The role of notch signaling in the development of intrahepatic bile ducts","volume":"127","author":"Kodama","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib75","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1053\/j.gastro.2009.02.051","article-title":"Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9","volume":"136","author":"Antoniou","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib76","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1242\/dev.129.8.1829","article-title":"Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1\u03b2","volume":"129","author":"Coffinier","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib77","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1002\/hep.26254","article-title":"Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1","volume":"57","author":"Jeliazkova","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib78","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/hep.23048","article-title":"Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice","volume":"50","author":"Tchorz","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib79","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/MOG.0b013e32834550b4","article-title":"Hedgehog signaling in cholangiocytes","volume":"27","author":"Omenetti","year":"2011","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib80","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/labinvest.3700537","article-title":"Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation","volume":"87","author":"Omenetti","year":"2007","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib81","first-page":"3331","article-title":"Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans","volume":"118","author":"Omenetti","year":"2008","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib82","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1136\/gut.2008.148619","article-title":"The hedgehog pathway regulates remodelling responses to biliary obstruction in rats","volume":"57","author":"Omenetti","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib83","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jhep.2005.06.025","article-title":"Mdr2 (Abcb4)\u2212\/\u2212 mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes","volume":"43","author":"Popov","year":"2005","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib84","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1053\/j.gastro.2004.04.009","article-title":"Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice","volume":"127","author":"Fickert","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib85","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1053\/j.gastro.2005.10.018","article-title":"24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice","volume":"130","author":"Fickert","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib86","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/labinvest.2014.94","article-title":"Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis","volume":"94","author":"Tabibian","year":"2014","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib87","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s12016-014-8417-z","article-title":"Genetics in PSC: what do the \u201crisk genes\u201d teach us?","volume":"48","author":"Folseraas","year":"2015","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib88","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1053\/j.gastro.2009.11.046","article-title":"Genome-wide association analysis in primary sclerosing cholangitis","volume":"138","author":"Karlsen","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib89","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.dld.2013.10.021","article-title":"The bile acid TGR5 membrane receptor: from basic research to clinical application","volume":"46","author":"Duboc","year":"2014","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib90","doi-asserted-by":"crossref","first-page":"e12403","DOI":"10.1371\/journal.pone.0012403","article-title":"Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis","volume":"5","author":"Hov","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib91","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000324127","article-title":"TGR5 in the biliary tree","volume":"29","author":"Keitel","year":"2011","journal-title":"Dig Dis"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib92","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrgastro.2015.12","article-title":"Novel therapeutic targets in primary biliary cirrhosis","volume":"12","author":"Dyson","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib93","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1053\/j.gastro.2004.11.005","article-title":"Bacterial CpG induces hyper-IgM production in CD27+ memory B cells in primary biliary cirrhosis","volume":"128","author":"Kikuchi","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib94","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/hep.21522","article-title":"AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers","volume":"45","author":"Moritoki","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib95","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/cei.12032","article-title":"CXCR3 axis in patients with primary biliary cirrhosis: a possible novel mechanism of the effect of ursodeoxycholic acid","volume":"172","author":"Manousou","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib96","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1084\/jem.20051911","article-title":"NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis","volume":"203","author":"Irie","year":"2006","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib97","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.4049\/jimmunol.177.3.1655","article-title":"Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-\u03b2 receptor II dominant-negative mice","volume":"177","author":"Oertelt","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib98","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1002\/hep.21385","article-title":"IL-2 receptor alpha\u2212\/\u2212 mice and the development of primary biliary cirrhosis","volume":"44","author":"Wakabayashi","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib99","first-page":"1615","article-title":"Pathogenesis of primary biliary cirrhosis","volume":"56","author":"Jones","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib100","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/hep.26067","article-title":"Therapeutic effect of cytotoxic T lymphocyte antigen 4\/immunoglobulin on a murine model of primary biliary cirrhosis","volume":"57","author":"Dhirapong","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib101","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/cei.12415","article-title":"Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3+ regulatory T cells","volume":"178","author":"Tanaka","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib102","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/ajg.2013.51","article-title":"B-cell depletion with rituximab in patients with primary biliary cirrhosis refractory to ursodeoxycholic acid","volume":"108","author":"Myers","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib103","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jss.2012.05.082","article-title":"Rotavirus infection of human cholangiocytes parallels the murine model of biliary atresia","volume":"177","author":"Coots","year":"2012","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib104","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1002\/hep.510270603","article-title":"Detection of reovirus RNA in hepatobiliary tissues from patients with extrahepatic biliary atresia and choledochal cysts","volume":"27","author":"Tyler","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib105","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/00005176-199811000-00007","article-title":"Presence of human papillomavirus in extrahepatic biliary atresia","volume":"27","author":"Drut","year":"1998","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib106","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jpedsurg.2004.11.035","article-title":"Immunoglobulin deposits in liver tissue from infants with biliary atresia and the correlation to cytomegalovirus infection","volume":"40","author":"Fischler","year":"2005","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib107","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/MPG.0b013e318296e525","article-title":"Extrahepatic cholangiocyte cilia are abnormal in biliary atresia","volume":"57","author":"Karjoo","year":"2013","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib108","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/modpathol.2011.212","article-title":"Cholangiocyte cilia are abnormal in syndromic and non-syndromic biliary atresia","volume":"25","author":"Chu","year":"2012","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib109","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jpedsurg.2008.07.007","article-title":"Cholangiocyte secretion of chemokines in experimental biliary atresia","volume":"44","author":"Jafri","year":"2009","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib110","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1172\/JCI73742","article-title":"Biliary repair and\u00a0carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation","volume":"124","author":"Li","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib111","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jhep.2013.09.021","article-title":"Perforin and granzymes work in synergy to mediate cholangiocyte injury in experimental biliary atresia","volume":"60","author":"Shivakumar","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib112","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.biocel.2014.04.002","article-title":"Regulation of microRNAs and their role in liver development, regeneration and disease","volume":"54","author":"Finch","year":"2014","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib113","doi-asserted-by":"crossref","first-page":"G535","DOI":"10.1152\/ajpgi.00338.2009","article-title":"MicroRNA-21 is upregulated during the proliferative phase of liver regeneration, targets Pellino-1, and inhibits NF-\u03baB signaling","volume":"298","author":"Marquez","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib114","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1752-0509-7-104","article-title":"Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia","volume":"7","author":"Bessho","year":"2013","journal-title":"BMC Syst Biol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib115","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cld.2012.12.005","article-title":"Liver transplant for cholestatic liver diseases","volume":"17","author":"Carrion","year":"2013","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib116","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1159\/000360515","article-title":"Pathogenesis of primary biliary cirrhosis and its fatigue","volume":"32","author":"Griffiths","year":"2014","journal-title":"Dig Dis"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib117","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/hep.26909","article-title":"Pruritus in cholestasis: facts and fiction","volume":"60","author":"Beuers","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib118","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/CS20110184","article-title":"Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications","volume":"121","author":"Roma","year":"2011","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib119","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ncpgasthep0521","article-title":"Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis","volume":"3","author":"Beuers","year":"2006","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib120","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0016-5085(97)70183-5","article-title":"Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis","volume":"113","author":"Poupon","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib121","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1053\/gast.1996.v110.pm8613058","article-title":"Effects of ursodeoxycholic acid on survival in patients with primary biliary cirrhosis","volume":"110","author":"Lindor","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib122","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1053\/j.gastro.2004.11.009","article-title":"The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis","volume":"128","author":"Corpechot","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib123","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1111\/j.1572-0241.2006.00699.x","article-title":"Prognosis of ursodeoxycholic acid-treated patients with primary biliary cirrhosis. Results of a 10-yr cohort study involving 297 patients","volume":"101","author":"ter Borg","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib124","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/hep.22428","article-title":"Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis","volume":"48","author":"Corpechot","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib125","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/hep.23082","article-title":"High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis","volume":"50","author":"Lindor","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib126","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jhep.2009.04.009","article-title":"EASL Clinical practice guidelines: management of cholestatic liver diseases","volume":"51","year":"2009","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib127","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1021\/jm025529g","article-title":"6\u03b1-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity","volume":"45","author":"Pellicciari","year":"2002","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib128","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0092-8674(00)00062-3","article-title":"Targeted disruption of the nuclear receptor FXR\/BAR impairs bile acid and lipid homeostasis","volume":"102","author":"Sinal","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib129","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1053\/j.gastro.2014.12.005","article-title":"Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid","volume":"148","author":"Hirschfield","year":"2015","journal-title":"Gastroenterology"},{"issue":"Suppl","key":"10.1016\/j.jcmgh.2015.05.005_bib130","doi-asserted-by":"crossref","first-page":"S525","DOI":"10.1016\/S0168-8278(14)61463-X","article-title":"O168 The first primary biliary cirrhosis (PBC) phase 3 trial in two decades\u2014an international study of the FXR agonist obeticholic acid in PBC patients","volume":"60","author":"Nevens","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib131","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0016-5085(86)90457-9","article-title":"Differing effects of nor-ursodeoxycholic or ursodeoxycholic acid on hepatic histology and bile acid metabolism in the rabbit","volume":"91","author":"Cohen","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib132","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.24691","article-title":"A\u00a0biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes","volume":"55","author":"Hohenester","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib133","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jhep.2013.01.026","article-title":"Differential effects of norUDCA and UDCA in obstructive cholestasis in mice","volume":"58","author":"Fickert","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib134","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1002\/hep.23238","article-title":"B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice","volume":"50","author":"Moritoki","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib135","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/hep.24748","article-title":"Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid","volume":"55","author":"Tsuda","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib136","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jhep.2011.05.040","article-title":"Towards common denominators in primary biliary cirrhosis: the role of IL-12","volume":"56","author":"Lleo","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib137","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1056\/NEJMoa0810440","article-title":"Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants","volume":"360","author":"Hirschfield","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib138","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1053\/j.gastro.2013.06.052","article-title":"Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management","volume":"145","author":"Eaton","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib139","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/hep.24085","article-title":"Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity","volume":"53","author":"Liaskou","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib140","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bioorg.2014.07.003","article-title":"Human lysyl oxidase-like 2","volume":"57","author":"Moon","year":"2014","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.jcmgh.2015.05.005_bib141","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jhep.2012.10.011","article-title":"The dynamic biliary epithelia: molecules, pathways, and disease","volume":"58","author":"O\u2019Hara","year":"2013","journal-title":"J\u00a0Hepatol"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X15000995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X15000995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T13:30:24Z","timestamp":1652275824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X15000995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":141,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S2352345X15000995"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2015.05.005","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional and Structural Features of Cholangiocytes in Health and Disease","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2015.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}