{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:55:21Z","timestamp":1793141721964,"version":"4.5.0"},"reference-count":172,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.jcmgh.2017.02.004","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T23:32:43Z","timestamp":1487633563000},"page":"303-315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"title":["Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function"],"prefix":"10.1016","volume":"3","author":[{"given":"Mario C.","family":"Manresa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cormac T.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2017.02.004_bib1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrgastro.2010.39","article-title":"Hypoxia: an alarm signal during intestinal inflammation","volume":"7","author":"Colgan","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1749-6632.2012.06526.x","article-title":"Myosin light chain kinase: pulling the strings of epithelial tight junction function","volume":"1258","author":"Cunningham","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jdermsci.2015.11.009","article-title":"Could tight junctions regulate the barrier function of the aged skin?","volume":"81","author":"Svoboda","year":"2016","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib4","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1038\/jid.2012.43","article-title":"The human skin barrier is organized as stacked bilayers of fully extended ceramides with cholesterol molecules associated with the ceramide sphingoid moiety","volume":"132","author":"Iwai","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib5","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/mi.2015.40","article-title":"Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease","volume":"8","author":"Nalle","year":"2015","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib6","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1523-1755.2004.761_12.x","article-title":"Regulation of intestinal epithelial gene expression in hypoxia","volume":"66","author":"Taylor","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib7","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.coph.2013.08.014","article-title":"Fluid and electrolyte secretion in the inflamed gut: novel targets for treatment of inflammation-induced diarrhea","volume":"13","author":"Gareau","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/MOG.0000000000000143","article-title":"Host-microbe interactions in the small bowel","volume":"31","author":"Davies","year":"2015","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib9","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1113\/jphysiol.2011.227058","article-title":"Epithelial biology in the gastrointestinal system: insights into normal physiology and disease pathogenesis","volume":"590","author":"Barrett","year":"2012","journal-title":"J\u00a0Physiol Lond"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev-pathol-011811-120905","article-title":"The life and death of epithelia during inflammation: lessons learned from the gut","volume":"7","author":"Koch","year":"2012","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev.physiol.010908.163145","article-title":"Stem cells, self-renewal, and differentiation in the intestinal epithelium","volume":"71","author":"van der Flier","year":"2009","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib12","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/mi.2013.6","article-title":"Fundamental role for HIF-1 alpha in constitutive expression of human beta defensin-1","volume":"6","author":"Kelly","year":"2013","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1046\/j.1440-1746.2000.02059.x","article-title":"Apoptosis in the intestinal epithelium: its relevance in normal and pathophysiological conditions","volume":"15","author":"Ramachandran","year":"2000","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib14","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1101\/gad.1295405","article-title":"Wnt signaling in the intestinal epithelium: from endoderm to cancer","volume":"19","author":"Gregorieff","year":"2005","journal-title":"Genes Dev"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib15","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1101\/gad.287404","article-title":"Loss of Apc\u00a0in\u00a0vivo immediately perturbs Wnt signaling, differentiation, and migration","volume":"18","author":"Sansom","year":"2004","journal-title":"Genes Dev"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib16","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1053\/j.gastro.2010.06.068","article-title":"Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function","volume":"139","author":"Tambuwala","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib17","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1242\/jcs.107.12.3569","article-title":"Regulation of cell number in the mammalian gastrointestinal-tract - the importance of apoptosis","volume":"107","author":"Hall","year":"1994","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib18","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.bbadis.2015.07.012","article-title":"Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell\u00a0apoptosis","volume":"1852","author":"Wen","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib19","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.1038\/onc.2014.416","article-title":"Oncogenic KRAS signalling promotes the Wnt\/beta-catenin pathway through LRP6 in colorectal cancer","volume":"34","author":"Lemieux","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib20","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.bbamem.2008.07.015","article-title":"Epithelial cell-cell junctions and plasma membrane domains","volume":"1788","author":"Giepmans","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev-physiol-012110-142150","article-title":"Tight, junction pore and leak pathways: a dynamic duo","volume":"73","author":"Shen","year":"2011","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib22","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1152\/physrev.00019.2012","article-title":"Claudins and the modulation of tight junction permeability","volume":"93","author":"Gunzel","year":"2013","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib23","doi-asserted-by":"crossref","first-page":"29745","DOI":"10.1074\/jbc.273.45.29745","article-title":"The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton","volume":"273","author":"Fanning","year":"1998","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib24","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1074\/jbc.M411365200","article-title":"The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1","volume":"280","author":"Muller","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib25","doi-asserted-by":"crossref","first-page":"8237","DOI":"10.1073\/pnas.0908869107","article-title":"MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function","volume":"107","author":"Yu","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib26","doi-asserted-by":"crossref","first-page":"G1487","DOI":"10.1152\/ajpgi.2001.281.6.G1487","article-title":"Regulation of human jejunal transmucosal resistance and MLC phosphorylation by Na+-glucose cotransport","volume":"281","author":"Berglund","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib27","doi-asserted-by":"crossref","first-page":"C1378","DOI":"10.1152\/ajpcell.1997.273.4.C1378","article-title":"Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation","volume":"273","author":"Turner","year":"1997","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib28","first-page":"A109","article-title":"In\u00a0vivo redistribution of tight junction proteins in mouse intestine following T cell-dependent TNF release","volume":"126","author":"Clayburgh","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib29","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1053\/j.gastro.2006.08.022","article-title":"IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction","volume":"131","author":"Wang","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib30","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.gastro.2005.05.002","article-title":"Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution","volume":"129","author":"Heller","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib31","first-page":"29","article-title":"Microbe-host crosstalk between short-chain fatty acids and intestinal epithelial HIF provides a new mechanism to augment tissue barrier function","author":"Zheng","year":"2015","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib32","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiome shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib33","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1128\/IAI.00453-12","article-title":"Epithelial cells augment barrier function via activation of the Toll-like receptor 2\/phosphatidylinositol 3-kinase pathway upon recognition of Salmonella enterica Serovar typhimurium curli fibrils in the gut","volume":"81","author":"Oppong","year":"2013","journal-title":"Infect Immun"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib35","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nri2707","article-title":"Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function","volume":"10","author":"Abreu","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fmicb.2016.00185","article-title":"Intestinal short chain fatty acids and their link with diet and human health","volume":"7","author":"Rios-Covian","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.chom.2012.08.003","article-title":"Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish","volume":"12","author":"Semova","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib39","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1053\/j.gastro.2016.07.009","article-title":"Antibiotics suppress activation of intestinal mucosal mast cells and reduce dietary lipid absorption in Sprague-Dawley rats","volume":"151","author":"Sato","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib40","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1038\/ismej.2012.4","article-title":"Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon","volume":"6","author":"Ze","year":"2012","journal-title":"ISME J"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib41","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12907","article-title":"A\u00a0discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes","volume":"506","author":"Larsbrink","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib42","doi-asserted-by":"crossref","first-page":"e1000879","DOI":"10.1371\/journal.ppat.1000879","article-title":"The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis","volume":"6","author":"van Vliet","year":"2010","journal-title":"Plos Pathog"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib43","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.gastro.2006.04.020","article-title":"Muc2-deficient mice spontaneously develop colitis, indicating that Muc2 is critical for colonic protection","volume":"131","author":"Van der Sluis","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib44","doi-asserted-by":"crossref","first-page":"15064","DOI":"10.1073\/pnas.0803124105","article-title":"The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria","volume":"105","author":"Johansson","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib45","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1128\/AEM.02509-07","article-title":"Mucin degradation by Bifidobacterium strains isolated from the human intestinal microbiota","volume":"74","author":"Ruas-Madiedo","year":"2008","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib46","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1128\/AEM.01226-07","article-title":"The mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract","volume":"74","author":"Derrien","year":"2008","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib47","doi-asserted-by":"crossref","first-page":"G327","DOI":"10.1152\/ajpgi.00422.2010","article-title":"Importance and regulation of the colonic mucus barrier in a mouse model of colitis","volume":"300","author":"Petersson","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib48","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrmicro2974","article-title":"The gut microbiota - masters of host development and physiology","volume":"11","author":"Sommer","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib49","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1136\/gut.46.2.218","article-title":"Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon","volume":"46","author":"Barcelo","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib50","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1128\/IAI.01374-15","article-title":"Intestinal epithelial Toll-like receptor 4 signaling affects epithelial function and colonic microbiota and promotes a risk for transmissible colitis","volume":"84","author":"Dheer","year":"2016","journal-title":"Infect Immun"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib51","doi-asserted-by":"crossref","first-page":"G1055","DOI":"10.1152\/ajpgi.00328.2004","article-title":"Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis","volume":"288","author":"Fukata","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib52","doi-asserted-by":"crossref","first-page":"e0141710","DOI":"10.1371\/journal.pone.0141710","article-title":"Expression of CCL20 and its corresponding receptor CCR6 is enhanced in active inflammatory bowel disease, and TLR3 mediates CCL20 expression in colonic epithelial cells","volume":"10","author":"Skovdahl","year":"2015","journal-title":"Plos One"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib53","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1086\/513809","article-title":"Enteroaggregative Escherichia coli produce intestinal inflammation and growth impairment and cause interleukin-8 release from intestinal epithelial cells","volume":"177","author":"Steiner","year":"1998","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib54","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/gut.49.4.526","article-title":"MIP-2 secreted by epithelial cells increases neutrophil and lymphocyte recruitment in the mouse intestine","volume":"49","author":"Ohtsuka","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib55","doi-asserted-by":"crossref","first-page":"7343","DOI":"10.1038\/srep07343","article-title":"Differential expression of mucosal trefoil factors and mucins in pediatric inflammatory bowel diseases","volume":"4","author":"Hensel","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/nrm1249","article-title":"Trefoil factors: initiators of mucosal healing","volume":"4","author":"Taupin","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib57","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1038\/mi.2008.48","article-title":"Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease","volume":"1","author":"Wehkamp","year":"2008","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib58","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nature01520","article-title":"Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin","volume":"422","author":"Salzman","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib59","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1053\/j.gastro.2004.05.020","article-title":"Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice","volume":"127","author":"Vandenbroucke","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib60","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/j.gastro.2009.03.007","article-title":"Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency","volume":"137","author":"Podolsky","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib61","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1136\/gut.2006.118646","article-title":"Reduced mucosal antimicrobial activity in Crohn's disease of the colon","volume":"56","author":"Nuding","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib62","doi-asserted-by":"crossref","first-page":"e6285","DOI":"10.1371\/journal.pone.0006285","article-title":"Dysregulation of human beta-defensin-2 protein in inflammatory bowel disease","volume":"4","author":"Aldhous","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib63","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1152\/physiol.00029.2010","article-title":"Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans","volume":"25","author":"Taylor","year":"2010","journal-title":"Physiology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib64","first-page":"3316","article-title":"Oxygenation of human tumors - evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements","volume":"51","author":"Vaupel","year":"1991","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib65","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00109-007-0277-z","article-title":"Hypoxia and gastrointestinal disease","volume":"85","author":"Taylor","year":"2007","journal-title":"J\u00a0Mol Med (Berl)"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib66","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1023\/A:1012334727509","article-title":"Changes of colonic mucosal microcirculation and histology in two colitis models - an experimental study using intravital microscopy and a new histological scoring system","volume":"46","author":"Kruschewski","year":"2001","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib67","doi-asserted-by":"crossref","first-page":"C350","DOI":"10.1152\/ajpcell.00191.2015","article-title":"Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A review in the theme: cellular responses to hypoxia","volume":"309","author":"Zheng","year":"2015","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib68","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.1128\/MCB.12.12.5447","article-title":"A\u00a0nuclear factor induced by hypoxia via denovo protein-synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation","volume":"12","author":"Semenza","year":"1992","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib69","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"Hypoxia-inducible factor-1 is a basic-helix-loop-helix-pas heterodimer regulated by cellular O-2 tension","volume":"92","author":"Wang","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib70","doi-asserted-by":"crossref","first-page":"11205","DOI":"10.1074\/jbc.272.17.11205","article-title":"Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit","volume":"272","author":"Pugh","year":"1997","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib71","first-page":"7106","article-title":"Relationship of hypoxia-inducible factor (HIF)-1 alpha and HIF-2 alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines","volume":"60","author":"Blancher","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib72","first-page":"7075","article-title":"Hypoxia-inducible expression of tumor-associated carbonic anhydrases","volume":"60","author":"Wykoff","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib73","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1128\/MCB.23.24.9361-9374.2003","article-title":"Differential roles of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha in hypoxic gene regulation","volume":"23","author":"Hu","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib74","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1172\/JCI30117","article-title":"Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in\u00a0vivo","volume":"117","author":"Rankin","year":"2007","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib75","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","article-title":"The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis","volume":"399","author":"Maxwell","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib76","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/cvr\/cvq045","article-title":"Hypoxia-inducible factor-1-dependent\u00a0mechanisms of vascularization and vascular remodelling","volume":"86","author":"Rey","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib77","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.bbrc.2011.10.089","article-title":"Disruption of HIF-1 alpha in hepatocytes impairs glucose metabolism in diet-induced obesity mice","volume":"415","author":"Ochiai","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib78","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.smim.2016.09.004","article-title":"The hypoxia-inducible factor (HIF) couples immunity with metabolism","volume":"28","author":"Halligan","year":"2016","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib79","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1101\/gad.924501","article-title":"FIH-1: a novel protein that interacts with HIF-1 alpha and VHL to mediate repression of HIF-1 transcriptional activity","volume":"15","author":"Mahon","year":"2001","journal-title":"Genes Dev"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib80","first-page":"53","article-title":"PHD2: from hypoxia regulation to disease progression","volume":"4","author":"Meneses","year":"2016","journal-title":"Hypoxia (Auckl)"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib81","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0076-6879(07)35002-7","article-title":"Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2","volume":"435","author":"Hewitson","year":"2007","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib82","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/35017054","article-title":"Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein","volume":"2","author":"Ohh","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib83","doi-asserted-by":"crossref","first-page":"7987","DOI":"10.1073\/pnas.95.14.7987","article-title":"Regulation of hypoxia-inducible factor 1 alpha is mediated by an O-2-dependent degradation domain via the ubiquitin-proteasome pathway","volume":"95","author":"Huang","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib84","doi-asserted-by":"crossref","first-page":"30772","DOI":"10.1074\/jbc.M304982200","article-title":"Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor","volume":"278","author":"Hirsila","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib85","doi-asserted-by":"crossref","first-page":"9899","DOI":"10.1074\/jbc.M312254200","article-title":"Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases","volume":"279","author":"Koivunen","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib86","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.1068592","article-title":"Asparagine hydroxylation of the HIF transactivation domain: a hypoxic switch","volume":"295","author":"Lando","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib87","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1042\/bj20021162","article-title":"Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803","volume":"367","author":"McNeill","year":"2002","journal-title":"Biochem J"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib88","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3748\/wjg.v22.i3.1017","article-title":"How to predict clinical relapse in inflammatory bowel disease patients","volume":"22","author":"Liverani","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib89","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1053\/j.gastro.2004.01.063","article-title":"Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences","volume":"126","author":"Loftus","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib90","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1053\/j.gastro.2016.09.047","article-title":"Mechanisms, management, and treatment of fibrosis in patients with inflammatory bowel diseases","volume":"152","author":"Rieder","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib91","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/labinvest.2013.9","article-title":"Hydroxylases as therapeutic targets in inflammatory bowel disease","volume":"93","author":"Cummins","year":"2013","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib92","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMra020831","article-title":"Inflammatory bowel disease","volume":"347","author":"Podolsky","year":"2002","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib93","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1517\/14712598.2014.858695","article-title":"Targeting TNF-alpha for the treatment of inflammatory bowel disease","volume":"14","author":"Billiet","year":"2014","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib94","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0140-6736(97)80083-9","article-title":"Randomised controlled trial of CDP571 antibody to tumour necrosis factor-alpha in Crohn's disease","volume":"349","author":"Stack","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib95","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1136\/gut.2004.049460","article-title":"Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine","volume":"54","author":"Kandiel","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib96","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1056\/NEJMra0804647","article-title":"Mechanisms of disease: inflammatory bowel disease","volume":"361","author":"Abraham","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib97","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1053\/j.gastro.2011.01.056","article-title":"Hypoxia and metabolic factors that influence inflammatory bowel disease pathogenesis","volume":"140","author":"Glover","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib98","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1172\/JCI42917","article-title":"PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice","volume":"121","author":"Qiu","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib99","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature05698","article-title":"Epithelial NEMO links innate immunity to chronic intestinal inflammation","volume":"446","author":"Nenci","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib100","doi-asserted-by":"crossref","first-page":"9454","DOI":"10.1074\/jbc.M707962200","article-title":"A\u00a0novel role for villin in intestinal epithelial cell survival and homeostasis","volume":"283","author":"Wang","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib101","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.200902153","article-title":"Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in\u00a0vivo","volume":"189","author":"Marchiando","year":"2010","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib102","doi-asserted-by":"crossref","first-page":"G367","DOI":"10.1152\/ajpgi.00173.2003","article-title":"TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation","volume":"286","author":"Ma","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib103","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1053\/j.gastro.2008.09.023","article-title":"The ErbB4 growth factor receptor is required for colon epithelial cell survival in the presence of TNF","volume":"136","author":"Frey","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib104","doi-asserted-by":"crossref","first-page":"8366","DOI":"10.1073\/pnas.1432897100","article-title":"TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis","volume":"100","author":"Marini","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib105","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1136\/gut.2003.036632","article-title":"Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor antibody treatment","volume":"53","author":"Zeissig","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib106","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0002-9440(10)62264-X","article-title":"Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression","volume":"166","author":"Wang","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib107","doi-asserted-by":"crossref","first-page":"G422","DOI":"10.1152\/ajpgi.00412.2004","article-title":"Mechanism of TNF-alpha modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression","volume":"288","author":"Ma","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib108","first-page":"2018","article-title":"Detection of hypoxia in human squamous cell carcinoma by EF5 binding","volume":"60","author":"Evans","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib109","first-page":"799","article-title":"VEGF release is associated with reduced oxygen tensions in experimental inflammatory arthritis","volume":"20","author":"Etherington","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib110","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.micinf.2016.09.004","article-title":"Hypoxia and inflammatory bowel disease","volume":"19","author":"Cummins","year":"2017","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib111","doi-asserted-by":"crossref","first-page":"R1369","DOI":"10.1152\/ajpregu.00349.2014","article-title":"Hypoxia-sensitive pathways in inflammation-driven fibrosis","volume":"307","author":"Manresa","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib112","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1172\/JCI200421086","article-title":"Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis","volume":"114","author":"Karhausen","year":"2004","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib113","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/jcp.56.3.209","article-title":"Hypoxia inducible factor 1 alpha and 2 alpha overexpression in inflammatory bowel disease","volume":"56","author":"Giatromanolaki","year":"2003","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib114","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1172\/JCI84433","article-title":"Hypoxia-dependent regulation of inflammatory pathways in immune cells","volume":"126","author":"Taylor","year":"2016","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib115","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1053\/j.gastro.2007.10.012","article-title":"The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis","volume":"134","author":"Cummins","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib116","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1053\/j.gastro.2007.09.033","article-title":"Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition","volume":"134","author":"Robinson","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib117","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.4049\/jimmunol.1002541","article-title":"Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD","volume":"185","author":"Hindryckx","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib118","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1476-9255-10-36","article-title":"Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn's disease\/infectious colitis and healthy controls","volume":"10","author":"Van Welden","year":"2013","journal-title":"J\u00a0Inflamm (Lond)"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib119","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.193.9.1027","article-title":"Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia","volume":"193","author":"Furuta","year":"2001","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib120","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/jcb.20947","article-title":"Selective induction of mucin-3 by hypoxia in intestinal epithelia","volume":"99","author":"Louis","year":"2006","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib121","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/mi.2015.67","article-title":"Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis","volume":"9","author":"Fluck","year":"2016","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib122","doi-asserted-by":"crossref","first-page":"E2784","DOI":"10.1073\/pnas.1202366109","article-title":"Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa","volume":"109","author":"Clambey","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib123","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1053\/j.gastro.2008.03.009","article-title":"Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade","volume":"134","author":"Shah","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib124","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1091\/mbc.E14-07-1194","article-title":"HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity","volume":"26","author":"Saeedi","year":"2015","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib125","doi-asserted-by":"crossref","first-page":"20580","DOI":"10.1074\/jbc.M115.653584","article-title":"PHD3 stabilizes the tight junction protein occludin and protects intestinal epithelial barrier function","volume":"290","author":"Chen","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib126","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.nbd.2004.08.001","article-title":"Hypoxia-induced changes in tight junction permeability of brain capillary endothelial cells are associated with IL-1beta and nitric oxide","volume":"17","author":"Yamagata","year":"2004","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib127","doi-asserted-by":"crossref","first-page":"e84767","DOI":"10.1371\/journal.pone.0084767","article-title":"Inhibition of HIF prolyl-4-hydroxylases by FG-4497 reduces brain tissue injury and edema formation during ischemic stroke","volume":"9","author":"Reischl","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib128","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1128\/MCB.00324-14","article-title":"Hypoxia-inducible factor\/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin, leading to hypoxia-induced inflammation","volume":"34","author":"Xie","year":"2014","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib129","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00109-010-0683-5","article-title":"Ras regulates interleukin-1 beta-induced HIF-1 alpha transcriptional activity in glioblastoma","volume":"89","author":"Sharma","year":"2011","journal-title":"J\u00a0Mol Med (Berl)"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib130","doi-asserted-by":"crossref","first-page":"7516","DOI":"10.4049\/jimmunol.178.12.7516","article-title":"Cutting edge: essential role of hypoxia inducible factor-1 alpha in development of lipopolysaccharide-induced sepsis","volume":"178","author":"Peyssonnaux","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib131","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1042\/BJ20080476","article-title":"Regulation of hypoxia-inducible factor-1 alpha by NF-kappa B","volume":"412","author":"van Uden","year":"2008","journal-title":"Biochem J"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib132","doi-asserted-by":"crossref","DOI":"10.1038\/nature06905","article-title":"NF-kappa B links innate immunity to the hypoxic response through transcriptional regulation of HIF-1 alpha","volume":"453","author":"Rius","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib133","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/sj.bjc.6606020","article-title":"A\u00a0hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-kappa B promotes gastric tumour growth and angiogenesis","volume":"104","author":"Nam","year":"2011","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib134","doi-asserted-by":"crossref","first-page":"e1001285","DOI":"10.1371\/journal.pgen.1001285","article-title":"Evolutionary conserved regulation of HIF-1 beta by NF-kappa B","volume":"7","author":"van Uden","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib135","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1749-6632.2009.05024.x","article-title":"The role of NF-kappa B in hypoxia-induced gene expression","volume":"1177","author":"Taylor","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib136","doi-asserted-by":"crossref","first-page":"18154","DOI":"10.1073\/pnas.0602235103","article-title":"Prolyl hydroxylase-1 negatively regulates I kappa B kinase-beta, giving insight into hypoxia-induced NF kappa B activity","volume":"103","author":"Cummins","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib137","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.bbrc.2016.04.085","article-title":"Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-kappa B-dependent manner","volume":"474","author":"Fitzpatrick","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib138","doi-asserted-by":"crossref","first-page":"18490","DOI":"10.1073\/pnas.1309718110","article-title":"Regulation of IL-1 beta-induced NF-kappa B by hydroxylases links key hypoxic and inflammatory signaling pathways","volume":"110","author":"Scholz","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib139","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1053\/j.gastro.2009.09.049","article-title":"Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKK beta independent of hydroxylase activity","volume":"138","author":"Xue","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib140","doi-asserted-by":"crossref","first-page":"8927","DOI":"10.1074\/jbc.M109.078600","article-title":"Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kappa B-dependent pathway","volume":"285","author":"Fu","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib141","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1128\/MCB.00273-13","article-title":"EGLN3 Inhibition of NF-kappa B is mediated by prolyl hydroxylase-independent inhibition of I kappa B kinase gamma ubiquitination","volume":"33","author":"Fu","year":"2013","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib142","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1016\/S0002-9270(01)02657-0","article-title":"Prediction of response to iron sucrose in inflammatory bowel disease-associated anemia","volume":"96","author":"Gasche","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib143","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1016\/j.cgh.2015.03.029","article-title":"Persistent or recurrent anemia is associated with severe and disabling inflammatory bowel disease","volume":"13","author":"Koutroubakis","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib144","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1182\/blood-2010-02-270322","article-title":"Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia","volume":"116","author":"Kapitsinou","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib145","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1681\/ASN.2010010116","article-title":"Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD","volume":"21","author":"Bernhardt","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib146","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1681\/ASN.2015030241","article-title":"Roxadustat (FG-4592): correction of anemia in incident dialysis patients","volume":"27","author":"Besarab","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib147","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1182\/blood-2007-02-073254","article-title":"HIF-prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques","volume":"110","author":"Hsieh","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib148","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1681\/ASN.2014111139","article-title":"Four-week studies of oral hypoxia-inducible factor-prolyl hydroxylase inhibitor GSK1278863 for treatment of anemia","volume":"27","author":"Holdstock","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib149","doi-asserted-by":"crossref","first-page":"G677","DOI":"10.1152\/ajpgi.00104.2011","article-title":"Themes in fibrosis and gastrointestinal inflammation","volume":"300","author":"Fiocchi","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib150","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1097\/MIB.0000000000000080","article-title":"Fibrosis in ulcerative colitis: mechanisms, features, and consequences of a neglected problem","volume":"20","author":"Gordon","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib151","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.crohns.2008.05.009","article-title":"Intestinal fibrosis in inflammatory bowel disease - current knowledge and future perspectives","volume":"2","author":"Rieder","year":"2008","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib152","first-page":"3810","article-title":"Hypoxia promotes fibrogenesis in\u00a0vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition","volume":"117","author":"Higgins","year":"2007","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib153","doi-asserted-by":"crossref","first-page":"F1274","DOI":"10.1152\/ajprenal.00287.2012","article-title":"miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-alpha activation","volume":"304","author":"Fang","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib154","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1172\/JCI69073","article-title":"Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury","volume":"124","author":"Kapitsinou","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib155","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1128\/MCB.00609-13","article-title":"Loss of epithelial hypoxia-inducible factor prolyl hydroxylase 2 accelerates skin wound healing in mice","volume":"33","author":"Kalucka","year":"2013","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib156","doi-asserted-by":"crossref","first-page":"e93373","DOI":"10.1371\/journal.pone.0093373","article-title":"Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury","volume":"9","author":"Zimmermann","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib157","doi-asserted-by":"crossref","first-page":"G1076","DOI":"10.1152\/ajpgi.00229.2016","article-title":"Hydroxylases regulate intestinal fibrosis through the suppression of ERK mediated TGF-\u03b21 signaling","volume":"311","author":"Manresa","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib158","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/mi.2011.57","article-title":"Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn's disease","volume":"5","author":"Lawrenz","year":"2012","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib159","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1523-1755.2005.00157.x","article-title":"Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants","volume":"67","author":"Pat","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib160","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00408-005-2560-5","article-title":"Role of extracellular signal-regulated kinase, p38 kinase, and activator protein-1 in transforming growth factor-beta 1-induced alpha smooth muscle actin expression in human fetal lung fibroblasts in\u00a0vitro","volume":"184","author":"Hu","year":"2006","journal-title":"Lung"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib161","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jconrel.2015.09.022","article-title":"Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis","volume":"217","author":"Tambuwala","year":"2015","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib162","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1172\/JCI69244","article-title":"Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis","volume":"123","author":"Chaturvedi","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib163","doi-asserted-by":"crossref","first-page":"16369","DOI":"10.1073\/pnas.1113483108","article-title":"Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation","volume":"108","author":"Wong","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib164","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","author":"Semenza","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib165","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.eururo.2004.04.008","article-title":"Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer","volume":"46","author":"Theodoropoulos","year":"2004","journal-title":"Eur Urol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib166","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11060-005-9103-z","article-title":"Inhibition of hypoxia inducible factor-1 alpha (HIF-1 alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas","volume":"78","author":"Jensen","year":"2006","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib167","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.orthres.2004.03.002","article-title":"Hypoxia induces HIF-1 alpha and VEGF expression in chondrosarcoma cells and chondrocytes","volume":"22","author":"Lin","year":"2004","journal-title":"J\u00a0Ortho Res"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib168","doi-asserted-by":"crossref","first-page":"17790","DOI":"10.18632\/oncotarget.7461","article-title":"Nuclear beta-arrestin1 is a critical cofactor of hypoxia-inducible factor-1 alpha signaling in endothelin-1-induced ovarian tumor progression","volume":"7","author":"Cianfrocca","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib169","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1158\/0008-5472.CAN-05-2519","article-title":"Role of hypoxia-inducible factor (HIF)-1 alpha-versus HIF-2 alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-1, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway","volume":"66","author":"Carroll","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib170","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000088478","article-title":"VEGF as a key mediator of angiogenesis in cancer","volume":"69","author":"Carmeliet","year":"2005","journal-title":"Oncology"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib171","doi-asserted-by":"crossref","first-page":"E3234","DOI":"10.1073\/pnas.1410041111","article-title":"Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis","volume":"111","author":"Wang","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2017.02.004_bib172","doi-asserted-by":"crossref","first-page":"E2047","DOI":"10.1073\/pnas.1602883113","article-title":"Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and\u00a0ALKBH5-mediated m(6)A-demethylation of NANOG mRNA","volume":"113","author":"Zhang","year":"2016","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X17300358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X17300358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T09:25:41Z","timestamp":1658654741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X17300358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":172,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S2352345X17300358"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2017.02.004","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2017.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}