{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T21:47:03Z","timestamp":1788040023829,"version":"build-2784847793"},"reference-count":83,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.jcmgh.2017.03.005","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T06:16:16Z","timestamp":1489472176000},"page":"47-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":111,"title":["Regulation of Gastric Carcinogenesis by Inflammatory\u00a0Cytokines"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5010-4970","authenticated-orcid":false,"given":"Kevin A.","family":"Bockerstett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"DiPaolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2017.03.005_bib1","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.semcancer.2004.06.006","article-title":"Inflammation as a tumor promoter in cancer induction","volume":"14","author":"Philip","year":"2004","journal-title":"Semin Cancer Biol"},{"issue":"Suppl 1","key":"10.1016\/j.jcmgh.2017.03.005_bib3","first-page":"S37","article-title":"Helicobacter pylori and gastric carcinogenesis","volume":"19","author":"Correa","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1172\/JCI30111","article-title":"Inflammation, atrophy, and gastric cancer","volume":"117","author":"Fox","year":"2007","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib5","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/cncr.10375","article-title":"Patterns of gastric atrophy in intestinal type gastric carcinoma","volume":"94","author":"El-Zimaity","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib6","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0016-5085(98)70581-5","article-title":"Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection","volume":"114","author":"Wang","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1053\/gast.1996.v110.pm8536852","article-title":"Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL\/6 mice and p53 hemizygous transgenic mice","volume":"110","author":"Fox","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib8","first-page":"639","article-title":"Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma","volume":"79","author":"Schmidt","year":"1999","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib9","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1074\/jbc.M111.294355","volume":"287","author":"Diegelmann","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1053\/j.gastro.2008.10.018","article-title":"RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F","volume":"136","author":"Leppkes","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib11","first-page":"534","article-title":"IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis","volume":"118","author":"Sugimoto","year":"2008","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib12","first-page":"tr8","article-title":"The Jak-STAT pathway stimulated by interferon gamma","volume":"2004","author":"Horvath","year":"2004","journal-title":"Sci STKE"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib13","first-page":"tr10","article-title":"The Jak-STAT pathway stimulated by interferon alpha or interferon beta","volume":"2004","author":"Horvath","year":"2004","journal-title":"Sci STKE"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib14","first-page":"tr9","article-title":"The Jak-STAT pathway stimulated by interleukin 6","volume":"2004","author":"Horvath","year":"2004","journal-title":"Sci STKE"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib15","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.cyto.2008.07.017","article-title":"An overview of IL-17 function and signaling","volume":"43","author":"Gaffen","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/bjo.80.1.63","article-title":"Effects of the cytokines on the proliferation of and collagen synthesis by human cataract lens epithelial cells","volume":"80","author":"Nishi","year":"1996","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib17","doi-asserted-by":"crossref","first-page":"e2344","DOI":"10.1038\/cddis.2016.201","article-title":"Luteolin-7-glucoside inhibits IL-22\/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model","volume":"7","author":"Palombo","year":"2016","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib18","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1152\/ajpcell.00108.2016","article-title":"TNF-alpha augments RANKL-dependent intestinal M cell differentiation in enteroid cultures","volume":"311","author":"Wood","year":"2016","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib19","first-page":"e63","article-title":"Mechanisms of TGFbeta-induced epithelial-mesenchymal transition","volume":"5","author":"Moustakas","year":"2016","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.yexcr.2016.05.004","article-title":"Interleukin 22 early affects keratinocyte differentiation, but not proliferation, in a three-dimensional model of normal human skin","volume":"345","author":"Donetti","year":"2016","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib21","doi-asserted-by":"crossref","unstructured":"El-Omar EM. Interleukin-1 polymorphisms associated with increased risk of gastric cancer.\u00a02000;404:398\u2013402.","DOI":"10.1038\/35006081"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib22","doi-asserted-by":"crossref","first-page":"6431","DOI":"10.1158\/1078-0432.CCR-05-0942","article-title":"The -251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffuse-type histopathology in Chinese population","volume":"11","author":"Lee","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib23","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1007\/s10552-013-0284-z","article-title":"Circulating cytokines and gastric cancer risk","volume":"24","author":"Epplein","year":"2013","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib24","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1158\/1055-9965.EPI-05-0326","article-title":"Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan","volume":"14","author":"Taguchi","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib25","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0016-5085(03)00157-4","article-title":"Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms","volume":"124","author":"El-Omar","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib26","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1053\/gast.2001.28000","article-title":"Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma","volume":"121","author":"Machado","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib27","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1093\/jnci\/94.22.1680","article-title":"Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma","volume":"94","author":"Figueiredo","year":"2002","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib28","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.20061308","article-title":"Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides","volume":"203","author":"Liang","year":"2006","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib29","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bbrc.2008.07.060","article-title":"The prevalence of Th17 cells in patients with gastric cancer","volume":"374","author":"Zhang","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib30","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jss.2012.07.055","article-title":"Prevalence and clinical relevance of Th17 cells in patients with gastric cancer","volume":"178","author":"Yamada","year":"2012","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib31","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.3892\/or.2013.2570","article-title":"Prevalence of Th17 and Treg cells in gastric cancer patients and its correlation with clinical parameters","volume":"30","author":"Li","year":"2013","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib32","first-page":"1271","article-title":"Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric cancer","volume":"25","author":"Iida","year":"2011","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib33","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1111\/j.1349-7006.2010.01624.x","article-title":"Distribution of Th17 cells and FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancer","volume":"101","author":"Maruyama","year":"2010","journal-title":"Cancer Sci"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib34","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1007\/s12032-012-0273-1","article-title":"Expression of interleukin-17 and its clinical significance in gastric cancer patients","volume":"29","author":"Meng","year":"2012","journal-title":"Med Oncol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib35","doi-asserted-by":"crossref","first-page":"20439","DOI":"10.1038\/srep20439","article-title":"Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: an updated meta-analysis","volume":"6","author":"Dai","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib36","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/ni.1770","article-title":"Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells","volume":"10","author":"Trifari","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib37","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/bjc.2014.336","article-title":"IL-22 produced by cancer-associated fibroblasts promotes gastric cancer cell invasion via STAT3 and ERK signaling","volume":"111","author":"Fukui","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib38","doi-asserted-by":"crossref","first-page":"11673","DOI":"10.3748\/wjg.v21.i41.11673","article-title":"Mitogen-activated protein kinase signaling pathway and invasion and metastasis of gastric cancer","volume":"21","author":"Yang","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib39","doi-asserted-by":"crossref","first-page":"e75192","DOI":"10.1371\/journal.pone.0075192","article-title":"Gastric epithelial expression of IL-12 cytokine family in Helicobacter pylori infection in human: is it head or tail of the coin?","volume":"8","author":"Al-Sammak","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib40","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.bbamcr.2009.07.009","article-title":"Cytokine signalling via gp130 in gastric cancer","volume":"1793","author":"Howlett","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib41","first-page":"617","article-title":"STAT3 is overactivated in gastric cancer stem-like cells","volume":"17","author":"Hajimoradi","year":"2016","journal-title":"Cell J"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib42","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1440-1746.2008.05671.x","article-title":"STAT3 expression in gastric cancer indicates a poor prognosis","volume":"24","author":"Kim","year":"2009","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib43","doi-asserted-by":"crossref","first-page":"e2799","DOI":"10.1097\/MD.0000000000002799","article-title":"A\u00a0causal role of genetically elevated circulating interleukin-10 in the development of digestive cancers: evidence from mendelian randomization analysis based on 29,307 subjects","volume":"95","author":"Niu","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib44","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1158\/1078-0432.CCR-13-1221","article-title":"Interleukin-32 increases human gastric cancer cell invasion associated with tumor progression and metastasis","volume":"20","author":"Tsai","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jcmgh.2014.12.003","article-title":"IL33 is a stomach alarm that initiates a skewed Th2 response to injury and infection","volume":"1","author":"Buzzelli","year":"2015","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib46","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0171-2985(11)80414-6","article-title":"Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice","volume":"189","author":"Gessner","year":"1993","journal-title":"Immunobiology"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib47","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0769-2625(87)80030-2","article-title":"Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets","volume":"138","author":"Locksley","year":"1987","journal-title":"Ann Inst Pasteur Immunol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib48","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/S0016-5085(97)70004-0","article-title":"Murine CD4 T-cell response to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load","volume":"113","author":"Mohammadi","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib49","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2174\/1568026043451276","article-title":"Th1-mediated pathology in mouse models of human disease is ameliorated by concurrent Th2 responses to parasite antigens","volume":"4","author":"Whary","year":"2004","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib50","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1158\/1055-9965.EPI-05-0095","article-title":"Intestinal helminthiasis in Colombian children promotes a Th2 response to Helicobacter pylori: possible implications for gastric carcinogenesis","volume":"14","author":"Whary","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib51","doi-asserted-by":"crossref","first-page":"7456","DOI":"10.4049\/jimmunol.166.12.7456","article-title":"The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice","volume":"166","author":"Eaton","year":"2001","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib52","doi-asserted-by":"crossref","first-page":"12944","DOI":"10.1073\/pnas.2135193100","article-title":"Treatment of Helicobacter gastritis with IL-4 requires somatostatin","volume":"100","author":"Zavros","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib53","doi-asserted-by":"crossref","first-page":"6305","DOI":"10.3748\/wjg.v11.i40.6305","article-title":"Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization","volume":"11","author":"Mizuno","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib54","doi-asserted-by":"crossref","first-page":"G852","DOI":"10.1152\/ajpgi.00175.2016","article-title":"TLR9 activation suppresses inflammation in response to Helicobacter pylori infection","volume":"311","author":"Varga","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib55","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4049\/jimmunol.165.2.1022","article-title":"Helicobacter pylori-induced mucosal inflammation Is Th1 mediated and exacerbated in IL-4, but not IFN-, gene-deficient mice","volume":"165","author":"Smythies","year":"2000","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib56","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1128\/IAI.01788-06","article-title":"Wild-type and interleukin-10-deficient regulatory T cells reduce effector T-cell-mediated gastroduodenitis in Rag2-\/- mice, but only wild-type regulatory T cells suppress Helicobacter pylori gastritis","volume":"75","author":"Lee","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib57","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1136\/gutjnl-2011-300539","article-title":"IL-11 is a parietal cell cytokine that induces atrophic gastritis","volume":"61","author":"Howlett","year":"2012","journal-title":"Gut"},{"issue":"Suppl 2","key":"10.1016\/j.jcmgh.2017.03.005_bib58","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1046\/j.1365-2036.16.s2.3.x","article-title":"Conditional loss of TGF-beta signalling leads to increased susceptibility to gastrointestinal carcinogenesis in mice","volume":"16","author":"Hahm","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib59","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/labinvest.2012.47","article-title":"Gastric tumor development in Smad3-deficient mice initiates from forestomach\/glandular transition zone along the lesser curvature","volume":"92","author":"Nam","year":"2012","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib60","first-page":"6113","article-title":"Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice","volume":"59","author":"Takaku","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib61","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1128\/IAI.01437-15","article-title":"Gastric metaplasia induced by Helicobacter pylori is associated with enhanced SOX9 expression via interleukin-1 signaling","volume":"84","author":"Serizawa","year":"2015","journal-title":"Infect Immun"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib62","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1172\/JCI82655","article-title":"Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression","volume":"126","author":"Menheniott","year":"2016","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib63","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/labinvest.3700260","article-title":"Interferon gamma induction of gastric mucous neck cell hypertrophy","volume":"85","author":"Kang","year":"2005","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib64","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/labinvest.2012.73","article-title":"IFNgamma contributes to the development of gastric epithelial cell metaplasia in Huntington interacting protein 1 related (Hip1r)-deficient mice","volume":"92","author":"Liu","year":"2012","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib65","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1053\/j.gastro.2014.02.007","article-title":"Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells","volume":"146","author":"Petersen","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib66","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1016\/j.ajpath.2012.08.017","article-title":"Transgenic expression of interferon-gamma in mouse stomach leads to inflammation, metaplasia, and dysplasia","volume":"181","author":"Syu","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib67","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1158\/0008-5472.CAN-10-4009","article-title":"IFN-gamma inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis","volume":"71","author":"Tu","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib68","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1189\/jlb.0410217","article-title":"gp130 at the nexus of inflammation, autoimmunity, and cancer","volume":"88","author":"Silver","year":"2010","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib69","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1053\/j.gastro.2003.10.066","article-title":"Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130","volume":"126","author":"Judd","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib70","first-page":"1727","article-title":"STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice","volume":"118","author":"Ernst","year":"2008","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib71","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1053\/j.gastro.2006.07.018","article-title":"STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis","volume":"131","author":"Judd","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib72","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ccr.2008.10.011","article-title":"Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice","volume":"14","author":"Tu","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib73","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/cncr.25524","article-title":"Autoimmune disease and subsequent risk of developing alimentary tract cancers among 4.5 million US male veterans","volume":"117","author":"Landgren","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib74","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1093\/annonc\/mdr590","article-title":"Effect of autoimmune diseases on mortality and survival in subsequent digestive tract cancers","volume":"23","author":"Hemminki","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib75","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1002\/1521-4141(200107)31:7<2094::AID-IMMU2094>3.0.CO;2-S","article-title":"A\u00a0T cell receptor transgenic model of severe, spontaneous organ-specific autoimmunity","volume":"31","author":"McHugh","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib76","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1158\/0008-5472.CAN-12-3957","article-title":"Autoimmune gastritis mediated by CD4+ T cells promotes the development of gastric cancer","volume":"73","author":"Nguyen","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib77","doi-asserted-by":"crossref","first-page":"e104698","DOI":"10.1371\/journal.pone.0104698","article-title":"In\u00a0vitro induced regulatory T cells are unique from endogenous regulatory T cells and effective at suppressing late stages of ongoing autoimmunity","volume":"9","author":"Nguyen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib78","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.4049\/jimmunol.179.7.4685","article-title":"Autoantigen-specific TGFbeta-induced Foxp3+ regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells","volume":"179","author":"DiPaolo","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib79","doi-asserted-by":"crossref","first-page":"7135","DOI":"10.4049\/jimmunol.175.11.7135","article-title":"CD4+CD25+ T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells","volume":"175","author":"DiPaolo","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib80","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.4049\/jimmunol.181.3.1908","article-title":"Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells","volume":"181","author":"Stummvoll","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib81","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.intimp.2009.01.022","article-title":"Pre-differentiated Th1 and Th17 effector T cells in autoimmune gastritis: Ag-specific regulatory T cells are more potent suppressors than polyclonal regulatory T cells","volume":"9","author":"Huter","year":"2009","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib82","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/jgh.12144","article-title":"Interleukin-21 and tumor necrosis factor-alpha are critical for the development of autoimmune gastritis in mice","volume":"28","author":"Nishiura","year":"2013","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2017.03.005_bib83","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2016-312779","article-title":"A\u00a0signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach","author":"Petersen","year":"2017","journal-title":"Gut"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X17300516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X17300516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T14:07:16Z","timestamp":1568902036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X17300516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":83,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S2352345X17300516"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2017.03.005","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of Gastric Carcinogenesis by Inflammatory\u00a0Cytokines","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2017.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}