{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:48:24Z","timestamp":1790819304520,"version":"4.1.0"},"reference-count":83,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000},"content-version":"vor","delay-in-days":164,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000901","name":"Juvenile Diabetes Research Foundation International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019125","name":"Sorbonne Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1-2011-592"],"award-info":[{"award-number":["1-2011-592"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 DK089540"],"award-info":[{"award-number":["U01 DK089540"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/j.jcmgh.2019.06.005","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T05:06:20Z","timestamp":1561093580000},"page":"487-511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis"],"prefix":"10.1016","volume":"8","author":[{"given":"Evans","family":"Quilichini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Fabre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thassadite","family":"Dirami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Stedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias","family":"De Vas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge","family":"Ozguc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond C.","family":"Pasek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Cereghini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Morillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Couvelard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Gannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3526-7832","authenticated-orcid":false,"given":"C\u00e9cile","family":"Haumaitre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2019.06.005_bib1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.canlet.2013.08.015","article-title":"Chronic pancreatitis: a path to pancreatic cancer","volume":"345","author":"Pinho","year":"2014","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib2","doi-asserted-by":"crossref","first-page":"18907","DOI":"10.1073\/pnas.0810111105","article-title":"Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia","volume":"105","author":"De La","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ccr.2007.01.012","article-title":"Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice","volume":"11","author":"Guerra","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib4","doi-asserted-by":"crossref","first-page":"17060","DOI":"10.1038\/nrdp.2017.60","article-title":"Chronic pancreatitis","volume":"3","author":"Kleeff","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib5","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1172\/JCI57131","article-title":"Pancreatic ductal cells in development, regeneration, and neoplasia","volume":"121","author":"Reichert","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.semcdb.2017.01.005","article-title":"The molecular and morphogenetic basis of pancreas organogenesis","volume":"66","author":"Larsen","year":"2017","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib7","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1242\/dev.01189","article-title":"Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization","volume":"131","author":"Cano","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib8","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1053\/j.gastro.2006.10.050","article-title":"Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis","volume":"131","author":"Cano","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/labinvest.3700207","article-title":"Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice","volume":"85","author":"Zhang","year":"2005","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/bdrc.21063","article-title":"Primary cilia in pancreatic development and disease","volume":"102","author":"Lodh","year":"2014","journal-title":"Birth Defects Res C Embryo Today"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib11","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1093\/hmg\/ddg355","article-title":"Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas","volume":"12","author":"Maestro","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib12","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.devcel.2009.11.003","article-title":"Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth","volume":"17","author":"Solar","year":"2009","journal-title":"Dev Cell"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib13","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1242\/dev.110759","article-title":"Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors","volume":"142","author":"De Vas","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib14","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1242\/dev.056499","article-title":"Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas","volume":"138","author":"Kopp","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib15","doi-asserted-by":"crossref","first-page":"12643","DOI":"10.1038\/s41598-017-12721-9","article-title":"Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cells","volume":"7","author":"Houbracken","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib16","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1073\/pnas.0405776102","article-title":"Lack of TCF2\/vHNF1 in mice leads to pancreas agenesis","volume":"102","author":"Haumaitre","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib17","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1038\/sj.emboj.7600160","article-title":"A\u00a0transcriptional network in polycystic kidney disease","volume":"23","author":"Gresh","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib18","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.gastro.2003.09.001","article-title":"Defects in cholangiocyte fibrocystin expression and ciliary structure in the PCK rat","volume":"125","author":"Masyuk","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib19","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1002\/hep.24292","article-title":"A\u00a0classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis","volume":"53","author":"Raynaud","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib20","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1002\/dvdy.20729","article-title":"Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice","volume":"235","author":"Kilic","year":"2006","journal-title":"Dev Dyn"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib21","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1053\/j.gastro.2011.12.007","article-title":"Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas","volume":"142","author":"Westmoreland","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib22","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1083\/jcb.201101005","article-title":"Regulating the transition from centriole to basal body","volume":"193","author":"Kobayashi","year":"2011","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2046-2530-2-6","article-title":"Functional aspects of primary cilia\u00a0in signaling, cell cycle and tumorigenesis","volume":"2","author":"Basten","year":"2013","journal-title":"Cilia"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3727\/105221617X15034976037343","article-title":"Increased YAP activation is associated with hepatic cyst epithelial cell proliferation in ARPKD\/CHF","volume":"17","author":"Jiang","year":"2017","journal-title":"Gene Expr"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib25","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrm3416","article-title":"Transduction of mechanical and cytoskeletal cues by YAP and TAZ","volume":"13","author":"Halder","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib26","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1016\/j.febslet.2014.04.012","article-title":"YAP\/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth","volume":"588","author":"Low","year":"2014","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib27","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nrm.2017.87","article-title":"Mechanobiology of YAP and TAZ in physiology and disease","volume":"18","author":"Panciera","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib28","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/hep.27425","article-title":"Connective tissue growth factor and integrin \u03b1v\u03b26: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice","volume":"61","author":"Pi","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib29","doi-asserted-by":"crossref","first-page":"L344","DOI":"10.1152\/ajplung.00300.2014","article-title":"Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis","volume":"308","author":"Liu","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib30","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1053\/j.gastro.2013.02.037","article-title":"Hippo signaling regulates differentiation and maintenance in the exocrine pancreas","volume":"144","author":"Gao","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib31","doi-asserted-by":"crossref","first-page":"16759","DOI":"10.1038\/srep16759","article-title":"Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis","volume":"5","author":"Morvaridi","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib32","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1053\/j.gastro.2016.05.006","article-title":"YAP1 and TAZ control pancreatic cancer initiation in mice by direct up-regulation of JAK\u2013STAT3 signaling","volume":"151","author":"Gruber","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib33","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1242\/dev.01925","article-title":"Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates","volume":"132","author":"Means","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib34","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ccr.2012.08.001","article-title":"EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma","volume":"22","author":"Navas","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib35","doi-asserted-by":"crossref","first-page":"30904","DOI":"10.1038\/srep30904","article-title":"TGF-\u03b21 promotes acinar to ductal metaplasia of human pancreatic acinar cells","volume":"6","author":"Liu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib36","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1136\/gutjnl-2011-300266","article-title":"Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia","volume":"61","author":"Pr\u00e9vot","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jcmgh.2017.05.005","article-title":"Acinar-to-ductal metaplasia induced by transforming growth factor beta facilitates KRASG12D-driven pancreatic tumorigenesis","volume":"4","author":"Chuvin","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib38","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1535-6108(03)00140-5","article-title":"Notch mediates TGF\u03b1-induced changes in epithelial differentiation during pancreatic tumorigenesis","volume":"3","author":"Miyamoto","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0925-4773(00)00317-8","article-title":"Notch gene expression during pancreatic organogenesis","volume":"94","author":"Lammert","year":"2000","journal-title":"Mech Dev"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib40","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/path.2293","article-title":"Evidence of Notch pathway activation in the ectatic ducts of chronic pancreatitis","volume":"214","author":"Bhanot","year":"2008","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib41","doi-asserted-by":"crossref","first-page":"32360","DOI":"10.1074\/jbc.272.51.32360","article-title":"Cloning and expression of the Rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth","volume":"272","author":"Mallo","year":"1997","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib42","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1016\/j.febslet.2010.06.010","article-title":"PPARgamma in adipocyte differentiation and metabolism--novel insights from genome-wide studies","volume":"584","author":"Siersbaek","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib43","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3389\/fphys.2012.00344","article-title":"Pancreatic stellate cells: a starring role in normal and diseased pancreas","volume":"3","author":"Apte","year":"2012","journal-title":"Front Physiol"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib44","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1016\/j.amjsurg.2007.05.004","article-title":"Pancreatic cancer-associated stroma production","volume":"194","author":"Korc","year":"2007","journal-title":"Am J Surg"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib45","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-4598-10-8","article-title":"Cyr61\/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis","volume":"10","author":"Haque","year":"2011","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib46","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1097\/01.mcg.0000155547.83901.a3","article-title":"Epithelial differentiation in pancreatic development and neoplasia: new niches for nestin and Notch","volume":"39","author":"Leach","year":"2005","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib47","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1053\/j.gastro.2011.07.003","article-title":"Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice","volume":"141","author":"Criscimanna","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib48","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev-physiol-021014-071727","article-title":"Regeneration and repair of the exocrine pancreas","volume":"77","author":"Murtaugh","year":"2015","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib49","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1073\/pnas.0400073101","article-title":"PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells","volume":"101","author":"Zhang","year":"2004","journal-title":"PNAS"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib50","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1681\/ASN.2007070770","article-title":"Fibrocystin\/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function","volume":"19","author":"Kim","year":"2008","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib51","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5114\/ceji.2014.42129","article-title":"Multiple gene mutations in patients with type 2 autoimmune pancreatitis and its clinical features","volume":"39","author":"Dong","year":"2014","journal-title":"Cent Eur J Immunol"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib52","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1172\/JCI0214099","article-title":"Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease","volume":"109","author":"Hou","year":"2002","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib53","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1083\/jcb.151.3.709","article-title":"Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella","volume":"151","author":"Pazour","year":"2000","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib54","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1242\/dev.050054","article-title":"Cilia in vertebrate development and disease","volume":"139","author":"Oh","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib55","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.cell.2007.04.035","article-title":"HEF1-dependent Aurora A activation induces disassembly of the primary cilium","volume":"129","author":"Pugacheva","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib56","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1053\/j.gastro.2005.12.005","article-title":"The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse","volume":"130","author":"Pierreux","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib57","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.mod.2009.09.006","article-title":"Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation","volume":"126","author":"Zhang","year":"2009","journal-title":"Mech Dev"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib58","first-page":"5017","article-title":"Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells","volume":"22","author":"Augereau","year":"2016","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib59","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.genom.7.080505.115610","article-title":"The ciliopathies: an emerging class of human genetic disorders","volume":"7","author":"Badano","year":"2006","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib60","first-page":"157","article-title":"Loss of ONECUT1 expression in human pancreatic cancer cells","volume":"19","author":"Jiang","year":"2008","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib61","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/labinvest.2014.47","article-title":"Loss of HNF6 expression correlates with human pancreatic cancer progression","volume":"94","author":"Pekala","year":"2014","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib62","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.neo.2016.02.002","article-title":"Prox1-heterozygosis sensitizes the pancreas to oncogenic Kras-induced neoplastic transformation","volume":"18","author":"Drosos","year":"2016","journal-title":"Neoplasia"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib63","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1158\/0008-5472.CAN-08-1290","article-title":"Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia","volume":"69","author":"Seeley","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib64","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/ncb2303","article-title":"The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal","volume":"13","author":"Zhao","year":"2011","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib65","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00000658-199907000-00010","article-title":"Connective tissue growth factor is a regulator for fibrosis in human chronic pancreatitis","volume":"230","author":"di Mola","year":"1999","journal-title":"Ann Surg"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib66","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cytogfr.2012.07.001","article-title":"Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2)","volume":"24","author":"Charrier","year":"2013","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib67","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1074\/mcp.M112.023507","article-title":"Laminin, gamma 2 (LAMC2): a promising new putative pancreatic cancer biomarker identified by proteomic analysis of pancreatic adenocarcinoma tissues","volume":"12","author":"Kosanam","year":"2013","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib68","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1073\/pnas.0912589107","article-title":"Isolation and characterization of centroacinar\/terminal ductal progenitor cells in adult mouse pancreas","volume":"107","author":"Rovira","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib69","doi-asserted-by":"crossref","first-page":"13438","DOI":"10.1073\/pnas.1002423107","article-title":"Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma","volume":"107","author":"Mazur","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib70","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00000658-199801000-00014","article-title":"Enhanced expression of TGF-betas and their receptors in human acute pancreatitis","volume":"227","author":"Friess","year":"1998","journal-title":"Ann Surg"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib71","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1053\/j.gastro.2013.01.074","article-title":"Control of cell identity in pancreas development and regeneration","volume":"144","author":"Stanger","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib72","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1053\/j.gastro.2006.06.023","article-title":"Pancreas recovery following cerulein-induced pancreatitis is impaired in plasminogen-deficient mice","volume":"131","author":"Lugea","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib73","first-page":"3326","article-title":"Systematic review of TCF2 anomalies in renal cysts and diabetes syndrome\/maturity onset diabetes of the young type 5","volume":"123","author":"Chen","year":"2010","journal-title":"Chin Med J"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib74","doi-asserted-by":"crossref","first-page":"11252","DOI":"10.1073\/pnas.1200853109","article-title":"Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis","volume":"109","author":"Grisanzio","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074562","article-title":"Integrative bioinformatics links HNF1B with clear cell carcinoma and tumor-associated thrombosis","volume":"8","author":"Cuff","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib76","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.urology.2010.03.042","article-title":"Downregulation of HNF-1B in renal cell carcinoma is associated with tumor progression and poor prognosis","volume":"76","author":"Buchner","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib77","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/sj.bjc.6602984","article-title":"Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines","volume":"94","author":"Terasawa","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib78","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.3892\/ol.2013.1606","article-title":"DNA methylation as an epigenetic biomarker in colorectal cancer","volume":"6","author":"Silva","year":"2013","journal-title":"Oncol Lett"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib79","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1093\/carcin\/bgs151","article-title":"Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer","volume":"33","author":"Li","year":"2012","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib80","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1093\/carcin\/bgu193","article-title":"Transcriptome analysis of pancreatic cancer reveals a tumor suppressor function for HNF1A","volume":"35","author":"Hoskins","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib81","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41467-018-02942-5","article-title":"Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer","volume":"9","author":"Klein","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib82","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1186\/s12885-016-2540-6","article-title":"Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma","volume":"16","author":"Janky","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jcmgh.2019.06.005_bib83","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ccell.2019.03.002","article-title":"Complete regression of advanced pancreatic ductal adenocarcinomas upon combined inhibition of EGFR and C-RAF","volume":"35","author":"Blasco","year":"2019","journal-title":"Cancer Cell"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X19300840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X19300840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:24:03Z","timestamp":1762453443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X19300840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":83,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"alternative-id":["S2352345X19300840"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2019.06.005","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2019.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}