{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:31:20Z","timestamp":1793035880009,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T00:00:00Z","timestamp":1571529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/j.jcmgh.2019.10.008","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T02:01:12Z","timestamp":1571882472000},"page":"425-446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice"],"prefix":"10.1016","volume":"9","author":[{"given":"Tomohide","family":"Kurahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Egawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunimaro","family":"Furuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Hikita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6250-1324","authenticated-orcid":false,"given":"Takahiro","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-607X","authenticated-orcid":false,"given":"Ryotaro","family":"Sakamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Kiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-902X","authenticated-orcid":false,"given":"Yoshihiro","family":"Kamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4398-2975","authenticated-orcid":false,"given":"I-Ching","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Morii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Doki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir V.","family":"Kalinichenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohide","family":"Tatsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5036-3457","authenticated-orcid":false,"given":"Tetsuo","family":"Takehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2019.10.008_bib1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJMra1001683","article-title":"Hepatocellular carcinoma","volume":"365","author":"El-Serag","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib2","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1053\/j.gastro.2011.12.061","article-title":"Epidemiology of viral hepatitis and hepatocellular carcinoma","volume":"142","author":"El-Serag","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/cr.2010.183","article-title":"NF-kappaB and STAT3: key players in liver inflammation and cancer","volume":"21","author":"He","year":"2011","journal-title":"Cell Res"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nri.2017.142","article-title":"NF-kappaB, inflammation, immunity and cancer: coming of age","volume":"18","author":"Taniguchi","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib5","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.hep.2003.09.034","article-title":"Transcription factors in liver development, differentiation, and regeneration","volume":"38","author":"Costa","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/ncb0205-108","article-title":"FoxM1 dances with mitosis","volume":"7","author":"Costa","year":"2005","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib7","doi-asserted-by":"crossref","first-page":"396","DOI":"10.4161\/cc.10.3.14709","article-title":"Multiple faces of FoxM1 transcription factor: lessons from transgenic mouse models","volume":"10","author":"Kalin","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib8","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1593\/neo.04277","article-title":"Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data","volume":"6","author":"Pilarsky","year":"2004","journal-title":"Neoplasia"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib9","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1158\/0008-5472.CAN-05-3003","article-title":"The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer","volume":"66","author":"Kim","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib10","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1158\/0008-5472.CAN-05-3138","article-title":"Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice","volume":"66","author":"Kalin","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib11","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1053\/j.gastro.2007.01.036","article-title":"The forkhead box M1 transcription factor contributes to the development and growth of mouse colorectal cancer","volume":"132","author":"Yoshida","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib12","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1158\/0008-5472.CAN-10-4087","article-title":"FoxM1 in tumorigenicity of the neuroblastoma cells and renewal of the neural progenitors","volume":"71","author":"Wang","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib13","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1101\/gad.1200704","article-title":"Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor","volume":"18","author":"Kalinichenko","year":"2004","journal-title":"Genes Dev"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1172\/JCI27527","article-title":"A\u00a0cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment","volume":"117","author":"Gusarova","year":"2007","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib15","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1111\/hepr.12854","article-title":"Increased expression of Forkhead box M1 transcription factor is associated with clinicopathological features and confers a poor prognosis in human hepatocellular carcinoma","volume":"47","author":"Egawa","year":"2017","journal-title":"Hepatology Research"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib16","doi-asserted-by":"crossref","first-page":"21022","DOI":"10.18632\/oncotarget.24781","article-title":"Targeting the mevalonate pathway is a novel therapeutic approach to inhibit oncogenic FoxM1 transcription factor in human hepatocellular carcinoma","volume":"9","author":"Ogura","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib17","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jhep.2012.04.020","article-title":"Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma","volume":"57","author":"Xia","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib18","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1128\/MCB.17.3.1626","article-title":"Hepatocyte nuclear factor 3\/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues","volume":"17","author":"Ye","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib19","doi-asserted-by":"crossref","first-page":"16881","DOI":"10.1073\/pnas.252570299","article-title":"The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration","volume":"99","author":"Wang","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib20","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1053\/jhep.2001.24666","article-title":"Earlier expression of the transcription factor HFH-11B diminishes induction of p21(CIP1\/WAF1) levels and accelerates mouse hepatocyte entry into S-phase following carbon tetrachloride liver injury","volume":"33","author":"Wang","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib21","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1128\/MCB.00934-12","article-title":"FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation","volume":"33","author":"Ren","year":"2013","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib22","doi-asserted-by":"crossref","first-page":"16958","DOI":"10.1021\/ja505986a","article-title":"Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing","volume":"136","author":"Nair","year":"2014","journal-title":"J\u00a0Am Chem Soc"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0016-5085(03)00689-9","article-title":"Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma","volume":"125","author":"Capurro","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1309\/AJCPK1ZC9WNHCCMU","article-title":"Arginase-1, HepPar-1, and Glypican-3 are the most effective panel of markers in distinguishing hepatocellular carcinoma from metastatic tumor on fine-needle aspiration specimens","volume":"138","author":"Timek","year":"2012","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005592","article-title":"Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells","volume":"4","author":"Bhat","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib26","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nchem.1114","article-title":"The transcription factor FOXM1 is a cellular target of the natural product thiostrepton","volume":"3","author":"Hegde","year":"2011","journal-title":"Nature Chemistry"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib27","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/hep.21802","article-title":"Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis","volume":"46","author":"Elsharkawy","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib28","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","article-title":"NF-kappaB in the liver: linking injury, fibrosis and hepatocellular carcinoma","volume":"8","author":"Luedde","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib29","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1158\/0008-5472.CAN-11-0640","article-title":"FoxM1: a master regulator of tumor metastasis","volume":"71","author":"Raychaudhuri","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib30","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1172\/JCI87631","article-title":"FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis","volume":"128","author":"Penke","year":"2018","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib31","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1158\/1541-7786.MCR-13-0007","article-title":"FoxM1 is overexpressed in Helicobacter pylori-induced gastric carcinogenesis and is negatively regulated by miR-370","volume":"11","author":"Feng","year":"2013","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib32","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1053\/j.gastro.2014.06.043","article-title":"Roles for chemokines in liver disease","volume":"147","author":"Marra","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib33","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/gutjnl-2015-310514","article-title":"Targeting of tumour-infiltrating macrophages via CCL2\/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma","volume":"66","author":"Li","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib34","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1158\/1535-7163.MCT-16-0124","article-title":"Blocking the CCL2-CCR2 axis using CCL2-neutralizing antibody is an effective therapy for hepatocellular cancer in a mouse model","volume":"16","author":"Teng","year":"2017","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib35","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1128\/MCB.00876-10","article-title":"Forkhead box M1 transcription factor is required for macrophage recruitment during liver repair","volume":"30","author":"Ren","year":"2010","journal-title":"Mol Cell Biol"},{"issue":"475","key":"10.1016\/j.jcmgh.2019.10.008_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aai8583","article-title":"The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice","volume":"10","author":"Sun","year":"2017","journal-title":"Science Signaling"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib37","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ydbio.2010.08.027","article-title":"Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia","volume":"347","author":"Wang","year":"2010","journal-title":"Dev Biol"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib38","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/emboj.2012.336","article-title":"Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition","volume":"32","author":"Balli","year":"2013","journal-title":"EMBO J"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib39","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/hep.28410","article-title":"Gab1 adaptor protein acts as a gatekeeper to balance hepatocyte death and proliferation during acetaminophen-induced liver injury in mice","volume":"63","author":"Furuta","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib40","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1038\/onc.2011.194","article-title":"Overexpression of GalNAc-transferase GalNAc-T3 promotes pancreatic cancer cell growth","volume":"30","author":"Taniuchi","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib41","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ymthe.2017.08.019","article-title":"Evaluation of GalNAc-siRNA conjugate activity in pre-clinical animal models with reduced asialoglycoprotein receptor expression","volume":"26","author":"Willoughby","year":"2018","journal-title":"Mol Ther"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib42","doi-asserted-by":"crossref","first-page":"G1310","DOI":"10.1152\/ajpgi.00365.2011","article-title":"Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2","volume":"302","author":"Miura","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2019.10.008_bib43","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1053\/j.gastro.2017.02.018","article-title":"Induction of chromosome instability by activation of yes-associated protein and Forkhead Box M1 in liver Cancer","volume":"152","author":"Weiler","year":"2017","journal-title":"Gastroenterology"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X19301444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X19301444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:22:52Z","timestamp":1762453372000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X19301444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020]]}},"alternative-id":["S2352345X19301444"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2019.10.008","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2019.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}