{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:27:36Z","timestamp":1790501256850,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/j.jcmgh.2019.11.011","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T20:16:21Z","timestamp":1574972181000},"page":"557-567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Biotin Supplementation Ameliorates Murine Colitis by Preventing NF-\u03baB Activation"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3241-1010","authenticated-orcid":false,"given":"Jonathan","family":"Skupsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrata","family":"Sabui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-1107","authenticated-orcid":false,"given":"Michael","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manando","family":"Nakasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Cahalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid M.","family":"Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2019.11.011_bib1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000362294","article-title":"Water-soluble vitamins","volume":"111","author":"Said","year":"2015","journal-title":"World Rev Nutr Diet"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-94-007-2199-9_1","article-title":"Biotin: biochemical, physiological and clinical aspects","volume":"56","author":"Said","year":"2012","journal-title":"Subcell Biochem"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib3","doi-asserted-by":"crossref","first-page":"7726","DOI":"10.1038\/ncomms8726","article-title":"Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p","volume":"6","author":"Madsen","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib4","first-page":"1763","article-title":"Epigenetic regulation of chromatin structure and gene function by biotin","volume":"136","author":"Hassan","year":"2006","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib5","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.jnutbio.2003.07.001","article-title":"Regulation of gene expression by biotin (review)","volume":"14","author":"Rodriguez-Melendez","year":"2003","journal-title":"J\u00a0Nutr Biochem"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib6","doi-asserted-by":"crossref","first-page":"C386","DOI":"10.1152\/ajpcell.00141.2016","article-title":"Biotin deficiency enhances the inflammatory response of human dendritic cells","volume":"311","author":"Agrawal","year":"2016","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib7","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/ajcn\/67.3.431","article-title":"Biotin deficiency induces changes in subpopulations of spleen lymphocytes in mice","volume":"67","author":"Baez-Saldana","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib8","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.4049\/jimmunol.1701200","article-title":"Biotin deficiency induces Th1- and Th17-mediated proinflammatory responses in human CD4(+) T lymphocytes via activation of the mTOR signaling pathway","volume":"200","author":"Elahi","year":"2018","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib9","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1139\/cjpp-2014-0460","article-title":"Regulation of immunological and inflammatory functions by biotin","volume":"93","author":"Kuroishi","year":"2015","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib10","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1189\/jlb.0607428","article-title":"Biotin deficiency up-regulates TNF-alpha production in murine macrophages","volume":"83","author":"Kuroishi","year":"2008","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00439-016-1751-x","article-title":"Mutations in SLC5A6 associated with brain, immune, bone, and intestinal dysfunction in a young child","volume":"136","author":"Subramanian","year":"2017","journal-title":"Hum Genet"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4103\/0974-7753.188040","article-title":"Serum biotin levels in women complaining of hair loss","volume":"8","author":"Trueb","year":"2016","journal-title":"Int J Trichology"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib13","doi-asserted-by":"crossref","first-page":"G64","DOI":"10.1152\/ajpgi.00379.2012","article-title":"Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption","volume":"304","author":"Ghosal","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/flgastro-2016-100762","article-title":"Practical guidance on the use of faecal calprotectin","volume":"9","author":"Brookes","year":"2018","journal-title":"Frontline Gastroenterol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib15","doi-asserted-by":"crossref","first-page":"6016","DOI":"10.3748\/wjg.v23.i33.6016","article-title":"Dextran sodium sulfate colitis murine model: an indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis","volume":"23","author":"Eichele","year":"2017","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib16","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/0016-5085(90)90290-H","article-title":"A\u00a0novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice","volume":"98","author":"Okayasu","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/imr.12550","article-title":"The interplay of IKK, NF-kappaB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation","volume":"277","author":"Kondylis","year":"2017","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2016.12.012","article-title":"30 years of NF-kappaB: a blossoming of relevance to human pathobiology","volume":"168","author":"Zhang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib19","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-kappaB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2796.2008.01953.x","article-title":"NF-kappaB in inflammatory bowel disease","volume":"263","author":"Atreya","year":"2008","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib21","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1053\/j.gastro.2018.12.008","article-title":"AGA technical review on the management of mild-to-moderate ulcerative colitis","volume":"156","author":"Singh","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib22","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1053\/j.gastro.2013.10.046","article-title":"American Gastroenterological Association Institute technical review on the use of thiopurines, methotrexate, and anti-TNF-alpha biologic drugs for the induction and maintenance of remission in inflammatory Crohn's disease","volume":"145","author":"Dassopoulos","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib23","doi-asserted-by":"crossref","first-page":"384","DOI":"10.14309\/ajg.0000000000000152","article-title":"ACG clinical guideline: ulcerative colitis in adults","volume":"114","author":"Rubin","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrgastro.2016.208","article-title":"Current and emerging therapeutic targets for IBD","volume":"14","author":"Neurath","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib25","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.3748\/wjg.v24.i47.5322","article-title":"Novel oral-targeted therapies for mucosal healing in ulcerative colitis","volume":"24","author":"Antonelli","year":"2018","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib26","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.cgh.2018.07.013","article-title":"Balancing benefit vs risk of immunosuppressive therapy for individual patients with inflammatory bowel diseases","volume":"17","author":"Beaugerie","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib27","first-page":"744","article-title":"Vitamin status in patients with inflammatory bowel disease","volume":"84","author":"Fernandez-Banares","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib28","first-page":"428","article-title":"The effect of total enteral tube feeding on the vitamin status of malnourished patients with inflammatory bowel disease","volume":"58","author":"Abad-Lacruz","year":"1988","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib29","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/BF01537009","article-title":"Biotin effects in Crohn's disease","volume":"33","author":"Okabe","year":"1988","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib30","first-page":"697","article-title":"[Decreased plasma biotin levels in patients with Crohn's disease]","volume":"83","author":"Urabe","year":"1986","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib31","first-page":"67","article-title":"The association between index of nutritional quality and ulcerative colitis: a case-control study","volume":"23","author":"Vahid","year":"2018","journal-title":"J\u00a0Res Med Sci"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib33","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1136\/gut.2008.148395","article-title":"Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis","volume":"57","author":"Noble","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib34","doi-asserted-by":"crossref","first-page":"G561","DOI":"10.1152\/ajpgi.00240.2016","article-title":"Role of the sodium-dependent multivitamin transporter (SMVT) in the maintenance of intestinal mucosal integrity","volume":"311","author":"Sabui","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib35","doi-asserted-by":"crossref","first-page":"C73","DOI":"10.1152\/ajpcell.00319.2017","article-title":"Biotin and pantothenic acid oversupplementation to conditional SLC5A6 KO mice prevents the development of intestinal mucosal abnormalities and growth defects","volume":"315","author":"Sabui","year":"2018","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib36","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1038\/s41598-017-04041-9","article-title":"Uridine ameliorates dextran sulfate sodium (DSS)-induced colitis in mice","volume":"7","author":"Jeengar","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib37","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.med.51.1.289","article-title":"Role of cytokines in the pathogenesis of inflammatory bowel disease","volume":"51","author":"Papadakis","year":"2000","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrgastro.2015.186","article-title":"Immunopathogenesis of IBD: current state of the art","volume":"13","author":"de Souza","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib39","doi-asserted-by":"crossref","first-page":"G123","DOI":"10.1152\/ajpgi.00112.2015","article-title":"Salmonella infection inhibits intestinal biotin transport: cellular and molecular mechanisms","volume":"309","author":"Ghosal","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib40","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1136\/gutjnl-2019-318427","article-title":"Leaky gut: mechanisms, measurement and clinical implications in humans","volume":"68","author":"Camilleri","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib41","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/MOG.0b013e32816aa392","article-title":"Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications","volume":"23","author":"Mankertz","year":"2007","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib42","series-title":"Physiology of the gastrointestinal tract","first-page":"587","article-title":"Tight junctions and the intestinal barrier","author":"Ma","year":"2018"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib43","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2147\/JIR.S140188","article-title":"Mechanisms of NF-kappaB p65 and strategies for therapeutic manipulation","volume":"11","author":"Giridharan","year":"2018","journal-title":"J\u00a0Inflamm Res"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib44","doi-asserted-by":"crossref","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib45","first-page":"2121","article-title":"Biotin absorption by distal rat intestine","volume":"117","author":"Bowman","year":"1987","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib46","series-title":"Handbook of vitamins","first-page":"361","article-title":"Biotin","author":"Mock","year":"2007"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib47","doi-asserted-by":"crossref","first-page":"G941","DOI":"10.1152\/ajpgi.00278.2014","article-title":"Chronic alcohol exposure inhibits biotin uptake by pancreatic acinar cells: possible involvement of epigenetic mechanisms","volume":"307","author":"Srinivasan","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib48","doi-asserted-by":"crossref","first-page":"G365","DOI":"10.1152\/ajpgi.00157.2014","article-title":"Biotin uptake by mouse and human pancreatic beta cells\/islets: a regulated, lipopolysaccharide-sensitive carrier-mediated process","volume":"307","author":"Ghosal","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib49","doi-asserted-by":"crossref","first-page":"G494","DOI":"10.1152\/ajpgi.00465.2010","article-title":"Inhibition of intestinal biotin absorption by chronic alcohol feeding: cellular and molecular mechanisms","volume":"300","author":"Subramanya","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jcmgh.2017.02.010","article-title":"Uncovering pathogenic mechanisms of inflammatory bowel disease using mouse models of Crohn's disease-like ileitis: what is the right model?","volume":"4","author":"Cominelli","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib51","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jcmgh.2015.01.006","article-title":"Experimental models of inflammatory bowel diseases","volume":"1","author":"Kiesler","year":"2015","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib52","first-page":"G306","article-title":"Regulation of intestinal biotin transport in the rat: effect of biotin deficiency and supplementation","volume":"256","author":"Said","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.intimp.2012.10.022","article-title":"Establishment and validation of a new semi-chronic dextran sulfate sodium-induced model of colitis in mice","volume":"15","author":"Sha","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib54","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s000110050177","article-title":"The efficacy of BAY y 1015 in dextran sulfate model of mouse colitis","volume":"46","author":"Murthy","year":"1997","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib55","first-page":"e1289","article-title":"Analysis of intestinal permeability in mice","volume":"4","author":"Gupta","year":"2014","journal-title":"Bioprotocol"},{"key":"10.1016\/j.jcmgh.2019.11.011_bib56","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2829","article-title":"Purification of total RNA from DSS-treated murine tissue via lithium chloride precipitation","volume":"8","author":"Viennois","year":"2018","journal-title":"Bio Protoc"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X19301663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X19301663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:25:52Z","timestamp":1762453552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X19301663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020]]}},"alternative-id":["S2352345X19301663"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2019.11.011","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biotin Supplementation Ameliorates Murine Colitis by Preventing NF-\u03baB Activation","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2019.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}