{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:04:38Z","timestamp":1792065878268,"version":"4.4.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T00:00:00Z","timestamp":1585958400000},"content-version":"vor","delay-in-days":94,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008672","name":"Wilhelm Sander-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/j.jcmgh.2020.04.002","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T02:21:02Z","timestamp":1586917262000},"page":"391-418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"title":["Characterization of a p53\/miR-34a\/CSF1R\/STAT3 Feedback Loop in Colorectal Cancer"],"prefix":"10.1016","volume":"10","author":[{"given":"Xiaolong","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Kaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matjaz","family":"Rokavec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kirchner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Horst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Hermeking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2020.04.002_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41571-018-0134-8","article-title":"A\u00a0framework for the development of effective anti-metastatic agents","volume":"16","author":"Anderson","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"issue":"Suppl 4","key":"10.1016\/j.jcmgh.2020.04.002_bib2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/annonc\/mdp130","article-title":"Advanced colorectal cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up","volume":"20","author":"Van Cutsem","year":"2009","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrclinonc.2016.171","article-title":"From tumour heterogeneity to advances in precision treatment of colorectal cancer","volume":"14","author":"Punt","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nrc.2017.118","article-title":"EMT in cancer","volume":"18","author":"Brabletz","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0042-6822(83)90476-2","article-title":"Isolation of v-fms and its human cellular homolog","volume":"126","author":"Heisterkamp N Fau - Groffen","year":"1983","journal-title":"Virology"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib7","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1128\/jvi.48.3.770-773.1983","article-title":"Molecular cloning of the c-fms locus and its assignment to human chromosome 5","volume":"48","author":"Roussel","year":"1983","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev.bi.57.070188.002303","article-title":"Growth factor receptor tyrosine kinases","volume":"57","author":"Yarden","year":"1988","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/320277a0","article-title":"Structural\u00a0alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus","volume":"320","author":"Coussens","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/325549a0","article-title":"Transforming potential of the c-fms proto-oncogene (CSF-1 receptor)","volume":"325","author":"Roussel","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0092-8674(90)90801-K","article-title":"Signal transduction by receptors with tyrosine kinase activity","volume":"61","author":"Ullrich","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib12","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/ni.2360","article-title":"IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia","volume":"13","author":"Wang","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib13","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cell.2010.06.011","article-title":"Cell signaling by receptor tyrosine kinases","volume":"141","author":"Lemmon","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib14","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1182\/blood.V86.8.2948.2948","article-title":"Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts","volume":"86","author":"Novak","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40425-017-0257-y","article-title":"Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy","volume":"5","author":"Cannarile","year":"2017","journal-title":"J\u00a0Immunother Cancer"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib16","first-page":"865","article-title":"Macrophage-colony stimulating factor (CSF1) predicts breast cancer progression and mortality","volume":"35","author":"Richardsen","year":"2015","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib17","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1515\/CCLM.2003.098","article-title":"Hematopoietic growth factors in colorectal cancer patients","volume":"41","author":"Mroczko","year":"2003","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35042675","article-title":"Surfing the p53 network","volume":"408","author":"Vogelstein","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrc3318","article-title":"MicroRNAs in the p53 network: micromanagement of tumour suppression","volume":"12","author":"Hermeking","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib20","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.4161\/cc.10.24.18552","article-title":"miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions","volume":"10","author":"Siemens","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib21","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1038\/emboj.2013.236","article-title":"SNAIL and miR-34a feed-forward regulation of ZNF281\/ZBP99 promotes epithelial-mesenchymal transition","volume":"32","author":"Hahn","year":"2013","journal-title":"EMBO J"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib22","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1172\/JCI73531","article-title":"IL-6R\/STAT3\/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis","volume":"124","author":"Rokavec","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib23","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1053\/j.gastro.2017.04.017","article-title":"Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells","volume":"153","author":"Li","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib24","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1053\/j.gastro.2018.08.011","article-title":"Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1","volume":"155","author":"Oner","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib25","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.4161\/cc.7.16.6533","article-title":"Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer","volume":"7","author":"Lodygin","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00428-010-1030-5","article-title":"Frequent concomitant inactivation of miR-34a and miR-34b\/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas","volume":"458","author":"Vogt","year":"2011","journal-title":"Virchows Archiv"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib27","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1158\/1078-0432.CCR-12-1703","article-title":"Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and beta-catenin predicts distant metastasis of colon cancer","volume":"19","author":"Siemens","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib28","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001453","article-title":"Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value","volume":"10","author":"Marisa","year":"2013","journal-title":"PLoS Med"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib30","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/omi.2012.0039","article-title":"A\u00a0seven-gene signature aggregates a subgroup of stage II colon cancers with stage III","volume":"16","author":"Laibe","year":"2012","journal-title":"Omics"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib31","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nm.3967","article-title":"The consensus molecular subtypes of colorectal cancer","volume":"21","author":"Guinney","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib32","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/ng.3224","article-title":"Stromal contribution to the colorectal cancer transcriptome","volume":"47","author":"Isella","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib33","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ng.3225","article-title":"Stromal gene expression defines poor-prognosis subtypes in colorectal cancer","volume":"47","author":"Calon","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib34","doi-asserted-by":"crossref","first-page":"15107","DOI":"10.1038\/ncomms15107","article-title":"Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer","volume":"8","author":"Isella","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib35","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/ng.3818","article-title":"Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors","volume":"49","author":"Li","year":"2017","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib36","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3892\/ijo.2014.2469","article-title":"Differential expression of miRNAs in colon cancer between African and Caucasian Americans: implications for cancer racial health disparities","volume":"45","author":"Li","year":"2014","journal-title":"Int J Oncol"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib37","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/0092-8674(88)90243-7","article-title":"A\u00a0point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential","volume":"55","author":"Roussel","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib38","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1038\/s41467-019-09970-9","article-title":"Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages","volume":"10","author":"Bencheikh","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib39","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1074\/jbc.M112.442731","article-title":"Receptor-type protein-tyrosine phosphatase zeta is a functional receptor for interleukin-34","volume":"288","author":"Nandi","year":"2013","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib40","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1038\/s41467-019-09438-w","article-title":"MEK1\/2 inhibitor withdrawal reverses acquired resistance driven by BRAF(V600E) amplification whereas KRAS(G13D) amplification promotes EMT-chemoresistance","volume":"10","author":"Sale","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib41","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","article-title":"The epithelial-mesenchymal transition generates cells with properties of stem cells","volume":"133","author":"Mani","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib42","doi-asserted-by":"crossref","first-page":"e1167","DOI":"10.1038\/cddis.2014.136","article-title":"Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation","volume":"5","author":"Cioce","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib43","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1038\/onc.2014.226","article-title":"Autocrine CSF1R signaling mediates switching between invasion and proliferation downstream of TGFbeta in claudin-low breast tumor cells","volume":"34","author":"Patsialou","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib44","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1158\/0008-5472.CAN-11-1232","article-title":"Autocrine CSF-1 and CSF-1 receptor coexpression promotes renal cell carcinoma growth","volume":"72","author":"Menke","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib45","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.18632\/oncotarget.23289","article-title":"Interleukin-34 sustains pro-tumorigenic signals in colon cancer tissue","volume":"9","author":"Franze","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib46","doi-asserted-by":"crossref","first-page":"32421","DOI":"10.18632\/oncotarget.8718","article-title":"miR-1207-5p suppresses lung cancer growth and metastasis by targeting CSF1","volume":"7","author":"Dang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib47","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/CS20150176","article-title":"Interleukin 34: a new modulator of human and experimental inflammatory bowel disease","volume":"129","author":"Zwicker","year":"2015","journal-title":"Clin Sci"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib48","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.12659\/MSM.900893","article-title":"Changes in the Expression of miR-34a and its Target Genes Following Spinal Cord Injury In Rats","volume":"22","author":"Chen","year":"2016","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib49","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1096\/fj.12-214692","article-title":"miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1","volume":"27","author":"Cimino","year":"2013","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib50","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.celrep.2019.12.028","article-title":"Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses","volume":"30","author":"Blagih","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib51","doi-asserted-by":"crossref","first-page":"8265","DOI":"10.1038\/s41598-017-08047-1","article-title":"An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer","volume":"7","author":"Chen","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib52","doi-asserted-by":"crossref","first-page":"e242","DOI":"10.1038\/oncsis.2016.51","article-title":"Multi-omics landscapes of colorectal cancer subtypes discriminated by an individualized prognostic signature for 5-fluorouracil-based chemotherapy","volume":"5","author":"Tong","year":"2016","journal-title":"Oncogenesis"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib53","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.3390\/cancers6031769","article-title":"Drug resistance in cancer: an overview","volume":"6","author":"Housman","year":"2014","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib54","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.18632\/oncotarget.1202","article-title":"Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness","volume":"4","author":"Siemens","year":"2013","journal-title":"Oncotarget"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib55","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.010462","article-title":"Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis","volume":"10","author":"Kaller","year":"2011","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033844","article-title":"miR-34a repression in proneural malignant gliomas upregulates expression of its target PDGFRA and promotes tumorigenesis","volume":"7","author":"Silber","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067581","article-title":"MiR-34a\/c-Dependent PDGFR-alpha\/beta Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer","volume":"8","author":"Garofalo","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib58","doi-asserted-by":"crossref","first-page":"245","DOI":"10.14499\/indonesianjpharm25iss4pp245","article-title":"Optimization of Sodium Dodecyl Sulphate as a Formazan Solvent and Comparison of 3-(4,-5-Dimethylthiazo-2-Yl)-2,5-Diphenyltetrazolium Bromide (Mtt) Assay with Wst-1 Assay in Mcf-7 Cells","volume":"25","author":"Septisetyani","year":"2014","journal-title":"Indonesian J Pharm"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib59","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib60","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4161\/cc.6.3.3808","article-title":"c-MYC delays prometaphase by direct transactivation of MAD2 and BubR1: identification of mechanisms underlying c-MYC-induced DNA damage and chromosomal instability","volume":"6","author":"Menssen","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib61","first-page":"M135","article-title":"Function of the c-Myc oncoprotein in chromatin remodeling and transcription","volume":"1471","author":"Amati","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib62","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1038\/sj.onc.1210293","article-title":"MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells","volume":"26","author":"Welch","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib63","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1158\/1078-0432.CCR-17-1234","article-title":"Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies","volume":"24","author":"Sveen","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib64","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib65","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib66","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1158\/0008-5472.CAN-13-2203","article-title":"p53-induced miR-15a\/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer","volume":"74","author":"Shi","year":"2014","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2020.04.002_bib67","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1084\/jem.20120812","article-title":"AP4 is a mediator of epithelial-mesenchymal transition and metastasis in\u00a0colorectal cancer","volume":"210","author":"Jackstadt","year":"2013","journal-title":"J Experimental Medicine"}],"updated-by":[{"DOI":"10.1016\/j.jcmgh.2025.101670","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000}},{"DOI":"10.1016\/j.jcmgh.2025.101670","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000}}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X20300461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X20300461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T19:58:49Z","timestamp":1768939129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X20300461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"alternative-id":["S2352345X20300461"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2020.04.002","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of a p53\/miR-34a\/CSF1R\/STAT3 Feedback Loop in Colorectal Cancer","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2020.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}