{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:34:57Z","timestamp":1790130897956,"version":"4.0.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005081","name":"Beijing Council of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013104","name":"Shanghai Health and Medical Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.jcmgh.2020.09.001","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T04:54:00Z","timestamp":1599627240000},"page":"831-839","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["NTCP Deficiency Causes Gallbladder Abnormalities in Mice and Human Beings"],"prefix":"10.1016","volume":"11","author":[{"given":"Fengfeng","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Juan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Yuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Bao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Qi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-She","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2020.09.001_bib1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1152\/physrev.00027.2002","article-title":"Bile salt transporters: molecular characterization, function, and regulation","volume":"83","author":"Trauner","year":"2003","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib2","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00049","article-title":"Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus","volume":"1","author":"Yan","year":"2012","journal-title":"eLife"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/hep.27694","article-title":"Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice","volume":"62","author":"Slijepcevic","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib4","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.3892\/etm.2016.3752","article-title":"Clinical and molecular study of a pediatric patient with sodium taurocholate cotransporting polypeptide deficiency","volume":"12","author":"Deng","year":"2016","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib5","doi-asserted-by":"crossref","first-page":"11853","DOI":"10.1074\/jbc.RA118.007179","article-title":"Increased sulfation of bile acids in mice and human subjects with sodium taurocholate cotransporting polypeptide deficiency","volume":"294","author":"Mao","year":"2019","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib6","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/hep.27240","article-title":"Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype","volume":"61","author":"Vaz","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib7","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nm1501","article-title":"Identification of a hormonal basis for gallbladder filling","volume":"12","author":"Choi","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/hep.24702","article-title":"The human gallbladder secretes fibroblast growth factor 19 into bile: Towards defining the role of fibroblast growth factor 19 in the enterobiliary tract","volume":"55","author":"Zweers","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib9","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000017305","article-title":"Clinical and histopathologic features of sodium taurocholate cotransporting polypeptide deficiency in pediatric patients","volume":"98","author":"Dong","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib10","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.jcmgh.2020.05.011","article-title":"A new treatment for chronic hepatitis B and D offers novel insights into obesity and hepatic steatosis","volume":"10","author":"Schierwagen","year":"2020","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib11","first-page":"e138","article-title":"Abnormal bilirubin metabolism in patients with sodium taurocholate cotransporting polypeptide deficiency","volume":"71","author":"Yant","year":"2020","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib12","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0022-2275(20)40677-7","article-title":"Critical tables for calculating the cholesterol saturation of native bile","volume":"19","author":"Carey","year":"1978","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib13","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1021\/ac503816u","article-title":"Metabolic profiling of bile acids in human and mouse blood by LC\u2013MS\/MS in combination with phospholipid-depletion solid-phase extraction","volume":"87","author":"Han","year":"2014","journal-title":"analytical chemistry"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib14","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/hep.29020","article-title":"Defects in myosin VB are associated with a spectrum of previously undiagnosed low \u03b3-glutamyltransferase cholestasis","volume":"65","author":"Qiu","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib15","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/pr500920q","article-title":"Profiling of serum bile acids in a healthy chinese population using UPLC\u2013MS\/MS","volume":"14","author":"Xie","year":"2015","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1172\/JCI117658","article-title":"Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse","volume":"95","author":"Oude Elferink","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib17","doi-asserted-by":"crossref","first-page":"10713","DOI":"10.1038\/ncomms10713","article-title":"Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis","volume":"7","author":"Gomez-Ospina","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2020.09.001_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004840","article-title":"Hepatitis D virus infection of mice expressing human sodium taurocholate co-transporting polypeptide","volume":"11","author":"He","year":"2015","journal-title":"PLOS Pathogens"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X20301387?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X20301387?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:26:47Z","timestamp":1762453607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X20301387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"alternative-id":["S2352345X20301387"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2020.09.001","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NTCP Deficiency Causes Gallbladder Abnormalities in Mice and Human Beings","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2020.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}