{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:39:10Z","timestamp":1792089550128,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.jcmgh.2021.02.010","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T12:18:35Z","timestamp":1614687515000},"page":"465-487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Paraspeckle Promotes Hepatocellular Carcinoma Immune Escape by Sequestering IFNGR1 mRNA"],"prefix":"10.1016","volume":"12","author":[{"given":"Jie","family":"Zan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuya","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiya","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongda","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2021.02.010_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4240\/wjgs.v12.i3.85","article-title":"Evolution and current status of the subclassification of intermediate hepatocellular carcinoma","volume":"12","author":"Yi","year":"2020","journal-title":"World J Gastrointest Surg"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12030641","article-title":"Inflammatory mechanisms of HCC development","volume":"12","author":"Refolo","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12040791","article-title":"Embolotherapeutic strategies for hepatocellular carcinoma: 2020 update","volume":"12","author":"Kishore","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.21037\/jgo.2017.03.13","article-title":"Locoregional and systemic therapy for hepatocellular carcinoma","volume":"8","author":"Gbolahan","year":"2017","journal-title":"J\u00a0Gastrointest Oncol"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12030720","article-title":"Liver transplantation for pediatric liver cancer","volume":"12","author":"Sindhi","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib6","article-title":"Checkpoint inhibitor blockade and epigenetic reprogrammability in CD8(+) T-cell activation and exhaustion","volume":"8","author":"Belizario","year":"2020","journal-title":"Ther Adv Vaccines Immunother"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12040775","article-title":"Recent advances in immunotherapy for hepatocellular carcinoma","volume":"12","author":"Nakano","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib8","first-page":"187","article-title":"A\u00a0review of immune checkpoint blockade therapy in endometrial cancer","volume":"40","author":"Green","year":"2020","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/978-981-10-6020-5_18","article-title":"Immune checkpoint blockade in breast cancer therapy","volume":"1026","author":"Bu","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib10","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1038\/s41401-018-0062-2","article-title":"Cancer immune checkpoint blockade therapy and its associated autoimmune cardiotoxicity","volume":"39","author":"Zhang","year":"2018","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib11","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.it.2020.01.001","article-title":"Dynamic post-transcriptional events governing CD8(+) T cell homeostasis and effector function","volume":"41","author":"Salerno","year":"2020","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib12","article-title":"Promising cytomegalovirus-based vaccine vector induces robust CD8(+) T-cell response","volume":"20","author":"Liu","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib13","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1016\/S0140-6736(17)31046-2","article-title":"Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1\/2 dose escalation and expansion trial","volume":"389","author":"El-Khoueiry","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib14","doi-asserted-by":"crossref","first-page":"10335","DOI":"10.2147\/OTT.S214870","article-title":"Evaluating the safety and efficacy of nivolumab in patients with advanced hepatocellular carcinoma: evidence to date","volume":"12","author":"Tella","year":"2019","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib15","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ncrna.2019.11.002","article-title":"Nuclear paraspeckles function in mediating gene regulatory and apoptotic pathways","volume":"4","author":"Pisani","year":"2019","journal-title":"Noncoding RNA Res"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib16","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.molcel.2018.05.019","article-title":"Functional domains of NEAT1 architectural lncRNA induce paraspeckle assembly through phase separation","volume":"70","author":"Yamazaki","year":"2018","journal-title":"Mol Cell"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1083\/jcb.201504117","article-title":"Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles","volume":"210","author":"Hennig","year":"2015","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib18","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.2147\/OTT.S236350","article-title":"Long noncoding RNA NEAT1 upregulates survivin and facilitates gallbladder cancer progression by sponging microRNA-335","volume":"13","author":"Yang","year":"2020","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib19","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/s41598-020-57759-4","article-title":"The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers","volume":"10","author":"Knutsen","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib20","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1002\/cam4.2746","article-title":"LncRNA NEAT1 knockdown attenuates autophagy to elevate 5-FU sensitivity in colorectal cancer via targeting miR-34a","volume":"9","author":"Liu","year":"2020","journal-title":"Cancer Med"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib21","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2018.1503913","article-title":"NEAT1 paraspeckle promotes human hepatocellular carcinoma progression by strengthening IL-6\/STAT3 signaling","volume":"7","author":"Wang","year":"2018","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib22","doi-asserted-by":"crossref","first-page":"787","DOI":"10.33594\/000000055","article-title":"Hepatocellular carcinoma and nuclear paraspeckles: induction in chemoresistance and prediction\u00a0for poor survival","volume":"52","author":"Kessler","year":"2019","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib23","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3389\/fgene.2020.00250","article-title":"LncRNA NEAT1 interacted with DNMT1 to regulate malignant phenotype of cancer cell and cytotoxic T cell infiltration via epigenetic inhibition of p53, cGAS, and STING in lung cancer","volume":"11","author":"Ma","year":"2020","journal-title":"Front Genet"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2016.08.069","article-title":"Loss of IFN-gamma pathway genes in tumor cells as a mechanism of resistance to anti-CTLA-4 therapy","volume":"167","author":"Gao","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib25","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1038\/bjc.2015.101","article-title":"IFN-gamma from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer","volume":"112","author":"Abiko","year":"2015","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib26","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4049\/jimmunol.177.1.315","article-title":"IFN-gamma and its receptor subunit IFNGR1 are recruited to the IFN-gamma-activated sequence element at the promoter site of IFN-gamma-activated genes: evidence of transactivational activity in IFNGR1","volume":"177","author":"Ahmed","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib27","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1083\/jcb.201601071","article-title":"Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization","volume":"214","author":"West","year":"2016","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib28","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1021\/acs.biochem.5b01240","article-title":"Structure, dynamics, and interaction of p54(nrb)\/NonO RRM1 with 5\u2032 splice site RNA sequence","volume":"55","author":"Duvignaud","year":"2016","journal-title":"Biochemistry"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib29","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.4110\/in.2020.20.e11","article-title":"Current status and future direction of immunotherapy in hepatocellular carcinoma: what do the data suggest?","volume":"20","author":"Lee","year":"2020","journal-title":"Immune Netw"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib30","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s12072-019-09967-y","article-title":"Clinical immunology and immunotherapy for hepatocellular carcinoma: current progress and challenges","volume":"13","author":"Wang","year":"2019","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib31","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/17512433.2019.1598859","article-title":"Novel immunotherapeutic approaches for hepatocellular carcinoma treatment","volume":"12","author":"Busato","year":"2019","journal-title":"Expert Rev Clin Pharmacol"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib32","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3389\/fgene.2018.00471","article-title":"Long non-coding RNA NEAT1: a novel target for diagnosis and therapy in human tumors","volume":"9","author":"Dong","year":"2018","journal-title":"Front Genet"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib33","first-page":"6914","article-title":"Long noncoding RNA NEAT1 promotes the growth of gastric cancer cells by regulating miR-497-5p\/PIK3R1 axis","volume":"23","author":"Xia","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib34","first-page":"1125","article-title":"Long noncoding RNA nuclear paraspeckle assembly transcript 1 interacts with microRNA107 to modulate breast cancer growth and metastasis by targeting carnitine palmitoyltransferase1","volume":"55","author":"Xiong","year":"2019","journal-title":"Int J Oncol"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib35","doi-asserted-by":"crossref","first-page":"9887","DOI":"10.2147\/OTT.S228917","article-title":"LncRNA NEAT1 promotes proliferation, migration and invasion via regulating miR-296-5p\/CNN2 axis in hepatocellular carcinoma cells","volume":"12","author":"Li","year":"2019","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib36","article-title":"NEDD4 E3 ligase: functions and mechanism in human cancer","author":"Wang","year":"2020","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib37","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1074\/jbc.M112.416339","article-title":"Ubiquitin-dependent regulation of phospho-AKT dynamics by the\u00a0ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response","volume":"288","author":"Fan","year":"2013","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib38","doi-asserted-by":"crossref","first-page":"174","DOI":"10.24920\/21804","article-title":"Landscape of PD-1\/PD-L1 regulation and targeted immunotherapy","volume":"33","author":"Ni","year":"2018","journal-title":"Chin Med Sci J"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib39","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1038\/emboj.2008.94","article-title":"Alu element-mediated gene silencing","volume":"27","author":"Chen","year":"2008","journal-title":"EMBO J"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib40","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1139\/o11-030","article-title":"The mitotic phosphorylation of p54(nrb) modulates its RNA binding activity","volume":"89","author":"Bruelle","year":"2011","journal-title":"Biochem Cell Biol"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib41","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2014.01.009","article-title":"Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli","volume":"53","author":"Imamura","year":"2014","journal-title":"Mol Cell"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib42","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1186\/s12885-019-6145-8","article-title":"IFN-gamma down-regulates the PD-1 expression and assist nivolumab in PD-1-blockade effect on CD8+ T-lymphocytes in pancreatic cancer","volume":"19","author":"Ding","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jcmgh.2021.02.010_bib43","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1159\/000485116","article-title":"Yin Yang 1 dynamically regulates antiviral innate immune responses during viral infection","volume":"44","author":"Zan","year":"2017","journal-title":"Cell Physiol Biochem"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X21000436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X21000436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:28:06Z","timestamp":1762453686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X21000436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"alternative-id":["S2352345X21000436"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2021.02.010","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paraspeckle Promotes Hepatocellular Carcinoma Immune Escape by Sequestering IFNGR1 mRNA","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2021.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}