{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:04:35Z","timestamp":1790744675942,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA159942"],"award-info":[{"award-number":["R01CA159942"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK102597"],"award-info":[{"award-number":["R01DK102597"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007172","name":"Cincinnati Children's Hospital Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007909","name":"Fibrolamellar Cancer Foundation","doi-asserted-by":"publisher","award":["FCF-0015"],"award-info":[{"award-number":["FCF-0015"]}],"id":[{"id":"10.13039\/100007909","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007909","name":"Fibrolamellar Cancer Foundation","doi-asserted-by":"publisher","award":["P30 DK078392"],"award-info":[{"award-number":["P30 DK078392"]}],"id":[{"id":"10.13039\/100007909","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.jcmgh.2021.06.026","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T06:59:14Z","timestamp":1625727554000},"page":"1669-1682","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["HDAC1-Dependent Repression of Markers of Hepatocytes and P21 Is Involved in Development of Pediatric Liver Cancer"],"prefix":"10.1016","volume":"12","author":[{"given":"Maria","family":"Rivas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Michael E.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruhi","family":"Gulati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenasri","family":"Kumbaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talita Ferreira","family":"Margues Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubov","family":"Timchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Krepischi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soona","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bondoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Tiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Geller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai","family":"Timchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2021.06.026_bib1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-med-090514-013832","article-title":"Liver cancer: connections with obesity, fatty liver, and cirrhosis","volume":"67","author":"Marengo","year":"2016","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1053\/j.gastro.2016.11.048","article-title":"Liver cancer cell of origin, molecular class, and effects on patient prognosis","volume":"152","author":"Sia","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib3","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/hep.28602","article-title":"Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice","volume":"64","author":"Shin","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib4","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/carcin\/bgx050","article-title":"FXR-gankyrin axis is involved in development of pediatric liver cancer","volume":"38","author":"Valanejad","year":"2017","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s42003-018-0077-8","article-title":"PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma","volume":"1","author":"Valanejad","year":"2018","journal-title":"Commun Biol"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib6","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1002\/hep.29677","article-title":"C\/EBP\u03b1-dependent pre-neoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive pediatric liver cancer","volume":"67","author":"Cast","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/1093526619875228","article-title":"Hepatoblastoma and pediatric hepatocellular carcinoma: an update","volume":"23","author":"Ranganathan","year":"2020","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib8","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jcmgh.2021.03.001","article-title":"Help for sick kids \u2013 new insights into hepatoblastoma","volume":"12","author":"Timchenko","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib9","first-page":"1","article-title":"Molecular signatures of aggressive pediatric liver cancer","volume":"2","author":"Johnston","year":"2021","journal-title":"Arch Stem Cell Ther"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-3-642-21631-2_2","article-title":"The biology of HDAC in cancer: the nuclear and epigenetic components","volume":"206","author":"Hagelkruys","year":"2011","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib11","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1080\/15384047.2016.1235664","article-title":"Connectivity map identifies HDAC inhibition as a treatment option of high-risk hepatoblastoma","volume":"17","author":"Beck","year":"2016","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.17140\/CSMMOJ-1-104","article-title":"Elimination of tumor suppressor proteins during liver carcinogenesis","volume":"1","author":"Timchenko","year":"2015","journal-title":"Cancer Studies Mol Med"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib13","first-page":"1449","article-title":"Upregulation of C\/EBP\u03b1 contributes to colorectal cancer growth, metastasis and indicates poor survival outcome","volume":"8","author":"Mi","year":"2018","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib14","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1101\/gad.1183304","article-title":"Liver tumors escape negative control of proliferation via PI3K\/Akt-mediated block of C\/EBP\u03b1 growth inhibitory activity","volume":"18","author":"Wang","year":"2004","journal-title":"Gen Dev"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib15","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1128\/MCB.25.4.1325-1338.2005","article-title":"Dephosphorylated C\/EBP\u03b1 accelerates cell proliferation through sequestering retinoblastoma protein","volume":"25","author":"Wang","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/hep.27295","article-title":"Cooperation of C\/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration in mice","volume":"61","author":"Jin","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12688","article-title":"Ghrelin deletion protects against age-associated hepatic steatosis by downregulating the C\/EBP\u03b1-p300\/DGAT1 pathway","volume":"17","author":"Guillory","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib18","doi-asserted-by":"crossref","first-page":"29116","DOI":"10.1074\/jbc.M104130200","article-title":"Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21 (WAF1\/Cip1) gene by the p53 tumor suppressor protein","volume":"276","author":"Koutsodontis","year":"2001","journal-title":"Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib19","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.1021\/bi026141q","article-title":"The role\u00a0of Sp1 family members, the proximal GC-rich motifs,\u00a0and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1\/Cip1 gene promoter","volume":"41","author":"Koutsodontis","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib20","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1158\/0008-5472.CAN-07-5807","article-title":"Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1\/2","volume":"68","author":"Lin","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib21","doi-asserted-by":"crossref","first-page":"5504","DOI":"10.1128\/MCB.19.8.5504","article-title":"Histone deacetylase 1 can repress transcription by binding to Sp1","volume":"19","author":"Doetzlhofer","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib22","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1074\/jbc.M408063200","article-title":"ICI182 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line","volume":"280","author":"Varshochi","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib23","doi-asserted-by":"crossref","first-page":"97871","DOI":"10.18632\/oncotarget.14208","article-title":"DNA methylation landscape of hepatoblastomas reveals arrest at early stages of liver differentiation and cancer-related alterations","volume":"8","author":"Maschietto","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s41065-020-00149-7","article-title":"PP2A and tumor radiotherapy","volume":"157","author":"Lei","year":"2020","journal-title":"Hereditas"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/bs.acr.2019.03.009","article-title":"PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer","volume":"144","author":"Fowle","year":"2019","journal-title":"Adv Cancer Res"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib26","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.canlet.2017.11.024","article-title":"PPP2R5A: a multirole protein phosphatase subunit in regulating cancer development","volume":"414","author":"Mao","year":"2018","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.canlet.2017.11.035","article-title":"LB-100, a novel protein phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation","volume":"415","author":"Ho","year":"2018","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/hep.31919","article-title":"Olaparib inhibits tumor growth of hepatoblastoma in patient derived xenograft models","author":"Johnston","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib29","first-page":"2183","article-title":"Unique responses of hepatocellular carcinoma and cholangiocarcinoma cell lines toward cantharidin and norcantharidin","volume":"9","author":"Ma","year":"2018","journal-title":"J\u00a0Cancer"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib30","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/j.1349-7006.2010.01523.x","article-title":"2010. Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2\/M cell-cycle arrest and apoptosis","volume":"101","author":"Li","year":"2010","journal-title":"Cancer Sci"},{"key":"10.1016\/j.jcmgh.2021.06.026_bib31","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1158\/1078-0432.CCR-16-2299","article-title":"Safety, tolerability, and preliminary activity of LB-100, an inhibitor of protein phosphatase 2A, in patients with relapsed solid tumors: an open-label, dose escalation, first-in-human, phase I trial","volume":"23","author":"Chung","year":"2017","journal-title":"Clin Cancer Res"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X21001417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X21001417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:29:07Z","timestamp":1762453747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X21001417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021]]}},"alternative-id":["S2352345X21001417"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2021.06.026","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HDAC1-Dependent Repression of Markers of Hepatocytes and P21 Is Involved in Development of Pediatric Liver Cancer","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2021.06.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}