{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:32:56Z","timestamp":1793410376767,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014437","name":"Wenner-Gren Stiftelserna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005760","name":"University of Gothenburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008546","name":"Diabetesf\u00f6rbundet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008546","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014552","name":"Adlerbertska Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014552","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.jcmgh.2021.09.018","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T18:58:05Z","timestamp":1633633085000},"page":"405-423","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways"],"prefix":"10.1016","volume":"13","author":[{"given":"Yeshwant","family":"Kurhe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Caputo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmelie","family":"Cansby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit Kumar","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W.","family":"Howell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns-Ulrich","family":"Marschall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Mahlapuu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2021.09.018_bib1","doi-asserted-by":"crossref","first-page":"16018","DOI":"10.1038\/nrdp.2016.18","article-title":"Hepatocellular carcinoma","volume":"2","author":"Llovet","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jhep.2013.10.003","article-title":"Focus. We\u2019ve hit the iceberg \u2013 the threat of NASH-related HCC arrives","volume":"60","author":"Friedman","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhep.2013.08.011","article-title":"Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team","volume":"60","author":"Dyson","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib4","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrgastro.2013.41","article-title":"Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis","volume":"10","author":"Anstee","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib5","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1185\/03007995.2010.506375","article-title":"Population-based risk factors and resource utilization for HCC: US perspective","volume":"26","author":"Sanyal","year":"2010","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib6","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41575-018-0009-6","article-title":"Triggering and resolution of inflammation in NASH","volume":"15","author":"Schuster","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib8","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41575-019-0145-7","article-title":"From NASH to HCC: current concepts and future challenges","volume":"16","author":"Anstee","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib9","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1053\/j.gastro.2014.11.039","article-title":"Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States","volume":"148","author":"Wong","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib10","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.cgh.2014.08.013","article-title":"Temporal trends of nonalcoholic fatty liver disease-related hepatocellular carcinoma in the veteran affairs population","volume":"13","author":"Mittal","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib11","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.2337\/db15-0060","article-title":"Genetic disruption of protein kinase STK25 ameliorates metabolic defects in a diet-induced type 2 diabetes model","volume":"64","author":"Amrutkar","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib12","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1096\/fj.14-264937","article-title":"Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH","volume":"29","author":"Amrutkar","year":"2015","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib13","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1096\/fj.201600562R","article-title":"STK25 is a critical determinant in nonalcoholic steatohepatitis","volume":"30","author":"Amrutkar","year":"2016","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00125-015-3801-7","article-title":"Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans","volume":"59","author":"Amrutkar","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib15","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.jcmgh.2018.12.004","article-title":"Targeted delivery of Stk25 antisense oligonucleotides to hepatocytes protects mice against nonalcoholic fatty liver disease","volume":"7","author":"Cansby","year":"2019","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/hep4.1128","article-title":"Serine\/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice","volume":"2","author":"Nunez-Duran","year":"2018","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1194\/jlr.RA119000316","article-title":"Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver","volume":"61","author":"Nerstedt","year":"2020","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nrgastro.2016.185","article-title":"Autophagy in the liver: functions in health and disease","volume":"14","author":"Ueno","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib19","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2018.06.008","article-title":"Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease","volume":"69","author":"Lebeaupin","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0163-7258(96)00062-9","article-title":"N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation","volume":"71","author":"Verna","year":"1996","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib21","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s41575-018-0033-6","article-title":"Mouse models of hepatocellular carcinoma: an overview and highlights for immunotherapy research","volume":"15","author":"Brown","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097136","article-title":"HCC development is associated to peripheral insulin resistance in a mouse model of NASH","volume":"9","author":"De Minicis","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib23","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1053\/j.gastro.2010.03.052","article-title":"Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice","volume":"139","author":"Miura","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jcmgh.2016.12.004","article-title":"TRIF differentially regulates hepatic steatosis and inflammation\/fibrosis in\u00a0mice","volume":"3","author":"Yang","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib25","doi-asserted-by":"crossref","first-page":"G449","DOI":"10.1152\/ajpgi.00199.2012","article-title":"Animal models of chronic liver diseases","volume":"304","author":"Liu","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib26","first-page":"237","article-title":"Modeling liver fibrosis in rodents","volume":"117","author":"Constandinou","year":"2005","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1749-8104-8-21","article-title":"Acute inactivation of the serine-threonine kinase Stk25 disrupts neuronal migration","volume":"8","author":"Matsuki","year":"2013","journal-title":"Neural Dev"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib28","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1053\/j.gastro.2018.11.019","article-title":"NADPH oxidase 1 in liver macrophages promotes inflammation and tumor development in mice","volume":"156","author":"Liang","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib29","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.celrep.2015.02.027","article-title":"YAP inhibition restores hepatocyte differentiation in advanced HCC, leading to tumor regression","volume":"10","author":"Fitamant","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib30","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.cell.2018.09.053","article-title":"Obesity drives STAT-1-dependent NASH and STAT-3-dependent HCC","volume":"175","author":"Grohmann","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1126\/science.1140485","article-title":"Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production","volume":"317","author":"Naugler","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib32","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.cell.2005.04.014","article-title":"IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis","volume":"121","author":"Maeda","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib33","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ccr.2014.07.001","article-title":"ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development","volume":"26","author":"Nakagawa","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib34","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ccr.2008.06.016","article-title":"Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis","volume":"14","author":"Sakurai","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/hep.28874","article-title":"IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice","volume":"65","author":"Bergmann","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib36","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrclinonc.2011.30","article-title":"HCC and angiogenesis: possible targets and future directions","volume":"8","author":"Zhu","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib37","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jhep.2013.12.025","article-title":"Macrophage heterogeneity in liver injury and fibrosis","volume":"60","author":"Tacke","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib38","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1053\/j.gastro.2013.01.002","article-title":"Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma","volume":"144","author":"Hernandez-Gea","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib39","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/hep.30191","article-title":"FUN14 domain-containing 1-mediated mitophagy suppresses hepatocarcinogenesis by inhibition of inflammasome activation in mice","volume":"69","author":"Li","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib40","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/hep.31280","article-title":"PGC1alpha suppresses metastasis of HCC by inhibiting Warburg effect via PPARgamma-dependent WNT\/beta-catenin\/PDK1 axis","volume":"73","author":"Zuo","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib41","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.semcancer.2010.10.011","article-title":"Mitogen-activated protein kinases in hepatocellular carcinoma development","volume":"21","author":"Min","year":"2011","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib42","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1053\/j.gastro.2006.01.006","article-title":"Ubiquitous activation of Ras and Jak\/Stat pathways in human HCC","volume":"130","author":"Calvisi","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib43","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jhep.2015.07.039","article-title":"CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt\/mTOR\/SREBP1c and P38\/PPARalpha pathways","volume":"63","author":"Li","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/hep.31020","article-title":"Deficiency in embryonic stem cell marker reduced expression 1 activates mitogen-activated protein kinase kinase 6-dependent p38 mitogen-activated protein kinase signaling to drive hepatocarcinogenesis","volume":"72","author":"Luk","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib45","doi-asserted-by":"crossref","first-page":"10544","DOI":"10.1073\/pnas.0603499103","article-title":"Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation","volume":"103","author":"Sakurai","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib46","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ccr.2009.12.048","article-title":"Hepatocyte IKKbeta\/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation","volume":"17","author":"He","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib47","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","article-title":"Emt: 2016","volume":"166","author":"Nieto","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib48","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/cncr.29936","article-title":"Annual report to the nation on the status of cancer, 1975-2012, featuring the increasing incidence of liver cancer","volume":"122","author":"Ryerson","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib49","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1200\/JCO.2005.03.196","article-title":"Hepatocellular carcinoma: the need for progress","volume":"23","author":"Thomas","year":"2005","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib50","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jhep.2016.05.007","article-title":"Role of epithelial to mesenchymal transition in hepatocellular carcinoma","volume":"65","author":"Giannelli","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib51","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1038\/s41467-019-09597-w","article-title":"Identification of the kinase STK25 as an upstream activator of LATS signaling","volume":"10","author":"Lim","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib52","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54863","article-title":"STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism","volume":"9","author":"Bae","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib55","doi-asserted-by":"crossref","first-page":"9974","DOI":"10.1096\/fj.201900356RR","article-title":"Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in humans","volume":"33","author":"Cansby","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib56","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/hep4.1702","article-title":"STE20-type protein kinase MST4 controls NAFLD progression by regulating lipid droplet dynamics and metabolic stress in hepatocytes","volume":"5","author":"Caputo","year":"2021","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib57","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002671RR","article-title":"Silencing of STE20-type kinase MST3 in mice with antisense oligonucleotide treatment ameliorates diet-induced nonalcoholic fatty liver disease","volume":"35","author":"Caputo","year":"2021","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2021.09.018_bib58","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1096\/fj.13-228494","article-title":"Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet","volume":"27","author":"Cansby","year":"2013","journal-title":"FASEB J"}],"updated-by":[{"DOI":"10.1016\/j.jcmgh.2026.101898","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000}}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X21002083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X21002083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:30:23Z","timestamp":1762453823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X21002083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"alternative-id":["S2352345X21002083"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2021.09.018","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2021.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}