{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T22:14:12Z","timestamp":1778969652459,"version":"3.51.4"},"reference-count":75,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.jcmgh.2021.11.006","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T02:18:09Z","timestamp":1637633889000},"page":"695-716","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Nedd4-2\u2013dependent Ubiquitination Potentiates the Inhibition of Human NHE3 by Cholera Toxin and Enteropathogenic Escherichia coli"],"prefix":"10.1016","volume":"13","author":[{"given":"Kayte A.","family":"Jenkin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiran","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songbai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peijian","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Chris","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2021.11.006_bib1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/01.mcg.0000177231.13770.07","article-title":"Infectious diarrhea in developed and developing countries","volume":"39","author":"Cheng","year":"2005","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrmicro2053","article-title":"Enteric infection meets intestinal function: how bacterial pathogens cause diarrhoea","volume":"7","author":"Viswanathan","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev.physiol.67.031103.153004","article-title":"Molecular physiology of intestinal Na+\/H+ exchanger","volume":"67","author":"Zachos","year":"2005","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/969","article-title":"Renal and intestinal absorptive defects in mice lacking the NHE3 Na+\/H+ exchanger","volume":"19","author":"Schultheis","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib5","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1093\/hmg\/ddv367","article-title":"Reduced sodium\/proton exchanger NHE3 activity causes congenital sodium diarrhea","volume":"24","author":"Janecke","year":"2015","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib6","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1196\/annals.1326.024","article-title":"Molecular mechanisms of disturbed electrolyte transport in intestinal inflammation","volume":"1072","author":"Seidler","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ng.764","article-title":"Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47","volume":"43","author":"Anderson","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib8","doi-asserted-by":"crossref","first-page":"C758","DOI":"10.1152\/ajpcell.00421.2014","article-title":"Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activity","volume":"308","author":"Zhu","year":"2015","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jcmgh.2018.02.009","article-title":"The role of ion transporters in the pathophysiology of infectious diarrhea","volume":"6","author":"Das","year":"2018","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib10","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1172\/JCI200318326","article-title":"Intestinal ion transport and the pathophysiology of diarrhea","volume":"111","author":"Field","year":"2003","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib11","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1074\/jbc.274.7.3978","article-title":"Acute inhibition of Na\/H exchanger NHE-3 by cAMP: role of protein kinase a and NHE-3 phosphoserines 552 and 605","volume":"274","author":"Zhao","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib12","doi-asserted-by":"crossref","first-page":"26906","DOI":"10.1074\/jbc.M011338200","article-title":"Dopamine acutely stimulates Na\/H exchanger (NHE3) endocytosis via clathrin-coated vesicles: dependence on protein kinase A-mediated NHE3 phosphorylation","volume":"276","author":"Hu","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib13","doi-asserted-by":"crossref","first-page":"jcs218610","DOI":"10.1242\/jcs.218610","article-title":"Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane","volume":"131","author":"Singh","year":"2018","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.femsre.2004.07.002","article-title":"Enteropathogenic Escherichia coli: unravelling pathogenesis","volume":"29","author":"Chen","year":"2005","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib15","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1111\/j.1462-5822.2008.01163.x","article-title":"The enteropathogenic Escherichia coli effector protein EspF decreases sodium hydrogen exchanger 3 activity","volume":"10","author":"Hodges","year":"2008","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib16","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.tcb.2011.08.007","article-title":"Endosomal transport via ubiquitination","volume":"21","author":"Piper","year":"2011","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib17","doi-asserted-by":"crossref","first-page":"18360","DOI":"10.1074\/jbc.M113.541706","article-title":"Unique regulation of human Na+\/H+ exchanger 3 (NHE3) by Nedd4-2 ligase that differs from non-primate NHE3s","volume":"289","author":"No","year":"2014","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/cdd.2009.84","article-title":"Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions","volume":"17","author":"Yang","year":"2010","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib19","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1096\/fj.13-243840","article-title":"Dopamine D3 receptor inhibits the ubiquitin-specific peptidase 48 to promote NHE3 degradation","volume":"28","author":"Armando","year":"2014","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib20","doi-asserted-by":"crossref","first-page":"16476","DOI":"10.1096\/fj.202001875R","article-title":"Ubiquitin-specific peptidase 7 (USP7) and USP10 mediate deubiquitination of human NHE3 regulating its expression and activity","volume":"34","author":"Han","year":"2020","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev-pathol-052016-100332","article-title":"Humanized mouse models of clinical disease","volume":"12","author":"Walsh","year":"2017","journal-title":"Annual Review of Pathology"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib22","doi-asserted-by":"crossref","first-page":"G180","DOI":"10.1152\/ajpgi.00069.2012","article-title":"Human intestinal epithelial cell line SK-CO15 is a new model system to study Na(+)\/H(+) exchanger 3","volume":"303","author":"Yoo","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib23","doi-asserted-by":"crossref","first-page":"G667","DOI":"10.1152\/ajpgi.00189.2013","article-title":"Reduced colonic microbial diversity is associated with colitis in NHE3-deficient mice","volume":"305","author":"Larmonier","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib24","doi-asserted-by":"crossref","first-page":"14132","DOI":"10.1073\/pnas.241245898","article-title":"Estrogen action and male fertility: roles of the sodium\/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function","volume":"98","author":"Zhou","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib25","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1172\/JCI79552","article-title":"Restoration of Na+\/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss","volume":"125","author":"He","year":"2015","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib26","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1053\/j.gastro.2009.09.055","article-title":"Lysophosphatidic acid stimulates the intestinal brush border Na+\/H+ exchanger 3 and fluid absorption via LPA5 and NHERF2","volume":"138","author":"Lin","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib27","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1172\/JCI0216112","article-title":"Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion","volume":"110","author":"Ma","year":"2002","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib28","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1053\/j.gastro.2003.11.005","article-title":"Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor","volume":"126","author":"Thiagarajah","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib29","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/labinvest.3700661","article-title":"Invasive Escherichia coli are a feature of Crohn\u2019s disease","volume":"87","author":"Sasaki","year":"2007","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib30","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1053\/j.gastro.2004.06.014","article-title":"Differing roles of protein kinase C-zeta in disruption of tight junction barrier by enteropathogenic and enterohemorrhagic Escherichia coli","volume":"127","author":"Tomson","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib31","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1046\/j.1432-1033.2003.03779.x","article-title":"Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C","volume":"270","author":"Ghanekar","year":"2003","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib32","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.1074\/jbc.RA118.002835","article-title":"Selective inhibition of intestinal guanosine 3,5-cyclic monophosphate signaling by small-molecule protein kinase inhibitors","volume":"293","author":"Bijvelds","year":"2018","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib33","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.tim.2003.10.002","article-title":"Translating tissue culture results into animal models: the case of Salmonella typhimurium","volume":"11","author":"Hurley","year":"2003","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib34","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1128\/IAI.73.2.1161-1170.2005","article-title":"Mouse model of enteropathogenic Escherichia coli infection","volume":"73","author":"Savkovic","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib35","first-page":"G781","article-title":"Enteropathogenic E coli attenuates secretagogue-induced net intestinal ion transport but not Cl- secretion","volume":"276","author":"Hecht","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib36","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1152\/physrev.00020.2005","article-title":"Role of ubiquitylation in cellular membrane transport","volume":"86","author":"Staub","year":"2006","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib37","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.1093\/emboj\/20.24.7052","article-title":"Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression","volume":"20","author":"Debonneville","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib38","doi-asserted-by":"crossref","first-page":"45753","DOI":"10.1074\/jbc.M407858200","article-title":"cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na+ channel through convergent phosphorylation of Nedd4-2","volume":"279","author":"Snyder","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib39","doi-asserted-by":"crossref","first-page":"28672","DOI":"10.1074\/jbc.272.45.28672","article-title":"Identification of sites required for down-regulation of Na\/H exchanger NHE3 activity by cAMP-dependent protein kinase","volume":"272","author":"Kurashima","year":"1997","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib40","doi-asserted-by":"crossref","first-page":"F249","DOI":"10.1152\/ajprenal.00082.2004","article-title":"Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+\/H+ exchanger NHE3 at PKA consensus sites","volume":"289","author":"Kocinsky","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib41","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nrgastro.2015.111","article-title":"Secretory diarrhoea: mechanisms and emerging therapies","volume":"12","author":"Thiagarajah","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib42","first-page":"11","article-title":"Gut microbiota and diarrhea: an updated review","author":"Li","year":"2021","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib43","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1053\/j.gastro.2009.05.043","article-title":"Changes in mucosal homeostasis predispose NHE3 knockout mice to increased susceptibility to DSS-induced epithelial injury","volume":"137","author":"Kiela","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005616","article-title":"Age-dependent susceptibility to enteropathogenic Escherichia coli (EPEC) infection in mice","volume":"12","author":"Dupont","year":"2016","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib45","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1128\/iai.64.12.5315-5325.1996","article-title":"Intimin from enteropathogenic Escherichia coli restores murine virulence to a Citrobacter rodentium eaeA mutant: induction of an immunoglobulin A response to intimin and EspB","volume":"64","author":"Frankel","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib46","doi-asserted-by":"crossref","first-page":"F462","DOI":"10.1152\/ajprenal.90300.2008","article-title":"Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2","volume":"295","author":"Shi","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib47","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/ncomms1284","article-title":"Respiratory distress and perinatal lethality in Nedd4-2-deficient mice","volume":"2","author":"Boase","year":"2011","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib48","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1681\/ASN.2013090936","article-title":"Colon-specific deletion of epithelial sodium channel causes sodium loss and aldosterone resistance","volume":"25","author":"Malsure","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib49","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1042\/CS20200065","article-title":"An inducible intestinal epithelial cell-specific NHE3 knockout mouse model mimicking congenital sodium diarrhea","volume":"134","author":"Xue","year":"2020","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib50","doi-asserted-by":"crossref","first-page":"20207","DOI":"10.1074\/jbc.M611329200","article-title":"Nedd4-2 catalyzes ubiquitination and degradation of cell surface ENaC","volume":"282","author":"Zhou","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib51","doi-asserted-by":"crossref","first-page":"11612","DOI":"10.1074\/jbc.RA118.003082","article-title":"beta1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells","volume":"293","author":"Ho","year":"2018","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib52","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejphar.2014.03.005","article-title":"The phosphorylation of endogenous Nedd4-2 in Na(+)-absorbing human airway epithelial cells","volume":"732","author":"Ismail","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib53","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1128\/iai.65.8.3277-3285.1997","article-title":"Activation of host cell protein kinase C by enteropathogenic Escherichia coli","volume":"65","author":"Crane","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib54","doi-asserted-by":"crossref","first-page":"G959","DOI":"10.1152\/ajpgi.00274.2005","article-title":"Rapid activation of Na+\/H+ exchange by EPEC is PKC mediated","volume":"291","author":"Hodges","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib55","doi-asserted-by":"crossref","first-page":"9110","DOI":"10.1073\/pnas.90.19.9110","article-title":"Functional characteristics of a cloned epithelial Na+\/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C","volume":"90","author":"Tse","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib56","doi-asserted-by":"crossref","first-page":"8697","DOI":"10.1074\/jbc.M110.186858","article-title":"Protein kinase C-dependent ubiquitination and clathrin-mediated endocytosis of the cationic amino acid transporter CAT-1","volume":"286","author":"Vina-Vilaseca","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib57","doi-asserted-by":"crossref","first-page":"19177","DOI":"10.1074\/jbc.M112.355909","article-title":"Protein kinase C (PKC)-promoted endocytosis of glutamate transporter GLT-1 requires ubiquitin ligase Nedd4-2-dependent ubiquitination but not phosphorylation","volume":"287","author":"Garc\u00eda-Tard\u00f3n","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib58","doi-asserted-by":"crossref","first-page":"F821","DOI":"10.1152\/ajprenal.00522.2015","article-title":"Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1","volume":"310","author":"Xu","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib59","doi-asserted-by":"crossref","first-page":"31601","DOI":"10.1074\/jbc.M000600200","article-title":"Acute regulation of Na+\/H+ exchanger NHE3 by parathyroid hormone via NHE3 phosphorylation and dynamin-dependent endocytosis","volume":"275","author":"Collazo","year":"2000","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib60","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1210\/en.2012-1813","article-title":"Gastrin induces sodium-hydrogen exchanger 3 phosphorylation and mTOR activation via a phosphoinositide 3-kinase-\/protein kinase C-dependent but AKT-independent pathway in renal proximal tubule cells derived from a normotensive male human","volume":"154","author":"Liu","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib61","doi-asserted-by":"crossref","first-page":"F1169","DOI":"10.1152\/ajprenal.00630.2012","article-title":"Chronic regulation of the renal Na(+)\/H(+) exchanger NHE3 by dopamine: translational and posttranslational mechanisms","volume":"304","author":"Hu","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib62","doi-asserted-by":"crossref","first-page":"F212","DOI":"10.1152\/ajprenal.00042.2007","article-title":"NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity","volume":"293","author":"Kocinsky","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib63","doi-asserted-by":"crossref","first-page":"37551","DOI":"10.1074\/jbc.274.53.37551","article-title":"The epithelial Na(+)\/H(+) exchanger, NHE3, is internalized through a clathrin-mediated pathway","volume":"274","author":"Chow","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib64","doi-asserted-by":"crossref","first-page":"11857","DOI":"10.1073\/pnas.1302918110","article-title":"Regulation of ubiquitin-dependent cargo sorting by multiple endocytic adaptors at the plasma membrane","volume":"110","author":"Mayers","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib65","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016808","article-title":"Ubiquitin-dependent sorting in endocytosis","volume":"6","author":"Piper","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib66","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1073\/pnas.0409817102","article-title":"Clathrin-independent endocytosis of ubiquitinated cargos","volume":"102","author":"Sigismund","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib67","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.devcel.2012.08.003","article-title":"Regulation of endocytic clathrin dynamics by cargo ubiquitination","volume":"23","author":"Henry","year":"2012","journal-title":"Dev Cell"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib68","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.200610154","article-title":"Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1","volume":"177","author":"Wolfe","year":"2007","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib69","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1242\/jcs.03385","article-title":"Decoding ubiquitin sorting signals for clathrin-dependent endocytosis by CLASPs","volume":"120","author":"Traub","year":"2007","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib70","doi-asserted-by":"crossref","first-page":"C887","DOI":"10.1152\/ajpcell.00630.2005","article-title":"IFN-{gamma} and TNF-{alpha} regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1","volume":"291","author":"Amin","year":"2006","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib71","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1074\/jbc.274.10.6476","article-title":"Regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of small and large intestines","volume":"274","author":"Pinto","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib72","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.2353\/ajpath.2009.080640","article-title":"The bacterial virulence factor lymphostatin compromises intestinal epithelial barrier function by modulating rho GTPases","volume":"174","author":"Babbin","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib73","article-title":"Development of a unique small molecule modulator of CXCR4","volume":"7","author":"Liang","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib74","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/j.1460-2075.1986.tb04306.x","article-title":"Microinjected antibodies against the cytoplasmic domain of vesicular stomatis virus glycoprotein block its tranport to the cell surface","volume":"5","author":"Kreis","year":"1986","journal-title":"EMBO J"},{"key":"10.1016\/j.jcmgh.2021.11.006_bib75","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1091\/mbc.e11-04-0328","article-title":"Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+\/H+ exchanger NHE3 by glucocorticoids","volume":"22","author":"He","year":"2011","journal-title":"Mol Biol Cell"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X2100240X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X2100240X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:29:34Z","timestamp":1762453774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X2100240X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":75,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"alternative-id":["S2352345X2100240X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2021.11.006","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nedd4-2\u2013dependent Ubiquitination Potentiates the Inhibition of Human NHE3 by Cholera Toxin and Enteropathogenic Escherichia coli","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2021.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}