{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:01:37Z","timestamp":1785380497630,"version":"3.55.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.jcmgh.2022.01.017","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T05:34:30Z","timestamp":1643348070000},"page":"1365-1391","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["FACI Is a Novel CREB-H\u2013Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity"],"prefix":"10.1016","volume":"13","author":[{"given":"Yun","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Zhuo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Wei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George L.","family":"Tipoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Han","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Ming","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Ping","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2778-3530","authenticated-orcid":false,"given":"Dong-Yan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2022.01.017_bib1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41575-019-0250-7","article-title":"Regulation of intestinal lipid metabolism: current concepts and relevance to disease","volume":"17","author":"Ko","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/MOL.0000000000000084","article-title":"Intestinal lipid absorption and lipoprotein formation","volume":"25","author":"Hussain","year":"2014","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0021-9150(00)00456-1","article-title":"Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular risk","volume":"151","author":"Ros","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib4","doi-asserted-by":"crossref","first-page":"E1183","DOI":"10.1152\/ajpendo.90899.2008","article-title":"Intestinal lipid absorption","volume":"296","author":"Iqbal","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tem.2017.12.001","article-title":"Recent advances in triacylglycerol mobilization by the gut","volume":"29","author":"Xiao","year":"2018","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev-physiol-021909-135801","article-title":"The biogenesis of chylomicrons","volume":"72","author":"Mansbach","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib7","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrendo.2017.91","article-title":"SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology","volume":"13","author":"Shimano","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/MOL.0b013e3283508fed","article-title":"The role of CREB-H transcription factor in triglyceride metabolism","volume":"23","author":"Lee","year":"2012","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib9","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nm.2347","article-title":"The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism","volume":"17","author":"Lee","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib10","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1093\/nar\/gki332","article-title":"The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma","volume":"33","author":"Chin","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1161\/CIRCGENETICS.111.960864","article-title":"Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia","volume":"5","author":"Johansen","year":"2012","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib12","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1161\/ATVBAHA.120.314168","article-title":"Loss-of-function CREB3L3 variants in patients with severe hypertriglyceridemia","volume":"40","author":"Dron","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib13","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.3390\/ijms19051396","article-title":"CREBH regulates systemic glucose and lipid metabolism","volume":"19","author":"Nakagawa","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib14","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.molmet.2016.09.004","article-title":"Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression","volume":"5","author":"Kikuchi","year":"2016","journal-title":"Mol Metab"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib15","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jcmgh.2020.11.004","article-title":"Enterohepatic transcription factor CREB3L3 protects atherosclerosis via SREBP competitive inhibition","volume":"11","author":"Nakagawa","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib16","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1242\/jcs.067819","article-title":"N-linked glycosylation is required for optimal proteolytic activation of membrane-bound transcription factor CREB-H","volume":"123","author":"Chan","year":"2010","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib17","doi-asserted-by":"crossref","first-page":"23938","DOI":"10.1038\/srep23938","article-title":"\u03b2-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H","volume":"6","author":"Cheng","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12864-019-5563-y","article-title":"Transcriptional profiling of PPAR\u03b1-\/- and CREB3L3-\/- livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPAR\u03b1","volume":"20","author":"Ruppert","year":"2019","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib19","doi-asserted-by":"crossref","first-page":"8878","DOI":"10.1016\/S0021-9258(19)52477-2","article-title":"Characterization of the asialoglycoprotein receptor in a continuous hepatoma line","volume":"256","author":"Schwartz","year":"1981","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib20","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1073\/pnas.91.2.674","article-title":"Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha","volume":"91","author":"Wu","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib21","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/282615a0","article-title":"Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line","volume":"282","author":"Aden","year":"1979","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib22","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41586-018-0590-4","volume":"562","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1152\/physiolgenomics.00269.2006","article-title":"Deconvoluting the intestine: molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talk","volume":"29","author":"Li","year":"2007","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature24489","article-title":"A\u00a0single-cell survey of the small intestinal epithelium","volume":"551","author":"Haber","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib25","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/tra.12677","article-title":"Conformational regulation of AP1 and AP2 clathrin adaptor complexes","volume":"20","author":"Beacham","year":"2019","journal-title":"Traffic"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib26","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20140069","article-title":"Adaptor protein complexes and intracellular transport","volume":"34","author":"Park","year":"2014","journal-title":"Biosci Rep"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib27","doi-asserted-by":"crossref","first-page":"C260","DOI":"10.1152\/ajpcell.1984.247.3.C260","article-title":"Epithelial properties of human colonic carcinoma cell line Caco-2: electrical parameters","volume":"247","author":"Grasset","year":"1984","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib28","first-page":"2674","article-title":"Evidence for thromboxane biosynthesis in established cell lines derived from human lung adenocarcinomas","volume":"48","author":"Hubbard","year":"1988","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib29","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1083\/jcb.131.6.1715","article-title":"Characterization of a cis-Golgi matrix protein, GM130","volume":"131","author":"Nakamura","year":"1995","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib30","doi-asserted-by":"crossref","first-page":"17229","DOI":"10.1074\/jbc.270.29.17229","article-title":"The Hansenula polymorpha PER3 gene is essential for the import of PTS1 proteins into the peroxisomal matrix","volume":"270","author":"van der Klei","year":"1995","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib31","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1002\/j.1460-2075.1989.tb08530.x","article-title":"Multiple zones in the sequence of calreticulin (CRP55, calregulin, HACBP), a major calcium binding ER\/SR protein","volume":"8","author":"Smith","year":"1989","journal-title":"EMBO J"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib32","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1016\/j.bbagen.2013.05.016","article-title":"PLIN2, the major perilipin regulated during sebocyte differentiation, controls sebaceous lipid accumulation in\u00a0vitro and sebaceous gland size in\u00a0vivo","volume":"1830","author":"Dahlhoff","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib33","doi-asserted-by":"crossref","first-page":"13052","DOI":"10.1073\/pnas.0503900102","article-title":"Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch","volume":"102","author":"Lee","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib34","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.tcb.2018.06.007","article-title":"Rab GTPase function in endosome and lysosome biogenesis","volume":"28","author":"Langemeyer","year":"2018","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib35","first-page":"1060","article-title":"Measuring autophagosome flux","volume":"14","author":"du Toit","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib36","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1093\/bioinformatics\/btn392","article-title":"HELIQUEST: a web server to screen sequences with specific alpha-helical properties","volume":"24","author":"Gautier","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/biom8030045","article-title":"The many faces of amphipathic helices","volume":"8","author":"Gimenez-Andres","year":"2018","journal-title":"Biomolecules"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007797","article-title":"G\u00a0protein subunit dissociation and translocation regulate cellular response to receptor stimulation","volume":"4","author":"Chisari","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib39","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.devcel.2015.10.016","article-title":"Modular detection of GFP-labeled proteins for rapid screening by electron microscopy in cells and organisms","volume":"35","author":"Ariotti","year":"2015","journal-title":"Dev Cell"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib40","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1083\/jcb.143.2.501","article-title":"Visualization of phosphoinositides that bind pleckstrin homology domains: calcium- and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide pools","volume":"143","author":"Varnai","year":"1998","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib41","doi-asserted-by":"crossref","first-page":"8288","DOI":"10.1128\/MCB.24.18.8288-8300.2004","article-title":"Selective coactivator interactions in gene activation by SREBP-1a and -1c","volume":"24","author":"Toth","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib42","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/jcb.27407","article-title":"Novel mechanisms of regulation of the expression and transcriptional activity of hepatocyte nuclear factor 4alpha","volume":"120","author":"Guo","year":"2019","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib43","doi-asserted-by":"crossref","first-page":"12455","DOI":"10.1093\/nar\/gku925","article-title":"Requirement of CRTC1 coactivator for hepatitis B virus transcription","volume":"42","author":"Tang","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bbagrm.2018.01.021","article-title":"Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1","volume":"1861","author":"Gao","year":"2018","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib45","doi-asserted-by":"crossref","first-page":"50991","DOI":"10.1074\/jbc.M210262200","article-title":"Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor \u03b3 coactivator-1\u03b1 (PGC-1\u03b1)","volume":"277","author":"Ichida","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib46","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/j.2040-4603.2014.tb00548.x","article-title":"Energy metabolism in the liver","volume":"4","author":"Rui","year":"2014","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib47","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s42255-020-0205-x","article-title":"Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473","volume":"2","author":"Tran","year":"2020","journal-title":"Nat Metab"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib48","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of insulin action and insulin resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib49","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-nutr-071714-034338","article-title":"New insights into the regulation of chylomicron production","volume":"35","author":"Dash","year":"2015","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib50","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13014-016-0647-1","article-title":"Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia","volume":"11","author":"Matschke","year":"2016","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib51","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/oby.2004.104","article-title":"Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB","volume":"12","author":"Dieter","year":"2004","journal-title":"Obes Res"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib52","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/nrm2063","article-title":"Membrane-protein topology","volume":"7","author":"von Heijne","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib53","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1146\/annurev-biochem-072711-164947","article-title":"Intrinsically disordered proteins and intrinsically disordered protein regions","volume":"83","author":"Oldfield","year":"2014","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib54","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1007\/s00018-019-03273-4","article-title":"Understanding protein multifunctionality: from short linear motifs to cellular functions","volume":"76","author":"Zanzoni","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib55","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.bbapap.2013.03.010","article-title":"AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases","volume":"1834","author":"Arencibia","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib56","doi-asserted-by":"crossref","first-page":"6074","DOI":"10.3390\/ijms21176074","article-title":"The endosomal recycling pathway-At the crossroads of the cell","volume":"21","author":"O'Sullivan","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib57","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrm2755","article-title":"Pathways and mechanisms of endocytic recycling","volume":"10","author":"Grant","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib58","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.cmet.2016.01.001","article-title":"Intestinal phospholipid remodeling is required for dietary-lipid uptake and survival on a high-fat diet","volume":"23","author":"Wang","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib59","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1530\/JOE-19-0275","article-title":"SGK1 activation exacerbates diet-induced obesity, metabolic syndrome and hypertension","volume":"244","author":"Sierra-Ramos","year":"2020","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib60","doi-asserted-by":"crossref","first-page":"ITC81","DOI":"10.7326\/AITC201712050","article-title":"Dyslipidemia","volume":"167","author":"Kopin","year":"2017","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib61","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","article-title":"Visualizing and interpreting cancer genomics data via the Xena platform","volume":"38","author":"Goldman","year":"2020","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib62","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1093\/carcin\/bgy080","article-title":"Genome-wide association study of familial lung cancer","volume":"39","author":"Byun","year":"2018","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib63","doi-asserted-by":"crossref","unstructured":"Kiernan R, Br\u00e8s V, Ng RW, Coudart MP, El Messaoudi S, Sardet C, Jin DY, Emiliani S, Benkirane M. Post-activation turn-off of NF-\u03baB-dependent transcription is regulated by acetylation of p65. J Biol Chem 2003;278:2758\u20132766.","DOI":"10.1074\/jbc.M209572200"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib64","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.bbagrm.2017.02.007","article-title":"Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription","volume":"1860","author":"Deng","year":"2017","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib65","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/mt.2008.72","article-title":"Gene delivery to the juvenile mouse liver using AAV2\/8 vectors","volume":"16","author":"Cunningham","year":"2008","journal-title":"Mol Ther"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib66","doi-asserted-by":"crossref","first-page":"e292","DOI":"10.21769\/BioProtoc.292","article-title":"Isolation of epithelial cells from mouse gastrointestinal tract for Western blot or RNA analysis","volume":"2","author":"Zeineldin","year":"2012","journal-title":"Bio Protoc"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib67","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.2337\/dc12-0607","article-title":"Expansion of the homeostasis model assessment of beta-cell function and insulin resistance to enable clinical trial outcome modeling through the interactive adjustment of physiology and treatment effects: iHOMA2","volume":"36","author":"Hill","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib68","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12(4)","author":"Kim","year":"2015","journal-title":"Nat Methods"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib69","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9(4)","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib70","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib71","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15(12)","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib72","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41586-021-03827-2","article-title":"Dietary fructose improves intestinal cell survival and nutrient absorption","volume":"597","author":"Taylor","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2022.01.017_bib73","series-title":"Encyclopedia of lipidomics","first-page":"1","article-title":"Liquid extraction: Bligh and Dyer","author":"S\u00fcndermann","year":"2016"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X22000170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X22000170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:30:05Z","timestamp":1762453805000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X22000170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":73,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022]]}},"alternative-id":["S2352345X22000170"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2022.01.017","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FACI Is a Novel CREB-H\u2013Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2022.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}