{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:16:19Z","timestamp":1793398579626,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571184"],"award-info":[{"award-number":["31571184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018552","name":"Science and Technology Plan Project of Taizhou","doi-asserted-by":"publisher","award":["21ywb78"],"award-info":[{"award-number":["21ywb78"]}],"id":[{"id":"10.13039\/501100018552","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/j.jcmgh.2022.10.011","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T23:55:18Z","timestamp":1666396518000},"page":"887-901","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Vitamin D Receptor Activation Targets ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Hepatocytes in Cholestasic Mice"],"prefix":"10.1016","volume":"15","author":[{"given":"Zhijian","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liman","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqing","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2022.10.011_bib1","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3390\/cells8101249","article-title":"Mechanisms underlying hepatitis C virus-associated hepatic fibrosis","volume":"8","author":"Khatun","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jhep.2018.12.003","article-title":"Fibrosis and alcohol-related liver disease","volume":"70","author":"Lackner","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib3","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.bbrc.2017.11.202","article-title":"Impaired autophagy promotes bile acid-induced hepatic injury and accumulation of ubiquitinated proteins","volume":"495","author":"Kim","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib4","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1002\/hep.30348","article-title":"The epidermal growth factor receptor ligand amphiregulin protects from cholestatic liver injury and regulates bile acids synthesis","volume":"69","author":"Santamar\u00eda","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib5","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.jhep.2020.01.014","article-title":"FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis","volume":"72","author":"Panzitt","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000371688","article-title":"Nuclear receptors in acute and chronic cholestasis","volume":"33","author":"Gonzalez-Sanchez","year":"2015","journal-title":"Dig Dis"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib7","doi-asserted-by":"crossref","first-page":"14486","DOI":"10.1074\/jbc.M110.116004","article-title":"Regulation of bile acid synthesis by fat-soluble vitamins A and D","volume":"285","author":"Schmidt","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib8","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/hep.26453","article-title":"Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice","volume":"58","author":"Firrincieli","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/path.5750","article-title":"Yes-associated protein regulates the hepatoprotective effect of vitamin D receptor activation through promoting adaptive bile duct remodeling in cholestatic mice","volume":"255","author":"Xie","year":"2021","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib10","article-title":"Vitamin D(3)\/VDR inhibits inflammation through NF-\u03baB pathway accompanied by resisting apoptosis and inducing autophagy in abalone Haliotis discus hannai","author":"Huang","year":"2021","journal-title":"Cell Biol Toxicol"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib11","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1089\/ars.2014.5887","article-title":"Vitamin D receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy","volume":"22","author":"Yao","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib12","doi-asserted-by":"crossref","first-page":"8835207","DOI":"10.1155\/2020\/8835207","article-title":"Olaquindox-induced liver damage involved the crosstalk of oxidative stress and p53 in\u00a0vivo and in\u00a0vitro","volume":"2020","author":"Li","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib13","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.3390\/ijms22031083","article-title":"5-O-Demethylnobiletin alleviates ccl(4)-induced acute liver injury by equilibrating ROS-mediated apoptosis and autophagy induction","volume":"22","author":"Chang","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib14","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.3390\/cancers12113336","article-title":"The role of oxidative stress and its counteractive utility in colorectal cancer (CRC)","volume":"12","author":"Basak","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1499-3872(16)60164-9","article-title":"Quercetin protects liver injury induced by bile duct ligation via attenuation of Rac1 and NADPH oxidase1 expression in rats","volume":"16","author":"Kabirifar","year":"2017","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib16","first-page":"613950","article-title":"Gallic acid induces a reactive oxygen species-provoked c-Jun Nh2-terminal kinase-dependent apoptosis in lung fibroblasts","volume":"2013","author":"Chen","year":"2013","journal-title":"Evid Based complement Alternat Med"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib17","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.3390\/ijms18051088","article-title":"Inhibition of autophagy promotes salinomycin-induced apoptosis via reactive oxygen species-mediated PI3K\/AKT\/mTOR and ERK\/p38 MAPK-dependent signaling in human prostate cancer cells","volume":"18","author":"Kim","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib18","doi-asserted-by":"crossref","first-page":"119367","DOI":"10.1016\/j.lfs.2021.119367","article-title":"Estrogen cholestasis induces gut and liver injury in rats involving in activating PI3K\/Akt and MAPK signaling pathways","volume":"276","author":"Xiang","year":"2021","journal-title":"Life Sci"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.atherosclerosis.2011.04.022","article-title":"Labedipinedilol-A prevents lysophosphatidylcholine-induced vascular smooth muscle cell death through reducing reactive oxygen species production and anti-apoptosis","volume":"217","author":"Hsu","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib20","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1681\/ASN.2012040383","article-title":"Vitamin D receptor signaling in podocytes protects against diabetic nephropathy","volume":"23","author":"Wang","year":"2012","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib21","doi-asserted-by":"crossref","first-page":"109170","DOI":"10.1016\/j.biopha.2019.109170","article-title":"The vitamin D receptor (VDR) protects pancreatic beta cells against Forkhead box class O1 (FOXO1)-induced mitochondrial dysfunction and cell apoptosis","volume":"117","author":"Chen","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib22","first-page":"100922","article-title":"Inhibition of GTPase Rac1 expression by vitamin D mitigates pressure overload-induced cardiac hypertrophy","volume":"37","author":"Moradi","year":"2021","journal-title":"Int J Cardiol Heart Vasc"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib24","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1002\/hep.30937","article-title":"Vitamin D receptor activation in liver macrophages ameliorates hepatic inflammation, steatosis, and insulin resistance in mice","volume":"71","author":"Dong","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib25","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.freeradbiomed.2021.04.019","article-title":"Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice","volume":"169","author":"Jia","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.yexcr.2018.11.023","article-title":"Bile acid-induced apoptosis and bile acid synthesis are reduced by over-expression of augmenter of liver regeneration (ALR) in a STAT3-dependent mechanism","volume":"374","author":"Ibrahim","year":"2019","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib27","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.biopha.2017.10.166","article-title":"Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice","volume":"97","author":"Heidari","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib28","doi-asserted-by":"crossref","first-page":"620934","DOI":"10.3389\/fphar.2021.620934","article-title":"Crizotinib and sunitinib induce hepatotoxicity and mitochondrial apoptosis in L02 cells via ROS and Nrf2 signaling pathway","volume":"12","author":"Guo","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib29","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ncb2070","article-title":"The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing","volume":"12","author":"Jun","year":"2010","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib30","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202013158","article-title":"Beclin-1-mediated activation of autophagy improves proximal and distal urea cycle disorders","volume":"13","author":"Soria","year":"2021","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib31","first-page":"918","article-title":"RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly","volume":"25","author":"Sheng","year":"2018","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib33","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/jcp.29835","article-title":"Asprosin promotes \u03b2-cell apoptosis by inhibiting the autophagy of \u03b2-cell via AMPK-mTOR pathway","volume":"236","author":"Wang","year":"2021","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib34","doi-asserted-by":"crossref","first-page":"12568","DOI":"10.18632\/oncotarget.7276","article-title":"Inverse agonist of estrogen-related receptor \u03b1 suppresses the growth of triple negative breast cancer cells through ROS generation and interaction with multiple cell signaling pathways","volume":"7","author":"Wu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib35","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3390\/biom10050761","article-title":"High levels of ROS impair lysosomal acidity and autophagy flux in glucose-deprived fibroblasts by activating atm and ERK pathways","volume":"10","author":"Song","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib36","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/CAD.0000000000000816","article-title":"The signaling axis of Rac1-TFEB regulates autophagy and tumorigenesis","volume":"30","author":"Ma","year":"2019","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12026-014-8594-0","article-title":"Vitamin D in primary biliary cirrhosis, a plausible marker of advanced disease","volume":"61","author":"Agmon-Levin","year":"2015","journal-title":"Immunol Res"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib38","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.clinre.2013.05.016","article-title":"Vitamin D in autoimmune liver disease","volume":"37","author":"Smyk","year":"2013","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib39","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/ibd\/izy092","article-title":"Ancient nuclear receptor VDR with new functions: microbiome and inflammation","volume":"24","author":"Bakke","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib40","doi-asserted-by":"crossref","first-page":"109355","DOI":"10.1016\/j.cbi.2020.109355","article-title":"Vitamin D alleviates liver fibrosis by inhibiting histidine-rich calcium binding protein (HRC)","volume":"334","author":"Lu","year":"2021","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib41","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/hep.24690","article-title":"Activation of autophagy protects against acetaminophen-induced hepatotoxicity","volume":"55","author":"Ni","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib42","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.4161\/auto.21211","article-title":"ROS-induced mitochondrial depolarization initiates PARK2\/PARKIN-dependent mitochondrial degradation by autophagy","volume":"8","author":"Wang","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib43","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/cdd.2009.121","article-title":"Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL","volume":"17","author":"Luo","year":"2010","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib44","doi-asserted-by":"crossref","first-page":"20722","DOI":"10.1074\/jbc.M413934200","article-title":"Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death","volume":"280","author":"Pyo","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib45","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1002\/jcp.25785","article-title":"Crosstalk of autophagy and apoptosis: involvement of the dual role of autophagy under ER stress","volume":"232","author":"Song","year":"2017","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib46","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1152\/ajprenal.00332.2018","article-title":"Vitamin D receptor activation protects against lipopolysaccharide-induced acute kidney injury through suppression of tubular cell apoptosis","volume":"316","author":"Du","year":"2019","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib47","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.3892\/ijmm.2015.2150","article-title":"Vitamin D\/VDR signaling pathway ameliorates 2,4,6-trinitrobenzene sulfonic acid-induced colitis by inhibiting intestinal epithelial apoptosis","volume":"35","author":"Zhu","year":"2015","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib48","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1080\/15548627.2020.1822088","article-title":"Vitamin D3-VDR-PTPN6 axis mediated autophagy contributes to the inhibition of macrophage foam cell formation","volume":"17","author":"Kumar","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib49","doi-asserted-by":"crossref","first-page":"11845","DOI":"10.1096\/fj.201900727R","article-title":"Imbalance of autophagy and apoptosis in intestinal epithelium lacking the vitamin D receptor","volume":"33","author":"Lu","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib50","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fonc.2012.00171","article-title":"The interplay between autophagy and ROS in tumorigenesis","volume":"2","author":"Kongara","year":"2012","journal-title":"Front Oncol"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib51","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cbi.2016.07.020","article-title":"6-Gingerol induces autophagy to protect HUVECs survival from apoptosis","volume":"256","author":"Wang","year":"2016","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib52","doi-asserted-by":"crossref","first-page":"3549704","DOI":"10.1155\/2020\/3549704","article-title":"Salidroside ameliorates mitochondria-dependent neuronal apoptosis after spinal cord ischemia-reperfusion injury partially through inhibiting oxidative stress and promoting mitophagy","volume":"2020","author":"Gu","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5582\/bst.2018.01247","article-title":"Anti-inflammatory, anti-oxidative stress and novel therapeutic targets for cholestatic liver injury","volume":"13","author":"Zhang","year":"2019","journal-title":"Biosci Trends"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib54","doi-asserted-by":"crossref","first-page":"1714896","DOI":"10.1155\/2018\/1714896","article-title":"VDR agonist prevents diabetic endothelial dysfunction through inhibition of prolyl isomerase-1-mediated mitochondrial oxidative stress and inflammation","volume":"2018","author":"Zhang","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib55","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1089\/ars.2011.3960","article-title":"NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's disease","volume":"16","author":"Choi","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib56","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.3390\/molecules25051073","article-title":"Activation of JNK and p38 in MCF-7 cells and the in\u00a0vitro anticancer activity of alnus hirsuta extract","volume":"25","author":"Ryu","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib57","first-page":"4998","article-title":"Exosomes released by human umbilical cord mesenchymal stem cells protect against renal interstitial fibrosis through ROS-mediated P38MAPK\/ERK signaling pathway","volume":"12","author":"Liu","year":"2020","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib58","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.3390\/ijms21186911","article-title":"NOX1 inhibition attenuates kidney ischemia-reperfusion injury via inhibition of ROS-mediated ERK signaling","volume":"21","author":"Jung","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1911534","article-title":"Intestinal microbiota drives cholestasis-induced specific hepatic gene expression patterns","volume":"13","author":"Juanola","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib60","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/s41419-020-02841-y","article-title":"ALV-J inhibits autophagy through the GADD45\u03b2\/MEKK4\/P38MAPK signaling pathway and mediates apoptosis following autophagy","volume":"11","author":"Liao","year":"2020","journal-title":"Cell Death Disease"},{"key":"10.1016\/j.jcmgh.2022.10.011_bib61","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/s41419-019-1653-7","article-title":"Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK\/ERK activation","volume":"10","author":"Pan","year":"2019","journal-title":"Cell Death Disease"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X22002223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X22002223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:32:56Z","timestamp":1762453976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X22002223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"alternative-id":["S2352345X22002223"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2022.10.011","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D Receptor Activation Targets ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Hepatocytes in Cholestasic Mice","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2022.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}