{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:25:35Z","timestamp":1793391935506,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1066"],"award-info":[{"award-number":["SFB 1066"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 1292"],"award-info":[{"award-number":["CRC 1292"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["634413"],"award-info":[{"award-number":["634413"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["777377"],"award-info":[{"award-number":["777377"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130018"],"award-info":[{"award-number":["82130018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970524"],"award-info":[{"award-number":["81970524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/j.jcmgh.2022.12.005","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T20:32:16Z","timestamp":1670877136000},"page":"841-867","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":140,"title":["Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis"],"prefix":"10.1016","volume":"15","author":[{"given":"Ai-Ting","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Ook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Zhen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misbah","family":"Aslam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung-Sook","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Dong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2716-8239","authenticated-orcid":false,"given":"Detlef","family":"Schuppan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2022.12.005_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111556","article-title":"The liver fibrosis niche: novel insights into the interplay between fibrosis-composing mesenchymal cells, immune cells, endothelial cells, and extracellular matrix","volume":"143","author":"Matsuda","year":"2020","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib3","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0140-6736(08)60383-9","article-title":"Liver cirrhosis","volume":"371","author":"Schuppan","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib5","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1053\/j.gastro.2020.09.065","article-title":"Fibrosis regression after eradication of hepatitis C virus: from bench to bedside","volume":"160","author":"Rockey","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib6","doi-asserted-by":"crossref","first-page":"9448","DOI":"10.1073\/pnas.1201840109","article-title":"Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis","volume":"109","author":"Kisseleva","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib7","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1053\/j.gastro.2020.01.027","article-title":"Identification of lineage-specific transcription factors that prevent activation of hepatic stellate cells and promote fibrosis resolution","volume":"158","author":"Liu","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib8","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1172\/JCI66028","article-title":"Evolving therapies for liver fibrosis","volume":"123","author":"Schuppan","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib9","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.matbio.2018.04.006","article-title":"Liver fibrosis: direct antifibrotic agents and targeted therapies","volume":"68-69","author":"Schuppan","year":"2018","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib10","doi-asserted-by":"crossref","first-page":"36505","DOI":"10.1074\/jbc.274.51.36505","article-title":"Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts","volume":"274","author":"Park","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib11","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/j.1742-4658.2011.08051.x","article-title":"Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha","volume":"278","author":"Keane","year":"2011","journal-title":"FEBS J"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1074\/mcp.RA118.001046","article-title":"Identification of novel natural substrates of fibroblast activation protein-alpha by differential degradomics and proteomics","volume":"18","author":"Zhang","year":"2019","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib13","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3390\/cells10051142","article-title":"Oncogenesis, microenvironment modulation and clinical potentiality of FAP in glioblastoma: lessons learned from other solid tumors","volume":"10","author":"Shi","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib14","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.3390\/cells9092027","article-title":"Targeting cancer associated fibroblasts in liver fibrosis and liver cancer using nanocarriers","volume":"9","author":"Kaps","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1034\/j.1600-0676.2002.01503.x","article-title":"Intrahepatic expression of the hepatic stellate cell marker fibroblast activation protein correlates with the degree of fibrosis in hepatitis C virus infection","volume":"22","author":"Levy","year":"2002","journal-title":"Liver"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib16","doi-asserted-by":"crossref","first-page":"L271","DOI":"10.1152\/ajplung.00071.2019","article-title":"Loss of cells expressing fibroblast activation protein has variable effects in models of TGF-beta and chronic bleomycin-induced fibrosis","volume":"317","author":"Kimura","year":"2019","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.matbio.2017.12.003","article-title":"Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts","volume":"67","author":"Avery","year":"2018","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib18","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41467-018-02892-y","article-title":"Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis","volume":"9","author":"Mizoguchi","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib19","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1158\/0008-5472.CAN-15-2973","article-title":"FAP promotes immunosuppression by cancer-associated fibroblasts in the tumor microenvironment via STAT3-CCL2 signaling","volume":"76","author":"Yang","year":"2016","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib20","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.ajpath.2020.01.004","article-title":"Fibroblast activation protein regulates lesion burden and the fibroinflammatory response in Apoe-deficient mice in a sexually dimorphic manner","volume":"190","author":"Monslow","year":"2020","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib21","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41586-019-1263-7","article-title":"Distinct fibroblast subsets drive inflammation and damage in arthritis","volume":"570","author":"Croft","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib22","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1021\/jm500031w","article-title":"Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP)","volume":"57","author":"Jansen","year":"2014","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib23","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1053\/j.gastro.2011.01.040","article-title":"Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice","volume":"140","author":"Popov","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib25","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.2174\/156652412803833607","article-title":"Fibroblast activation protein in remodeling tissues","volume":"12","author":"Jacob","year":"2012","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib24","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/prca.201300095","article-title":"Understanding fibroblast activation protein (FAP): substrates, activities, expression and targeting for cancer therapy","volume":"8","author":"Hamson","year":"2014","journal-title":"Proteomics Clin Appl"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib26","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.3390\/cancers13051100","article-title":"Cancer-associated fibroblasts as players in cancer development and progression and their role in targeted radionuclide imaging and therapy","volume":"13","author":"Koustoulidou","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2967\/jnumed.120.244806","article-title":"The latest developments in imaging of fibroblast activation protein","volume":"62","author":"Altmann","year":"2021","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib28","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ebiom.2018.01.028","article-title":"IL-4 receptor alpha signaling through macrophages differentially regulates liver fibrosis progression and reversal","volume":"29","author":"Weng","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41575-018-0082-x","article-title":"The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"16","author":"Kazankov","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib30","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib31","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1136\/annrheumdis-2020-217408","article-title":"Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging","volume":"79","author":"Schmidkonz","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib32","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41584-019-0261-3","article-title":"Functionally distinct fibroblast subsets in RA","volume":"15","author":"McHugh","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib33","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1002\/hep.510290631","article-title":"Fibroblast activation protein: a cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis","volume":"29","author":"Levy","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib34","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.stem.2016.01.010","article-title":"Direct reprogramming of hepatic myofibroblasts into hepatocytes in\u00a0vivo attenuates liver fibrosis","volume":"18","author":"Song","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib35","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.jhep.2004.02.005","article-title":"Role of hepatic stellate cell\/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat","volume":"40","author":"Mabuchi","year":"2004","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib36","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1038\/labinvest.3780384","article-title":"Hepatic stellate cell proliferation is an early platelet-derived growth factor-mediated cellular event in rat cholestatic liver injury","volume":"81","author":"Kinnman","year":"2001","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib37","first-page":"458","article-title":"The effects of short-term application of a combination of platelet-derived and insulin-like growth factors on periodontal wound healing","volume":"62","author":"Lynch","year":"1991","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib38","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jhep.2005.06.025","article-title":"Mdr2 (Abcb4)-\/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes","volume":"43","author":"Popov","year":"2005","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib39","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.4049\/jimmunol.178.8.5288","article-title":"Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis","volume":"178","author":"Fallowfield","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib40","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1755-1536-6-18","article-title":"The role of mouse strain differences in the susceptibility to fibrosis: a systematic review","volume":"6","author":"Walkin","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib41","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/s005350070049","article-title":"Increased expression of osteopontin in activated Kupffer cells and hepatic macrophages during macrophage migration in Propionibacterium acnes-treated rat liver","volume":"35","author":"Wang","year":"2000","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib42","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1002\/hep.31582","article-title":"Osteopontin takes center stage in chronic liver disease","volume":"73","author":"Song","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib43","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jhep.2005.07.024","article-title":"Osteopontin expression in normal and fibrotic liver. altered liver healing in osteopontin-deficient mice","volume":"44","author":"Lorena","year":"2006","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib44","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1093\/cvr\/cvaa142","article-title":"Deletion of fibroblast activation protein provides atheroprotection","volume":"117","author":"Stein","year":"2021","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib45","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.molmet.2018.10.011","article-title":"Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice","volume":"19","author":"Panaro","year":"2019","journal-title":"Mol Metab"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12900-8","article-title":"Selective homogeneous assay for circulating endopeptidase fibroblast activation protein (FAP)","volume":"7","author":"Bainbridge","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib47","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.1074\/jbc.M115.710582","article-title":"Fibroblast activation protein cleaves and inactivates fibroblast growth factor 21","volume":"291","author":"Dunshee","year":"2016","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib48","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1096\/fj.14-268425","article-title":"Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice","volume":"30","author":"Liu","year":"2016","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib49","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1136\/gutjnl-2016-312473","article-title":"Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal","volume":"66","author":"Ikenaga","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib50","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100374R","article-title":"Selective depletion of hepatic stellate cells-specific LOXL1 alleviates liver fibrosis","volume":"35","author":"Yang","year":"2021","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib51","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1089\/ars.2016.6953","article-title":"Gliptins suppress inflammatory macrophage activation to mitigate inflammation, fibrosis, oxidative stress, and vascular dysfunction in models of nonalcoholic steatohepatitis and liver fibrosis","volume":"28","author":"Wang","year":"2018","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib52","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1002\/hep.30333","article-title":"Mouse models of nonalcoholic steatohepatitis: toward optimization of their relevance to human nonalcoholic steatohepatitis","volume":"69","author":"Farrell","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2022.12.005_bib53","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1007\/s12072-021-10210-w","article-title":"Hepatic stellate cells-specific LOXL1 deficiency abrogates hepatic inflammation, fibrosis, and corrects lipid metabolic abnormalities in non-obese NASH mice","volume":"15","author":"Yang","year":"2021","journal-title":"Hepatol Int"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X22002533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X22002533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:27:55Z","timestamp":1778873275000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X22002533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"alternative-id":["S2352345X22002533"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2022.12.005","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2022.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}