{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:09:45Z","timestamp":1781194185878,"version":"3.54.1"},"reference-count":77,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/j.jcmgh.2022.12.011","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T19:51:55Z","timestamp":1672084315000},"page":"869-885","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Long-term Temporal Stability of Peripheral Blood DNA Methylation Profiles in Patients With Inflammatory Bowel Disease"],"prefix":"10.1016","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-7220","authenticated-orcid":false,"given":"Vincent","family":"Joustra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Y.F.","family":"Li Yim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishtu","family":"Hageman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeni","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Satsangi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter J.","family":"de Jonge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Henneman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"D\u2019Haens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2022.12.011_bib1","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nrgastro.2017.110","article-title":"The IBD interactome: an integrated view of aetiology, pathogenesis and therapy","volume":"14","author":"de Souza","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrgastro.2015.186","article-title":"Immunopathogenesis of IBD: current state of the art","volume":"13","author":"de Souza","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76361-2","article-title":"Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study","volume":"10","author":"Carreras-Torres","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1053\/j.gastro.2013.05.050","article-title":"Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics","volume":"145","author":"Ventham","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib6","series-title":"Epigenetic Mechanisms of Gene Regulation","author":"Riggs","year":"1996"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib7","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1101\/gad.2037511","article-title":"CpG islands and the regulation of transcription","volume":"25","author":"Deaton","year":"2011","journal-title":"Genes Dev"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41575-019-0230-y","article-title":"Epigenetics of colorectal cancer: biomarker and therapeutic potential","volume":"17","author":"Jung","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib9","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/ibd\/izaa074","article-title":"CpG methylation in TGFbeta1 and IL-6 genes as surrogate biomarkers for diagnosis of IBD in children","volume":"26","author":"Samarani","year":"2020","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib10","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/art.41516","article-title":"Multiomics and machine learning accurately predict clinical response to adalimumab and etanercept therapy in patients with rheumatoid arthritis","volume":"73","author":"Tao","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib11","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000083","article-title":"Identification of epigenetic methylation signatures with clinical value in Crohn's disease","volume":"10","author":"Moret-Tatay","year":"2019","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1053\/j.gastro.2017.10.007","article-title":"DNA methylation and transcription patterns in intestinal epithelial cells from pediatric patients with inflammatory bowel diseases differentiate disease subtypes and associate with outcome","volume":"154","author":"Howell","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib13","first-page":"A24","article-title":"Epigenetic alterations at diagnosis predict susceptibility, prognosis and treatment escalation in inflammatory bowel disease-IBD character","volume":"66","author":"Kalla","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13148-016-0230-5","article-title":"Peripheral blood methylation profiling of female Crohn\u2019s disease patients","volume":"8","author":"Li Yim","year":"2016","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1053\/j.gastro.2020.08.017","article-title":"Transcription and DNA methylation patterns of blood-derived CD8(+) T cells are associated with age and inflammatory bowel disease but do not predict prognosis","volume":"160","author":"Gasparetto","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/ecco-jcc\/jjv176","article-title":"DNA methylation profiling in inflammatory bowel disease provides new insights into disease pathogenesis","volume":"10","author":"McDermott","year":"2016","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13507","article-title":"IBD BIOM consortium; IBD CHARACTER consortium. Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease","volume":"7","author":"Ventham","year":"2016","journal-title":"Nat Comm"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib18","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1097\/MIB.0000000000000179","article-title":"Two-stage genome-wide methylation profiling in childhood-onset Crohn\u02bcs disease implicates epigenetic alterations at the VMP1\/MIR21 and HLA Loci","volume":"20","author":"Adams","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib19","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1002\/ibd.22956","article-title":"Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases","volume":"18","author":"Harris","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib20","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1101\/gr.138347.112","article-title":"A\u00a0functional methylome map of ulcerative colitis","volume":"22","author":"Hasler","year":"2012","journal-title":"Genome Res"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib21","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1053\/j.gastro.2019.01.270","article-title":"Blood-derived DNA methylation signatures of Crohn disease and severity of intestinal inflammation","volume":"156","author":"Somineni","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12967-018-1751-9","article-title":"Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes","volume":"17","author":"Perez","year":"2019","journal-title":"J\u00a0Transl Med"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib23","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2217\/epi.12.37","article-title":"Sensitive periods in epigenetics: bringing us closer to complex behavioral phenotypes","volume":"4","author":"Nagy","year":"2012","journal-title":"Epigenomics"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13059-020-02223-9","article-title":"Equivalent DNA methylation variation between monozygotic co-twins and unrelated individuals reveals universal epigenetic inter-individual dissimilarity","volume":"22","author":"Planterose Jimenez","year":"2021","journal-title":"Genome Biol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib25","doi-asserted-by":"crossref","first-page":"10604","DOI":"10.1073\/pnas.0500398102","article-title":"Epigenetic differences arise during the lifetime of monozygotic twins","volume":"102","author":"Fraga","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib26","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fgene.2020.00171","article-title":"DNA methylation biomarkers in aging and age-related diseases","volume":"11","author":"Salameh","year":"2020","journal-title":"Front Genet"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12979-021-00223-2","article-title":"Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children","volume":"18","author":"Dobbs","year":"2021","journal-title":"Immun Ageing"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib28","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s11357-012-9463-1","article-title":"Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring","volume":"35","author":"Gentilini","year":"2013","journal-title":"Age (Dordr)"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1196\/annals.1395.005","article-title":"Cross-talk between aging and cancer: the epigenetic language","volume":"1100","author":"Fraga","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib30","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1089\/rej.2012.1324","article-title":"The role of DNA methylation in aging, rejuvenation, and age-related disease","volume":"15","author":"Johnson","year":"2012","journal-title":"Rejuvenation Res"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12859-015-0527-y","article-title":"Cell-composition effects in the analysis of DNA methylation array data: a mathematical perspective","volume":"16","author":"Houseman","year":"2015","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib32","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40364-019-0161-3","article-title":"Longitudinal study of leukocyte DNA methylation and biomarkers for cancer risk in older adults","volume":"7","author":"Bartlett","year":"2019","journal-title":"Biomark Res"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib33","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/bioinformatics\/btv560","article-title":"missMethyl: an R package for analyzing data from Illumina\u2019s HumanMethylation450 platform","volume":"32","author":"Phipson","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib34","doi-asserted-by":"crossref","first-page":"5366","DOI":"10.1038\/ncomms6366","article-title":"Age-related variations in the methylome associated with gene expression in human monocytes and T cells","volume":"5","author":"Reynolds","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib35","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1474-9726.2012.00851.x","article-title":"Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function","volume":"11","author":"Hearps","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib36","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1158\/1055-9965.EPI-14-0767","article-title":"Temporal stability and determinants of white blood cell DNA methylation in the breakthrough generations study","volume":"24","author":"Flanagan","year":"2015","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib37","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1080\/15592294.2018.1530008","article-title":"Variation in DNA methylation of human blood over a 1-year period using the Illumina MethylationEPIC array","volume":"13","author":"Zaimi","year":"2018","journal-title":"Epigenetics"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/15592294.2017.1411443","article-title":"Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time","volume":"13","author":"Forest","year":"2018","journal-title":"Epigenetics"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib39","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1158\/1055-9965.EPI-14-0853","article-title":"Intraindividual variation and short-term temporal trend in DNA methylation of human blood","volume":"24","author":"Shvetsov","year":"2015","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib40","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.143654","article-title":"A\u00a0longitudinal and transancestral analysis of DNA methylation patterns and disease activity in lupus patients","volume":"5","author":"Coit","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib41","article-title":"Epigenetic therapies in the precision medicine era","volume":"3","author":"Leite","year":"2020","journal-title":"Advanced Therapeutics"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib42","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib43","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.molcel.2012.10.016","article-title":"Genome-wide methylation profiles reveal quantitative views of human aging rates","volume":"49","author":"Hannum","year":"2013","journal-title":"Mol Cell"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib44","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib45","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13059-016-1068-z","article-title":"An epigenetic clock for gestational age at birth based on blood methylation data","volume":"17","author":"Knight","year":"2016","journal-title":"Genome Biol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib46","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1186\/s12864-015-2202-0","article-title":"Impact of SNPs on methylation readouts by Illumina Infinium HumanMethylation450 BeadChip Array: implications for comparative population studies","volume":"16","author":"Daca-Roszak","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib77","first-page":"155","article-title":"A\u00a0guideline of selecting and reporting intraclass correlation coefficients for reliability research","volume":"15","author":"Koo","year":"2016","journal-title":"J\u00a0Chiropr Med"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib47","article-title":"Systematic review and meta-analysis of peripheral blood DNA methylation studies in inflammatory bowel disease","author":"Joustra","year":"2022","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib48","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1038\/s41467-018-04365-8","article-title":"IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes","volume":"9","author":"Momozawa","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib49","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1093\/hmg\/ddi379","article-title":"Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn\u2019s disease","volume":"14","author":"Yamazaki","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib50","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/apt.15485","article-title":"Review article: the genetics of the human leucocyte antigen region in inflammatory bowel disease","volume":"50","author":"Ashton","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib51","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ng.3176","volume":"47","author":"Goyette","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib52","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1001","article-title":"Genome-wide association studies in Crohn's disease: past, present and future","volume":"7","author":"Verstockt","year":"2018","journal-title":"Clin Transl Immunology"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib53","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1053\/j.gastro.2019.09.041","article-title":"HLA-DQA1\u221705 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn\u2019s disease","volume":"158","author":"Sazonovs","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib54","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13072-016-0107-z","article-title":"Gap hunting\u201d to characterize clustered probe signals in Illumina methylation array data","volume":"9","author":"Andrews","year":"2016","journal-title":"Epigenetics & Chromatin"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib55","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13059-021-02347-6","article-title":"Genetic impacts on DNA methylation: research findings and future perspectives","volume":"22","author":"Villicana","year":"2021","journal-title":"Genome Biology"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib56","article-title":"Patterns of reliability: assessing the reproducibility and integrity of DNA methylation measurement","volume":"1","author":"Sugden","year":"2020","journal-title":"Patterns (N Y)"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib57","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1471-2172-11-61","article-title":"Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease","volume":"11","author":"Bogaert","year":"2010","journal-title":"BMC Immunol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/756290","article-title":"Peripheral blood based discrimination of ulcerative colitis and Crohn\u2019s disease from non-IBD colitis by genome-wide gene expression profiling","volume":"30","author":"Sipos","year":"2011","journal-title":"Dis Markers"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib59","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1002\/ibd.22942","article-title":"Mucosal genome-wide methylation changes in inflammatory bowel disease","volume":"18","author":"Cooke","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib60","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/ibd.21912","article-title":"Genome-wide methylation profiling in Crohn\u02bcs disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway","volume":"18","author":"Nimmo","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib61","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1080\/15592294.2020.1748916","article-title":"The DNA methylome of inflammatory bowel disease (IBD) reflects intrinsic and extrinsic factors in intestinal mucosal cells","volume":"15","author":"Agliata","year":"2020","journal-title":"Epigenetics"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib62","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.3748\/wjg.v12.i23.3628","article-title":"Genetics of inflammatory bowel disease: the role of the HLA complex","volume":"12","author":"Ahmad","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib63","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1001\/jamadermatol.2019.0098","article-title":"Association of HLA-C\u221706:02 status with differential response to ustekinumab in patients with psoriasis: a systematic review and meta-analysis","volume":"155","author":"van Vugt","year":"2019","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib64","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/j.jaci.2018.11.038","article-title":"HLA-C\u221706:02 genotype is a predictive biomarker of biologic treatment response in psoriasis","volume":"143","author":"Dand","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib65","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s13075-021-02612-w","article-title":"Impact of the HLA-DRB1 shared epitope on responses to treatment with tofacitinib or abatacept in patients with rheumatoid arthritis","volume":"23","author":"Hirose","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib66","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaut.2017.11.008","article-title":"Allele-specific methylation of type 1 diabetes susceptibility genes","volume":"89","author":"Kindt","year":"2018","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib67","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/ecco-jcc\/jjw169","article-title":"European evidence-based consensus on the diagnosis and management of Crohn\u2019s disease 2016: part 2: surgical management and special situations","volume":"11","author":"Gionchetti","year":"2017","journal-title":"J\u00a0Crohns Colitis"},{"issue":"Suppl 3","key":"10.1016\/j.jcmgh.2022.12.011_bib68","doi-asserted-by":"crossref","first-page":"s1","DOI":"10.1136\/gutjnl-2019-318484","article-title":"British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults","volume":"68","author":"Lamb","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib69","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib70","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s13059-014-0503-2","article-title":"Functional normalization of 450k methylation array data improves replication in large cancer studies","volume":"15","author":"Fortin","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib71","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib72","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib73","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13059-018-1448-7","article-title":"An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray","volume":"19","author":"Salas","year":"2018","journal-title":"Genome Biol"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib74","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib75","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1037\/0033-2909.86.2.420","article-title":"Intraclass correlations: uses in assessing rater reliability","volume":"86","author":"Shrout","year":"1979","journal-title":"Psychol Bull"},{"key":"10.1016\/j.jcmgh.2022.12.011_bib76","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s13059-021-02388-x","article-title":"Gene set enrichment analysis for genome-wide DNA methylation data","volume":"22","author":"Maksimovic","year":"2021","journal-title":"Genome Biol"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X22002624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X22002624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:34:15Z","timestamp":1762454055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X22002624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"alternative-id":["S2352345X22002624"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2022.12.011","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term Temporal Stability of Peripheral Blood DNA Methylation Profiles in Patients With Inflammatory Bowel Disease","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2022.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}