{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:29:58Z","timestamp":1791574198933,"version":"4.3.4"},"reference-count":90,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":166,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007185","name":"University of California, Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OT2OD24899"],"award-info":[{"award-number":["OT2OD24899"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/j.jcmgh.2023.06.010","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T20:46:36Z","timestamp":1687466796000},"page":"573-605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Types of Neurons in the Human Colonic Myenteric Plexus Identified by Multilayer Immunohistochemical Coding"],"prefix":"10.1016","volume":"16","author":[{"given":"Bao Nan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Humenick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Ping","family":"Yew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochelle A.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Wiklendt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil G.","family":"Dinning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick J.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wattchow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5635-0876","authenticated-orcid":false,"given":"Simon J.H.","family":"Brookes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2023.06.010_bib1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.cell.2014.04.050","article-title":"Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility","volume":"158","author":"Muller","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nrgastro.2012.32","article-title":"The enteric nervous system and neurogastroenterology","volume":"9","author":"Furness","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib3","series-title":"Physiology of the Gastrointestinal Tract","first-page":"557","article-title":"Enteric nervous systems structure and neurochemistry related to function and neuropathology","author":"Poole","year":"2012"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib4","series-title":"Physiology of the Gastrointestinal Tract","article-title":"Integrative functions of the enteric nervous system","author":"Wood","year":"2012"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib5","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1056\/NEJM194910132411501","article-title":"Hirschsprung\u2019s disease: a new concept of the etiology","volume":"241","author":"Swenson","year":"1949","journal-title":"N\u00a0Eng J Med"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib6","first-page":"130","article-title":"\u00dcber den Bau der Ganglien in den Geflechten des Darmes und der Gallenblase des Menschen und der S\u00e4ugethiere","volume":"1899","author":"Dogiel","year":"1899","journal-title":"Arch Anat Physiol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib7","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/nrn1769","article-title":"Opinion: an integrated approach to classifying neuronal phenotypes","volume":"6","author":"Migliore","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib8","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/0306-4522(96)00275-8","article-title":"Neurochemical classification of myenteric neurons in the guinea-pig ileum","volume":"75","author":"Costa","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib9","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.cell.2020.08.003","article-title":"The human and mouse enteric nervous system at single-cell resolution","volume":"182","author":"Drokhlyansky","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib10","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1365-2982.2006.00843.x","article-title":"Quantification of subclasses of human colonic myenteric neurons by immunoreactivity to Hu, choline acetyltransferase and nitric oxide synthase","volume":"19","author":"Murphy","year":"2007","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib11","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1369\/0022155414536732","article-title":"Elution of high-affinity (>10\u20139 KD) antibodies from tissue sections: clues to the molecular mechanism and use in sequential immunostaining","volume":"62","author":"Gendusa","year":"2014","journal-title":"J\u00a0Histochem Cytochem"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib12","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/nmo.12371","article-title":"Distinct subcellular localization of the neuronal marker HuCD reveals hypoxia-induced damage in enteric neurons","volume":"26","author":"Desmet","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.proghi.2009.10.001","article-title":"Cholinergic neurotransmission and muscarinic receptors in the enteric nervous system","volume":"44","author":"Harrington","year":"2010","journal-title":"Prog Histochem Cytochem"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib14","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/bph.14459","article-title":"Nitric oxide and its role as a non-adrenergic, non-cholinergic inhibitory neurotransmitter in the gastrointestinal tract","volume":"176","author":"Sanders","year":"2019","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1743-3150.2004.00478.x","article-title":"Pharmacology and function of nicotinic acetylcholine and P2X receptors in the enteric nervous system","volume":"16","author":"Galligan","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib16","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1111\/nmo.12408","article-title":"Quantification of in\u00a0vivo colonic motor patterns in healthy humans before and after a meal revealed by high-resolution fiber-optic manometry","volume":"26","author":"Dinning","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00441-009-0852-4","article-title":"ChAT and NOS in human myenteric neurons: co-existence and co-absence","volume":"338","author":"Beck","year":"2009","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13193","article-title":"Quantification and neurochemical coding of the myenteric plexus in humans: No regional variation between the distal colon and rectum","volume":"30","author":"Ng","year":"2018","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib19","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/cne.10599","article-title":"Chemical coding of the human gastrointestinal nervous system: cholinergic, VIPergic, and catecholaminergic phenotypes","volume":"459","author":"Anlauf","year":"2003","journal-title":"J\u00a0Compr Neurol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0306-4522(82)90272-X","article-title":"Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: their visualization and reactions to drug treatment","volume":"7","author":"Costa","year":"1982","journal-title":"Neuroscience"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib21","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s004410051007","article-title":"The projections of 5-hydroxytryptamine-accumulating neurones in the myenteric plexus of the small intestine of the guinea-pig","volume":"291","author":"Meedeniya","year":"1998","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.autneu.2004.03.005","article-title":"Immunohistochemical characterization of putative primary afferent (sensory) myenteric neurons in human small intestine","volume":"112","author":"Brehmer","year":"2004","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0306-4522(82)90271-8","article-title":"Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: their projections in the guinea-pig small intestine","volume":"7","author":"Furness","year":"1982","journal-title":"Neuroscience"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib24","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/nmo.12302","article-title":"Extensive projections of myenteric serotonergic neurons suggest they comprise the central processing unit in the colon","volume":"26","author":"Okamoto","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib25","first-page":"209","article-title":"Projections of chemically identified myenteric neurons of the small and large intestine of the mouse","volume":"190","author":"Sang","year":"1997","journal-title":"J\u00a0Anat"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF01454008","article-title":"Projections of neurochemically specified neurons in the porcine colon","volume":"103","author":"Barbiers","year":"1995","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13964","article-title":"Characterization of putative interneurons in the myenteric plexus of human colon","volume":"33","author":"Humenick","year":"2021","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib28","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13685","article-title":"Characterisation of projections of longitudinal muscle motor neurons in human colon","volume":"31","author":"Humenick","year":"2019","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib29","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/S0016-5085(97)70011-8","article-title":"The neurochemical coding and projections of circular muscle motor neurons in the human colon","volume":"113","author":"Porter","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/gut.51.1.70","article-title":"Cholinergic and nitrergic interneurones in the myenteric plexus of the human colon","volume":"51","author":"Porter","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib31","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/0016-5085(95)90396-8","article-title":"The morphology and projections of retrogradely labeled myenteric neurons in the human intestine","volume":"109","author":"Wattchow","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib32","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1053\/gast.1997.v113.pm9247469","article-title":"The polarity of neurochemically defined myenteric neurons in the human colon","volume":"113","author":"Wattchow","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0016-5085(88)90287-9","article-title":"Distribution and coexistence of peptides in nerve fibers of the external muscle of the human gastrointestinal tract","volume":"95","author":"Wattchow","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0891-0618(96)00189-5","article-title":"Appositions made by axons of descending interneurons in the guinea-pig small intestine, investigated by confocal microscopy","volume":"12","author":"Mann","year":"1997","journal-title":"J\u00a0Chem Neuroanat"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib35","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/BF00318359","article-title":"Sources of inputs to longitudinal muscle motor neurons and ascending interneurons in the guinea-pig small intestine","volume":"280","author":"Pompolo","year":"1995","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/cne.903560107","article-title":"Ultrastructural examination of the targets of serotonin-immunoreactive descending interneurons in the guinea pig small intestine","volume":"356","author":"Young","year":"1995","journal-title":"J\u00a0Compr Neurol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib37","unstructured":"Brehmer A. Structure of Enteric Neurons. Advances in Anatomy, Embryology, and Cell Biology. Vol. 186. Berlin, Germany: Springer-Verlag;\u00a02006."},{"key":"10.1016\/j.jcmgh.2023.06.010_bib38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00418-021-02002-y","article-title":"Classification of human enteric neurons","volume":"156","author":"Brehmer","year":"2021","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib39","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41593-020-00736-x","article-title":"Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing","volume":"24","author":"Morarach","year":"2021","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib40","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1177\/002215540004800509","article-title":"Seven-color fluorescence imaging of tissue samples based on Fourier spectroscopy and singular value decomposition","volume":"48","author":"Tsurui","year":"2000","journal-title":"J\u00a0Histochem Cytochem"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib41","doi-asserted-by":"crossref","first-page":"11982","DOI":"10.1073\/pnas.1300136110","article-title":"Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue","volume":"110","author":"Gerdes","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib42","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1038\/nprot.2007.320","article-title":"Fluorescence detection of protein clusters in individual cells and tissue sections by using toponome imaging system: sample preparation and measuring procedures","volume":"2","author":"Friedenberger","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib43","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/his.12446","article-title":"Sequential immunohistochemistry: a promising new tool for the pathology laboratory","volume":"65","author":"van den Brand","year":"2014","journal-title":"Histopathology"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib44","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0079-6123(08)60241-1","article-title":"Chemical coding of enteric neurons","volume":"68","author":"Costa","year":"1986","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib45","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.pa.29.040189.001445","article-title":"Chemical coding of neurons and plurichemical transmission","volume":"29","author":"Furness","year":"1989","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib46","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/cne.903530202","article-title":"Neurochemical coding of enteric neurons in the guinea pig stomach","volume":"353","author":"Schemann","year":"1995","journal-title":"J\u00a0Compr Neurol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s004410000260","article-title":"Neurochemical classification of enteric neurons in the guinea-pig distal colon","volume":"302","author":"Lomax","year":"2000","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib48","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00441-008-0684-7","article-title":"Immunohistochemical analysis of neuron types in the mouse small intestine","volume":"334","author":"Qu","year":"2008","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib49","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1053\/j.gastro.2020.09.032","article-title":"Combinatorial transcriptional profiling of mouse and human enteric neurons identifies shared and disparate subtypes in situ","volume":"160","author":"May-Zhang","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib50","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1093\/bib\/bbz063","article-title":"Machine learning and statistical methods for clustering single-cell RNA-sequencing data","volume":"21","author":"Petegrosso","year":"2020","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib51","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41576-018-0088-9","article-title":"Challenges in unsupervised clustering of single-cell RNA-seq data","volume":"20","author":"Kiselev","year":"2019","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-14395-4","article-title":"Principal component analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated","volume":"12","author":"Elhaik","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib53","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.neuron.2020.04.018","article-title":"Extraction of distinct neuronal cell types from within a genetically continuous population","volume":"107","author":"Kim","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib54","first-page":"5","article-title":"Molecular profiling of single neurons of known identity in 2 ganglia from the crab Cancer borealis","volume":"5","author":"Northcutt","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib55","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib56","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41586-021-03950-0","article-title":"A\u00a0multimodal cell census and atlas of the mammalian primary motor cortex","volume":"598","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2982.2001.00235.x","article-title":"Retrograde tracing of enteric neuronal pathways","volume":"13","author":"Brookes","year":"2001","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib58","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00418-007-0335-1","article-title":"Quantitative estimation of putative primary afferent neurons in the myenteric plexus of human small intestine","volume":"128","author":"Weidmann","year":"2007","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib59","series-title":"Innervation of the Gastrointestinal Tract","article-title":"Cellular organisation of the mammalian enteric nervous system","year":"2002"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib60","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/164_2016_121","article-title":"Sex-related differences in GI disorders","volume":"239","author":"Prusator","year":"2017","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib61","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/ijms20051024","article-title":"Age and sex-dependent differences in the neurochemical characterization of calcitonin gene-related peptide-like immunoreactive (CGRP-LI) nervous structures in the porcine descending colon","volume":"20","author":"Makowska","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib62","article-title":"Nitric oxide regulates estrus cycle dependent colonic motility in mice","volume":"15","author":"Balasuriya","year":"2021","journal-title":"Fronti Neurosci"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib63","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2982.2008.01245.x","article-title":"Effect of age on the enteric nervous system of the human colon","volume":"21","author":"Bernard","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib64","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000213852","article-title":"A\u00a0preliminary investigation of the effects of aging on the nerve cell number in the myenteric ganglia of the human colon","volume":"43","author":"Gomes","year":"1997","journal-title":"Gerontology"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib65","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.autneu.2004.05.007","article-title":"Age-related changes in the morphology of the myenteric plexus of the human colon","volume":"113","author":"Hanani","year":"2004","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib66","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14440","article-title":"How big is the little brain in the gut? Neuronal numbers in the enteric nervous system of mice, Guinea pig, and human","volume":"34","author":"Michel","year":"2022","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib67","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fnagi.2014.00276","article-title":"Age-related gene expression analysis in enteric ganglia of human colon after laser microdissection","volume":"6","author":"Hetz","year":"2014","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib68","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2018-316279","article-title":"Changes in neuromuscular structure and functions of human colon during ageing are region-dependent","volume":"68","author":"Broad","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib69","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14538","article-title":"Electrophysiological and morphological features of myenteric neurons of human colon revealed by intracellular recording and dye fills","volume":"35","author":"Yew","year":"2023","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib70","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/336123a0","article-title":"Trophic regulation of nerve cell morphology and innervation in the autonomic nervous system","volume":"336","author":"Purves","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib71","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1152\/jn.1944.7.3.163","article-title":"Reflex inhibition of intestinal motility mediated through decentralized prevertebral ganglia","volume":"7","author":"Kuntz","year":"1944","journal-title":"J\u00a0Neurophysiol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib72","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1126\/science.abd6176","article-title":"Microbiota-modulated CART+ enteric neurons autonomously regulate blood glucose","volume":"370","author":"Muller","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib73","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1016\/j.cell.2022.05.007","article-title":"An inter-organ neural circuit for appetite suppression","volume":"185","author":"Zhang","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib74","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00418-013-1163-0","article-title":"What neurons hide behind calretinin immunoreactivity in the human gut?","volume":"141","author":"Beuscher","year":"2014","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib75","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1046\/j.1471-4159.2001.00032.x","article-title":"Morphological and neurochemical identification of enteric neurones with mucosal projections in the human small intestine","volume":"76","author":"Hens","year":"2001","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s004410050001","article-title":"Inputs from intrinsic primary afferent neurons to nitric oxide synthase-immunoreactive neurons in the myenteric plexus of guinea pig ileum","volume":"299","author":"Li","year":"2000","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib77","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1523\/JNEUROSCI.09-01-00167.1989","article-title":"Ultrastructural analysis of substance P-immunoreactive nerve fibers in myenteric ganglia of guinea pig small intestine","volume":"9","author":"Llewellyn Smith","year":"1989","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib78","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0016-5085(89)91619-3","article-title":"Human myenteric plexus: confirmation of unfamiliar structures in adults and neonates","volume":"96","author":"Kumar","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib79","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1113\/jphysiol.1900.sp000825","article-title":"The movements and the innervation of the large intestine","volume":"26","author":"Bayliss","year":"1900","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib80","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/nmo.12129","article-title":"Ascending excitatory neural pathways modulate slow phasic myogenic contractions in the isolated human colon","volume":"25","author":"Carbone","year":"2013","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib81","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.863662","article-title":"Brookes SJH Sympathetic pathways target cholinergic neurons in the human myenteric plexus","volume":"16","author":"Parker","year":"2022","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib82","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pneurobio.2003.12.004","article-title":"Intrinsic primary afferent neurons and nerve circuits within the intestine","volume":"72","author":"Furness","year":"2004","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib83","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/cne.903140303","article-title":"Ramifications of the axons of AH-neurons injected with the intracellular marker biocytin in the myenteric plexus of the guinea pig small intestine","volume":"314","author":"Bornstein","year":"1991","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib84","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0306-4522(93)90434-H","article-title":"Simultaneous intracellular recordings from enteric neurons reveal that myenteric AH neurons transmit via slow excitatory postsynaptic potentials","volume":"55","author":"Kunze","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib85","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0306-4522(91)90119-9","article-title":"Immunohistochemical identification of cholinergic neurons in the myenteric plexus of guinea-pig small intestine","volume":"45","author":"Steele","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib86","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0304-3940(91)90484-B","article-title":"Identification of myenteric neurons which project to the mucosa of the guinea-pig small intestine","volume":"129","author":"Song","year":"1991","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib87","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1523\/JNEUROSCI.15-05-04013.1995","article-title":"Long aboral projections of Dogiel type II, AH neurons within the myenteric plexus of the guinea pig small intestine","volume":"15","author":"Brookes","year":"1995","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib88","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/cne.24594","article-title":"Distribution, projections, and association with calbindin baskets of motor neurons, interneurons, and sensory neurons in guinea-pig distal colon","volume":"527","author":"Smolilo","year":"2019","journal-title":"J\u00a0Compr Neurol"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib89","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/0306-4522(91)90050-X","article-title":"Identification and immunohistochemistry of cholinergic and non-cholinergic circular muscle motor neurons in the guinea-pig small intestine","volume":"42","author":"Brookes","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.jcmgh.2023.06.010_bib90","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1053\/gast.2001.22526","article-title":"Tachykinin-dependent and -independent components of peristalsis in the guinea pig isolated distal colon","volume":"120","author":"Tonini","year":"2001","journal-title":"Gastroenterology"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X23001248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X23001248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:33:30Z","timestamp":1762454010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X23001248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":90,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"alternative-id":["S2352345X23001248"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2023.06.010","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742692585.793601210","asserted-by":"object"}]},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Types of Neurons in the Human Colonic Myenteric Plexus Identified by Multilayer Immunohistochemical Coding","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2023.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}