{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:41:28Z","timestamp":1791222088840,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.jcmgh.2023.10.002","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T11:19:29Z","timestamp":1697282369000},"page":"279-291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["GPAT1 Deficiency in Mice Modulates NASH Progression in a Model-Dependent Manner"],"prefix":"10.1016","volume":"17","author":[{"given":"Kathleen R.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa R.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Boucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Reynold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie A.","family":"Daurio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Hirenallur-Shanthappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngwook","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Beebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trenton T.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra K.","family":"Bence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7234-4070","authenticated-orcid":false,"given":"Min","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2023.10.002_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101143","article-title":"Metabolic drivers of non-alcoholic fatty liver disease","volume":"50","author":"Bence","year":"2021","journal-title":"Mol Metab"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.4254\/wjh.v9.i11.533","article-title":"Hepatocellular carcinoma in non-alcoholic steatohepatitis: current knowledge and implications for management","volume":"9","author":"Cholankeril","year":"2017","journal-title":"World J Hepatol"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib3","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1053\/j.gastro.2017.01.003","article-title":"Changes in the prevalence of hepatitis C virus infection, nonalcoholic steatohepatitis, and alcoholic liver disease among patients with cirrhosis or liver failure on the waitlist for liver\u00a0transplantation","volume":"152","author":"Goldberg","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jhep.2017.09.021","article-title":"Hypertension, diabetes, atherosclerosis and NASH: cause or consequence?","volume":"68","author":"Lonardo","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/13543784.2022.2032640","article-title":"Nonalcoholic steatohepatitis (NASH) cirrhosis: a snapshot of therapeutic agents in clinical development and the optimal design for clinical trials","volume":"31","author":"Aggarwal","year":"2022","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.777075","article-title":"Human genetics to identify therapeutic targets for NAFLD: challenges and opportunities","volume":"12","author":"Du","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib7","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1002\/hep.32038","article-title":"Genetic variation in the mitochondrial glycerol-3-phosphate acyltransferase is associated with liver injury","volume":"74","author":"Hakim","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib8","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1038\/s41588-022-01199-5","article-title":"Multiomics study of nonalcoholic fatty liver disease","volume":"54","author":"Sveinbjornsson","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41588-023-01497-6","article-title":"Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease","author":"Chen","year":"2023","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib10","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1053\/j.gastro.2020.12.023","article-title":"Exome-wide association study on alanine aminotransferase identifies sequence variants in the GPAM and APOE associated with fatty liver disease","volume":"160","author":"Jamialahmadi","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib11","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41588-022-01078-z","article-title":"A\u00a0multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation","volume":"54","author":"Vujkovic","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbalip.2016.06.023","article-title":"Mitochondrial acyltransferases and glycerophospholipid metabolism","volume":"1862","author":"Gonzalez-Baro","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41594-022-00884-7","article-title":"Structural basis of the acyl-transfer mechanism of human GPAT1","volume":"30","author":"Johnson","year":"2023","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0163-7827(03)00051-1","article-title":"Enzymes of triacylglycerol synthesis and their regulation","volume":"43","author":"Coleman","year":"2004","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib15","doi-asserted-by":"crossref","first-page":"25629","DOI":"10.1074\/jbc.M503181200","article-title":"Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs","volume":"280","author":"Hammond","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cmet.2005.06.006","article-title":"Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice","volume":"2","author":"Neschen","year":"2005","journal-title":"Cell Metab"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib17","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1096\/fj.05-4568com","article-title":"Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation","volume":"20","author":"Linden","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib18","doi-asserted-by":"crossref","first-page":"14807","DOI":"10.1074\/jbc.M611550200","article-title":"Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance","volume":"282","author":"Nagle","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bbrc.2006.08.071","article-title":"Hepatic knockdown of mitochondrial GPAT1 in ob\/ob mice improves metabolic profile","volume":"349","author":"Xu","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib20","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.2337\/db09-1380","article-title":"Glycerol-3-phosphate acyltransferase 1 deficiency in ob\/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity","volume":"59","author":"Wendel","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib21","doi-asserted-by":"crossref","first-page":"18465","DOI":"10.1021\/acsomega.0c02350","article-title":"Glycerol-3-phosphate acyltransferase1 is a model-agnostic node in nonalcoholic fatty liver disease: implications for drug development and precision medicine","volume":"5","author":"Liao","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib22","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1128\/MCB.22.23.8204-8214.2002","article-title":"Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition","volume":"22","author":"Hammond","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib23","doi-asserted-by":"crossref","first-page":"27209","DOI":"10.1016\/S0021-9258(18)46970-0","article-title":"Purification and characterization of glycerophosphate acyltransferase from rat liver mitochondria","volume":"269","author":"Vancura","year":"1994","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib24","doi-asserted-by":"crossref","first-page":"E1176","DOI":"10.1152\/ajpendo.00666.2013","article-title":"Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity","volume":"306","author":"Cao","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib25","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jcmgh.2020.06.001","article-title":"Acetyl-CoA carboxylase inhibition improves multiple dimensions of NASH pathogenesis in model systems","volume":"10","author":"Ross","year":"2020","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib26","article-title":"Application of ultrasound and shear wave elastography imaging in a rat model of NAFLD\/NASH","author":"Morin","year":"2021","journal-title":"J\u00a0Vis Exp"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib27","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/lt.24412","article-title":"Relevance of activated hepatic stellate cells in predicting the development of pediatric liver allograft fibrosis","volume":"22","author":"Venturi","year":"2016","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib28","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12876-020-01356-2","article-title":"Human translatability of\u00a0the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis","volume":"20","author":"Hansen","year":"2020","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib29","doi-asserted-by":"crossref","first-page":"C1543","DOI":"10.1152\/ajpcell.00371.2007","article-title":"Glycerol-3-phosphate acyltransferase-1 regulates murine T-lymphocyte proliferation and cytokine production","volume":"295","author":"Collison","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10","article-title":"Tumor necrosis factor-alpha signaling in macrophages","volume":"20","author":"Parameswaran","year":"2010","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib31","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.cmet.2017.08.011","article-title":"Acetyl CoA carboxylase inhibition reduces hepatic steatosis but elevates plasma triglycerides in mice and humans: a bedside to bench investigation","volume":"26","author":"Kim","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib32","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.bbalip.2008.05.001","article-title":"Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation during lipogenic diet and altered phospholipid fatty acid composition","volume":"1781","author":"Lewin","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001547","article-title":"Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation","volume":"20","author":"Richardson","year":"2022","journal-title":"PLoS Biol"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib34","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev-pathol-050420-025929","article-title":"Lysophospholipid mediators in health and disease","volume":"17","author":"Kano","year":"2022","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib35","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/bph.14118","article-title":"Characterization of the properties of a selective, orally bioavailable autotaxin inhibitor in preclinical models of advanced stages of liver fibrosis","volume":"175","author":"Baader","year":"2018","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jcmgh.2023.10.002_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/cas.15835","article-title":"GPAM mediated lysophosphatidic acid synthesis regulates mitochondrial dynamics in acute myeloid leukemia","author":"Irifune","year":"2023","journal-title":"Cancer Sci"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X23001819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X23001819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:34:47Z","timestamp":1762454087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X23001819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"alternative-id":["S2352345X23001819"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2023.10.002","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GPAT1 Deficiency in Mice Modulates NASH Progression in a Model-Dependent Manner","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2023.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}