{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:15:48Z","timestamp":1762460148729,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK102597"],"award-info":[{"award-number":["R01DK102597"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007172","name":"Cincinnati Children's Hospital Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.jcmgh.2023.11.006","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T14:19:39Z","timestamp":1699971579000},"page":"347-360","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic Ablation of C\/EBP\u03b1-p300 Pathway Blocks Development of Obese Pregnancy Associated Liver Disorders in Offspring"],"prefix":"10.1016","volume":"17","author":[{"given":"Margaret A.","family":"Hanlon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruhi","family":"Gulati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmeen","family":"Fleifil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolai A.","family":"Timchenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2023.11.006_bib1","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/hep.31533","article-title":"Tackling nonalcoholic fatty liver disease: three targeted populations","volume":"73","author":"Wegermann","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib2","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/1471-0528.16199","article-title":"Overweight and obesity status from the prenatal period to adolescence and its association with no alcoholic fatty liver disease in young adults: cohort study","volume":"127","author":"Cantoral","year":"2020","journal-title":"BJOG"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib3","first-page":"72","article-title":"The role of genetic predisposition, programing during fetal life, family conditions, and post-natal diet in the development of pediatric fatty liver disease","author":"Mosca","year":"2019","journal-title":"Pediatrics"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib4","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/hep.31483","article-title":"Prenatal exposure to perfluoroalkyl substances associated with increased susceptibility to liver injury in children","volume":"72","author":"Stratakis","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib5","article-title":"Review of the increasing prevalence of metabolic-associated fatty liver disease (MAFLD) in children and adolescents worldwide and in Mexico and the implications for public health","volume":"27","author":"Ram\u00edrez Mej\u00eda","year":"2021","journal-title":"N\u00a0Med Sci Monit"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12887-016-0726-3","article-title":"Non-alcoholic fatty liver disease (Nafld) in obese children: effect of refined carbohydrates in diet","volume":"16","author":"F\u00e9lix","year":"2016","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib7","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1172\/JCI127502","article-title":"Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice","volume":"130","author":"De Jesus","year":"2020","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1017\/S2040174420000239","article-title":"Excessive early-life cholesterol exposure may have later-life consequences for nonalcoholic fatty liver disease","volume":"12","author":"Dumolt","year":"2021","journal-title":"J\u00a0Dev Orig Health Dis"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib9","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180050","article-title":"Maternal obesity increases the risk of metabolic disease and impacts renal health in offspring","volume":"38","author":"Glastras","year":"2018","journal-title":"Biosci Rep"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib10","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.3390\/nu13114063","article-title":"Early-life exposure to famine and risk of metabolic associated fatty liver disease in Chinese adults","volume":"13","author":"Liu","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib11","doi-asserted-by":"crossref","first-page":"R26","DOI":"10.1152\/ajpregu.00049.2014","article-title":"Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity","volume":"307","author":"Alfaradhi","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib12","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1002\/hep.23205","article-title":"Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression","volume":"50","author":"Bruce","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3727\/105221616X692135","article-title":"Enhanced steatosis and fibrosis in liver of adult offspring exposed to maternal high-fat diet","volume":"17","author":"Thompson","year":"2016","journal-title":"Gene Expr"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib14","doi-asserted-by":"crossref","first-page":"E674","DOI":"10.1152\/ajpendo.00474.2018","article-title":"Transgenerational impact of maternal obesogenic diet on offspring bile acid homeostasis and nonalcoholic fatty liver disease","volume":"316","author":"Thompson","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib15","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.1038\/onc.2017.151","article-title":"A\u00a0tumor suppressor role for C\/EBPalpha in solid tumors: more than fat and blood","volume":"36","author":"Louren\u00e7o","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib16","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.celrep.2016.06.019","article-title":"Activation of CDK4 triggers development of non-alcoholic fatty liver diseases","volume":"16","author":"Jin","year":"2016","journal-title":"Cell Reports"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib17","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1172\/JCI41933","article-title":"Elimination of C\/EBP\u03b1 through the ubiquitin-proteasome system promotes the development of liver cancer in mice","volume":"120","author":"Wang","year":"2010","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib18","doi-asserted-by":"crossref","unstructured":"Cast A, Valanejad L, Wright M, et\u00a0al. C\/EBP\u03b1-dependent pre-neoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive pediatric liver cancer. Hepatology 201;67:1857\u20131871.","DOI":"10.1002\/hep.29677"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib19","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.celrep.2018.07.014","article-title":"Elimination of age-associated hepatic steatosis and correction of aging phenotype by inhibition of cdk4-C\/EBP\u03b1-p300 axis","author":"Nguyen","year":"2018","journal-title":"Cell Reports"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib20","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/hep4.1381","article-title":"Liver proliferation is an essential driver of fibrosis in mouse models of NAFLD","volume":"3","author":"Cast","year":"2019","journal-title":"Hepatology Communications"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.tox.2019.02.008","article-title":"Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C\/EBPalpha-SIRT1 pathway","volume":"417","author":"Hu","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/carcin\/bgx050","article-title":"FXR-Gankyrin axis is involved in development of pediatric liver cancer","author":"Valanejad","year":"2017","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s42003-018-0077-8","article-title":"PARP1-dependent chromosomal domains determine the development of aggressive hepatoblastoma","volume":"1","author":"Valanejad","year":"2018","journal-title":"Communications Biology"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12688","article-title":"Ghrelin deletion protects against age-associated hepatic steatosis by downregulating the C\/EBP\u03b1-p300\/DGAT1 pathway","volume":"17","author":"Guillory","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib25","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.celrep.2013.02.009","article-title":"Increased expression of enzymes of triglyceride synthesis plays is essential for the development of hepatic steatosis","volume":"3","author":"Jin","year":"2013","journal-title":"Cell Reports"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib26","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1074\/jbc.M113.526780","article-title":"Age-associated change of C\/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4 treatments","volume":"289","author":"Hong","year":"2014","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib27","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.7150\/ijbs.49785","article-title":"Oleate acid-stimulated HMMR expression by CEBP\u03b1 is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma","volume":"16","author":"Liu","year":"2020","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib28","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.jcmgh.2021.06.026","article-title":"HDAC1-dependent repression of markers of hepatocytes and P21 is involved in development of pediatric liver cancer","volume":"12","author":"Rivas","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib29","doi-asserted-by":"crossref","first-page":"e1372","DOI":"10.1371\/journal.pone.0001372","article-title":"A\u00a0ribosomal S-6 kinase-mediated signal to C\/EBP-beta is critical for the development of liver fibrosis","volume":"2","author":"Buck","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib30","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/hep.21655","article-title":"Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis","volume":"45","author":"Yamaguchi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib31","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1111\/cas.13341","article-title":"Gankyrin induces STAT3 activation in tumor microenvironment and sorafenib resistance in hepatocellular carcinoma","volume":"108","author":"Sakurai","year":"2017","journal-title":"Cancer Sci"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib32","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1051\/medsci\/20163210008","article-title":"Cell cycle regulators CDK4 and E2F1 control glucose and lipid homeostasis","volume":"32","author":"Denechaud","year":"2016","journal-title":"Med Sci (Paris)"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib33","first-page":"137","article-title":"E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis","volume":"1","author":"Denechaud","year":"2016","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2023.11.006_bib34","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fendo.2017.00311","article-title":"E2F1, a novel regulator of metabolism","volume":"8","author":"Denechaud","year":"2017","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X23002011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X23002011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:36:25Z","timestamp":1762454185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X23002011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"alternative-id":["S2352345X23002011"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2023.11.006","relation":{},"ISSN":["2352-345X"],"issn-type":[{"type":"print","value":"2352-345X"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic Ablation of C\/EBP\u03b1-p300 Pathway Blocks Development of Obese Pregnancy Associated Liver Disorders in Offspring","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2023.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}