{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:01:19Z","timestamp":1791230479894,"version":"4.1.0"},"reference-count":129,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007316","name":"National Cancer Institute Division of Cancer Prevention","doi-asserted-by":"publisher","award":["P01 CA269019"],"award-info":[{"award-number":["P01 CA269019"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T32 DK007568"],"award-info":[{"award-number":["T32 DK007568"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK118022"],"award-info":[{"award-number":["R01 DK118022"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA014236"],"award-info":[{"award-number":["P30 CA014236"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK03487"],"award-info":[{"award-number":["P30 DK03487"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","cmghjournal.org","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.jcmgh.2024.01.017","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T01:28:34Z","timestamp":1707182914000},"page":"1025-1038","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Promises and Limitations of Current Models for Understanding Barrett\u2019s Esophagus and Esophageal Adenocarcinoma"],"prefix":"10.1016","volume":"17","author":[{"given":"Omar","family":"Martinez-Uribe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7763-8465","authenticated-orcid":false,"given":"Katherine S.","family":"Garman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2024.01.017_bib1","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1056\/NEJMoa1103042","article-title":"Incidence of adenocarcinoma among patients with Barrett\u2019s esophagus","volume":"365","author":"Hvid-Jensen","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib2","author":"Institute"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.14740\/wjon1254","article-title":"Esophageal cancer: an updated surveillance epidemiology and end results database analysis","volume":"11","author":"Then","year":"2020","journal-title":"World J Oncol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib5","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1053\/j.gastro.2012.12.022","article-title":"Identification of lineage-uncommitted, long-lived, label-retaining cells in healthy human esophagus and stomach, and in metaplastic esophagus","volume":"144","author":"Pan","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib6","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1126\/science.1218835","article-title":"A\u00a0single progenitor population switches behavior to maintain and repair esophageal epithelium","volume":"337","author":"Doupe","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib7","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1038\/s41467-018-06796-9","article-title":"Single cell RNA-seq reveals profound transcriptional similarity between Barrett\u2019s oesophagus and oesophageal submucosal glands","volume":"9","author":"Owen","year":"2018","journal-title":"Nature Communications"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib8","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.abd1449","article-title":"Molecular phenotyping reveals the identity of Barrett\u2019s esophagus and its malignant transition","volume":"373","author":"Nowicki-Osuch","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib9","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/his.12707","article-title":"Ductal metaplasia in oesophageal submucosal glands is associated with inflammation and oesophageal adenocarcinoma","volume":"67","author":"Garman","year":"2015","journal-title":"Histopathology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib10","doi-asserted-by":"crossref","first-page":"re8","DOI":"10.1126\/scisignal.aaa7540","article-title":"Reserve stem cells: differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract","volume":"8","author":"Mills","year":"2015","journal-title":"Sci Signal"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib11","article-title":"Clonal cell states link Barrett\u2019s esophagus and esophageal adenocarcinoma","author":"Gier","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41575-021-00531-4","article-title":"Evolutionary dynamics in Barrett oesophagus: implications for surveillance, risk stratification and therapy","volume":"19","author":"Schmidt","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib13","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.14309\/ajg.0000000000001940","article-title":"An endoscopic and histologic study on healing of radiofrequency ablation wounds in patients with Barrett\u2019s esophagus","volume":"117","author":"Konda","year":"2022","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib14","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/path.1804","article-title":"On the histogenesis of Barrett\u2019s oesophagus and its associated squamous islands: a three-dimensional study of their morphological relationship with native oesophageal gland ducts","volume":"206","author":"Coad","year":"2005","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib15","doi-asserted-by":"crossref","first-page":"G1231","DOI":"10.1152\/ajpgi.00509.2011","article-title":"Review: experimental models for Barrett\u2019s esophagus and esophageal adenocarcinoma","volume":"302","author":"Garman","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ccr.2011.12.004","article-title":"Bile acid and inflammation activate gastric cardia stem cells in a mouse model of barrett-like metaplasia","volume":"21","author":"Quante","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib26","doi-asserted-by":"crossref","first-page":"203","DOI":"10.18632\/oncotarget.10667","article-title":"Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett\u2019s-like esophagus","volume":"8","author":"Lee","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib38","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature24269","article-title":"Transitional basal cells at the squamous-columnar junction generate Barrett\u2019s oesophagus","volume":"550","author":"Jiang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib22","doi-asserted-by":"crossref","first-page":"32980","DOI":"10.18632\/oncotarget.5431","article-title":"Immature myeloid progenitors promote disease progression in a mouse model of Barrett\u2019s-like metaplasia","volume":"6","author":"Kong","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib23","doi-asserted-by":"crossref","first-page":"347","DOI":"10.18632\/oncotarget.28198","article-title":"Telomere shortening accelerates tumor initiation in the L2-IL1B mouse model of Barrett esophagus and emerges as a possible biomarker","volume":"13","author":"Sahm","year":"2022","journal-title":"Oncotarget"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib24","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1053\/j.gastro.2020.04.033","article-title":"Notch signaling mediates differentiation in Barrett\u2019s esophagus and promotes progression to adenocarcinoma","volume":"159","author":"Kunze","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib25","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1038\/s41598-021-84011-4","article-title":"Notch signaling drives development of Barrett\u2019s metaplasia from Dclk1-positive epithelial tuft cells in the murine gastric mucosa","volume":"11","author":"Kunze","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/carcin\/bgaa109","article-title":"Elimination of NF-kappaB signaling in vimentin+ stromal cells attenuates tumorigenesis in a mouse model of Barrett\u2019s esophagus","volume":"42","author":"Anand","year":"2021","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib19","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1053\/j.gastro.2019.04.013","article-title":"High-fat diet accelerates carcinogenesis in a mouse model of Barrett\u2019s esophagus via interleukin 8 and alterations to the gut microbiome","volume":"157","author":"Munch","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib21","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s13046-022-02472-5","article-title":"APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett\u2019s-associated esophageal adenocarcinomas","volume":"41","author":"Ballout","year":"2022","journal-title":"J\u00a0Exp Clin Cancer Res"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/01635580701499529","article-title":"A\u00a0novel dietary-related model of esophagitis and Barrett\u2019s esophagus, a premalignant lesion","volume":"59","author":"Guy","year":"2007","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib31","first-page":"10","article-title":"Chronic high-fat diet induces early Barrett\u2019s esophagus in mice through lipidome remodeling","author":"Molendijk","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib32","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s11605-013-2386-z","article-title":"Development and characterization of a surgical mouse model of reflux esophagitis and Barrett\u2019s esophagus","volume":"18","author":"Pham","year":"2014","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib33","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jcmgh.2017.03.009","article-title":"Columnar metaplasia in three types of surgical mouse models of esophageal reflux","volume":"4","author":"Terabe","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-39907-8","article-title":"IL-1beta transgenic mouse model of inflammation driven esophageal and oral squamous cell carcinoma","volume":"13","author":"Muthupalani","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib58","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1245\/s10434-014-3537-5","article-title":"Impact of inflammation-metaplasia-adenocarcinoma sequence and inflammatory microenvironment in esophageal carcinogenesis using surgical rat models","volume":"21","author":"Miyashita","year":"2014","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib59","doi-asserted-by":"crossref","first-page":"15715","DOI":"10.3748\/wjg.v20.i42.15715","article-title":"Esophageal Helicobacter pylori colonization aggravates esophageal injury caused by reflux","volume":"20","author":"Chu","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib54","first-page":"21","article-title":"Molecular profile of Barrett\u2019s esophagus and gastroesophageal reflux disease in the development of translational physiological and pharmacological studies","author":"Korbut","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib51","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.3748\/wjg.v23.i33.6077","article-title":"High yield reproducible rat model recapitulating human Barrett\u2019s carcinogenesis","volume":"23","author":"Matsui","year":"2017","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib52","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/07357907.2018.1499029","article-title":"Serial endoscopic evaluation of esophageal disease in a cancer model: a paradigm shift for esophageal adenocarcinoma (EAC) drug discovery and development","volume":"36","author":"Omstead","year":"2018","journal-title":"Cancer Invest"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib56","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jcmgh.2018.06.007","article-title":"Columnar-lined esophagus develops via wound repair in a surgical model of reflux esophagitis","volume":"6","author":"Agoston","year":"2018","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib57","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.gastro.2018.09.046","article-title":"Acidic bile salts induce epithelial to mesenchymal transition via VEGF signaling in non-neoplastic Barrett\u2019s cells","volume":"156","author":"Zhang","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib61","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-14095-z","article-title":"Effects of paternal high-fat diet and maternal rearing environment on the gut microbiota and behavior","volume":"12","author":"Korgan","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib62","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s40168-019-0738-y","article-title":"Batch effect exerts a bigger influence on the rat urinary metabolome and gut microbiota than uraemia: a cautionary tale","volume":"7","author":"Randall","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib74","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/bjs.1800750208","article-title":"Experimental columnar metaplasia in the canine oesophagus","volume":"75","author":"Gillen","year":"1988","journal-title":"Br J Surg"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib75","first-page":"176","article-title":"Mechanisms of columnar metaplasia and squamous regeneration in experimental Barrett\u2019s esophagus","volume":"115","author":"Li","year":"1994","journal-title":"Surgery"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib76","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba4526","article-title":"Esophageal extracellular matrix hydrogel mitigates metaplastic change in a dog model of Barrett\u2019s esophagus","volume":"6","author":"Naranjo","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib78","first-page":"401","article-title":"Transhiatal esophagogastric anastomosis and postoperative monitoring of thoracic esophageal leiomyosarcoma in a dog","volume":"61","author":"Lee","year":"2020","journal-title":"Can Vet J"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib79","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1007\/s10620-006-9739-3","article-title":"Characterization of esophageal submucosal glands in pig tissue and cultures","volume":"52","author":"Abdulnour-Nakhoul","year":"2007","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib80","doi-asserted-by":"crossref","first-page":"G180","DOI":"10.1152\/ajpgi.00036.2017","article-title":"Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair","volume":"313","author":"Kruger","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib81","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jcmgh.2017.07.005","article-title":"Porcine esophageal submucosal gland culture model shows capacity for proliferation and differentiation","volume":"4","author":"von Furstenberg","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib17","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1007\/s00262-020-02650-4","article-title":"Characterizing caspase-1 involvement during esophageal disease progression","volume":"69","author":"Barber","year":"2020","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms9122432","article-title":"High-fructose diet\u00a0alters intestinal microbial profile and correlates with early tumorigenesis in a mouse model of Barrett\u2019s esophagus","volume":"9","author":"Proano-Vasco","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib27","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s12029-018-0079-2","article-title":"Prognostic value of cyclin D1 and CD44 expression in gastric adenocarcinoma","volume":"50","author":"Ibrahim","year":"2019","journal-title":"J\u00a0Gastrointest Cancer"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib28","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/ajg.2009.629","article-title":"Elevated serum gastrin is associated with a history of advanced neoplasia in Barrett\u2019s esophagus","volume":"105","author":"Wang","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib34","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1007\/s10620-021-07344-0","article-title":"Simvastatin inhibits histologic changes associated with gastroduodenal reflux in a murine model","volume":"67","author":"Gergen","year":"2022","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib35","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.celrep.2014.03.074","article-title":"A\u00a0pSMAD\/CDX2 complex is essential for the intestinalization of epithelial metaplasia","volume":"7","author":"Mari","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220050","article-title":"Glyco-conjugated bile acids drive the initial metaplastic gland formation from multi-layered glands through crypt-fission in a murine model","volume":"14","author":"Straub","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/mps4010006","article-title":"Novel in\u00a0vivo mouse cryoablation model to explore unique therapeutic approaches for premalignant columnar lesions","volume":"4","author":"Correia","year":"2021","journal-title":"Methods Protoc"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41467-019-13847-2","article-title":"Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5(-)CD44(+) cells","volume":"11","author":"Fu","year":"2020","journal-title":"Nature Communications"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib40","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1172\/JCI78850","article-title":"BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis","volume":"125","author":"Jiang","year":"2015","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib41","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.jcmgh.2023.01.003","article-title":"Inhibition of BMP2 and BMP4 represses Barrett\u2019s esophagus while enhancing the regeneration of squamous epithelium in preclinical models","volume":"15","author":"Correia","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib42","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.jcmgh.2021.05.021","article-title":"GATA4 controls epithelial morphogenesis in the developing stomach to promote establishment of glandular columnar epithelium","volume":"12","author":"DeLaForest","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib43","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jcmgh.2021.03.008","article-title":"Loss of SMAD4 is sufficient to promote tumorigenesis in a model of dysplastic Barrett\u2019s esophagus","volume":"12","author":"Gotovac","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib44","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1053\/j.gastro.2019.01.263","article-title":"Systems biology analyses show hyperactivation of transforming growth factor-beta and JNK signaling pathways in esophageal cancer","volume":"156","author":"Blum","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib45","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1053\/j.gastro.2022.07.045","article-title":"The ephrin B2 receptor tyrosine kinase is a regulator of proto-oncogene MYC and molecular programs central to Barrett\u2019s neoplasia","volume":"163","author":"Venkitachalam","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib46","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41392-023-01419-2","article-title":"Patient-derived xenograft models in cancer therapy: technologies and applications","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080889","article-title":"Application of highly immunocompromised mice for the establishment of patient-derived xenograft (PDX) models","volume":"8","author":"Okada","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib48","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13550-021-00875-7","article-title":"CXCR4 peptide-based fluorescence endoscopy in a mouse model of Barrett\u2019s esophagus","volume":"12","author":"Marcazzan","year":"2022","journal-title":"EJNMMI Res"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib49","first-page":"1384","article-title":"Bile acids but not acidic acids induce Barrett\u2019s esophagus","volume":"8","author":"Sun","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib50","first-page":"3863","article-title":"An improved surgical procedure to establish a gastroesophageal reflux model with a high incidence of Barrett\u2019s esophagus in rats","volume":"16","author":"Wen","year":"2018","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib53","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/dote.12210","article-title":"In\u00a0vivo molecular imaging of HER2 expression in a rat model of Barrett\u2019s esophagus adenocarcinoma","volume":"28","author":"Realdon","year":"2015","journal-title":"Dis Esophagus"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib55","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/labinvest.3700079","article-title":"Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett\u2019s esophagus","volume":"84","author":"Su","year":"2004","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007384","article-title":"Barrett\u2019s esophagus and esophageal cancer: links to microbes and the microbiome","volume":"14","author":"Ajayi","year":"2018","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib63","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1007\/s10620-016-4263-6","article-title":"Alteration of esophageal microbiome by antibiotic treatment does not affect incidence of rat esophageal adenocarcinoma","volume":"61","author":"Sawada","year":"2016","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib64","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.3389\/fmicb.2020.01148","article-title":"Methods for establishment and maintenance of germ-free rat models","volume":"11","author":"Qv","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib65","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s10620-010-1465-1","article-title":"Rabeprazole impedes the development of reflux-induced esophageal cancer in a surgical rat model","volume":"56","author":"Miyashita","year":"2011","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112862","article-title":"Role of proton pump inhibitor on esophageal carcinogenesis and pancreatic acinar cell metaplasia development: an experimental in\u00a0vivo study","volume":"9","author":"Dall\u2019Olmo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib67","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/1756283X10392444","article-title":"Correlation between serum gastrin and cellular proliferation in Barrett\u2019s esophagus","volume":"4","author":"Green","year":"2011","journal-title":"Therap Adv Gastroenterol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib68","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1053\/gast.2003.50091","article-title":"Gastrin induces proliferation in Barrett\u2019s metaplasia through activation of the CCK2 receptor","volume":"124","author":"Haigh","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib69","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.3892\/or.2014.3137","article-title":"Effect of aspirin treatment on the prevention of esophageal adenocarcinoma in a rat experimental model","volume":"31","author":"Esquivias","year":"2014","journal-title":"Oncology Reports"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib70","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10238-014-0301-x","article-title":"Chemoprevention of esophageal adenocarcinoma in a rat model by ursodeoxycholic acid","volume":"15","author":"Ojima","year":"2015","journal-title":"Clin Exp Med"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.surg.2018.02.003","article-title":"Preventive effect of oral hangeshashinto (TJ-14) on the development of reflux-induced esophageal cancer","author":"Miyashita","year":"2018","journal-title":"Surgery"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib72","doi-asserted-by":"crossref","first-page":"e206","DOI":"10.1097\/SLA.0000000000003455","article-title":"Targeting the hedgehog pathway using itraconazole to prevent progression of Barrett\u2019s esophagus to invasive esophageal adenocarcinoma","volume":"273","author":"Kelly","year":"2021","journal-title":"Ann Surg"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib73","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/BF02236137","article-title":"Esophagitis produced by reflux of duodenal contents in rats","volume":"7","author":"Levrat","year":"1962","journal-title":"Am J Dig Dis"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib77","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4314\/ovj.v8i1.5","article-title":"Comparative oncology: integrating human and veterinary medicine","volume":"8","author":"Sultan","year":"2018","journal-title":"Open Vet J"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib82","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1053\/j.gastro.2023.08.039","article-title":"Genetic defect in submucosal gland-associated caveolin-3: a new paradigm in esophageal adenocarcinoma risk","volume":"165","author":"Garman","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib83","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202300223R","article-title":"A\u00a0LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease","volume":"37","author":"Schaaf","year":"2023","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib84","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s00535-013-0862-6","article-title":"Toll-like receptor 4 activation in Barrett\u2019s esophagus results in a strong increase in COX-2 expression","volume":"49","author":"Verbeek","year":"2014","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106261","article-title":"Squamous tissue lymphocytes in the esophagus of controls and patients with reflux esophagitis and Barrett\u2019s esophagus are characterized by a non-inflammatory phenotype","volume":"9","author":"Lind","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib86","article-title":"Motion sensing superpixels (MOSES) is a systematic computational framework to quantify and discover cellular motion phenotypes","volume":"8","author":"Zhou","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib87","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1053\/j.gastro.2013.08.008","article-title":"Bile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis","volume":"145","author":"Matsuzaki","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib88","doi-asserted-by":"crossref","first-page":"G615","DOI":"10.1152\/ajpgi.00268.2016","article-title":"Barrett\u2019s metaplasia develops from cellular reprograming of esophageal squamous epithelium due to gastroesophageal reflux","volume":"312","author":"Minacapelli","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib89","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s11605-013-2287-1","article-title":"Bile acid at low pH reduces squamous differentiation and activates EGFR signaling in esophageal squamous cells in 3-D culture","volume":"17","author":"Ghatak","year":"2013","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib90","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13046-018-1021-y","article-title":"Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage","volume":"38","author":"Zhou","year":"2019","journal-title":"J\u00a0Exp Clin Cancer Res"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib91","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1007\/s10620-017-4821-6","article-title":"Response to TNF-alpha is increasing along with the progression in Barrett\u2019s esophagus","volume":"62","author":"Chemnitzer","year":"2017","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib92","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/j.ajpath.2013.02.036","article-title":"Dendritic cells in Barrett\u2019s esophagus carcinogenesis: an inadequate microenvironment for antitumor immunity?","volume":"182","author":"Somja","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib93","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12876-019-0957-5","article-title":"In-depth characterization of the Wnt-signaling\/beta-catenin pathway in an in\u00a0vitro model of Barrett\u2019s sequence","volume":"19","author":"Gotzel","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib94","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1038\/s41598-021-82557-x","article-title":"GATA4 blocks squamous epithelial cell gene expression in human esophageal squamous cells","volume":"11","author":"Stavniichuk","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib117","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1042\/BC20100071","article-title":"A\u00a0comparison of primary oesophageal squamous epithelial cells with HET-1A in organotypic culture","volume":"102","author":"Underwood","year":"2010","journal-title":"Biol Cell"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib118","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.canlet.2009.12.015","article-title":"Genetic alterations in a telomerase-immortalized human esophageal epithelial cell line: implications for carcinogenesis","volume":"293","author":"Cheung","year":"2010","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib119","doi-asserted-by":"crossref","first-page":"G470","DOI":"10.1152\/ajpgi.90262.2008","article-title":"Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett\u2019s esophagus","volume":"295","author":"Zhang","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib120","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1053\/j.gastro.2010.03.035","article-title":"Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett\u2019s esophagus","volume":"139","author":"Huo","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib121","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1158\/0008-5472.CAN-08-3703","article-title":"Unlike esophageal squamous cells, Barrett\u2019s epithelial cells resist apoptosis by activating the nuclear factor-kappaB pathway","volume":"69","author":"Hormi-Carver","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib122","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1136\/gutjnl-2015-309272","article-title":"In oesophageal squamous cells, nitric oxide causes S-nitrosylation of Akt and blocks SOX2 (sex determining region Y-box 2) expression","volume":"65","author":"Asanuma","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib123","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1074\/jbc.M209148200","article-title":"Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in\u00a0vitro and in\u00a0vivo","volume":"278","author":"Andl","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2019.154782","article-title":"Activin A-mediated epithelial de-differentiation contributes to injury repair in an in\u00a0vitro gastrointestinal reflux model","volume":"123","author":"Roudebush","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib124","first-page":"729","article-title":"Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation","volume":"1","author":"Harada","year":"2003","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib102","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1002\/jcp.23007","article-title":"Development and characterization of an organotypic model of Barrett\u2019s esophagus","volume":"227","author":"Kosoff","year":"2012","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib125","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1093\/carcin\/bgg076","article-title":"Extended lifespan of Barrett\u2019s esophagus epithelium transduced with the human telomerase catalytic subunit: a useful in\u00a0vitro model","volume":"24","author":"Palanca-Wessels","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib126","doi-asserted-by":"crossref","first-page":"G278","DOI":"10.1152\/ajpgi.00092.2011","article-title":"Deoxycholic acid causes DNA damage while inducing apoptotic resistance through NF-kappaB activation in benign Barrett\u2019s epithelial cells","volume":"301","author":"Huo","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib127","doi-asserted-by":"crossref","first-page":"8580","DOI":"10.1158\/0008-5472.CAN-07-2023","article-title":"In non-neoplastic Barrett\u2019s epithelial cells, acid exerts early antiproliferative effects through activation of the Chk2 pathway","volume":"67","author":"Zhang","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib128","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1442-2050.2007.00683.x","article-title":"Characterization of telomerase-immortalized, non-neoplastic, human Barrett\u2019s cell line (BAR-T)","volume":"20","author":"Jaiswal","year":"2007","journal-title":"Dis Esophagus"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib129","article-title":"Malignant transformation of non-neoplastic Barrett\u2019s epithelial cells through well-defined genetic manipulations","volume":"5","author":"Zhang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib130","doi-asserted-by":"crossref","first-page":"G129","DOI":"10.1152\/ajpgi.00085.2014","article-title":"In Barrett\u2019s esophagus patients and Barrett\u2019s cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids","volume":"307","author":"Peng","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib95","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/jnci\/djp499","article-title":"Verification and unmasking of widely used human esophageal adenocarcinoma cell lines","volume":"102","author":"Boonstra","year":"2010","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib96","doi-asserted-by":"crossref","first-page":"7996","DOI":"10.1158\/0008-5472.CAN-07-2064","article-title":"Mistaken identity of widely used esophageal adenocarcinoma cell line TE-7","volume":"67","author":"Boonstra","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib97","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1053\/j.gastro.2018.03.047","article-title":"Detection of mutations in Barrett\u2019s esophagus before progression to high-grade dysplasia or adenocarcinoma","volume":"155","author":"Stachler","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib98","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/ng.3013","article-title":"Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis","volume":"46","author":"Weaver","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib99","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/ng.3343","article-title":"Paired exome analysis of Barrett\u2019s esophagus and adenocarcinoma","volume":"47","author":"Stachler","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib100","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1053\/j.gastro.2015.11.040","article-title":"Magnitude of missed esophageal adenocarcinoma after Barrett\u2019s esophagus diagnosis: a systematic review and meta-analysis","volume":"150","author":"Visrodia","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib101","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nprot.2011.437","article-title":"Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture","volume":"7","author":"Kalabis","year":"2012","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib103","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.4161\/15384101.2014.972875","article-title":"Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett\u2019s-like metaplasia via KLF4","volume":"13","author":"Vega","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib105","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1053\/j.gastro.2011.07.050","article-title":"Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett\u2019s epithelium","volume":"141","author":"Sato","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib106","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-71589-4","article-title":"Towards personalized induction therapy for esophageal adenocarcinoma: organoids derived from endoscopic biopsy recapitulate the pre-treatment tumor","volume":"10","author":"Derouet","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib107","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.gastro.2023.09.040","article-title":"Targeting stem cells and dysplastic features with dual MEK\/ERK and STAT3 suppression in gastric carcinogenesis","volume":"166","author":"Kim","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib108","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jcmgh.2018.01.011","article-title":"Esophageal 3D culture systems as modeling tools in esophageal epithelial pathobiology and personalized medicine","volume":"5","author":"Whelan","year":"2018","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib109","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.canlet.2018.08.017","article-title":"Modeling Wnt signaling by CRISPR-Cas9 genome editing recapitulates neoplasia in human Barrett epithelial organoids","volume":"436","author":"Liu","year":"2018","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib110","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.762184","article-title":"Patient-derived organoids in precision medicine: drug screening, organoid-on-a-chip and living organoid biobank","volume":"11","author":"Zhou","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib111","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jcmgh.2019.11.008","article-title":"Human colon-on-a-chip enables continuous in\u00a0vitro analysis of colon mucus layer accumulation and physiology","volume":"9","author":"Sontheimer-Phelps","year":"2020","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib112","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jcmgh.2021.08.015","article-title":"Organ-on-chip approaches for intestinal 3D in\u00a0vitro modeling","volume":"13","author":"Pimenta","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib113","series-title":"Assay guidance manual","article-title":"Authentication of human and mouse cell lines by short tandem repeat (STR) DNA genotype analysis","author":"Almeida","year":"2004"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib114","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1053\/j.gastro.2017.12.009","article-title":"Development and validation of a model to determine risk of progression of Barrett\u2019s esophagus to neoplasia","volume":"154","author":"Parasa","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib115","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1159\/000521706","article-title":"Today\u2019s mistakes and tomorrow\u2019s wisdom in development and use of biomarkers for Barrett\u2019s esophagus","volume":"38","author":"Frei","year":"2022","journal-title":"Visc Med"},{"key":"10.1016\/j.jcmgh.2024.01.017_bib116","first-page":"1488","article-title":"Kyoto international consensus report on anatomy, pathophysiology and clinical significance of the gastro-oesophageal junction","volume":"71","author":"Sugano","year":"2022","journal-title":"Gut"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X24000201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X24000201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T13:53:50Z","timestamp":1715954030000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X24000201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":129,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024]]}},"alternative-id":["S2352345X24000201"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2024.01.017","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Promises and Limitations of Current Models for Understanding Barrett\u2019s Esophagus and Esophageal Adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2024.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}