{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:08:50Z","timestamp":1791144530914,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":115,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","cmghjournal.org","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.jcmgh.2024.04.008","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T06:34:50Z","timestamp":1715063690000},"page":"101351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Concomitant NAFLD Facilitates Liver Metastases and PD-1-Refractory by Recruiting MDSCs via CXCL5\/CXCR2 in Colorectal Cancer"],"prefix":"10.1016","volume":"18","author":[{"given":"Yue","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaogang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9919-5981","authenticated-orcid":false,"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2024.04.008_bib1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11901-017-0378-2","article-title":"Natural History of NAFLD\/NASH","volume":"16","author":"Ekstedt","year":"2017","journal-title":"Curr Hepatol Rep"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib2","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib3","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1016\/j.cgh.2021.12.002","article-title":"2019 Global NAFLD prevalence: a systematic review and meta-analysis","volume":"20","author":"Le","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib4","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nm1469","article-title":"Tumor metastasis: mechanistic insights and clinical challenges","volume":"12","author":"Steeg","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib5","doi-asserted-by":"crossref","first-page":"6390","DOI":"10.1158\/1078-0432.CCR-15-1636","article-title":"Molecular pathways: targeting the microenvironment of liver metastases","volume":"23","author":"Milette","year":"2017","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib6","doi-asserted-by":"crossref","first-page":"55368","DOI":"10.18632\/oncotarget.10552","article-title":"Incidence and origin of histologically confirmed liver metastases: an explorative case-study of 23,154 patients","volume":"7","author":"de Ridder","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib8","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"Arnold","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib9","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/hep.30702","article-title":"Unexpected rapid increase in the burden of NAFLD in China from 2008 to 2018: a systematic review and meta-analysis","volume":"70","author":"Zhou","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib10","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000005809","article-title":"The relationship of nonalcoholic fatty liver disease and metabolic syndrome for colonoscopy colorectal neoplasm","volume":"96","author":"Pan","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib11","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/gut.2011.237974","article-title":"High prevalence of colorectal neoplasm in patients with non-alcoholic steatohepatitis","volume":"60","author":"Wong","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib12","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1002\/ijc.23173","article-title":"Inflammation and cancer: an ancient link with novel potentials","volume":"121","author":"Hussain","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib13","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1093\/cid\/cix1118","article-title":"Effect of concomitant positive hepatitis B surface antigen on the risk of liver metastasis: a retrospective clinical study of 4033 consecutive cases of newly diagnosed colorectal cancer","volume":"66","author":"Huo","year":"2018","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib14","first-page":"1398","article-title":"Active chronic hepatitis B increases the risk of colorectal liver metastasis: a retrospective cross-sectional study","volume":"12","author":"Yang","year":"2021","journal-title":"J\u00a0Cancer"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib15","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S2468-1253(22)00165-0","article-title":"The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis","volume":"7","author":"Riazi","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib16","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/hep.26094","article-title":"Recruitment of a myeloid cell subset (CD11b\/Gr1 mid) via CCL2\/CCR2 promotes the development of colorectal cancer liver metastasis","volume":"57","author":"Zhao","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/hep.23280","article-title":"Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications","volume":"51","author":"Fabbrini","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib18","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1053\/j.gastro.2007.03.059","article-title":"Obesity, inflammation, and insulin resistance","volume":"132","author":"Shoelson","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118507","article-title":"Nonalcoholic fatty liver disease and colorectal cancer: correlation and missing links","volume":"262","author":"Chakraborty","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib20","first-page":"1069","article-title":"Liver metastasis rare in colorectal cancer patients with fatty liver","volume":"44","author":"Hayashi","year":"1997","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib21","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3389\/fonc.2020.00251","article-title":"Effect of non-alcoholic fatty liver disease on the risk of synchronous liver metastasis: analysis of 451 consecutive patients of newly diagnosed colorectal cancer","volume":"10","author":"Lv","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib22","first-page":"121","article-title":"Not just eosinophilic fasciitis","volume":"14","author":"Chirila","year":"2021","journal-title":"J\u00a0Med Life"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib23","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3748\/wjg.v21.i3.913","article-title":"Association of nonalcoholic fatty liver disease and liver cancer","volume":"21","author":"Schulz","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib24","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/hep.30693","article-title":"NOD-like receptor C4 inflammasome regulates the growth of colon cancer liver metastasis in NAFLD","volume":"70","author":"Ohashi","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib25","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.it.2016.01.004","article-title":"The nature of myeloid-derived suppressor cells in the tumor microenvironment","volume":"37","author":"Kumar","year":"2016","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","article-title":"Polarization of tumor-associated neutrophil phenotype by TGF-beta: \"N1\" versus \"N2\" TAN","volume":"16","author":"Fridlender","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1189\/jlb.5MR1216-508R","article-title":"Neutrophils as active regulators of the immune system in the tumor microenvironment","volume":"102","author":"Shaul","year":"2017","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib28","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.1158\/0008-5472.CAN-14-3173","article-title":"TNF receptor-2 facilitates an immunosuppressive microenvironment in the liver to promote the colonization and growth of hepatic metastases","volume":"75","author":"Ham","year":"2015","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib29","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/s41423-020-00534-2","article-title":"Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis","volume":"18","author":"Zeng","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib30","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1158\/0008-5472.CAN-16-3199","article-title":"CXCL1 is critical for premetastatic niche formation and metastasis in colorectal cancer","volume":"77","author":"Wang","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib31","first-page":"313","article-title":"Accumulated myeloid-derived suppressor cells demonstrate distinct phenotypes and functions in two non-alcoholic steatohepatitis mouse models","volume":"4","author":"Tsunashima","year":"2015","journal-title":"Hepatobiliary Surg Nutr"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib32","article-title":"Characterization of liver monocytic myeloid-derived suppressor cells and their role in a murine model of non-alcoholic fatty liver disease","volume":"11","author":"Yao","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232113048","article-title":"Granulocytic MDSC with deficient CCR5 alleviates lipogenesis and inflammation in nonalcoholic fatty liver disease","volume":"23","author":"Liao","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib34","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/01.mcp.0000144502.50149.e0","article-title":"Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective","volume":"11","author":"Bisset","year":"2005","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib35","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00024382-199810000-00004","article-title":"Proliferative effects of CXC chemokines in rat hepatocytes in\u00a0vitro and in\u00a0vivo","volume":"10","author":"Colletti","year":"1998","journal-title":"Shock"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib36","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/hep.510230315","article-title":"The role of cytokine networks in the local liver injury following hepatic ischemia\/reperfusion in the rat","volume":"23","author":"Colletti","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib37","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.canlet.2018.10.027","article-title":"PAI-1 secreted from metastatic ovarian cancer cells triggers the tumor-promoting role of the mesothelium in a feedback loop to accelerate peritoneal dissemination","volume":"442","author":"Peng","year":"2019","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib38","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/cac2.12010","article-title":"CXCL5\/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target","volume":"40","author":"Zhang","year":"2020","journal-title":"Cancer Commun (Lond)"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib39","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1158\/1078-0432.CCR-18-3567","article-title":"A\u00a0C-X-C chemokine receptor type 2-dominated cross-talk between tumor cells and macrophages drives gastric cancer metastasis","volume":"25","author":"Zhou","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib40","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41574-022-00675-6","article-title":"Macrophage functional diversity in NAFLD: more than inflammation","volume":"18","author":"Barreby","year":"2022","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib41","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.trsl.2017.09.001","article-title":"Altered expression of MALAT1 lncRNA in nonalcoholic steatohepatitis fibrosis regulates CXCL5 in hepatic stellate cells","volume":"190","author":"Leti","year":"2017","journal-title":"Transl Res"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib42","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.phrs.2019.04.016","article-title":"Elafibranor restricts lipogenic and inflammatory responses in a human skin stem cell-derived model of NASH","volume":"144","author":"Boeckmans","year":"2019","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib43","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1111\/febs.14466","article-title":"A\u00a0guide to chemokines and their receptors","volume":"285","author":"Hughes","year":"2018","journal-title":"FEBS J"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1432-1327.1998.2550067.x","article-title":"Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78","volume":"255","author":"Wuyts","year":"1998","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1074-7613(00)80165-X","article-title":"Chemokines: a new classification system and their role in immunity","volume":"12","author":"Zlotnik","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib46","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1248\/bpb.34.120","article-title":"Reparixin, an inhibitor of CXCR1 and CXCR2 receptor activation, attenuates blood pressure and hypertension-related mediators expression in spontaneously hypertensive rats","volume":"34","author":"Kim","year":"2011","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib47","first-page":"1559","article-title":"A\u00a0multicenter phase 2 randomized controlled study on the efficacy and safety of Reparixin in the treatment of hospitalized patients with COVID-19 pneumonia","volume":"11","author":"Landoni","year":"2022","journal-title":"Infect Dis Ther"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib48","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1200\/JCO.19.02107","article-title":"Phase II open-label study of pembrolizumab in treatment-refractory, microsatellite instability-high\/mismatch repair-deficient metastatic colorectal cancer: KEYNOTE-164","volume":"38","author":"Le","year":"2020","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189848","article-title":"Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with advanced colorectal carcinoma","volume":"12","author":"O\u2019Neil","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib50","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3389\/fimmu.2020.01371","article-title":"Myeloid-derived suppressor cells in tumors: from mechanisms to antigen specificity and microenvironmental regulation","volume":"11","author":"Yang","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib51","article-title":"Hepatic steatosis predicts higher incidence of recurrence in colorectal cancer liver metastasis patients","volume":"11","author":"Chen","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib52","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/bjs.9057","article-title":"Fatty liver disease as a predictor of local recurrence following resection of colorectal liver metastases","volume":"100","author":"Hamady","year":"2013","journal-title":"Br J Surg"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib53","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/bjc.2016.155","article-title":"The impact of hepatic fibrosis on the incidence of liver metastasis from colorectal cancer","volume":"115","author":"Kondo","year":"2016","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib54","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.2147\/CMAR.S210185","article-title":"Predictive and prognostic value of hepatic steatosis in conversion therapy for colorectal liver-limited metastases: a propensity score matching analysis","volume":"11","author":"Jian","year":"2019","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib55","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s00384-013-1656-2","article-title":"Hepatic steatosis is associated with lower incidence of liver metastasis from colorectal cancer","volume":"28","author":"Murono","year":"2013","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib56","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.hpb.2015.12.002","article-title":"The influence of steatosis on the short- and long-term results of resection of liver metastases from colorectal carcinoma","volume":"18","author":"Ramos","year":"2016","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib57","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3389\/fonc.2020.00251","article-title":"Effect of non-alcoholic fatty liver disease on the risk of synchronous liver metastasis: analysis of 451 consecutive patients of newly diagnosed colorectal cancer","volume":"10","author":"Lv","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.jcmgh.2024.04.008_bib58","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.metabol.2018.11.014","article-title":"Obesity and nonalcoholic fatty liver disease: from pathophysiology to therapeutics","volume":"92","author":"Polyzos","year":"2019","journal-title":"Metabolism"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X2400105X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X2400105X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T08:49:30Z","timestamp":1721206170000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X2400105X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"alternative-id":["S2352345X2400105X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2024.04.008","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Concomitant NAFLD Facilitates Liver Metastases and PD-1-Refractory by Recruiting MDSCs via CXCL5\/CXCR2 in Colorectal Cancer","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2024.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}],"article-number":"101351"}}