{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:47:16Z","timestamp":1793040436631,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":136,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"NIAAA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","cmghjournal.org","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.jcmgh.2024.05.010","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T03:02:06Z","timestamp":1716433326000},"page":"101362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["A Protein Complex of Liver Origin Activates a Pro-inflammatory Program That Drives Hepatic and Intestinal Injury in Alcohol-Associated Liver Disease"],"prefix":"10.1016","volume":"18","author":[{"given":"Xiaodong","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Desert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukanta","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuolun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Santosh Babu","family":"Komakula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipti","family":"Athavale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lantvit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7941-6804","authenticated-orcid":false,"given":"Natalia","family":"Nieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2024.05.010_bib1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/hep.23258","article-title":"Alcoholic liver disease","volume":"51","author":"O\u2019Shea","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib2","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1053\/j.gastro.2016.02.042","article-title":"Standard definitions and common data elements for clinical trials in patients with alcoholic hepatitis: recommendation from the NIAAA Alcoholic Hepatitis Consortia","volume":"150","author":"Crabb","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib3","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/853175","article-title":"Oxidative stress and inflammation: essential partners in alcoholic liver disease","volume":"2012","author":"Ambade","year":"2012","journal-title":"International Journal of Hepatology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib4","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.jhep.2009.03.007","article-title":"Signalling pathways in alcohol-induced liver inflammation","volume":"50","author":"Mandrekar","year":"2009","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib5","doi-asserted-by":"crossref","first-page":"22672","DOI":"10.1074\/jbc.M114.552141","article-title":"High mobility group box-1 (HMGB1) participates in the pathogenesis of alcoholic liver disease (ALD)","volume":"289","author":"Ge","year":"2014","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib6","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/0024-3205(86)90554-0","article-title":"Serum interleukin-1 (IL-1) activity in alcoholic hepatitis","volume":"39","author":"McClain","year":"1986","journal-title":"Life Sci"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib7","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1172\/JCI60777","article-title":"IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice","volume":"122","author":"Petrasek","year":"2012","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib8","first-page":"251","article-title":"Macrophages and alcohol-related liver inflammation","volume":"37","author":"Ju","year":"2015","journal-title":"Alcohol Res"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.alcohol.2019.05.004","article-title":"Mechanisms, biomarkers and targets for therapy in alcohol-associated liver injury: from genetics to nutrition\u2014summary of the ISBRA 2018 symposium","volume":"83","author":"Kirpich","year":"2020","journal-title":"Alcohol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib10","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1002\/hep.29760","article-title":"Gut-liver axis alterations in alcoholic liver disease: are bile acids the answer?","volume":"67","author":"Bajaj","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/j.gastro.2014.10.042","article-title":"Gut-liver axis in alcoholic liver disease","volume":"148","author":"Szabo","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20020395","article-title":"Gut-liver axis, gut microbiota, and its modulation in the management of liver diseases: a review of the literature","volume":"20","author":"Milosevic","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib13","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.jhep.2018.05.021","article-title":"Intestinal HIF-1alpha deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction","volume":"69","author":"Shao","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib14","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/hep.23009","article-title":"Endotoxemia and gut barrier dysfunction in alcoholic liver disease","volume":"50","author":"Rao","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib15","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jhep.2008.10.028","article-title":"Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats","volume":"50","author":"Keshavarzian","year":"2009","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-immunol-030409-101323","article-title":"HMGB1 is a therapeutic target for sterile inflammation and infection","volume":"29","author":"Andersson","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib17","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1189\/jlb.1008585","article-title":"HMGB1 loves company","volume":"86","author":"Bianchi","year":"2009","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.immunol.021908.132603","article-title":"HMGB1 and RAGE in inflammation and cancer","volume":"28","author":"Sims","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nri1372","article-title":"Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses","volume":"4","author":"Seong","year":"2004","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00002371-200501000-00001","article-title":"Addicted to death: invasive cancer and the immune response to unscheduled cell death","volume":"28","author":"Zeh","year":"2005","journal-title":"J\u00a0Immunother"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib21","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jhep.2020.04.033","article-title":"Danger signals in liver injury and restoration of homeostasis","volume":"73","author":"Han","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib22","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.it.2005.04.009","article-title":"HMGB1: guiding immunity from within","volume":"26","author":"Dumitriu","year":"2005","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib23","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.4254\/wjh.v7.i23.2459","article-title":"Contribution of the toxic advanced glycation end-products-receptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma","volume":"7","author":"Takino","year":"2015","journal-title":"World J Hepatol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib24","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1136\/gutjnl-2015-310752","article-title":"Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury","volume":"66","author":"Arriazu","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40001-015-0090-z","article-title":"Role of receptor for advanced glycation end products (RAGE) in liver disease","volume":"20","author":"Yamagishi","year":"2015","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib26","doi-asserted-by":"crossref","DOI":"10.4238\/gmr.15027419","article-title":"Expression of toll-like receptors in hepatic cirrhosis and hepatocellular carcinoma","volume":"15","author":"Sun","year":"2016","journal-title":"Genet Mol Res"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib27","doi-asserted-by":"crossref","first-page":"16336","DOI":"10.1074\/jbc.M608467200","article-title":"Post-translational methylation of high mobility group box 1 (HMGB1) causes its cytoplasmic localization in neutrophils","volume":"282","author":"Ito","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib28","doi-asserted-by":"crossref","first-page":"5800","DOI":"10.4049\/jimmunol.0801873","article-title":"HMGB1 is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism","volume":"182","author":"Oh","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib29","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1003893107","article-title":"A\u00a0critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release","volume":"107","author":"Yang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib30","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2119\/molmed.2011.00389","article-title":"Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1)","volume":"18","author":"Yang","year":"2012","journal-title":"Mol Med"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib31","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/0016-5085(92)91122-K","article-title":"Serum levels of cytokines in chronic liver diseases","volume":"103","author":"Tilg","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-2249.1994.tb06609.x","article-title":"Circulating proinflammatory cytokines (IL-1 beta, TNF-alpha, and IL-6) and IL-1 receptor antagonist (IL-1Ra) in fulminant hepatic failure and acute hepatitis","volume":"98","author":"Sekiyama","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib33","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/j.pain.2014.06.007","article-title":"Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis","volume":"155","author":"Agalave","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib34","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1002\/hep.30093","article-title":"High mobility group box-1 drives fibrosis progression signaling via the receptor for advanced glycation end products in mice","volume":"68","author":"Ge","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib35","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1053\/j.gastro.2008.08.057","article-title":"A\u00a0randomized, double-blinded, placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis","volume":"135","author":"Boetticher","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib36","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1002\/hep.30055","article-title":"Gut-liver axis beyond the microbiome: how the fungal mycobiome contributes to alcoholic liver disease","volume":"68","author":"Szabo","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib37","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.it.2018.05.002","article-title":"Liver-microbiome axis in health and disease","volume":"39","author":"Adolph","year":"2018","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib38","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1002\/hep.29676","article-title":"Modulation of the intestinal bile acid\/farnesoid X receptor\/fibroblast growth factor 15 axis improves alcoholic liver disease in mice","volume":"67","author":"Hartmann","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib39","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/hep.26976","article-title":"Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia\/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection","volume":"59","author":"Huang","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib40","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.3389\/fmicb.2018.03166","article-title":"Disorganized gut microbiome contributed to liver cirrhosis progression: a meta-omics-based study","volume":"9","author":"Shao","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib41","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1136\/gut.45.3.416","article-title":"Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1alpha in alcoholic liver disease","volume":"45","author":"Fisher","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib42","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1053\/j.gastro.2009.01.056","article-title":"Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis","volume":"136","author":"Dominguez","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib43","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/(SICI)1096-9896(199809)186:1<82::AID-PATH151>3.0.CO;2-D","article-title":"Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis","volume":"186","author":"Afford","year":"1998","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib44","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1002\/hep.24599","article-title":"An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice","volume":"54","author":"Mandrekar","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib45","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/hep4.1448","article-title":"Ablation of Hmgb1 in intestinal epithelial cells causes intestinal lipid accumulation and reduces NASH in mice","volume":"4","author":"Gaskell","year":"2020","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib46","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jhep.2023.11.005","article-title":"Redox-sensitive high-mobility group box-1 isoforms contribute to liver fibrosis progression and resolution in mice","volume":"80","author":"Ge","year":"2024","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib47","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/hep.24701","article-title":"Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin alpha(V)beta(3) engagement and PI3K\/pAkt\/NFkappaB signaling","volume":"55","author":"Urtasun","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib48","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1136\/gutjnl-2013-306373","article-title":"Osteopontin induces ductular reaction contributing to liver fibrosis","volume":"63","author":"Wang","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib49","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/hep.26931","article-title":"Osteopontin binding to lipopolysaccharide lowers tumor necrosis factor-alpha and prevents early alcohol-induced liver injury in mice","volume":"59","author":"Ge","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib50","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/gene.1030","article-title":"Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line","volume":"30","author":"Constien","year":"2001","journal-title":"Genesis"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib51","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1053\/j.gastro.2012.05.053","article-title":"Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice","volume":"143","author":"Sodhi","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib52","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1530-0277.1982.tb05017.x","article-title":"The feeding of alcohol in liquid diets: two decades of applications and 1982 update","volume":"6","author":"Lieber","year":"1982","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib53","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/gt.2013.53","article-title":"Liver-directed adeno-associated virus serotype 8 gene transfer rescues a lethal murine model of citrullinemia type 1","volume":"20","author":"Chandler","year":"2013","journal-title":"Gene Ther"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib54","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.gene.2012.07.009","article-title":"Human thyroxine binding globulin (TBG) promoter directs efficient and sustaining transgene expression in liver-specific pattern","volume":"506","author":"Yan","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib55","first-page":"4557","article-title":"A\u00a0guide to histomorphological evaluation of intestinal inflammation in mouse models","volume":"7","author":"Erben","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib56","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1002\/hep.21427","article-title":"Oxidative-stress and IL-6 mediate the fibrogenic effects of [corrected] Kupffer cells on stellate cells","volume":"44","author":"Nieto","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib57","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1002\/hep.22592","article-title":"Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanisms","volume":"48","author":"Cubero","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2024.05.010_bib58","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat Protoc"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X24001164?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X24001164?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:10:14Z","timestamp":1729123814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X24001164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"alternative-id":["S2352345X24001164"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2024.05.010","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Protein Complex of Liver Origin Activates a Pro-inflammatory Program That Drives Hepatic and Intestinal Injury in Alcohol-Associated Liver Disease","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2024.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}],"article-number":"101362"}}