{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:39:05Z","timestamp":1789623545525,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":105,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA268426"],"award-info":[{"award-number":["R01CA268426"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["T32CA009672"],"award-info":[{"award-number":["T32CA009672"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK128102"],"award-info":[{"award-number":["R01DK128102"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX005777"],"award-info":[{"award-number":["I01BX005777"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.jcmgh.2025.101520","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T03:02:19Z","timestamp":1745290939000},"page":"101520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["IL-22BP Modulates Injury in Acute Pancreatitis but Delays Tissue Recovery in Chronic Pancreatitis"],"prefix":"10.1016","volume":"19","author":[{"given":"Lei","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Spiteri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Pasca","family":"Di Magliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto C.","family":"Olivei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake J.","family":"McGue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5987-0404","authenticated-orcid":false,"given":"Timothy L.","family":"Frankel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2025.101520_bib1","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1053\/j.gastro.2007.01.055","article-title":"Acute pancreatitis: bench to the bedside","volume":"132","author":"Pandol","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101520_bib2","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1053\/j.gastro.2010.06.010","article-title":"Organ failure and infection of pancreatic necrosis as determinants of mortality in patients with acute pancreatitis","volume":"139","author":"Petrov","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101520_bib3","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1053\/j.gastro.2007.03.001","article-title":"Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy","volume":"132","author":"Witt","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101520_bib4","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1053\/j.gastro.2013.01.069","article-title":"Genetic risk factors for pancreatic disorders","volume":"144","author":"Whitcomb","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101520_bib5","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1053\/j.gastro.2016.09.064","article-title":"Aryl hydrocarbon receptor ligands in cigarette smoke induce production of interleukin-22 to promote pancreatic fibrosis in models of chronic pancreatitis","volume":"151","author":"Xue","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101520_bib6","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1053\/j.gastro.2007.09.009","article-title":"In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia","volume":"133","author":"Strobel","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101520_bib7","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1053\/j.gastro.2004.12.008","article-title":"Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration","volume":"128","author":"Jensen","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101520_bib8","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1146\/annurev-immunol-032414-112123","article-title":"Interleukin-22: immunobiology and pathology","volume":"33","author":"Dudakov","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/apm.13221","article-title":"Role of IL-22 in homeostasis and diseases of the skin","volume":"130","author":"Lopez","year":"2022","journal-title":"APMIS"},{"key":"10.1016\/j.jcmgh.2025.101520_bib10","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ni.2025","article-title":"Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22","volume":"12","author":"Sonnenberg","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib11","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.20102149","article-title":"Memory\/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology","volume":"208","author":"Kamanaka","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.jcmgh.2025.101520_bib12","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1038\/aps.2014.91","article-title":"Interleukin-22 exacerbates airway inflammation induced by short-term exposure to cigarette smoke in mice","volume":"35","author":"Li","year":"2014","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jcmgh.2025.101520_bib13","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1053\/j.gastro.2019.12.010","article-title":"Interleukin 22 signaling regulates acinar cell plasticity to promote pancreatic tumor development in mice","volume":"158","author":"Perusina Lanfranca","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101520_bib14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00109-009-0457-0","article-title":"IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not","volume":"87","author":"Wolk","year":"2009","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.jcmgh.2025.101520_bib15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.7150\/ijbs.3967","article-title":"Interleukin-22 ameliorates cerulein-induced pancreatitis in mice by inhibiting the autophagic pathway","volume":"8","author":"Feng","year":"2012","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jcmgh.2025.101520_bib16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4291\/wjgp.v7.i1.108","article-title":"Mechanisms of interleukin-22\u2019s beneficial effects in acute pancreatitis","volume":"7","author":"Huan","year":"2016","journal-title":"World J Gastrointest Pathophysiol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib17","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1053\/j.gastro.2012.08.051","article-title":"Aryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitis","volume":"143","author":"Xue","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101520_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.766586","article-title":"IL-22 binding protein (IL-22BP) in the regulation of IL-22 biology","volume":"12","author":"Zenewicz","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib19","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.str.2008.06.005","article-title":"Structure of IL-22 bound to its high-affinity IL-22R1 chain","volume":"16","author":"Jones","year":"2008","journal-title":"Structure"},{"key":"10.1016\/j.jcmgh.2025.101520_bib20","doi-asserted-by":"crossref","first-page":"9511","DOI":"10.1073\/pnas.171303198","article-title":"A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist","volume":"98","author":"Xu","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2025.101520_bib21","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.immuni.2020.10.012","article-title":"Group 3 innate lymphoid cells program a distinct subset of IL-22BP-producing dendritic cells demarcating solitary intestinal lymphoid tissues","volume":"53","author":"Guendel","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jcmgh.2025.101520_bib22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/mi.2013.28","article-title":"Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid","volume":"7","author":"Martin","year":"2014","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature11535","article-title":"IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine","volume":"491","author":"Huber","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2025.101520_bib24","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.3390\/cells9102205","article-title":"Microbiota-dependent effects of IL-22","volume":"9","author":"Sabihi","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jcmgh.2025.101520_bib25","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/mi.2015.83","article-title":"IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis","volume":"9","author":"Martin","year":"2016","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.aah5903","article-title":"A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease","volume":"354","author":"Pelczar","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jcmgh.2025.101520_bib27","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00550-19","article-title":"Interleukin-22 (IL-22) binding protein constrains IL-22 activity, host defense, and oxidative phosphorylation genes during pneumococcal pneumonia","volume":"87","author":"Trevejo-Nunez","year":"2019","journal-title":"Infect Immun"},{"key":"10.1016\/j.jcmgh.2025.101520_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jcmgh.2016.09.009","article-title":"Mitogen-activated protein kinase kinase activity maintains acinar-to-ductal metaplasia and is required for organ regeneration in pancreatitis","volume":"3","author":"Halbrook","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib29","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/j.yexcr.2009.01.009","article-title":"Prosurvival Bcl-2 proteins stabilize pancreatic mitochondria and protect against necrosis in experimental pancreatitis","volume":"315","author":"Sung","year":"2009","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jcmgh.2025.101520_bib30","first-page":"517","article-title":"Action of secretagogues on a new preparation of functionally intact, isolated pancreatic acini","volume":"235","author":"Williams","year":"1978","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib31","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1053\/j.gastro.2017.08.071","article-title":"Autophagy, inflammation, and immune dysfunction in the pathogenesis of pancreatitis","volume":"153","author":"Gukovskaya","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101520_bib32","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1006\/jsre.2002.6387","article-title":"Coordinate regulation of secretory stress proteins (PSP\/reg, PAP I, PAP II, and PAP III) in the rat exocrine pancreas during experimental acute pancreatitis","volume":"105","author":"Graf","year":"2002","journal-title":"J Surg Res"},{"key":"10.1016\/j.jcmgh.2025.101520_bib33","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.bbadis.2012.11.004","article-title":"Chemokines in tissue fibrosis","volume":"1832","author":"Sahin","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jcmgh.2025.101520_bib34","article-title":"Activated hepatic stellate cells induce infiltration and formation of CD163(+) macrophages via CCL2\/CCR2 pathway","volume":"8","author":"Xi","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jcmgh.2025.101520_bib35","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1158\/0008-5472.CAN-13-1558-T","article-title":"Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance","volume":"73","author":"Zhang","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2025.101520_bib36","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/jid.2012.463","article-title":"IL-22 promotes fibroblast-mediated wound repair in the skin","volume":"133","author":"McGee","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib37","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/gutjnl-2016-312078","article-title":"Myeloid cells are required for PD-1\/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer","volume":"66","author":"Zhang","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2025.101520_bib38","doi-asserted-by":"crossref","first-page":"7158","DOI":"10.1038\/ncomms8158","article-title":"Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis","volume":"6","author":"Xue","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2025.101520_bib39","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib40","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.yexcr.2010.12.017","article-title":"CXCR3 in T cell function","volume":"317","author":"Groom","year":"2011","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jcmgh.2025.101520_bib41","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1189\/jlb.0811443","article-title":"Neutrophil-derived matrix metalloproteinase-9 is a potent activator of trypsinogen in acinar cells in acute pancreatitis","volume":"91","author":"Awla","year":"2012","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41385-019-0206-9","article-title":"Targeting the IL-22\/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection","volume":"13","author":"Hebert","year":"2020","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11518-0","article-title":"Interleukin-22 level is negatively correlated with neutrophil recruitment in the lungs in a Pseudomonas aeruginosa pneumonia model","volume":"7","author":"Broquet","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2025.101520_bib44","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1084\/jem.20160770","article-title":"IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake","volume":"214","author":"Jinnohara","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.jcmgh.2025.101520_bib45","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/mi.2016.101","article-title":"Immunopathogenesis of pancreatitis","volume":"10","author":"Watanabe","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib46","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1440-1746.2011.06782.x","article-title":"Th17 cells are increased with severity of liver inflammation in patients with chronic hepatitis C","volume":"27","author":"Chang","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib47","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.3389\/fimmu.2018.01418","article-title":"Pivotal role of IL-22 binding protein in the epithelial autoregulation of interleukin-22 signaling in the control of skin inflammation","volume":"9","author":"Fukaya","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib48","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.4049\/jimmunol.1700021","article-title":"Limited presence of IL-22 binding protein, a natural IL-22 inhibitor, strengthens psoriatic skin inflammation","volume":"198","author":"Martin","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib49","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1084\/jem.20092054","article-title":"Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A","volume":"207","author":"Sonnenberg","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.jcmgh.2025.101520_bib50","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1038\/s41598-018-23510-3","article-title":"Regulation of IL-22BP in psoriasis","volume":"8","author":"Voglis","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2025.101520_bib51","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/eji.200535503","article-title":"IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis","volume":"36","author":"Wolk","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib52","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1053\/j.gastro.2011.06.051","article-title":"A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus","volume":"141","author":"Zhang","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101520_bib53","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.4049\/jimmunol.1700587","article-title":"A protective function of IL-22BP in ischemia reperfusion and acetaminophen-induced liver injury","volume":"199","author":"Kleinschmidt","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib54","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/hep.26916","article-title":"Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment","volume":"59","author":"Zhao","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2025.101520_bib55","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.4049\/jimmunol.1700155","article-title":"The development of steady-state activation hubs between adult LTi ILC3s and primed macrophages in small intestine","volume":"199","author":"Savage","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib56","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/gut.2006.105833","article-title":"Suppression of transforming growth factor beta signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations","volume":"56","author":"Wildi","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2025.101520_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2025.101520_bib58","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jcmgh.2019.05.006","article-title":"Myeloid cell-derived HB-EGF drives tissue recovery after pancreatitis","volume":"8","author":"Wen","year":"2019","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2025.101520_bib59","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.121932","article-title":"Spatial and phenotypic immune profiling of metastatic colon cancer","volume":"3","author":"Lazarus","year":"2018","journal-title":"JCI Insight"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X2500061X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X2500061X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T16:14:55Z","timestamp":1762618495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X2500061X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":59,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025]]}},"alternative-id":["S2352345X2500061X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2025.101520","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-22BP Modulates Injury in Acute Pancreatitis but Delays Tissue Recovery in Chronic Pancreatitis","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2025.101520","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}],"article-number":"101520"}}