{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:22:48Z","timestamp":1783488168253,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":111,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171750"],"award-info":[{"award-number":["82171750"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82150104"],"award-info":[{"award-number":["82150104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371771"],"award-info":[{"award-number":["82371771"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.jcmgh.2025.101528","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T19:20:03Z","timestamp":1745868003000},"page":"101528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["CMTM3 Promotes Colitis-associated Carcinogenesis via CLTC Stabilization and Modulation of VE-cadherin"],"prefix":"10.1016","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2715-429X","authenticated-orcid":false,"given":"Rongbin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingsu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingzhang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2025.101528_bib1","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1038\/s41388-023-02676-9","article-title":"Feedback activation of EGFR\/wild-type RAS signaling axis limits KRASG12D inhibitor efficacy in KRASG12D-mutated colorectal cancer","volume":"42","author":"Feng","year":"2023","journal-title":"Oncogene"},{"key":"10.1016\/j.jcmgh.2025.101528_bib2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1053\/j.gastro.2012.07.009","article-title":"Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation","volume":"143","author":"Chiba","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101528_bib3","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.gastro.2021.10.035","article-title":"Colorectal cancer in inflammatory bowel disease: mechanisms and management","volume":"162","author":"Shah","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101528_bib4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/carcin\/bgs006","article-title":"Inflammation, DNA methylation and colitis-associated cancer","volume":"33","author":"Hartnett","year":"2012","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jcmgh.2025.101528_bib5","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jcmgh.2025.101528_bib6","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrgastro.2015.150","article-title":"The global burden of IBD: from 2015 to 2025","volume":"12","author":"Kaplan","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2025.101528_bib7","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1126\/science.aad0135","article-title":"A gut-vascular barrier controls the systemic dissemination of bacteria","volume":"350","author":"Spadoni","year":"2015","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.jcmgh.2025.101528_bib8","first-page":"CD005392","article-title":"Anti-angiogenic therapies for metastatic colorectal cancer","author":"Wagner","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jcmgh.2025.101528_bib9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.canlet.2016.11.015","article-title":"CMTM3 decreases EGFR expression and EGF-mediated tumorigenicity by promoting Rab5 activity in gastric cancer","volume":"386","author":"Yuan","year":"2017","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jcmgh.2025.101528_bib10","doi-asserted-by":"crossref","first-page":"41092","DOI":"10.18632\/oncotarget.5732","article-title":"CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activation","volume":"6","author":"Liu","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jcmgh.2025.101528_bib11","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1161\/ATVBAHA.116.308792","article-title":"CMTM3 (CKLF-like marvel transmembrane domain 3) mediates angiogenesis by regulating cell surface availability of VE-cadherin in endothelial adherens junctions","volume":"37","author":"Chrifi","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcmgh.2025.101528_bib12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature23643","article-title":"CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity","volume":"549","author":"Burr","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2025.101528_bib13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13099-023-00533-4","article-title":"CMTM3 protects the gastric epithelial cells from apoptosis and promotes IL-8 by stabilizing NEMO during Helicobacter pylori infection","volume":"15","author":"Zhang","year":"2023","journal-title":"Gut Pathog"},{"key":"10.1016\/j.jcmgh.2025.101528_bib14","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.ccell.2023.08.008","article-title":"CMTM6 shapes antitumor T cell response through modulating protein expression of CD58 and PD-L1","volume":"41","author":"Miao","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jcmgh.2025.101528_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216585","article-title":"CMTM6 promotes hepatocellular carcinoma progression through stabilizing \u03b2-catenin","volume":"583","author":"Liu","year":"2024","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jcmgh.2025.101528_bib16","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.1158\/0008-5472.CAN-08-3694","article-title":"CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis","volume":"69","author":"Wang","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2025.101528_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2017.07.082","article-title":"DNA methylation of CMTM3, SSTR2, and MDFI genes in colorectal cancer","volume":"630","author":"Li","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.jcmgh.2025.101528_bib18","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1038\/onc.2017.23","article-title":"EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis","volume":"36","author":"Hardbower","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.jcmgh.2025.101528_bib19","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1053\/j.gastro.2017.03.053","article-title":"EGFR in tumor-associated myeloid cells promotes development of colorectal cancer in mice and associates with outcomes of patients","volume":"153","author":"Srivatsa","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101528_bib20","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1038\/s41401-023-01079-6","article-title":"Predictive biomarkers of immunotherapy response with pharmacological applications in solid tumors","volume":"44","author":"Kov\u00e1cs","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jcmgh.2025.101528_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s13402-022-00733-1","article-title":"In vivo study revealed pro-tumorigenic effect of CMTM3 in hepatocellular carcinoma involving the regulation of peroxisome proliferator-activated receptor gamma (PPAR\u03b3)","volume":"46","author":"Wang","year":"2023","journal-title":"Cell Oncol (Dordr)"},{"key":"10.1016\/j.jcmgh.2025.101528_bib22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.devcel.2013.08.020","article-title":"VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity","volume":"26","author":"Giannotta","year":"2013","journal-title":"Dev Cell"},{"key":"10.1016\/j.jcmgh.2025.101528_bib23","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1161\/ATVBAHA.116.307610","article-title":"Endothelial cell junctional adhesion molecules: role and regulation of expression in inflammation","volume":"36","author":"Reglero-Real","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcmgh.2025.101528_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107906","article-title":"Zinc finger protein St18 protects against septic death by inhibiting VEGF-A from macrophages","volume":"32","author":"Maruyama","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.jcmgh.2025.101528_bib25","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.1091\/mbc.e05-05-0440","article-title":"p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin","volume":"16","author":"Xiao","year":"2005","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jcmgh.2025.101528_bib26","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1091\/mbc.e08-07-0735","article-title":"p120-catenin inhibits VE-cadherin internalization through a Rho-independent mechanism","volume":"20","author":"Chiasson","year":"2009","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jcmgh.2025.101528_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1478-811X-11-37","article-title":"The C-terminus region of \u03b2-arrestin1 modulates VE-cadherin expression and endothelial cell permeability","volume":"11","author":"Hebda","year":"2013","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.jcmgh.2025.101528_bib28","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1172\/JCI124884","article-title":"IFN-\u03b3 drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption","volume":"129","author":"Langer","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jcmgh.2025.101528_bib29","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1161\/CIRCULATIONAHA.112.134304","article-title":"Effective treatment of edema and endothelial barrier dysfunction with imatinib","volume":"126","author":"Aman","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jcmgh.2025.101528_bib30","doi-asserted-by":"crossref","first-page":"L259","DOI":"10.1152\/ajplung.00323.2014","article-title":"Differential and opposing effects of imatinib on LPS- and ventilator-induced lung injury","volume":"308","author":"Letsiou","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jcmgh.2025.101528_bib31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/cas.12304","article-title":"CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer","volume":"105","author":"Su","year":"2014","journal-title":"Cancer Sci"},{"key":"10.1016\/j.jcmgh.2025.101528_bib32","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s12094-015-1288-9","article-title":"CMTM3 is reduced in prostate cancer and inhibits migration, invasion and growth of LNCaP cells","volume":"17","author":"Hu","year":"2015","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.jcmgh.2025.101528_bib33","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s12094-013-1092-3","article-title":"CMTM3 is frequently reduced in clear cell renal cell carcinoma and exhibits tumor suppressor activities","volume":"16","author":"Xie","year":"2014","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.jcmgh.2025.101528_bib34","article-title":"CMTM3 inhibits human testicular cancer cell growth through inducing cell-cycle arrest and apoptosis","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2025.101528_bib35","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1038\/s41467-021-25417-6","article-title":"PTEN\u03b1 functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer","volume":"12","author":"Sun","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2025.101528_bib36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1749-6632.2000.tb06320.x","article-title":"Molecular basis of angiogenesis. Role of VEGF and VE-cadherin","volume":"902","author":"Carmeliet","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jcmgh.2025.101528_bib37","doi-asserted-by":"crossref","first-page":"L419","DOI":"10.1152\/ajplung.2000.279.3.L419","article-title":"Mechanisms regulating endothelial cell barrier function","volume":"279","author":"Stevens","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jcmgh.2025.101528_bib38","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1038\/s41467-018-06568-5","article-title":"REV-ERB\u03b1 integrates colon clock with experimental colitis through regulation of NF-\u03baB\/NLRP3 axis","volume":"9","author":"Wang","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2025.101528_bib39","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1038\/s41467-019-10176-2","article-title":"Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2025.101528_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112944","article-title":"Huai hua san alleviates dextran sulphate sodium-induced colitis and modulates colonic microbiota","volume":"259","author":"Liu","year":"2020","journal-title":"J Ethnopharmacol"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X25000694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X25000694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T21:13:59Z","timestamp":1752614039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X25000694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025]]}},"alternative-id":["S2352345X25000694"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2025.101528","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CMTM3 Promotes Colitis-associated Carcinogenesis via CLTC Stabilization and Modulation of VE-cadherin","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2025.101528","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}],"article-number":"101528"}}