{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:00:46Z","timestamp":1783576846158,"version":"3.55.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":195,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG024824"],"award-info":[{"award-number":["P30AG024824"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK34933"],"award-info":[{"award-number":["DK34933"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["F31DK134183"],"award-info":[{"award-number":["F31DK134183"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001642","name":"Glenn Foundation for Medical Research","doi-asserted-by":"publisher","award":["R01CA148828"],"award-info":[{"award-number":["R01CA148828"]}],"id":[{"id":"10.13039\/100001642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001642","name":"Glenn Foundation for Medical Research","doi-asserted-by":"publisher","award":["R01CA245546"],"award-info":[{"award-number":["R01CA245546"]}],"id":[{"id":"10.13039\/100001642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001642","name":"Glenn Foundation for Medical Research","doi-asserted-by":"publisher","award":["R01DK095201"],"award-info":[{"award-number":["R01DK095201"]}],"id":[{"id":"10.13039\/100001642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["T32HD007505"],"award-info":[{"award-number":["T32HD007505"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.jcmgh.2025.101591","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T22:26:46Z","timestamp":1752964006000},"page":"101591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["FMO5 Plays a Sex-specific Role in Goblet Cell Maturation and Mucus Barrier Formation"],"prefix":"10.1016","volume":"19","author":[{"given":"Megan L.","family":"Schaller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline M.","family":"Sykes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Mecano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeet","family":"Solanki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Rebernick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa","family":"Beydoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amara","family":"Bugarin-Lapuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2487-4816","authenticated-orcid":false,"given":"Yatrik M.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott F.","family":"Leiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2025.101591_bib1","doi-asserted-by":"crossref","first-page":"15064","DOI":"10.1073\/pnas.0803124105","article-title":"The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria","volume":"105","author":"Johansson","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2025.101591_bib2","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1073\/pnas.1120269109","article-title":"Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin","volume":"109","author":"Ambort","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2025.101591_bib3","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1016\/j.jmb.2014.04.027","article-title":"Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain assembly","volume":"426","author":"Nilsson","year":"2014","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jcmgh.2025.101591_bib4","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1083\/jcb.85.3.626","article-title":"Mechanism of rapid mucus secretion in goblet cells stimulated by acetylcholine","volume":"85","author":"Specian","year":"1980","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jcmgh.2025.101591_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.gastro.2006.04.020","article-title":"Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection","volume":"131","author":"Van der Sluis","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101591_bib6","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/(SICI)1096-9896(199907)188:3<304::AID-PATH375>3.0.CO;2-A","article-title":"Defective post-transcriptional processing of MUC2 mucin in ulcerative colitis and in Crohn's disease increases detectability of the MUC2 protein core","volume":"188","author":"Hanski","year":"1999","journal-title":"J Pathol"},{"key":"10.1016\/j.jcmgh.2025.101591_bib7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1136\/gutjnl-2012-303207","article-title":"Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis","volume":"63","author":"Johansson","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2025.101591_bib8","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0022-3476(98)70145-3","article-title":"The sugar permeability test reflects disease activity in children and adolescents with inflammatory bowel disease","volume":"133","author":"Miki","year":"1998","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcmgh.2025.101591_bib9","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1126\/science.aac9257","article-title":"Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span","volume":"350","author":"Leiser","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jcmgh.2025.101591_bib10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/17425255.2017.1239718","article-title":"Drug metabolism by flavin-containing monooxygenases of human and mouse","volume":"13","author":"Phillips","year":"2017","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.jcmgh.2025.101591_bib11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.gene.2004.09.021","article-title":"The fmo genes of Caenorhabditis elegans and C. briggsae: characterisation, gene expression and comparative genomic analysis","volume":"346","author":"Petalcorin","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.jcmgh.2025.101591_bib12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1021\/tx00044a001","article-title":"Structural and catalytic properties of the mammalian flavin-containing monooxygenase","volume":"8","author":"Cashman","year":"1995","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jcmgh.2025.101591_bib13","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1124\/dmd.107.017384","volume":"35","author":"Kousba","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.jcmgh.2025.101591_bib14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41594-019-0347-2","article-title":"Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs","volume":"27","author":"Nicoll","year":"2020","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.jcmgh.2025.101591_bib15","unstructured":"The Human Protein Atlas-Fmo5. Accessed December 7, 2021."},{"key":"10.1016\/j.jcmgh.2025.101591_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bcp.2015.05.013","article-title":"The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing","volume":"96","author":"Gonzalez Malagon","year":"2015","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jcmgh.2025.101591_bib17","doi-asserted-by":"crossref","first-page":"21528","DOI":"10.1073\/pnas.1215849110","article-title":"Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila","volume":"109","author":"Rera","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2025.101591_bib18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-2172-13-41","article-title":"Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases","volume":"13","author":"Rose","year":"2012","journal-title":"BMC Immunol"},{"key":"10.1016\/j.jcmgh.2025.101591_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.62775","article-title":"NHR-49\/PPAR-\u03b1 and HLH-30\/TFEB cooperate for","volume":"10","author":"Wani","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.jcmgh.2025.101591_bib20","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1091\/mbc.e04-12-1061","article-title":"ACT-5 is an essential Caenorhabditis elegans actin required for intestinal microvilli formation","volume":"16","author":"MacQueen","year":"2005","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jcmgh.2025.101591_bib21","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41467-023-36181-0","article-title":"FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans","volume":"14","author":"Choi","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2025.101591_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3390\/jpm13020165","article-title":"Impact of female gender in inflammatory bowel diseases: a narrative review","volume":"13","author":"Lungaro","year":"2023","journal-title":"J Pers Med"},{"key":"10.1016\/j.jcmgh.2025.101591_bib23","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/aja.1001410407","article-title":"Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types","volume":"141","author":"Cheng","year":"1974","journal-title":"Am J Anat"},{"key":"10.1016\/j.jcmgh.2025.101591_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0016-5085(99)70222-2","article-title":"Clonal analysis of mouse intestinal epithelial progenitors","volume":"116","author":"Bjerknes","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101591_bib25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/00054725-200102000-00014","article-title":"Mechanisms and modulation of intestinal epithelial repair","volume":"7","author":"Dignass","year":"2001","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jcmgh.2025.101591_bib26","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1053\/j.gastro.2009.06.044","article-title":"The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium","volume":"137","author":"Gregorieff","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101591_bib27","doi-asserted-by":"crossref","first-page":"18857","DOI":"10.1074\/jbc.273.30.18857","article-title":"Dimerization of the human MUC2 mucin in the endoplasmic reticulum is followed by a N-glycosylation-dependent transfer of the mono- and dimers to the Golgi apparatus","volume":"273","author":"Asker","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcmgh.2025.101591_bib28","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1074\/jbc.M109060200","article-title":"Cloning and expression of human core 1 beta1,3-galactosyltransferase","volume":"277","author":"Ju","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcmgh.2025.101591_bib29","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s44318-023-00014-z","article-title":"The IRE1\u03b2-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells","volume":"43","author":"Neidhardt","year":"2024","journal-title":"EMBO J"},{"key":"10.1016\/j.jcmgh.2025.101591_bib30","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.febslet.2008.01.038","article-title":"RNase domains determine the functional difference between IRE1alpha and IRE1beta","volume":"582","author":"Imagawa","year":"2008","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jcmgh.2025.101591_bib31","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1053\/j.gastro.2018.06.043","article-title":"Sex-based differences in incidence of inflammatory bowel diseases-pooled analysis of population-based studies from western countries","volume":"155","author":"Shah","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101591_bib32","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.8061","article-title":"Identification of genes and functional coexpression modules closely related to ulcerative colitis by gene datasets analysis","volume":"7","author":"Zhu","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.jcmgh.2025.101591_bib33","first-page":"4557","article-title":"A guide to histomorphological evaluation of intestinal inflammation in mouse models","volume":"7","author":"Erben","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.jcmgh.2025.101591_bib34","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/ibd.21048","article-title":"World Gastroenterology Organization Practice Guidelines for the diagnosis and management of IBD in 2010","volume":"16","author":"Bernstein","year":"2010","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jcmgh.2025.101591_bib35","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0016-5085(98)70259-8","article-title":"Prostaglandins prevent decreased epithelial cell proliferation associated with dextran sodium sulfate injury in mice","volume":"115","author":"Tessner","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101591_bib36","doi-asserted-by":"crossref","first-page":"100851","DOI":"10.1016\/j.disamonth.2019.02.004","article-title":"A comprehensive review and update on ulcerative colitis","volume":"65","author":"Gajendran","year":"2019","journal-title":"Dis Mon"},{"key":"10.1016\/j.jcmgh.2025.101591_bib37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/jcp.43.2.143","article-title":"Mucin depletion in inflammatory bowel disease","volume":"43","author":"McCormick","year":"1990","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jcmgh.2025.101591_bib38","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMra1102942","article-title":"Ulcerative colitis","volume":"365","author":"Danese","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcmgh.2025.101591_bib39","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.7150\/ijbs.28576","article-title":"SRC-3 protects intestine from DSS-induced colitis by inhibiting inflammation and promoting goblet cell differentiation through enhancement of KLF4 expression","volume":"14","author":"Chen","year":"2018","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jcmgh.2025.101591_bib40","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1053\/j.gastro.2008.11.036","article-title":"Suppression of apoptosis, crypt hyperplasia, and altered differentiation in the colonic epithelia of bak-null mice","volume":"136","author":"Duckworth","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101591_bib41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S1286-4579(01)01387-9","article-title":"Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia","volume":"3","author":"Luperchio","year":"2001","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jcmgh.2025.101591_bib42","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1136\/gut.2.2.110","article-title":"The turnover and shedding of epithelial cells. I. The turnover in the gastro-intestinal tract","volume":"2","author":"Creamer","year":"1961","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2025.101591_bib43","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1124\/dmd.117.076612","article-title":"Identification of flavin-containing monooxygenase 5 (FMO5) as a regulator of glucose homeostasis and a potential sensor of gut bacteria","volume":"45","author":"Scott","year":"2017","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.jcmgh.2025.101591_bib44","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1371\/journal.pmed.0050054","article-title":"Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis","volume":"5","author":"Heazlewood","year":"2008","journal-title":"PLoS Med"},{"key":"10.1016\/j.jcmgh.2025.101591_bib45","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1126\/science.1069094","article-title":"Colorectal cancer in mice genetically deficient in the mucin Muc2","volume":"295","author":"Velcich","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jcmgh.2025.101591_bib46","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.cell.2015.10.072","article-title":"Epithelial IL-18 equilibrium controls barrier function in colitis","volume":"163","author":"Nowarski","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2025.101591_bib47","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/gut.35.3.353","article-title":"Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis","volume":"35","author":"Pullan","year":"1994","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2025.101591_bib48","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1742-1241.2007.01665.x","article-title":"Thickness and continuity of the adherent colonic mucus barrier in active and quiescent ulcerative colitis and Crohn\u2019s disease","volume":"62","author":"Strugala","year":"2008","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.jcmgh.2025.101591_bib49","first-page":"79","article-title":"Differential diagnosis of Crohn\u2019s disease of the colon from ulcerative colitis: ultrastructure study with the scanning electron microscope","volume":"8","author":"Trabucchi","year":"1986","journal-title":"Int J Tissue React"},{"key":"10.1016\/j.jcmgh.2025.101591_bib50","doi-asserted-by":"crossref","first-page":"G582","DOI":"10.1152\/ajpgi.00218.2013","article-title":"\u03b3\u03b4 T-cell-deficient mice show alterations in mucin expression, glycosylation, and goblet cells but maintain an intact mucus layer","volume":"306","author":"Kober","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2025.101591_bib51","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201904048","article-title":"IRE1\u03b2 negatively regulates IRE1\u03b1 signaling in response to endoplasmic reticulum stress","volume":"219","author":"Grey","year":"2020","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jcmgh.2025.101591_bib52","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.chom.2023.01.006","article-title":"Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress","volume":"31","author":"Naama","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jcmgh.2025.101591_bib53","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-3-642-20792-1_6","article-title":"Generation of transgenic mice by pronuclear microinjection in advanced protocols for animal transgenesis: an ISTT manual","author":"Becker","year":"2011","journal-title":"Springer Protocols: Sroinger-Verlag"},{"key":"10.1016\/j.jcmgh.2025.101591_bib54","doi-asserted-by":"crossref","first-page":"G98","DOI":"10.1152\/ajpgi.00081.2019","article-title":"Temporal induction of intestinal epithelial hypoxia-inducible factor-2\u03b1 is sufficient to drive colitis","volume":"317","author":"Solanki","year":"2019","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2025.101591_bib55","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/s42255-021-00406-7","article-title":"Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells","volume":"3","author":"Schwartz","year":"2021","journal-title":"Nat Metab"},{"key":"10.1016\/j.jcmgh.2025.101591_bib56","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143691","article-title":"HIF-2\u03b1 activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron","volume":"131","author":"Singhal","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jcmgh.2025.101591_bib57","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/cpmo.2","article-title":"Intestinal preparation techniques for histological analysis in the mouse","volume":"6","author":"Williams","year":"2016","journal-title":"Curr Protoc Mouse Biol"},{"key":"10.1016\/j.jcmgh.2025.101591_bib58","series-title":"Histology, Staining","author":"Gurina","year":"2023"},{"key":"10.1016\/j.jcmgh.2025.101591_bib59","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1136\/gut.40.6.782","article-title":"Histochemistry of the surface mucous gel layer of the human colon","volume":"40","author":"Matsuo","year":"1997","journal-title":"Gut"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X25001328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X25001328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T17:35:38Z","timestamp":1772904938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X25001328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":59,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025]]}},"alternative-id":["S2352345X25001328"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2025.101591","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.04.05.588360","asserted-by":"object"}]},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FMO5 Plays a Sex-specific Role in Goblet Cell Maturation and Mucus Barrier Formation","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2025.101591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2025.101585","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}],"article-number":"101591"}}