{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:37:25Z","timestamp":1786991845002,"version":"build-2736575974"},"reference-count":60,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["YA 721\/3-1"],"award-info":[{"award-number":["YA 721\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000963","name":"American Diabetes Association Research Foundation","doi-asserted-by":"publisher","award":["ID123839"],"award-info":[{"award-number":["ID123839"]}],"id":[{"id":"10.13039\/100000963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000963","name":"American Diabetes Association Research Foundation","doi-asserted-by":"publisher","award":["7-22-IBSPM-05"],"award-info":[{"award-number":["7-22-IBSPM-05"]}],"id":[{"id":"10.13039\/100000963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006808","name":"University of North Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK104828"],"award-info":[{"award-number":["R01 DK104828"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R44 131770"],"award-info":[{"award-number":["R44 131770"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P01 DK094779"],"award-info":[{"award-number":["P01 DK094779"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T32 DK007737"],"award-info":[{"award-number":["T32 DK007737"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK131526"],"award-info":[{"award-number":["R01 DK131526"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK109559"],"award-info":[{"award-number":["R01 DK109559"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 DK034987"],"award-info":[{"award-number":["P30 DK034987"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK136262"],"award-info":[{"award-number":["R01 DK136262"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK138462"],"award-info":[{"award-number":["R01 DK138462"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK135688"],"award-info":[{"award-number":["R01 DK135688"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["L40 AI147229"],"award-info":[{"award-number":["L40 AI147229"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011684","name":"Crohn's and Colitis Foundation of America","doi-asserted-by":"publisher","award":["567497"],"award-info":[{"award-number":["567497"]}],"id":[{"id":"10.13039\/100011684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA016086"],"award-info":[{"award-number":["P30 CA016086"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007028","name":"Leona M and Harry B Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K08 AI175655"],"award-info":[{"award-number":["K08 AI175655"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.jcmgh.2025.101618","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T23:13:27Z","timestamp":1756336407000},"page":"101618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Myeloid Cell Adhesion Molecule 1 (CADM1) Promotes Proinflammatory Signaling in Human Inflammatory Bowel Diseases"],"prefix":"10.1016","volume":"20","author":[{"given":"Kimberly C.","family":"Darlington","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria J.","family":"Shumway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandan","family":"Sona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zena","family":"Khaled","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin C.","family":"Steinbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Gartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn M.","family":"Clough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina C.","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaghan Kennedy","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"VanLandingham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Schaner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Silverstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwen","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Huan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Ching","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surekha","family":"Bantumilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brady","family":"Furey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezan A.","family":"Chaudhry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneera R.","family":"Kapadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.","family":"Sadiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Shanahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Rahbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Vilen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyun","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huidong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhawal","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzaffar","family":"Akram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maloy","family":"Mangada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Bain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1t\u00e9 Levente","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monirath","family":"Hav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesh","family":"Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence S.","family":"Furey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Sethupathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew N.","family":"Poy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4238-3674","authenticated-orcid":false,"given":"Shehzad Z.","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2025.101618_bib1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/07853890701197615","article-title":"Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine","volume":"39","author":"Goyette","year":"2007","journal-title":"Ann Med"},{"key":"10.1016\/j.jcmgh.2025.101618_bib2","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jcmgh.2025.101618_bib3","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1056\/NEJMra2002697","article-title":"Pathophysiology of Inflammatory Bowel Diseases","volume":"383","author":"Chang","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcmgh.2025.101618_bib4","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1053\/j.gastro.2005.02.009","article-title":"Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with 2 different commensal bacteria","volume":"128","author":"Kim","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101618_bib5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrgastro.2015.186","article-title":"Immunopathogenesis of IBD: current state of the art","volume":"13","author":"de Souza","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.738762","article-title":"New insights on CD8(+) T cells in inflammatory bowel disease and therapeutic approaches","volume":"12","author":"Casalegno Garduno","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib7","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.immuni.2019.03.017","article-title":"Cytokine networks in the pathophysiology of inflammatory bowel disease","volume":"50","author":"Friedrich","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jcmgh.2025.101618_bib8","doi-asserted-by":"crossref","first-page":"34864","DOI":"10.1074\/jbc.M110.120865","article-title":"N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion","volume":"285","author":"Fogel","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcmgh.2025.101618_bib9","doi-asserted-by":"crossref","first-page":"12516","DOI":"10.1523\/JNEUROSCI.2739-07.2007","article-title":"SynCAMs organize synapses through heterophilic adhesion","volume":"27","author":"Fogel","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.jcmgh.2025.101618_bib10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1084\/jem.20130904","article-title":"CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection","volume":"211","author":"Cortez","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/j.jcmgh.2025.101618_bib11","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1073\/pnas.0810550106","article-title":"miR-375 maintains normal pancreatic alpha- and beta-cell mass","volume":"106","author":"Poy","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2025.101618_bib12","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.153136","article-title":"Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes","volume":"7","author":"Sona","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.jcmgh.2025.101618_bib13","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1182\/blood-2005-02-0817","article-title":"The tumor suppressor TSLC1\/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM","volume":"106","author":"Boles","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jcmgh.2025.101618_bib14","doi-asserted-by":"crossref","first-page":"G668","DOI":"10.1152\/ajpgi.00222.2021","article-title":"Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types","volume":"321","author":"Shanahan","year":"2021","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib15","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.cell.2019.06.029","article-title":"Intra- and inter-cellular rewiring of the human colon during ulcerative colitis","volume":"178","author":"Smillie","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2025.101618_bib16","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nn.4590","article-title":"Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1","volume":"20","author":"Rathjen","year":"2017","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jcmgh.2025.101618_bib17","first-page":"330","article-title":"[On the dermonecrotizing factor of the malioidosis agent]","volume":"13","author":"Stober","year":"1969","journal-title":"J Hyg Epidemiol Microbiol Immunol"},{"issue":"15.25","key":"10.1016\/j.jcmgh.2025.101618_bib18","first-page":"1","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr Protoc Immunol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3389\/fcell.2019.00111","article-title":"Urinary cell adhesion molecule 1 is a novel biomarker that links tubulointerstitial damage to glomerular filtration rates in chronic kidney disease","volume":"7","author":"Hagiyama","year":"2019","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib20","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.2353\/ajpath.2009.080743","article-title":"Expression of a soluble isoform of cell adhesion molecule 1 in the brain and its involvement in directional neurite outgrowth","volume":"174","author":"Hagiyama","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/srep46174","article-title":"Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation","volume":"7","author":"Shirakabe","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2025.101618_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100988","article-title":"Increased ectodomain shedding of cell adhesion molecule 1 from pancreatic islets in type 2 diabetic pancreata: correlation with hemoglobin A1c levels","volume":"9","author":"Inoue","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2025.101618_bib23","article-title":"BET protein inhibition regulates macrophage chromatin accessibility and microbiota-dependent colitis","volume":"13","author":"Hoffner O'Connor","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib24","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1002\/eji.201546237","article-title":"Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses","volume":"46","author":"Simon","year":"2016","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib25","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/MOG.0b013e32833d4b71","article-title":"The role of the macrophage in sentinel responses in intestinal immunity","volume":"26","author":"Sheikh","year":"2010","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib26","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41575-019-0118-x","article-title":"Redefining the IBDs using genome-scale molecular phenotyping","volume":"16","author":"Furey","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jcmgh.2025.101618_bib28","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jneuroim.2012.05.016","article-title":"Cell adhesion molecule 1 (CADM1) on mast cells promotes interaction with dorsal root ganglion neurites by heterophilic binding to nectin-3","volume":"250","author":"Furuno","year":"2012","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib29","doi-asserted-by":"crossref","first-page":"6934","DOI":"10.4049\/jimmunol.174.11.6934","article-title":"The spermatogenic Ig superfamily\/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves","volume":"174","author":"Furuno","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib30","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.immuni.2023.01.002","article-title":"The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon","volume":"56","author":"Kong","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.jcmgh.2025.101618_bib31","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.168800","article-title":"Aberrant miR-29 is a predictive feature of severe phenotypes in pediatric Crohn's disease","volume":"9","author":"Shumway","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.jcmgh.2025.101618_bib32","doi-asserted-by":"crossref","first-page":"5834","DOI":"10.4049\/jimmunol.1100922","article-title":"Selective upregulation of microRNA expression in peripheral blood leukocytes in IL-10-\/- mice precedes expression in the colon","volume":"187","author":"Schaefer","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib33","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41575-022-00658-y","article-title":"The metabolic nature of inflammatory bowel diseases","volume":"19","author":"Adolph","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib34","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.3390\/ijms19082299","article-title":"Contribution of STAT3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment","volume":"19","author":"Kasembeli","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2025.101618_bib35","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/ibd.21884","article-title":"New insights into the role of STAT3 in IBD","volume":"18","author":"Li","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jcmgh.2025.101618_bib36","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.3748\/wjg.14.5110","article-title":"Role of STAT3 in inflammatory bowel disease","volume":"14","author":"Sugimoto","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib37","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00054725-200502000-00001","article-title":"Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation","volume":"11","author":"Musso","year":"2005","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jcmgh.2025.101618_bib38","doi-asserted-by":"crossref","first-page":"16777","DOI":"10.1074\/jbc.M207999200","article-title":"Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease","volume":"278","author":"Lovato","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcmgh.2025.101618_bib39","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nri3799","article-title":"Balancing natural killer cell activation through paired receptors","volume":"15","author":"Martinet","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib40","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3389\/fimmu.2017.00194","article-title":"CD4 CTL, a cytotoxic subset of CD4(+) T cells, their differentiation and function","volume":"8","author":"Takeuchi","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat Methods"},{"key":"10.1016\/j.jcmgh.2025.101618_bib42","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinform"},{"key":"10.1016\/j.jcmgh.2025.101618_bib43","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib44","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/nbt.2931","article-title":"Normalization of RNA-seq data using factor analysis of control genes or samples","volume":"32","author":"Risso","year":"2014","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib45","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jcmgh.2025.101618_bib46","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1002\/cpz1.90","article-title":"Gene set knowledge discovery with Enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr Protoc"},{"key":"10.1016\/j.jcmgh.2025.101618_bib47","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1515\/jib-2016-307","article-title":"miRquant 2.0: an expanded tool for accurate annotation and quantification of microRNAs and their isomiRs from small RNA-sequencing data","volume":"13","author":"Kanke","year":"2016","journal-title":"J Integr Bioinform"},{"key":"10.1016\/j.jcmgh.2025.101618_bib48","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jcmgh.2025.101618_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000386","article-title":"SHRiMP: accurate mapping of short color-space reads","volume":"5","author":"Rumble","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib50","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biology"},{"key":"10.1016\/j.jcmgh.2025.101618_bib51","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.jcmgh.2025.101618_bib52","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.jcmgh.2025.101618_bib53","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/s41374-020-0417-4","article-title":"Multiplexed ion beam imaging (MIBI) for characterization of the tumor microenvironment across tumor types","volume":"100","author":"Ptacek","year":"2020","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2025.101618_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2025.101618_bib55","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib56","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3389\/fmicb.2016.00868","article-title":"Effect of a ropy exopolysaccharide-producing bifidobacterium animalis subsp. lactis strain orally administered on DSS-induced colitis mice model","volume":"7","author":"Hidalgo-Cantabrana","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jcmgh.2025.101618_bib57","doi-asserted-by":"crossref","first-page":"260","DOI":"10.15430\/JCP.2015.20.4.260","article-title":"Adequate dextran sodium sulfate-induced colitis model in mice and effective outcome measurement method","volume":"20","author":"Park","year":"2015","journal-title":"J Cancer Prev"},{"key":"10.1016\/j.jcmgh.2025.101618_bib58","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1053\/gast.2002.1231527","article-title":"Rapid development of colitis in NSAID-treated IL-10-deficient mice","volume":"123","author":"Berg","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101618_bib59","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/ijc.2910350211","article-title":"Transfection by human oncogenes: concomitant induction of tumorigenicity and tumor-associated membrane alterations","volume":"35","author":"Collard","year":"1985","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jcmgh.2025.101618_bib60","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1038\/sj.onc.1207761","article-title":"Cloning of a soluble isoform of the SgIGSF adhesion molecule that binds the extracellular domain of the membrane-bound isoform","volume":"23","author":"Koma","year":"2004","journal-title":"Oncogene"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X25001596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X25001596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T08:19:38Z","timestamp":1765786778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X25001596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"alternative-id":["S2352345X25001596"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2025.101618","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myeloid Cell Adhesion Molecule 1 (CADM1) Promotes Proinflammatory Signaling in Human Inflammatory Bowel Diseases","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2025.101618","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}],"article-number":"101618"}}